Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7S7_LEIDO

TriTrypDb:

LdBPK_322900.1 , LdCL_320034900 , LDHU3_32.3670

Length:

872

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7S7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.480
CLV_C14_Caspase3-7	403	407	PF00656	0.691
CLV_C14_Caspase3-7	42	46	PF00656	0.736
CLV_C14_Caspase3-7	443	447	PF00656	0.579
CLV_C14_Caspase3-7	591	595	PF00656	0.702
CLV_C14_Caspase3-7	650	654	PF00656	0.744
CLV_C14_Caspase3-7	76	80	PF00656	0.625
CLV_C14_Caspase3-7	771	775	PF00656	0.670
CLV_NRD_NRD_1	138	140	PF00675	0.638
CLV_NRD_NRD_1	216	218	PF00675	0.649
CLV_NRD_NRD_1	28	30	PF00675	0.803
CLV_NRD_NRD_1	288	290	PF00675	0.704
CLV_NRD_NRD_1	432	434	PF00675	0.555
CLV_NRD_NRD_1	48	50	PF00675	0.705
CLV_NRD_NRD_1	501	503	PF00675	0.505
CLV_NRD_NRD_1	624	626	PF00675	0.691
CLV_NRD_NRD_1	7	9	PF00675	0.665
CLV_NRD_NRD_1	856	858	PF00675	0.682
CLV_PCSK_KEX2_1	137	139	PF00082	0.650
CLV_PCSK_KEX2_1	216	218	PF00082	0.644
CLV_PCSK_KEX2_1	27	29	PF00082	0.861
CLV_PCSK_KEX2_1	288	290	PF00082	0.702
CLV_PCSK_KEX2_1	432	434	PF00082	0.555
CLV_PCSK_KEX2_1	48	50	PF00082	0.705
CLV_PCSK_KEX2_1	501	503	PF00082	0.507
CLV_PCSK_KEX2_1	508	510	PF00082	0.595
CLV_PCSK_KEX2_1	624	626	PF00082	0.691
CLV_PCSK_KEX2_1	856	858	PF00082	0.555
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.627
CLV_PCSK_SKI1_1	216	220	PF00082	0.608
CLV_PCSK_SKI1_1	517	521	PF00082	0.568
CLV_PCSK_SKI1_1	9	13	PF00082	0.669
CLV_Separin_Metazoa	111	115	PF03568	0.663
CLV_Separin_Metazoa	413	417	PF03568	0.665
DEG_COP1_1	342	352	PF00400	0.489
DEG_SCF_FBW7_1	11	18	PF00400	0.785
DEG_SCF_FBW7_2	329	334	PF00400	0.413
DEG_SCF_TRCP1_1	439	444	PF00400	0.589
DEG_SPOP_SBC_1	145	149	PF00917	0.640
DEG_SPOP_SBC_1	15	19	PF00917	0.720
DEG_SPOP_SBC_1	699	703	PF00917	0.560
DOC_CKS1_1	102	107	PF01111	0.707
DOC_CKS1_1	12	17	PF01111	0.785
DOC_CKS1_1	176	181	PF01111	0.723
DOC_CYCLIN_RxL_1	3	14	PF00134	0.666
DOC_CYCLIN_yCln2_LP_2	176	182	PF00134	0.629
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.654
DOC_MAPK_gen_1	764	772	PF00069	0.669
DOC_MAPK_gen_1	856	865	PF00069	0.478
DOC_PP4_FxxP_1	109	112	PF00568	0.658
DOC_USP7_MATH_1	112	116	PF00917	0.701
DOC_USP7_MATH_1	146	150	PF00917	0.710
DOC_USP7_MATH_1	15	19	PF00917	0.739
DOC_USP7_MATH_1	161	165	PF00917	0.708
DOC_USP7_MATH_1	233	237	PF00917	0.498
DOC_USP7_MATH_1	527	531	PF00917	0.649
DOC_USP7_MATH_1	538	542	PF00917	0.682
DOC_USP7_MATH_1	588	592	PF00917	0.673
DOC_USP7_MATH_1	607	611	PF00917	0.859
DOC_USP7_MATH_1	634	638	PF00917	0.701
DOC_USP7_MATH_1	749	753	PF00917	0.719
DOC_USP7_MATH_1	75	79	PF00917	0.801
DOC_USP7_MATH_1	826	830	PF00917	0.783
DOC_WW_Pin1_4	101	106	PF00397	0.738
DOC_WW_Pin1_4	11	16	PF00397	0.670
DOC_WW_Pin1_4	113	118	PF00397	0.629
DOC_WW_Pin1_4	129	134	PF00397	0.685
DOC_WW_Pin1_4	175	180	PF00397	0.690
DOC_WW_Pin1_4	197	202	PF00397	0.786
DOC_WW_Pin1_4	22	27	PF00397	0.688
DOC_WW_Pin1_4	298	303	PF00397	0.688
DOC_WW_Pin1_4	327	332	PF00397	0.450
DOC_WW_Pin1_4	43	48	PF00397	0.613
DOC_WW_Pin1_4	573	578	PF00397	0.709
DOC_WW_Pin1_4	584	589	PF00397	0.642
DOC_WW_Pin1_4	595	600	PF00397	0.698
DOC_WW_Pin1_4	624	629	PF00397	0.675
DOC_WW_Pin1_4	665	670	PF00397	0.775
DOC_WW_Pin1_4	791	796	PF00397	0.675
LIG_14-3-3_CanoR_1	138	146	PF00244	0.789
LIG_14-3-3_CanoR_1	21	26	PF00244	0.793
LIG_14-3-3_CanoR_1	297	302	PF00244	0.598
LIG_14-3-3_CanoR_1	37	47	PF00244	0.560
LIG_14-3-3_CanoR_1	432	436	PF00244	0.688
LIG_14-3-3_CanoR_1	48	54	PF00244	0.539
LIG_14-3-3_CanoR_1	481	490	PF00244	0.518
LIG_14-3-3_CanoR_1	501	505	PF00244	0.360
LIG_14-3-3_CanoR_1	608	615	PF00244	0.736
LIG_14-3-3_CanoR_1	684	690	PF00244	0.674
LIG_14-3-3_CanoR_1	806	813	PF00244	0.713
LIG_Actin_WH2_2	417	434	PF00022	0.658
LIG_APCC_ABBA_1	208	213	PF00400	0.608
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BIR_III_4	594	598	PF00653	0.750
LIG_BRCT_BRCA1_1	114	118	PF00533	0.666
LIG_BRCT_BRCA1_1	768	772	PF00533	0.699
LIG_BRCT_BRCA1_1	775	779	PF00533	0.596
LIG_EVH1_2	105	109	PF00568	0.670
LIG_FHA_1	139	145	PF00498	0.699
LIG_FHA_1	183	189	PF00498	0.668
LIG_FHA_1	200	206	PF00498	0.637
LIG_FHA_1	331	337	PF00498	0.465
LIG_FHA_1	448	454	PF00498	0.718
LIG_FHA_1	455	461	PF00498	0.629
LIG_FHA_1	520	526	PF00498	0.752
LIG_FHA_1	808	814	PF00498	0.838
LIG_FHA_1	820	826	PF00498	0.643
LIG_FHA_1	860	866	PF00498	0.583
LIG_FHA_2	170	176	PF00498	0.639
LIG_FHA_2	246	252	PF00498	0.491
LIG_FHA_2	40	46	PF00498	0.744
LIG_FHA_2	401	407	PF00498	0.673
LIG_FHA_2	441	447	PF00498	0.570
LIG_FHA_2	60	66	PF00498	0.763
LIG_FHA_2	707	713	PF00498	0.724
LIG_FHA_2	74	80	PF00498	0.717
LIG_GBD_Chelix_1	474	482	PF00786	0.656
LIG_Integrin_RGD_1	68	70	PF01839	0.697
LIG_LIR_Apic_2	107	112	PF02991	0.666
LIG_LIR_Gen_1	358	369	PF02991	0.452
LIG_LIR_Gen_1	456	465	PF02991	0.611
LIG_LIR_Nem_3	358	364	PF02991	0.453
LIG_PCNA_PIPBox_1	354	363	PF02747	0.551
LIG_PCNA_yPIPBox_3	354	366	PF02747	0.549
LIG_PDZ_Class_1	867	872	PF00595	0.688
LIG_SH2_NCK_1	13	17	PF00017	0.659
LIG_SH2_STAP1	854	858	PF00017	0.686
LIG_SH2_STAT3	476	479	PF00017	0.657
LIG_SH2_STAT5	108	111	PF00017	0.676
LIG_SH2_STAT5	13	16	PF00017	0.832
LIG_SH2_STAT5	211	214	PF00017	0.617
LIG_SH2_STAT5	54	57	PF00017	0.587
LIG_SH2_STAT5	556	559	PF00017	0.586
LIG_SH3_1	198	204	PF00018	0.584
LIG_SH3_2	133	138	PF14604	0.635
LIG_SH3_2	524	529	PF14604	0.774
LIG_SH3_3	130	136	PF00018	0.711
LIG_SH3_3	176	182	PF00018	0.657
LIG_SH3_3	198	204	PF00018	0.774
LIG_SH3_3	521	527	PF00018	0.714
LIG_SH3_3	560	566	PF00018	0.583
LIG_SH3_3	571	577	PF00018	0.584
LIG_SH3_3	626	632	PF00018	0.740
LIG_SH3_3	657	663	PF00018	0.713
LIG_SH3_3	710	716	PF00018	0.679
LIG_SH3_3	822	828	PF00018	0.570
LIG_SH3_3	844	850	PF00018	0.753
LIG_SUMO_SIM_anti_2	862	867	PF11976	0.526
LIG_SUMO_SIM_par_1	172	178	PF11976	0.611
LIG_SUMO_SIM_par_1	861	867	PF11976	0.526
LIG_TRAF2_1	423	426	PF00917	0.654
LIG_TRAF2_1	503	506	PF00917	0.670
LIG_Vh1_VBS_1	310	328	PF01044	0.533
LIG_WW_1	105	108	PF00397	0.737
LIG_WW_3	134	138	PF00397	0.532
LIG_WW_3	761	765	PF00397	0.812
MOD_CDC14_SPxK_1	25	28	PF00782	0.736
MOD_CDC14_SPxK_1	46	49	PF00782	0.598
MOD_CDK_SPK_2	22	27	PF00069	0.795
MOD_CDK_SPK_2	303	308	PF00069	0.610
MOD_CDK_SPK_2	43	48	PF00069	0.613
MOD_CDK_SPxK_1	22	28	PF00069	0.730
MOD_CDK_SPxK_1	43	49	PF00069	0.612
MOD_CDK_SPxxK_3	22	29	PF00069	0.798
MOD_CK1_1	107	113	PF00069	0.654
MOD_CK1_1	120	126	PF00069	0.671
MOD_CK1_1	2	8	PF00069	0.699
MOD_CK1_1	203	209	PF00069	0.730
MOD_CK1_1	306	312	PF00069	0.597
MOD_CK1_1	39	45	PF00069	0.688
MOD_CK1_1	440	446	PF00069	0.728
MOD_CK1_1	456	462	PF00069	0.558
MOD_CK1_1	573	579	PF00069	0.804
MOD_CK1_1	582	588	PF00069	0.648
MOD_CK1_1	590	596	PF00069	0.584
MOD_CK1_1	598	604	PF00069	0.636
MOD_CK1_1	668	674	PF00069	0.797
MOD_CK1_1	688	694	PF00069	0.664
MOD_CK1_1	775	781	PF00069	0.639
MOD_CK1_1	789	795	PF00069	0.738
MOD_CK1_1	805	811	PF00069	0.662
MOD_CK1_1	818	824	PF00069	0.590
MOD_CK2_1	169	175	PF00069	0.639
MOD_CK2_1	245	251	PF00069	0.543
MOD_CK2_1	297	303	PF00069	0.596
MOD_CK2_1	467	473	PF00069	0.595
MOD_CK2_1	490	496	PF00069	0.516
MOD_CK2_1	500	506	PF00069	0.511
MOD_CK2_1	59	65	PF00069	0.756
MOD_CK2_1	706	712	PF00069	0.668
MOD_CK2_1	775	781	PF00069	0.602
MOD_GlcNHglycan	148	151	PF01048	0.635
MOD_GlcNHglycan	190	193	PF01048	0.624
MOD_GlcNHglycan	274	277	PF01048	0.668
MOD_GlcNHglycan	293	296	PF01048	0.520
MOD_GlcNHglycan	38	41	PF01048	0.650
MOD_GlcNHglycan	389	392	PF01048	0.594
MOD_GlcNHglycan	4	7	PF01048	0.702
MOD_GlcNHglycan	439	442	PF01048	0.547
MOD_GlcNHglycan	538	541	PF01048	0.718
MOD_GlcNHglycan	559	562	PF01048	0.616
MOD_GlcNHglycan	570	573	PF01048	0.637
MOD_GlcNHglycan	582	585	PF01048	0.754
MOD_GlcNHglycan	609	612	PF01048	0.796
MOD_GlcNHglycan	615	618	PF01048	0.734
MOD_GlcNHglycan	638	641	PF01048	0.700
MOD_GlcNHglycan	73	76	PF01048	0.810
MOD_GlcNHglycan	734	737	PF01048	0.763
MOD_GSK3_1	11	18	PF00069	0.670
MOD_GSK3_1	113	120	PF00069	0.684
MOD_GSK3_1	125	132	PF00069	0.624
MOD_GSK3_1	144	151	PF00069	0.688
MOD_GSK3_1	161	168	PF00069	0.709
MOD_GSK3_1	193	200	PF00069	0.640
MOD_GSK3_1	279	286	PF00069	0.595
MOD_GSK3_1	306	313	PF00069	0.653
MOD_GSK3_1	39	46	PF00069	0.669
MOD_GSK3_1	437	444	PF00069	0.726
MOD_GSK3_1	49	56	PF00069	0.730
MOD_GSK3_1	528	535	PF00069	0.735
MOD_GSK3_1	566	573	PF00069	0.772
MOD_GSK3_1	580	587	PF00069	0.745
MOD_GSK3_1	598	605	PF00069	0.624
MOD_GSK3_1	613	620	PF00069	0.715
MOD_GSK3_1	624	631	PF00069	0.658
MOD_GSK3_1	664	671	PF00069	0.768
MOD_GSK3_1	672	679	PF00069	0.657
MOD_GSK3_1	700	707	PF00069	0.784
MOD_GSK3_1	71	78	PF00069	0.818
MOD_GSK3_1	732	739	PF00069	0.774
MOD_GSK3_1	768	775	PF00069	0.776
MOD_GSK3_1	789	796	PF00069	0.676
MOD_GSK3_1	802	809	PF00069	0.792
MOD_GSK3_1	815	822	PF00069	0.600
MOD_N-GLC_1	579	584	PF02516	0.622
MOD_N-GLC_1	818	823	PF02516	0.786
MOD_NEK2_1	154	159	PF00069	0.695
MOD_NEK2_1	319	324	PF00069	0.580
MOD_NEK2_1	431	436	PF00069	0.690
MOD_NEK2_1	490	495	PF00069	0.515
MOD_NEK2_1	519	524	PF00069	0.460
MOD_NEK2_1	557	562	PF00069	0.671
MOD_NEK2_1	579	584	PF00069	0.803
MOD_NEK2_1	700	705	PF00069	0.613
MOD_NEK2_1	807	812	PF00069	0.659
MOD_PIKK_1	203	209	PF00454	0.791
MOD_PIKK_1	374	380	PF00454	0.506
MOD_PIKK_1	467	473	PF00454	0.709
MOD_PIKK_1	598	604	PF00454	0.805
MOD_PIKK_1	668	674	PF00454	0.803
MOD_PK_1	766	772	PF00069	0.682
MOD_PKA_1	138	144	PF00069	0.707
MOD_PKA_2	138	144	PF00069	0.662
MOD_PKA_2	2	8	PF00069	0.641
MOD_PKA_2	20	26	PF00069	0.520
MOD_PKA_2	245	251	PF00069	0.495
MOD_PKA_2	296	302	PF00069	0.599
MOD_PKA_2	36	42	PF00069	0.617
MOD_PKA_2	431	437	PF00069	0.688
MOD_PKA_2	500	506	PF00069	0.641
MOD_PKA_2	528	534	PF00069	0.718
MOD_PKA_2	607	613	PF00069	0.839
MOD_PKA_2	732	738	PF00069	0.685
MOD_PKA_2	805	811	PF00069	0.654
MOD_PKB_1	137	145	PF00069	0.624
MOD_PKB_1	746	754	PF00069	0.627
MOD_PKB_1	764	772	PF00069	0.650
MOD_Plk_1	319	325	PF00069	0.578
MOD_Plk_1	766	772	PF00069	0.682
MOD_Plk_2-3	169	175	PF00069	0.639
MOD_Plk_4	104	110	PF00069	0.690
MOD_Plk_4	169	175	PF00069	0.606
MOD_Plk_4	348	354	PF00069	0.453
MOD_Plk_4	768	774	PF00069	0.699
MOD_Plk_4	786	792	PF00069	0.673
MOD_ProDKin_1	101	107	PF00069	0.738
MOD_ProDKin_1	11	17	PF00069	0.670
MOD_ProDKin_1	113	119	PF00069	0.631
MOD_ProDKin_1	129	135	PF00069	0.683
MOD_ProDKin_1	175	181	PF00069	0.688
MOD_ProDKin_1	197	203	PF00069	0.783
MOD_ProDKin_1	22	28	PF00069	0.690
MOD_ProDKin_1	298	304	PF00069	0.684
MOD_ProDKin_1	327	333	PF00069	0.450
MOD_ProDKin_1	43	49	PF00069	0.612
MOD_ProDKin_1	573	579	PF00069	0.710
MOD_ProDKin_1	584	590	PF00069	0.642
MOD_ProDKin_1	595	601	PF00069	0.696
MOD_ProDKin_1	624	630	PF00069	0.675
MOD_ProDKin_1	665	671	PF00069	0.776
MOD_ProDKin_1	791	797	PF00069	0.675
TRG_DiLeu_BaEn_1	169	174	PF01217	0.605
TRG_DiLeu_BaEn_4	426	432	PF01217	0.534
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.590
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.579
TRG_DiLeu_BaLyEn_6	514	519	PF01217	0.535
TRG_DiLeu_BaLyEn_6	610	615	PF01217	0.732
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.650
TRG_ENDOCYTIC_2	361	364	PF00928	0.451
TRG_ER_diArg_1	136	139	PF00400	0.740
TRG_ER_diArg_1	216	218	PF00400	0.644
TRG_ER_diArg_1	26	29	PF00400	0.850
TRG_ER_diArg_1	431	433	PF00400	0.559
TRG_ER_diArg_1	435	438	PF00400	0.597
TRG_ER_diArg_1	47	49	PF00400	0.599
TRG_ER_diArg_1	500	502	PF00400	0.508
TRG_ER_diArg_1	515	518	PF00400	0.538
TRG_ER_diArg_1	623	625	PF00400	0.682
TRG_ER_diArg_1	763	766	PF00400	0.781
TRG_ER_diArg_1	856	858	PF00400	0.682
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	502	506	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L2	Leptomonas seymouri	35%	100%
A4HKR7	Leishmania braziliensis	66%	100%
A4I897	Leishmania infantum	99%	100%
E9B355	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q4Z9	Leishmania major	86%	99%