Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7S0_LEIDO

TriTrypDb:

LdBPK_321780.1 , LdCL_320023300 , LDHU3_32.2260

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7S0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	412	416	PF00656	0.602
CLV_NRD_NRD_1	216	218	PF00675	0.616
CLV_NRD_NRD_1	325	327	PF00675	0.590
CLV_NRD_NRD_1	407	409	PF00675	0.549
CLV_NRD_NRD_1	473	475	PF00675	0.639
CLV_PCSK_KEX2_1	216	218	PF00082	0.585
CLV_PCSK_KEX2_1	325	327	PF00082	0.590
CLV_PCSK_KEX2_1	407	409	PF00082	0.632
CLV_PCSK_KEX2_1	473	475	PF00082	0.639
CLV_PCSK_KEX2_1	63	65	PF00082	0.650
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.650
CLV_PCSK_SKI1_1	179	183	PF00082	0.504
CLV_PCSK_SKI1_1	408	412	PF00082	0.594
CLV_PCSK_SKI1_1	84	88	PF00082	0.513
DEG_APCC_DBOX_1	178	186	PF00400	0.637
DEG_APCC_DBOX_1	83	91	PF00400	0.498
DEG_Nend_UBRbox_3	1	3	PF02207	0.572
DEG_SPOP_SBC_1	237	241	PF00917	0.585
DEG_SPOP_SBC_1	421	425	PF00917	0.568
DOC_CKS1_1	301	306	PF01111	0.605
DOC_CKS1_1	318	323	PF01111	0.649
DOC_CKS1_1	445	450	PF01111	0.594
DOC_CYCLIN_RxL_1	88	100	PF00134	0.437
DOC_MAPK_gen_1	279	286	PF00069	0.456
DOC_PP1_RVXF_1	267	274	PF00149	0.533
DOC_PP2B_LxvP_1	400	403	PF13499	0.573
DOC_PP4_FxxP_1	293	296	PF00568	0.638
DOC_USP7_MATH_1	165	169	PF00917	0.574
DOC_USP7_MATH_1	173	177	PF00917	0.653
DOC_USP7_MATH_1	218	222	PF00917	0.606
DOC_USP7_MATH_1	238	242	PF00917	0.633
DOC_USP7_MATH_1	4	8	PF00917	0.565
DOC_USP7_MATH_1	439	443	PF00917	0.686
DOC_USP7_MATH_1	465	469	PF00917	0.644
DOC_WW_Pin1_4	20	25	PF00397	0.539
DOC_WW_Pin1_4	300	305	PF00397	0.700
DOC_WW_Pin1_4	317	322	PF00397	0.826
DOC_WW_Pin1_4	354	359	PF00397	0.510
DOC_WW_Pin1_4	388	393	PF00397	0.491
DOC_WW_Pin1_4	429	434	PF00397	0.676
DOC_WW_Pin1_4	43	48	PF00397	0.593
DOC_WW_Pin1_4	444	449	PF00397	0.553
DOC_WW_Pin1_4	463	468	PF00397	0.724
DOC_WW_Pin1_4	484	489	PF00397	0.583
DOC_WW_Pin1_4	9	14	PF00397	0.603
LIG_14-3-3_CanoR_1	126	130	PF00244	0.548
LIG_14-3-3_CanoR_1	134	140	PF00244	0.475
LIG_14-3-3_CanoR_1	269	274	PF00244	0.525
LIG_14-3-3_CanoR_1	287	296	PF00244	0.618
LIG_14-3-3_CanoR_1	325	333	PF00244	0.738
LIG_14-3-3_CanoR_1	364	372	PF00244	0.492
LIG_14-3-3_CanoR_1	440	444	PF00244	0.725
LIG_14-3-3_CanoR_1	473	482	PF00244	0.602
LIG_14-3-3_CanoR_1	497	502	PF00244	0.636
LIG_Actin_WH2_2	271	289	PF00022	0.534
LIG_Actin_WH2_2	340	357	PF00022	0.513
LIG_deltaCOP1_diTrp_1	104	111	PF00928	0.511
LIG_EH1_1	454	462	PF00400	0.697
LIG_FHA_1	296	302	PF00498	0.607
LIG_FHA_1	395	401	PF00498	0.582
LIG_FHA_1	498	504	PF00498	0.692
LIG_FHA_2	128	134	PF00498	0.572
LIG_FHA_2	187	193	PF00498	0.561
LIG_FHA_2	248	254	PF00498	0.634
LIG_LIR_Apic_2	291	296	PF02991	0.631
LIG_LIR_Gen_1	108	118	PF02991	0.480
LIG_LIR_Gen_1	267	278	PF02991	0.595
LIG_LIR_Gen_1	350	359	PF02991	0.502
LIG_LIR_Gen_1	375	383	PF02991	0.489
LIG_LIR_Nem_3	108	114	PF02991	0.490
LIG_LIR_Nem_3	267	273	PF02991	0.614
LIG_LIR_Nem_3	350	354	PF02991	0.486
LIG_LIR_Nem_3	357	363	PF02991	0.479
LIG_LIR_Nem_3	375	379	PF02991	0.383
LIG_LIR_Nem_3	42	48	PF02991	0.591
LIG_LIR_Nem_3	480	485	PF02991	0.584
LIG_PCNA_APIM_2	82	88	PF02747	0.428
LIG_Pex14_1	111	115	PF04695	0.481
LIG_Pex14_2	195	199	PF04695	0.559
LIG_Pex14_2	372	376	PF04695	0.505
LIG_SH2_CRK	115	119	PF00017	0.589
LIG_SH2_CRK	482	486	PF00017	0.589
LIG_SH2_SRC	206	209	PF00017	0.618
LIG_SH2_STAT5	115	118	PF00017	0.504
LIG_SH2_STAT5	206	209	PF00017	0.639
LIG_SH2_STAT5	85	88	PF00017	0.499
LIG_SH3_3	172	178	PF00018	0.549
LIG_SH3_3	204	210	PF00018	0.525
LIG_SH3_3	21	27	PF00018	0.761
LIG_SH3_3	232	238	PF00018	0.634
LIG_SH3_3	442	448	PF00018	0.644
LIG_SH3_3	77	83	PF00018	0.512
LIG_SUMO_SIM_par_1	119	128	PF11976	0.461
LIG_SUMO_SIM_par_1	396	401	PF11976	0.588
LIG_SUMO_SIM_par_1	499	505	PF11976	0.565
LIG_TRAF2_1	102	105	PF00917	0.543
LIG_TRAF2_1	403	406	PF00917	0.534
LIG_TRAF2_1	492	495	PF00917	0.559
LIG_WRC_WIRS_1	270	275	PF05994	0.517
LIG_WRC_WIRS_1	348	353	PF05994	0.490
MOD_CDK_SPxK_1	444	450	PF00069	0.647
MOD_CDK_SPxK_1	9	15	PF00069	0.553
MOD_CK1_1	124	130	PF00069	0.486
MOD_CK1_1	136	142	PF00069	0.463
MOD_CK1_1	240	246	PF00069	0.639
MOD_CK1_1	391	397	PF00069	0.656
MOD_CK1_1	420	426	PF00069	0.735
MOD_CK1_1	429	435	PF00069	0.620
MOD_CK1_1	468	474	PF00069	0.785
MOD_CK1_1	502	508	PF00069	0.591
MOD_CK1_1	7	13	PF00069	0.705
MOD_CK2_1	222	228	PF00069	0.616
MOD_CK2_1	247	253	PF00069	0.639
MOD_CK2_1	378	384	PF00069	0.489
MOD_DYRK1A_RPxSP_1	444	448	PF00069	0.599
MOD_GlcNHglycan	135	138	PF01048	0.511
MOD_GlcNHglycan	167	170	PF01048	0.570
MOD_GlcNHglycan	220	223	PF01048	0.588
MOD_GlcNHglycan	380	383	PF01048	0.494
MOD_GlcNHglycan	393	396	PF01048	0.470
MOD_GlcNHglycan	428	431	PF01048	0.733
MOD_GlcNHglycan	437	440	PF01048	0.616
MOD_GlcNHglycan	467	470	PF01048	0.651
MOD_GlcNHglycan	6	9	PF01048	0.651
MOD_GSK3_1	121	128	PF00069	0.493
MOD_GSK3_1	218	225	PF00069	0.633
MOD_GSK3_1	236	243	PF00069	0.675
MOD_GSK3_1	265	272	PF00069	0.493
MOD_GSK3_1	316	323	PF00069	0.653
MOD_GSK3_1	324	331	PF00069	0.573
MOD_GSK3_1	343	350	PF00069	0.697
MOD_GSK3_1	359	366	PF00069	0.449
MOD_GSK3_1	416	423	PF00069	0.809
MOD_GSK3_1	428	435	PF00069	0.577
MOD_GSK3_1	459	466	PF00069	0.682
MOD_GSK3_1	468	475	PF00069	0.782
MOD_LATS_1	277	283	PF00433	0.459
MOD_N-GLC_1	165	170	PF02516	0.545
MOD_N-GLC_1	30	35	PF02516	0.602
MOD_NEK2_1	185	190	PF00069	0.546
MOD_NEK2_1	242	247	PF00069	0.728
MOD_NEK2_1	359	364	PF00069	0.473
MOD_NEK2_2	439	444	PF00069	0.627
MOD_PIKK_1	288	294	PF00454	0.614
MOD_PIKK_1	473	479	PF00454	0.725
MOD_PIKK_1	66	72	PF00454	0.647
MOD_PK_1	417	423	PF00069	0.646
MOD_PK_1	499	505	PF00069	0.565
MOD_PK_1	76	82	PF00069	0.522
MOD_PKA_1	279	285	PF00069	0.481
MOD_PKA_1	473	479	PF00069	0.625
MOD_PKA_2	125	131	PF00069	0.552
MOD_PKA_2	133	139	PF00069	0.479
MOD_PKA_2	218	224	PF00069	0.580
MOD_PKA_2	324	330	PF00069	0.812
MOD_PKA_2	363	369	PF00069	0.491
MOD_PKA_2	416	422	PF00069	0.644
MOD_PKA_2	439	445	PF00069	0.609
MOD_PKA_2	472	478	PF00069	0.771
MOD_PKB_1	497	505	PF00069	0.599
MOD_Plk_1	158	164	PF00069	0.594
MOD_Plk_1	254	260	PF00069	0.584
MOD_Plk_1	417	423	PF00069	0.646
MOD_Plk_2-3	254	260	PF00069	0.584
MOD_Plk_4	113	119	PF00069	0.473
MOD_Plk_4	269	275	PF00069	0.526
MOD_Plk_4	32	38	PF00069	0.757
MOD_Plk_4	343	349	PF00069	0.523
MOD_Plk_4	394	400	PF00069	0.546
MOD_Plk_4	76	82	PF00069	0.569
MOD_ProDKin_1	20	26	PF00069	0.536
MOD_ProDKin_1	300	306	PF00069	0.698
MOD_ProDKin_1	317	323	PF00069	0.825
MOD_ProDKin_1	354	360	PF00069	0.506
MOD_ProDKin_1	388	394	PF00069	0.490
MOD_ProDKin_1	429	435	PF00069	0.676
MOD_ProDKin_1	43	49	PF00069	0.595
MOD_ProDKin_1	444	450	PF00069	0.552
MOD_ProDKin_1	463	469	PF00069	0.726
MOD_ProDKin_1	484	490	PF00069	0.586
MOD_ProDKin_1	9	15	PF00069	0.603
MOD_SUMO_rev_2	192	202	PF00179	0.534
TRG_DiLeu_BaEn_1	180	185	PF01217	0.523
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.459
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.441
TRG_ENDOCYTIC_2	115	118	PF00928	0.585
TRG_ENDOCYTIC_2	281	284	PF00928	0.445
TRG_ENDOCYTIC_2	482	485	PF00928	0.586
TRG_ER_diArg_1	216	219	PF00400	0.544
TRG_ER_diArg_1	284	287	PF00400	0.633
TRG_ER_diArg_1	352	355	PF00400	0.475
TRG_ER_diArg_1	407	409	PF00400	0.549
TRG_ER_diArg_1	443	446	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HKF7	Leishmania braziliensis	68%	100%
Q4Q5B0	Leishmania major	86%	100%