LeishMANIAdb
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CRAL/TRIO domain containing protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CRAL/TRIO domain containing protein, putative
Gene product:
CRAL/TRIO domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H7R8_LEIDO
TriTrypDb:
LdBPK_321330.1 * , LdCL_320019000 , LDHU3_32.1690
Length:
766

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7R8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7R8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 15 19 PF00656 0.462
CLV_C14_Caspase3-7 24 28 PF00656 0.373
CLV_C14_Caspase3-7 607 611 PF00656 0.464
CLV_C14_Caspase3-7 62 66 PF00656 0.574
CLV_C14_Caspase3-7 624 628 PF00656 0.532
CLV_NRD_NRD_1 118 120 PF00675 0.460
CLV_NRD_NRD_1 263 265 PF00675 0.765
CLV_NRD_NRD_1 312 314 PF00675 0.627
CLV_NRD_NRD_1 454 456 PF00675 0.384
CLV_NRD_NRD_1 494 496 PF00675 0.347
CLV_NRD_NRD_1 513 515 PF00675 0.236
CLV_NRD_NRD_1 672 674 PF00675 0.452
CLV_NRD_NRD_1 719 721 PF00675 0.399
CLV_PCSK_KEX2_1 117 119 PF00082 0.454
CLV_PCSK_KEX2_1 158 160 PF00082 0.527
CLV_PCSK_KEX2_1 246 248 PF00082 0.787
CLV_PCSK_KEX2_1 262 264 PF00082 0.704
CLV_PCSK_KEX2_1 312 314 PF00082 0.627
CLV_PCSK_KEX2_1 454 456 PF00082 0.385
CLV_PCSK_KEX2_1 493 495 PF00082 0.329
CLV_PCSK_KEX2_1 513 515 PF00082 0.295
CLV_PCSK_KEX2_1 694 696 PF00082 0.422
CLV_PCSK_KEX2_1 718 720 PF00082 0.415
CLV_PCSK_PC1ET2_1 158 160 PF00082 0.527
CLV_PCSK_PC1ET2_1 246 248 PF00082 0.551
CLV_PCSK_PC1ET2_1 694 696 PF00082 0.382
CLV_PCSK_PC7_1 113 119 PF00082 0.482
CLV_PCSK_PC7_1 450 456 PF00082 0.356
CLV_PCSK_SKI1_1 51 55 PF00082 0.411
CLV_PCSK_SKI1_1 518 522 PF00082 0.354
CLV_PCSK_SKI1_1 559 563 PF00082 0.344
CLV_PCSK_SKI1_1 664 668 PF00082 0.422
CLV_PCSK_SKI1_1 695 699 PF00082 0.353
CLV_PCSK_SKI1_1 95 99 PF00082 0.481
DEG_Nend_UBRbox_3 1 3 PF02207 0.636
DEG_SPOP_SBC_1 219 223 PF00917 0.641
DEG_SPOP_SBC_1 484 488 PF00917 0.297
DOC_ANK_TNKS_1 646 653 PF00023 0.496
DOC_CDC14_PxL_1 279 287 PF14671 0.549
DOC_CKS1_1 339 344 PF01111 0.605
DOC_CYCLIN_RxL_1 513 526 PF00134 0.317
DOC_CYCLIN_yCln2_LP_2 377 383 PF00134 0.389
DOC_CYCLIN_yCln2_LP_2 516 522 PF00134 0.360
DOC_MAPK_gen_1 274 281 PF00069 0.574
DOC_MAPK_gen_1 564 572 PF00069 0.356
DOC_MAPK_gen_1 668 677 PF00069 0.520
DOC_MAPK_gen_1 692 699 PF00069 0.386
DOC_MAPK_gen_1 749 756 PF00069 0.398
DOC_MAPK_gen_1 95 104 PF00069 0.421
DOC_MAPK_JIP1_4 518 524 PF00069 0.297
DOC_MAPK_MEF2A_6 514 523 PF00069 0.409
DOC_MAPK_MEF2A_6 749 756 PF00069 0.421
DOC_MAPK_NFAT4_5 749 757 PF00069 0.415
DOC_PP1_RVXF_1 567 573 PF00149 0.413
DOC_PP1_RVXF_1 671 678 PF00149 0.448
DOC_PP1_RVXF_1 693 700 PF00149 0.405
DOC_PP2B_LxvP_1 147 150 PF13499 0.447
DOC_PP4_FxxP_1 654 657 PF00568 0.540
DOC_USP7_MATH_1 184 188 PF00917 0.560
DOC_USP7_MATH_1 194 198 PF00917 0.558
DOC_USP7_MATH_1 202 206 PF00917 0.692
DOC_USP7_MATH_1 212 216 PF00917 0.593
DOC_USP7_MATH_1 25 29 PF00917 0.433
DOC_USP7_MATH_1 294 298 PF00917 0.640
DOC_USP7_MATH_1 362 366 PF00917 0.550
DOC_USP7_MATH_1 669 673 PF00917 0.454
DOC_USP7_MATH_1 67 71 PF00917 0.582
DOC_USP7_MATH_1 762 766 PF00917 0.522
DOC_WW_Pin1_4 198 203 PF00397 0.651
DOC_WW_Pin1_4 220 225 PF00397 0.645
DOC_WW_Pin1_4 254 259 PF00397 0.667
DOC_WW_Pin1_4 338 343 PF00397 0.626
DOC_WW_Pin1_4 360 365 PF00397 0.652
DOC_WW_Pin1_4 421 426 PF00397 0.375
DOC_WW_Pin1_4 609 614 PF00397 0.524
DOC_WW_Pin1_4 82 87 PF00397 0.401
LIG_14-3-3_CanoR_1 211 217 PF00244 0.541
LIG_14-3-3_CanoR_1 253 257 PF00244 0.646
LIG_14-3-3_CanoR_1 274 279 PF00244 0.597
LIG_14-3-3_CanoR_1 302 308 PF00244 0.648
LIG_14-3-3_CanoR_1 673 678 PF00244 0.569
LIG_14-3-3_CanoR_1 749 755 PF00244 0.436
LIG_Actin_WH2_2 36 53 PF00022 0.460
LIG_APCC_ABBA_1 754 759 PF00400 0.397
LIG_BIR_III_2 427 431 PF00653 0.356
LIG_BIR_III_2 610 614 PF00653 0.549
LIG_BIR_III_4 162 166 PF00653 0.561
LIG_BRCT_BRCA1_1 621 625 PF00533 0.539
LIG_BRCT_BRCA1_1 699 703 PF00533 0.389
LIG_Clathr_ClatBox_1 442 446 PF01394 0.356
LIG_deltaCOP1_diTrp_1 684 689 PF00928 0.420
LIG_deltaCOP1_diTrp_1 739 747 PF00928 0.418
LIG_DLG_GKlike_1 274 281 PF00625 0.574
LIG_eIF4E_1 16 22 PF01652 0.472
LIG_eIF4E_1 515 521 PF01652 0.360
LIG_eIF4E_1 660 666 PF01652 0.385
LIG_FHA_1 188 194 PF00498 0.629
LIG_FHA_1 2 8 PF00498 0.540
LIG_FHA_1 24 30 PF00498 0.485
LIG_FHA_1 288 294 PF00498 0.588
LIG_FHA_1 339 345 PF00498 0.619
LIG_FHA_1 38 44 PF00498 0.439
LIG_FHA_1 437 443 PF00498 0.431
LIG_FHA_1 500 506 PF00498 0.266
LIG_FHA_1 546 552 PF00498 0.356
LIG_FHA_1 639 645 PF00498 0.742
LIG_FHA_2 422 428 PF00498 0.404
LIG_FHA_2 579 585 PF00498 0.397
LIG_FHA_2 60 66 PF00498 0.588
LIG_FHA_2 610 616 PF00498 0.551
LIG_FHA_2 637 643 PF00498 0.591
LIG_FHA_2 83 89 PF00498 0.376
LIG_LIR_Apic_2 336 342 PF02991 0.652
LIG_LIR_Apic_2 651 657 PF02991 0.552
LIG_LIR_Gen_1 182 193 PF02991 0.630
LIG_LIR_Gen_1 277 285 PF02991 0.602
LIG_LIR_Gen_1 315 321 PF02991 0.596
LIG_LIR_Gen_1 439 448 PF02991 0.519
LIG_LIR_Gen_1 552 562 PF02991 0.359
LIG_LIR_Gen_1 696 706 PF02991 0.529
LIG_LIR_Nem_3 182 188 PF02991 0.668
LIG_LIR_Nem_3 277 281 PF02991 0.618
LIG_LIR_Nem_3 315 320 PF02991 0.597
LIG_LIR_Nem_3 439 443 PF02991 0.378
LIG_LIR_Nem_3 534 538 PF02991 0.518
LIG_LIR_Nem_3 552 558 PF02991 0.214
LIG_LIR_Nem_3 696 702 PF02991 0.520
LIG_LIR_Nem_3 88 94 PF02991 0.391
LIG_NRBOX 45 51 PF00104 0.418
LIG_Pex14_2 699 703 PF04695 0.447
LIG_SH2_CRK 405 409 PF00017 0.484
LIG_SH2_CRK 440 444 PF00017 0.457
LIG_SH2_CRK 517 521 PF00017 0.360
LIG_SH2_CRK 94 98 PF00017 0.403
LIG_SH2_NCK_1 181 185 PF00017 0.597
LIG_SH2_NCK_1 339 343 PF00017 0.606
LIG_SH2_PTP2 728 731 PF00017 0.415
LIG_SH2_SRC 160 163 PF00017 0.536
LIG_SH2_SRC 181 184 PF00017 0.597
LIG_SH2_STAP1 185 189 PF00017 0.634
LIG_SH2_STAP1 368 372 PF00017 0.571
LIG_SH2_STAP1 440 444 PF00017 0.356
LIG_SH2_STAT5 160 163 PF00017 0.526
LIG_SH2_STAT5 185 188 PF00017 0.569
LIG_SH2_STAT5 405 408 PF00017 0.331
LIG_SH2_STAT5 515 518 PF00017 0.360
LIG_SH2_STAT5 543 546 PF00017 0.320
LIG_SH2_STAT5 555 558 PF00017 0.360
LIG_SH2_STAT5 660 663 PF00017 0.489
LIG_SH2_STAT5 728 731 PF00017 0.404
LIG_SH2_STAT5 76 79 PF00017 0.419
LIG_SH2_STAT5 91 94 PF00017 0.441
LIG_SH3_3 221 227 PF00018 0.650
LIG_SH3_3 353 359 PF00018 0.570
LIG_SUMO_SIM_anti_2 277 283 PF11976 0.552
LIG_SUMO_SIM_par_1 379 386 PF11976 0.425
LIG_SUMO_SIM_par_1 441 446 PF11976 0.476
LIG_SUMO_SIM_par_1 500 506 PF11976 0.360
LIG_SUMO_SIM_par_1 520 526 PF11976 0.190
LIG_SxIP_EBH_1 274 288 PF03271 0.603
LIG_TRFH_1 421 425 PF08558 0.360
LIG_TRFH_1 82 86 PF08558 0.410
LIG_TYR_ITIM 403 408 PF00017 0.482
LIG_TYR_ITIM 553 558 PF00017 0.431
LIG_TYR_ITIM 92 97 PF00017 0.388
LIG_WRC_WIRS_1 185 190 PF05994 0.519
MOD_CDK_SPK_2 254 259 PF00069 0.630
MOD_CK1_1 153 159 PF00069 0.537
MOD_CK1_1 187 193 PF00069 0.708
MOD_CK1_1 201 207 PF00069 0.613
MOD_CK1_1 23 29 PF00069 0.477
MOD_CK1_1 277 283 PF00069 0.628
MOD_CK1_1 305 311 PF00069 0.637
MOD_CK1_1 319 325 PF00069 0.526
MOD_CK1_1 563 569 PF00069 0.377
MOD_CK1_1 60 66 PF00069 0.752
MOD_CK1_1 630 636 PF00069 0.698
MOD_CK2_1 254 260 PF00069 0.625
MOD_CK2_1 578 584 PF00069 0.349
MOD_CK2_1 636 642 PF00069 0.581
MOD_CK2_1 82 88 PF00069 0.482
MOD_Cter_Amidation 156 159 PF01082 0.523
MOD_GlcNHglycan 113 116 PF01048 0.442
MOD_GlcNHglycan 135 138 PF01048 0.355
MOD_GlcNHglycan 155 158 PF01048 0.498
MOD_GlcNHglycan 214 217 PF01048 0.734
MOD_GlcNHglycan 23 26 PF01048 0.440
MOD_GlcNHglycan 240 244 PF01048 0.772
MOD_GlcNHglycan 270 273 PF01048 0.618
MOD_GlcNHglycan 296 299 PF01048 0.613
MOD_GlcNHglycan 324 327 PF01048 0.663
MOD_GlcNHglycan 331 334 PF01048 0.640
MOD_GlcNHglycan 617 620 PF01048 0.787
MOD_GlcNHglycan 69 72 PF01048 0.496
MOD_GlcNHglycan 699 702 PF01048 0.429
MOD_GlcNHglycan 704 707 PF01048 0.508
MOD_GSK3_1 12 19 PF00069 0.520
MOD_GSK3_1 183 190 PF00069 0.687
MOD_GSK3_1 194 201 PF00069 0.606
MOD_GSK3_1 202 209 PF00069 0.543
MOD_GSK3_1 21 28 PF00069 0.402
MOD_GSK3_1 248 255 PF00069 0.627
MOD_GSK3_1 302 309 PF00069 0.648
MOD_GSK3_1 312 319 PF00069 0.593
MOD_GSK3_1 320 327 PF00069 0.475
MOD_GSK3_1 358 365 PF00069 0.607
MOD_GSK3_1 467 474 PF00069 0.344
MOD_GSK3_1 51 58 PF00069 0.700
MOD_GSK3_1 545 552 PF00069 0.373
MOD_GSK3_1 571 578 PF00069 0.413
MOD_GSK3_1 605 612 PF00069 0.518
MOD_GSK3_1 615 622 PF00069 0.685
MOD_GSK3_1 627 634 PF00069 0.653
MOD_GSK3_1 638 645 PF00069 0.712
MOD_GSK3_1 669 676 PF00069 0.472
MOD_GSK3_1 78 85 PF00069 0.490
MOD_LATS_1 300 306 PF00433 0.628
MOD_N-GLC_1 1 6 PF02516 0.611
MOD_N-GLC_1 153 158 PF02516 0.564
MOD_N-GLC_1 294 299 PF02516 0.662
MOD_N-GLC_1 302 307 PF02516 0.653
MOD_N-GLC_1 545 550 PF02516 0.356
MOD_NEK2_1 1 6 PF00069 0.650
MOD_NEK2_1 12 17 PF00069 0.455
MOD_NEK2_1 21 26 PF00069 0.303
MOD_NEK2_1 436 441 PF00069 0.353
MOD_NEK2_1 472 477 PF00069 0.249
MOD_NEK2_1 497 502 PF00069 0.297
MOD_NEK2_1 523 528 PF00069 0.334
MOD_NEK2_1 621 626 PF00069 0.644
MOD_NEK2_1 738 743 PF00069 0.363
MOD_NEK2_2 3 8 PF00069 0.539
MOD_NEK2_2 750 755 PF00069 0.406
MOD_PIKK_1 1 7 PF00454 0.611
MOD_PIKK_1 248 254 PF00454 0.585
MOD_PIKK_1 467 473 PF00454 0.285
MOD_PIKK_1 631 637 PF00454 0.638
MOD_PIKK_1 642 648 PF00454 0.514
MOD_PKA_1 262 268 PF00069 0.724
MOD_PKA_1 312 318 PF00069 0.579
MOD_PKA_1 51 57 PF00069 0.532
MOD_PKA_1 673 679 PF00069 0.439
MOD_PKA_2 252 258 PF00069 0.639
MOD_PKA_2 262 268 PF00069 0.599
MOD_PKA_2 312 318 PF00069 0.695
MOD_PKA_2 563 569 PF00069 0.276
MOD_PKA_2 669 675 PF00069 0.448
MOD_PKA_2 750 756 PF00069 0.478
MOD_Plk_1 12 18 PF00069 0.445
MOD_Plk_1 139 145 PF00069 0.326
MOD_Plk_1 302 308 PF00069 0.756
MOD_Plk_1 78 84 PF00069 0.481
MOD_Plk_4 184 190 PF00069 0.564
MOD_Plk_4 316 322 PF00069 0.644
MOD_Plk_4 363 369 PF00069 0.574
MOD_Plk_4 499 505 PF00069 0.433
MOD_Plk_4 551 557 PF00069 0.394
MOD_Plk_4 711 717 PF00069 0.490
MOD_ProDKin_1 198 204 PF00069 0.652
MOD_ProDKin_1 220 226 PF00069 0.635
MOD_ProDKin_1 254 260 PF00069 0.670
MOD_ProDKin_1 338 344 PF00069 0.625
MOD_ProDKin_1 360 366 PF00069 0.653
MOD_ProDKin_1 421 427 PF00069 0.375
MOD_ProDKin_1 609 615 PF00069 0.525
MOD_ProDKin_1 82 88 PF00069 0.397
MOD_SUMO_for_1 7 10 PF00179 0.530
MOD_SUMO_rev_2 260 270 PF00179 0.593
MOD_SUMO_rev_2 343 351 PF00179 0.539
TRG_DiLeu_BaEn_1 346 351 PF01217 0.471
TRG_DiLeu_BaEn_4 346 352 PF01217 0.519
TRG_DiLeu_BaLyEn_6 516 521 PF01217 0.337
TRG_ENDOCYTIC_2 185 188 PF00928 0.672
TRG_ENDOCYTIC_2 395 398 PF00928 0.449
TRG_ENDOCYTIC_2 405 408 PF00928 0.396
TRG_ENDOCYTIC_2 440 443 PF00928 0.465
TRG_ENDOCYTIC_2 517 520 PF00928 0.344
TRG_ENDOCYTIC_2 555 558 PF00928 0.469
TRG_ENDOCYTIC_2 94 97 PF00928 0.392
TRG_ER_diArg_1 117 119 PF00400 0.393
TRG_ER_diArg_1 166 169 PF00400 0.575
TRG_ER_diArg_1 262 264 PF00400 0.617
TRG_ER_diArg_1 454 457 PF00400 0.356
TRG_ER_diArg_1 492 495 PF00400 0.317
TRG_ER_diArg_1 512 514 PF00400 0.229
TRG_ER_diArg_1 717 720 PF00400 0.417
TRG_ER_diArg_1 749 752 PF00400 0.445
TRG_Pf-PMV_PEXEL_1 106 110 PF00026 0.418
TRG_Pf-PMV_PEXEL_1 159 164 PF00026 0.491

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P992 Leptomonas seymouri 46% 100%
A0A3S7X4P4 Leishmania donovani 25% 100%
A4HJI7 Leishmania braziliensis 24% 100%
A4HKB5 Leishmania braziliensis 62% 99%
A4I6Y2 Leishmania infantum 25% 100%
A4I7U4 Leishmania infantum 99% 100%
E9B204 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9B2Q2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q5F5 Leishmania major 86% 100%
Q4Q657 Leishmania major 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS