Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tip Of Extending FAZ protein 1

Species:

Leishmania donovani

UniProt:

A0A3S5H7S6_LEIDO

TriTrypDb:

LdBPK_322750.1 , LdCL_320033300 , LDHU3_32.3440

Length:

1006

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S5H7S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7S6

Function

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Biological processes
Term	Name	Level	Count
GO:0000281	mitotic cytokinesis	4	1
GO:0000910	cytokinesis	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0022402	cell cycle process	2	1
GO:0032465	regulation of cytokinesis	5	1
GO:0032954	regulation of cytokinetic process	6	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.701
CLV_C14_Caspase3-7	798	802	PF00656	0.670
CLV_C14_Caspase3-7	804	808	PF00656	0.584
CLV_C14_Caspase3-7	940	944	PF00656	0.482
CLV_NRD_NRD_1	148	150	PF00675	0.682
CLV_NRD_NRD_1	297	299	PF00675	0.726
CLV_NRD_NRD_1	371	373	PF00675	0.706
CLV_NRD_NRD_1	491	493	PF00675	0.679
CLV_NRD_NRD_1	503	505	PF00675	0.594
CLV_NRD_NRD_1	508	510	PF00675	0.564

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4HKQ1	Leishmania braziliensis	64%	99%
A4I882	Leishmania infantum	99%	100%
E9B340	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4Q514	Leishmania major	91%	100%

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