Major intrinsic family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aquaporin-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H7S4_LEIDO

TriTrypDb:

LdBPK_322510.1 , LdCL_320030500 , LDHU3_32.3130

Length:

278

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: antonio.jimenez@uah.es
Publication title: A functional BH3 domain in an aquaporin from Leishmania infantum
Publication 1st author(s): Genes
Publication Identifier(s): 27551533
Host organism: taxid:4932
Interaction detection method(s): two hybrid
Interaction type: physical association
Identification method participant A: predetermined participant
Identification method participant B: predetermined participant
ID(s) interactor A: Q07817
ID(s) interactor B: A4I001
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	33
GO:0110165	cellular anatomical entity	1	33
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A0A3S5H7S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7S4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006833	water transport	5	2
GO:0042044	fluid transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	33
GO:0015267	channel activity	4	33
GO:0022803	passive transmembrane transporter activity	3	33
GO:0022857	transmembrane transporter activity	2	33
GO:0005372	water transmembrane transporter activity	4	2
GO:0015250	water channel activity	5	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_4	1	3	PF02207	0.521
DEG_ODPH_VHL_1	69	82	PF01847	0.247
DOC_MAPK_MEF2A_6	20	27	PF00069	0.539
DOC_PP2B_LxvP_1	140	143	PF13499	0.244
LIG_FHA_1	135	141	PF00498	0.277
LIG_FHA_1	162	168	PF00498	0.292
LIG_FHA_1	217	223	PF00498	0.292
LIG_FHA_1	226	232	PF00498	0.245
LIG_FHA_1	252	258	PF00498	0.561
LIG_FHA_1	45	51	PF00498	0.293
LIG_FHA_1	64	70	PF00498	0.261
LIG_FHA_1	96	102	PF00498	0.359
LIG_FHA_2	8	14	PF00498	0.628
LIG_LIR_Gen_1	151	162	PF02991	0.280
LIG_LIR_Gen_1	41	50	PF02991	0.263
LIG_LIR_Gen_1	98	107	PF02991	0.295
LIG_LIR_Nem_3	151	157	PF02991	0.270
LIG_LIR_Nem_3	160	166	PF02991	0.290
LIG_LIR_Nem_3	183	187	PF02991	0.348
LIG_LIR_Nem_3	41	45	PF02991	0.269
LIG_LIR_Nem_3	98	102	PF02991	0.341
LIG_PDZ_Class_1	273	278	PF00595	0.503
LIG_SH2_STAT3	176	179	PF00017	0.415
LIG_SH2_STAT3	226	229	PF00017	0.333
LIG_SH2_STAT5	152	155	PF00017	0.217
LIG_SH2_STAT5	17	20	PF00017	0.572
LIG_SH2_STAT5	226	229	PF00017	0.296
LIG_SH2_STAT5	232	235	PF00017	0.301
LIG_SH2_STAT5	87	90	PF00017	0.459
LIG_SUMO_SIM_par_1	164	169	PF11976	0.243
LIG_TYR_ITIM	230	235	PF00017	0.352
LIG_WRC_WIRS_1	39	44	PF05994	0.294
MOD_CK2_1	46	52	PF00069	0.273
MOD_CK2_1	7	13	PF00069	0.602
MOD_CMANNOS	234	237	PF00535	0.292
MOD_GlcNHglycan	154	157	PF01048	0.488
MOD_GlcNHglycan	203	206	PF01048	0.457
MOD_GlcNHglycan	88	91	PF01048	0.248
MOD_NEK2_1	166	171	PF00069	0.279
MOD_NEK2_1	193	198	PF00069	0.316
MOD_NEK2_1	216	221	PF00069	0.256
MOD_NEK2_1	251	256	PF00069	0.504
MOD_NEK2_1	44	49	PF00069	0.305
MOD_PIKK_1	134	140	PF00454	0.370
MOD_PIKK_1	174	180	PF00454	0.533
MOD_PIKK_1	193	199	PF00454	0.392
MOD_PIKK_1	225	231	PF00454	0.333
MOD_PKA_2	25	31	PF00069	0.574
MOD_Plk_4	127	133	PF00069	0.362
MOD_Plk_4	166	172	PF00069	0.291
MOD_Plk_4	38	44	PF00069	0.299
MOD_SUMO_for_1	258	261	PF00179	0.524
TRG_ENDOCYTIC_2	232	235	PF00928	0.352
TRG_ENDOCYTIC_2	275	278	PF00928	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D2	Leptomonas seymouri	38%	98%
A0A0N1ILB4	Leptomonas seymouri	40%	100%
A0A0N1PB10	Leptomonas seymouri	76%	100%
A0A0S4IS36	Bodo saltans	40%	79%
A0A0S4IS78	Bodo saltans	58%	100%
A0A0S4JRP5	Bodo saltans	28%	83%
A0A0S4KLV5	Bodo saltans	41%	100%
A0A1X0ND19	Trypanosomatidae	40%	100%
A0A1X0NT73	Trypanosomatidae	66%	100%
A0A1X0NTY8	Trypanosomatidae	34%	100%
A0A3R7RFH0	Trypanosoma rangeli	66%	100%
A0A3S5H7B2	Leishmania donovani	36%	100%
A0A3S7X8F2	Leishmania donovani	41%	100%
A0A422N493	Trypanosoma rangeli	37%	100%
A0A422N886	Trypanosoma rangeli	43%	66%
A0A422NSX8	Trypanosoma rangeli	41%	100%
A0A6M3QG69	Musa acuminata	28%	99%
A0A804KTT0	Musa acuminata subsp. malaccensis	28%	97%
A4HBA6	Leishmania braziliensis	40%	100%
A4HCI0	Leishmania braziliensis	37%	100%
A4HIW6	Leishmania braziliensis	26%	100%
A4HKM8	Leishmania braziliensis	80%	100%
A4HKM9	Leishmania braziliensis	36%	100%
A4I001	Leishmania infantum	36%	100%
A4I859	Leishmania infantum	100%	100%
A4IAF4	Leishmania infantum	41%	100%
A6ZX66	Saccharomyces cerevisiae (strain YJM789)	25%	91%
A9Y006	Sus scrofa	26%	96%
B1VB61	Citrobacter freundii	28%	100%
C8ZJM1	Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)	26%	85%
E9AVX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B1F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	89%
E9B316	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B5H8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
F9UTW9	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	24%	100%
F9UUB3	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	25%	100%
F9UUD2	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	33%	100%
G5CTG1	Milnesium tardigradum	24%	80%
G5CTG2	Milnesium tardigradum	25%	100%
G5CTG3	Milnesium tardigradum	24%	98%
G5CTG4	Milnesium tardigradum	29%	88%
O22588	Arabidopsis thaliana	30%	100%
O26206	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	29%	100%
O28846	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	29%	100%
O43315	Homo sapiens	26%	94%
O64964	Zea mays	29%	100%
O68874	Shigella flexneri	29%	100%
O77750	Bos taurus	28%	86%
O82598	Arabidopsis thaliana	29%	100%
O94778	Homo sapiens	29%	100%
P08995	Glycine max	31%	100%
P09011	Rattus norvegicus	29%	100%
P0C112	Brucella abortus biovar 1 (strain 9-941)	28%	100%
P0CD89	Saccharomyces cerevisiae	26%	96%
P0CD91	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	91%
P0CD92	Saccharomyces cerevisiae	26%	85%
P0DO53	Musa acuminata	29%	100%
P0DO54	Musa acuminata	32%	100%
P21653	Nicotiana tabacum	32%	100%
P25794	Pisum sativum	30%	96%
P25818	Arabidopsis thaliana	31%	100%
P26587	Arabidopsis thaliana	28%	100%
P29972	Homo sapiens	27%	100%
P29975	Rattus norvegicus	28%	100%
P30302	Arabidopsis thaliana	26%	98%
P33560	Antirrhinum majus	32%	100%
P42067	Medicago sativa	30%	100%
P43286	Arabidopsis thaliana	25%	97%
P43287	Arabidopsis thaliana	26%	98%
P47862	Rattus norvegicus	25%	95%
P47863	Rattus norvegicus	30%	86%
P47865	Bos taurus	29%	100%
P49173	Nicotiana alata	27%	100%
P50156	Oryza sativa subsp. japonica	29%	100%
P50501	Pelophylax lessonae	26%	100%
P51180	Mus musculus	29%	100%
P55087	Homo sapiens	29%	86%
P55088	Mus musculus	29%	86%
P56401	Ovis aries	28%	100%
P56404	Mus musculus	28%	100%
P56405	Rattus norvegicus	33%	100%
P56627	Rattus norvegicus	27%	94%
P60844	Escherichia coli (strain K12)	29%	100%
P60845	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	29%	100%
P60925	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	26%	100%
P61837	Arabidopsis thaliana	28%	97%
P61838	Vicia faba	28%	97%
P73809	Synechocystis sp. (strain PCC 6803 / Kazusa)	27%	100%
P79099	Bos taurus	26%	100%
P93004	Arabidopsis thaliana	29%	99%
Q02013	Mus musculus	26%	100%
Q06611	Arabidopsis thaliana	28%	97%
Q08451	Solanum lycopersicum	27%	97%
Q08733	Arabidopsis thaliana	28%	97%
Q08DE6	Bos taurus	24%	95%
Q0DK16	Oryza sativa subsp. japonica	27%	97%
Q0IWF3	Oryza sativa subsp. japonica	31%	89%
Q0JPT5	Oryza sativa subsp. japonica	32%	92%
Q19KC1	Zea mays	27%	94%
Q23808	Cicadella viridis	27%	100%
Q25074	Haematobia irritans exigua	30%	100%
Q2YR68	Brucella abortus (strain 2308)	28%	100%
Q39196	Arabidopsis thaliana	28%	97%
Q40746	Oryza sativa subsp. japonica	27%	98%
Q41870	Zea mays	28%	97%
Q41951	Arabidopsis thaliana	30%	100%
Q41963	Arabidopsis thaliana	30%	100%
Q4Q2F7	Leishmania major	40%	100%
Q4Q538	Leishmania major	95%	100%
Q4QBK5	Leishmania major	37%	100%
Q54V53	Dictyostelium discoideum	27%	100%
Q54WT8	Dictyostelium discoideum	30%	95%
Q5I4F8	Notomys alexis	31%	100%
Q5I4F9	Notomys alexis	30%	85%
Q5R819	Pongo abelii	28%	100%
Q5Z6F0	Oryza sativa subsp. japonica	29%	100%
Q651D5	Oryza sativa subsp. japonica	29%	96%
Q67WJ8	Oryza sativa subsp. japonica	28%	93%
Q6EU94	Oryza sativa subsp. japonica	30%	96%
Q6K215	Oryza sativa subsp. japonica	28%	97%
Q6PQZ1	Sus scrofa	28%	100%
Q6Z2T3	Oryza sativa subsp. japonica	29%	93%
Q7EYH7	Oryza sativa subsp. japonica	26%	91%
Q7MIV9	Vibrio vulnificus (strain YJ016)	28%	100%
Q7N5C1	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	25%	100%
Q7NNP3	Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)	26%	100%
Q7NU39	Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)	32%	100%
Q7PWV1	Anopheles gambiae	30%	100%
Q7W917	Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)	28%	100%
Q7WKG2	Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)	28%	100%
Q7XLR1	Oryza sativa subsp. japonica	29%	99%
Q7XSQ9	Oryza sativa subsp. japonica	29%	97%
Q7XU31	Oryza sativa subsp. japonica	28%	100%
Q7XUA6	Oryza sativa subsp. japonica	26%	96%
Q84RL6	Zea mays	32%	100%
Q84RL7	Zea mays	30%	96%
Q84S07	Oryza sativa subsp. japonica	25%	100%
Q866S3	Ovis aries	25%	100%
Q87MQ5	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	28%	100%
Q88F17	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	29%	100%
Q89EG9	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	27%	100%
Q8DB17	Vibrio vulnificus (strain CMCP6)	28%	100%
Q8EHC1	Shewanella oneidensis (strain MR-1)	29%	100%
Q8FY85	Brucella suis biovar 1 (strain 1330)	28%	100%
Q8GRI8	Oryza sativa subsp. japonica	27%	98%
Q8GRT8	Oryza sativa subsp. japonica	26%	97%
Q8LAA6	Arabidopsis thaliana	26%	97%
Q8LFP7	Arabidopsis thaliana	27%	95%
Q8VZW1	Arabidopsis thaliana	24%	94%
Q8W036	Arabidopsis thaliana	26%	98%
Q8W037	Arabidopsis thaliana	26%	97%
Q8X6K6	Escherichia coli O157:H7	29%	100%
Q923J4	Dipodomys merriami	30%	86%
Q92482	Homo sapiens	25%	95%
Q92NM3	Rhizobium meliloti (strain 1021)	29%	100%
Q9AQU5	Zea mays	28%	95%
Q9AR14	Zea mays	28%	97%
Q9AT74	Zea mays	26%	92%
Q9AT75	Zea mays	26%	100%
Q9ATL2	Zea mays	29%	100%
Q9ATL3	Zea mays	26%	100%
Q9ATL4	Zea mays	30%	100%
Q9ATL8	Zea mays	30%	100%
Q9ATM4	Zea mays	29%	97%
Q9ATM6	Zea mays	26%	97%
Q9ATM7	Zea mays	26%	96%
Q9ATN0	Zea mays	27%	94%
Q9ATN1	Zea mays	29%	92%
Q9ATN2	Zea mays	27%	95%
Q9ATN4	Zea mays	29%	99%
Q9C4Z5	Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)	31%	100%
Q9C6T0	Arabidopsis thaliana	27%	86%
Q9FF53	Arabidopsis thaliana	26%	96%
Q9FGL2	Arabidopsis thaliana	28%	100%
Q9FIZ9	Arabidopsis thaliana	27%	98%
Q9FY14	Medicago truncatula	30%	100%
Q9HWZ3	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	25%	100%
Q9L772	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	28%	100%
Q9N2J4	Canis lupus familiaris	28%	100%
Q9NHW7	Aedes aegypti	29%	100%
Q9SAI4	Arabidopsis thaliana	23%	91%
Q9STX9	Arabidopsis thaliana	30%	100%
Q9SV84	Arabidopsis thaliana	29%	91%
Q9SXF8	Oryza sativa subsp. japonica	28%	97%
Q9U8P7	Dictyostelium discoideum	28%	100%
Q9V5Z7	Drosophila melanogaster	29%	100%
Q9XF58	Zea mays	26%	98%
Q9XF59	Zea mays	28%	96%
Q9ZV07	Arabidopsis thaliana	28%	96%
Q9ZVX8	Arabidopsis thaliana	26%	100%
S5ZH89	Musa acuminata	27%	97%
V5ANF5	Trypanosoma cruzi	66%	100%
V5B469	Trypanosoma cruzi	37%	100%
V5BW46	Trypanosoma cruzi	38%	100%