ABC transporter-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H7S2_LEIDO

TriTrypDb:

LdBPK_322190.1 , LdCL_320027300 , LDHU3_32.2710

Length:

737

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S5H7S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7S2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0005215	transporter activity	1	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0015399	primary active transmembrane transporter activity	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0022804	active transmembrane transporter activity	3	9
GO:0022857	transmembrane transporter activity	2	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0042626	ATPase-coupled transmembrane transporter activity	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140359	ABC-type transporter activity	3	9
GO:0140657	ATP-dependent activity	1	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	562	564	PF00675	0.336
CLV_NRD_NRD_1	624	626	PF00675	0.310
CLV_NRD_NRD_1	717	719	PF00675	0.369
CLV_PCSK_KEX2_1	562	564	PF00082	0.336
CLV_PCSK_KEX2_1	624	626	PF00082	0.293
CLV_PCSK_KEX2_1	717	719	PF00082	0.369
CLV_PCSK_SKI1_1	122	126	PF00082	0.728
CLV_PCSK_SKI1_1	134	138	PF00082	0.505
CLV_PCSK_SKI1_1	173	177	PF00082	0.350
CLV_PCSK_SKI1_1	367	371	PF00082	0.406
CLV_PCSK_SKI1_1	47	51	PF00082	0.484
CLV_PCSK_SKI1_1	563	567	PF00082	0.277
CLV_PCSK_SKI1_1	624	628	PF00082	0.355
CLV_PCSK_SKI1_1	662	666	PF00082	0.355
CLV_PCSK_SKI1_1	708	712	PF00082	0.386
DEG_APCC_DBOX_1	172	180	PF00400	0.418
DEG_APCC_DBOX_1	415	423	PF00400	0.621
DEG_APCC_DBOX_1	661	669	PF00400	0.536
DEG_SCF_FBW7_2	214	221	PF00400	0.510
DEG_SPOP_SBC_1	92	96	PF00917	0.507
DOC_CKS1_1	215	220	PF01111	0.522
DOC_MAPK_FxFP_2	476	479	PF00069	0.594
DOC_MAPK_gen_1	134	144	PF00069	0.355
DOC_MAPK_gen_1	559	567	PF00069	0.510
DOC_MAPK_MEF2A_6	134	142	PF00069	0.355
DOC_MAPK_MEF2A_6	173	181	PF00069	0.344
DOC_MAPK_MEF2A_6	367	376	PF00069	0.399
DOC_MAPK_MEF2A_6	689	696	PF00069	0.615
DOC_PP1_RVXF_1	120	126	PF00149	0.451
DOC_PP2B_LxvP_1	109	112	PF13499	0.511
DOC_PP4_FxxP_1	476	479	PF00568	0.594
DOC_USP7_MATH_1	159	163	PF00917	0.314
DOC_USP7_MATH_1	23	27	PF00917	0.676
DOC_USP7_MATH_1	338	342	PF00917	0.532
DOC_USP7_MATH_1	359	363	PF00917	0.393
DOC_USP7_MATH_1	497	501	PF00917	0.680
DOC_USP7_MATH_1	508	512	PF00917	0.694
DOC_USP7_MATH_1	595	599	PF00917	0.549
DOC_USP7_MATH_1	630	634	PF00917	0.536
DOC_WW_Pin1_4	16	21	PF00397	0.746
DOC_WW_Pin1_4	161	166	PF00397	0.299
DOC_WW_Pin1_4	214	219	PF00397	0.522
DOC_WW_Pin1_4	461	466	PF00397	0.639
DOC_WW_Pin1_4	8	13	PF00397	0.793
LIG_14-3-3_CanoR_1	15	20	PF00244	0.666
LIG_14-3-3_CanoR_1	240	249	PF00244	0.602
LIG_14-3-3_CanoR_1	302	310	PF00244	0.532
LIG_14-3-3_CanoR_1	320	325	PF00244	0.405
LIG_14-3-3_CanoR_1	36	42	PF00244	0.557
LIG_14-3-3_CanoR_1	416	420	PF00244	0.562
LIG_14-3-3_CanoR_1	421	426	PF00244	0.549
LIG_14-3-3_CanoR_1	430	435	PF00244	0.637
LIG_14-3-3_CanoR_1	624	631	PF00244	0.492
LIG_14-3-3_CanoR_1	79	85	PF00244	0.364
LIG_Actin_WH2_2	401	418	PF00022	0.432
LIG_Actin_WH2_2	688	705	PF00022	0.612
LIG_APCC_ABBA_1	163	168	PF00400	0.309
LIG_BIR_II_1	1	5	PF00653	0.793
LIG_BIR_III_2	156	160	PF00653	0.230
LIG_BRCT_BRCA1_1	51	55	PF00533	0.406
LIG_BRCT_BRCA1_1	639	643	PF00533	0.522
LIG_Clathr_ClatBox_1	677	681	PF01394	0.496
LIG_EH_1	640	644	PF12763	0.522
LIG_eIF4E_1	184	190	PF01652	0.406
LIG_FHA_1	185	191	PF00498	0.386
LIG_FHA_1	244	250	PF00498	0.503
LIG_FHA_1	273	279	PF00498	0.354
LIG_FHA_1	29	35	PF00498	0.633
LIG_FHA_1	321	327	PF00498	0.471
LIG_FHA_1	346	352	PF00498	0.532
LIG_FHA_1	364	370	PF00498	0.223
LIG_FHA_1	41	47	PF00498	0.595
LIG_FHA_1	449	455	PF00498	0.748
LIG_FHA_1	464	470	PF00498	0.622
LIG_FHA_1	521	527	PF00498	0.496
LIG_FHA_1	553	559	PF00498	0.539
LIG_FHA_1	682	688	PF00498	0.546
LIG_FHA_1	707	713	PF00498	0.529
LIG_FHA_1	80	86	PF00498	0.481
LIG_FHA_2	20	26	PF00498	0.675
LIG_FHA_2	243	249	PF00498	0.503
LIG_FHA_2	302	308	PF00498	0.536
LIG_FHA_2	437	443	PF00498	0.730
LIG_FHA_2	575	581	PF00498	0.471
LIG_FHA_2	616	622	PF00498	0.510
LIG_FHA_2	643	649	PF00498	0.496
LIG_FHA_2	683	689	PF00498	0.579
LIG_FHA_2	696	702	PF00498	0.530
LIG_FHA_2	96	102	PF00498	0.605
LIG_LIR_Apic_2	475	479	PF02991	0.552
LIG_LIR_Gen_1	618	626	PF02991	0.530
LIG_LIR_Gen_1	640	650	PF02991	0.573
LIG_LIR_Gen_1	672	683	PF02991	0.517
LIG_LIR_Nem_3	133	139	PF02991	0.314
LIG_LIR_Nem_3	475	481	PF02991	0.571
LIG_LIR_Nem_3	618	622	PF02991	0.473
LIG_LIR_Nem_3	640	646	PF02991	0.503
LIG_LIR_Nem_3	672	678	PF02991	0.517
LIG_LYPXL_yS_3	478	481	PF13949	0.589
LIG_SH2_CRK	358	362	PF00017	0.406
LIG_SH2_CRK	675	679	PF00017	0.517
LIG_SH2_NCK_1	358	362	PF00017	0.406
LIG_SH2_SRC	166	169	PF00017	0.336
LIG_SH2_STAP1	675	679	PF00017	0.517
LIG_SH2_STAT3	379	382	PF00017	0.307
LIG_SH2_STAT5	166	169	PF00017	0.330
LIG_SH2_STAT5	259	262	PF00017	0.374
LIG_SH2_STAT5	313	316	PF00017	0.555
LIG_SH2_STAT5	394	397	PF00017	0.352
LIG_SH3_3	135	141	PF00018	0.336
LIG_SH3_3	476	482	PF00018	0.570
LIG_SH3_3	599	605	PF00018	0.555
LIG_SH3_3	607	613	PF00018	0.478
LIG_SH3_3	647	653	PF00018	0.587
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.536
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.406
LIG_SUMO_SIM_anti_2	366	372	PF11976	0.406
LIG_SUMO_SIM_anti_2	455	460	PF11976	0.655
LIG_SUMO_SIM_anti_2	676	682	PF11976	0.496
LIG_SUMO_SIM_anti_2	690	698	PF11976	0.570
LIG_SUMO_SIM_par_1	457	464	PF11976	0.692
LIG_SUMO_SIM_par_1	47	52	PF11976	0.456
LIG_SUMO_SIM_par_1	60	65	PF11976	0.263
LIG_SUMO_SIM_par_1	676	682	PF11976	0.536
LIG_SUMO_SIM_par_1	708	714	PF11976	0.544
LIG_SUMO_SIM_par_1	724	730	PF11976	0.589
LIG_TRAF2_1	304	307	PF00917	0.536
LIG_UBA3_1	695	700	PF00899	0.544
LIG_WRC_WIRS_1	398	403	PF05994	0.353
LIG_WRC_WIRS_1	587	592	PF05994	0.510
LIG_WRC_WIRS_1	643	648	PF05994	0.555
MOD_CDK_SPxxK_3	8	15	PF00069	0.682
MOD_CK1_1	18	24	PF00069	0.752
MOD_CK1_1	243	249	PF00069	0.548
MOD_CK1_1	301	307	PF00069	0.535
MOD_CK1_1	363	369	PF00069	0.325
MOD_CK1_1	40	46	PF00069	0.576
MOD_CK1_1	407	413	PF00069	0.348
MOD_CK1_1	518	524	PF00069	0.538
MOD_CK1_1	586	592	PF00069	0.498
MOD_CK1_1	95	101	PF00069	0.552
MOD_CK2_1	19	25	PF00069	0.726
MOD_CK2_1	242	248	PF00069	0.536
MOD_CK2_1	301	307	PF00069	0.536
MOD_CK2_1	436	442	PF00069	0.738
MOD_CK2_1	574	580	PF00069	0.485
MOD_CK2_1	615	621	PF00069	0.510
MOD_CK2_1	642	648	PF00069	0.536
MOD_CK2_1	687	693	PF00069	0.650
MOD_CK2_1	695	701	PF00069	0.595
MOD_CK2_1	729	735	PF00069	0.686
MOD_CK2_1	95	101	PF00069	0.506
MOD_GlcNHglycan	148	151	PF01048	0.521
MOD_GlcNHglycan	199	202	PF01048	0.364
MOD_GlcNHglycan	2	5	PF01048	0.641
MOD_GlcNHglycan	237	240	PF01048	0.314
MOD_GlcNHglycan	339	343	PF01048	0.359
MOD_GlcNHglycan	362	365	PF01048	0.407
MOD_GlcNHglycan	409	412	PF01048	0.369
MOD_GlcNHglycan	51	54	PF01048	0.327
MOD_GlcNHglycan	535	538	PF01048	0.276
MOD_GlcNHglycan	591	594	PF01048	0.303
MOD_GlcNHglycan	597	600	PF01048	0.285
MOD_GlcNHglycan	606	609	PF01048	0.219
MOD_GlcNHglycan	632	635	PF01048	0.336
MOD_GlcNHglycan	655	658	PF01048	0.283
MOD_GlcNHglycan	688	692	PF01048	0.395
MOD_GlcNHglycan	728	732	PF01048	0.491
MOD_GlcNHglycan	8	11	PF01048	0.571
MOD_GlcNHglycan	95	98	PF01048	0.748
MOD_GSK3_1	15	22	PF00069	0.809
MOD_GSK3_1	248	255	PF00069	0.522
MOD_GSK3_1	268	275	PF00069	0.162
MOD_GSK3_1	359	366	PF00069	0.376
MOD_GSK3_1	397	404	PF00069	0.461
MOD_GSK3_1	406	413	PF00069	0.433
MOD_GSK3_1	504	511	PF00069	0.739
MOD_GSK3_1	582	589	PF00069	0.538
MOD_GSK3_1	591	598	PF00069	0.540
MOD_GSK3_1	600	607	PF00069	0.552
MOD_GSK3_1	611	618	PF00069	0.416
MOD_GSK3_1	637	644	PF00069	0.517
MOD_GSK3_1	669	676	PF00069	0.545
MOD_GSK3_1	702	709	PF00069	0.570
MOD_GSK3_1	88	95	PF00069	0.499
MOD_N-GLC_1	351	356	PF02516	0.324
MOD_NEK2_1	146	151	PF00069	0.273
MOD_NEK2_1	242	247	PF00069	0.510
MOD_NEK2_1	268	273	PF00069	0.339
MOD_NEK2_1	318	323	PF00069	0.579
MOD_NEK2_1	351	356	PF00069	0.548
MOD_NEK2_1	37	42	PF00069	0.616
MOD_NEK2_1	374	379	PF00069	0.354
MOD_NEK2_1	388	393	PF00069	0.328
MOD_NEK2_1	401	406	PF00069	0.435
MOD_NEK2_1	415	420	PF00069	0.562
MOD_NEK2_1	436	441	PF00069	0.712
MOD_NEK2_1	574	579	PF00069	0.500
MOD_NEK2_1	583	588	PF00069	0.515
MOD_NEK2_1	62	67	PF00069	0.423
MOD_NEK2_1	687	692	PF00069	0.568
MOD_NEK2_1	695	700	PF00069	0.522
MOD_NEK2_1	702	707	PF00069	0.525
MOD_NEK2_1	729	734	PF00069	0.659
MOD_NEK2_1	78	83	PF00069	0.427
MOD_OFUCOSY	538	543	PF10250	0.355
MOD_PIKK_1	252	258	PF00454	0.448
MOD_PIKK_1	318	324	PF00454	0.555
MOD_PIKK_1	410	416	PF00454	0.516
MOD_PIKK_1	508	514	PF00454	0.720
MOD_PIKK_1	515	521	PF00454	0.473
MOD_PIKK_1	557	563	PF00454	0.536
MOD_PKA_1	624	630	PF00069	0.536
MOD_PKA_2	301	307	PF00069	0.508
MOD_PKA_2	345	351	PF00069	0.536
MOD_PKA_2	388	394	PF00069	0.303
MOD_PKA_2	415	421	PF00069	0.614
MOD_PKA_2	624	630	PF00069	0.536
MOD_PKA_2	702	708	PF00069	0.651
MOD_PKA_2	78	84	PF00069	0.355
MOD_Plk_1	306	312	PF00069	0.517
MOD_Plk_1	351	357	PF00069	0.512
MOD_Plk_1	673	679	PF00069	0.534
MOD_Plk_1	687	693	PF00069	0.595
MOD_Plk_4	185	191	PF00069	0.380
MOD_Plk_4	272	278	PF00069	0.346
MOD_Plk_4	320	326	PF00069	0.529
MOD_Plk_4	37	43	PF00069	0.596
MOD_Plk_4	388	394	PF00069	0.307
MOD_Plk_4	397	403	PF00069	0.382
MOD_Plk_4	57	63	PF00069	0.464
MOD_Plk_4	642	648	PF00069	0.491
MOD_Plk_4	673	679	PF00069	0.498
MOD_Plk_4	706	712	PF00069	0.552
MOD_ProDKin_1	16	22	PF00069	0.742
MOD_ProDKin_1	161	167	PF00069	0.299
MOD_ProDKin_1	214	220	PF00069	0.522
MOD_ProDKin_1	461	467	PF00069	0.630
MOD_ProDKin_1	8	14	PF00069	0.793
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.355
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.406
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.536
TRG_ENDOCYTIC_2	358	361	PF00928	0.406
TRG_ENDOCYTIC_2	39	42	PF00928	0.602
TRG_ENDOCYTIC_2	478	481	PF00928	0.589
TRG_ENDOCYTIC_2	675	678	PF00928	0.533
TRG_ER_diArg_1	624	626	PF00400	0.536
TRG_ER_diArg_1	717	719	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7P4	Leptomonas seymouri	64%	100%
A0A0S4J6G3	Bodo saltans	28%	100%
A0A1X0NU80	Trypanosomatidae	35%	100%
A4HKJ6	Leishmania braziliensis	78%	99%
A4I828	Leishmania infantum	99%	100%
E9B2Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q570	Leishmania major	92%	99%