FAD dependent oxidoreductase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAD dependent oxidoreductase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7R6_LEIDO

TriTrypDb:

LdBPK_320980.1 , LdCL_320015500 , LDHU3_32.1300

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7R6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	2
GO:0016491	oxidoreductase activity	2	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	1
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0050660	flavin adenine dinucleotide binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.579
CLV_C14_Caspase3-7	685	689	PF00656	0.583
CLV_NRD_NRD_1	282	284	PF00675	0.357
CLV_NRD_NRD_1	301	303	PF00675	0.352
CLV_NRD_NRD_1	544	546	PF00675	0.342
CLV_NRD_NRD_1	617	619	PF00675	0.324
CLV_NRD_NRD_1	64	66	PF00675	0.344
CLV_NRD_NRD_1	95	97	PF00675	0.423
CLV_PCSK_KEX2_1	266	268	PF00082	0.400
CLV_PCSK_KEX2_1	282	284	PF00082	0.290
CLV_PCSK_KEX2_1	301	303	PF00082	0.375
CLV_PCSK_KEX2_1	544	546	PF00082	0.356
CLV_PCSK_KEX2_1	617	619	PF00082	0.342
CLV_PCSK_KEX2_1	64	66	PF00082	0.344
CLV_PCSK_KEX2_1	674	676	PF00082	0.387
CLV_PCSK_KEX2_1	95	97	PF00082	0.429
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.436
CLV_PCSK_PC1ET2_1	674	676	PF00082	0.387
CLV_PCSK_SKI1_1	249	253	PF00082	0.406
CLV_PCSK_SKI1_1	283	287	PF00082	0.383
CLV_PCSK_SKI1_1	370	374	PF00082	0.347
CLV_PCSK_SKI1_1	390	394	PF00082	0.249
CLV_PCSK_SKI1_1	452	456	PF00082	0.375
CLV_PCSK_SKI1_1	654	658	PF00082	0.365
CLV_PCSK_SKI1_1	692	696	PF00082	0.398
CLV_Separin_Metazoa	61	65	PF03568	0.536
DEG_Nend_Nbox_1	1	3	PF02207	0.343
DEG_ODPH_VHL_1	445	458	PF01847	0.497
DEG_SCF_FBW7_1	546	553	PF00400	0.464
DEG_SPOP_SBC_1	639	643	PF00917	0.627
DEG_SPOP_SBC_1	83	87	PF00917	0.558
DOC_CDC14_PxL_1	100	108	PF14671	0.629
DOC_CKS1_1	429	434	PF01111	0.549
DOC_CKS1_1	475	480	PF01111	0.617
DOC_CYCLIN_yCln2_LP_2	253	259	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	393	399	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	438	444	PF00134	0.527
DOC_MAPK_gen_1	327	336	PF00069	0.624
DOC_MAPK_gen_1	370	379	PF00069	0.561
DOC_MAPK_gen_1	95	102	PF00069	0.607
DOC_MAPK_HePTP_8	367	379	PF00069	0.547
DOC_MAPK_MEF2A_6	370	379	PF00069	0.561
DOC_MAPK_MEF2A_6	390	399	PF00069	0.411
DOC_MAPK_NFAT4_5	390	398	PF00069	0.507
DOC_MAPK_RevD_3	251	267	PF00069	0.531
DOC_MIT_MIM_1	297	306	PF04212	0.571
DOC_PP1_RVXF_1	265	272	PF00149	0.507
DOC_PP1_RVXF_1	450	457	PF00149	0.567
DOC_PP1_RVXF_1	96	103	PF00149	0.608
DOC_PP2B_LxvP_1	253	256	PF13499	0.580
DOC_PP2B_LxvP_1	284	287	PF13499	0.578
DOC_PP2B_LxvP_1	380	383	PF13499	0.677
DOC_PP2B_LxvP_1	393	396	PF13499	0.505
DOC_PP2B_LxvP_1	438	441	PF13499	0.574
DOC_USP7_MATH_1	215	219	PF00917	0.661
DOC_USP7_MATH_1	259	263	PF00917	0.573
DOC_USP7_MATH_1	285	289	PF00917	0.581
DOC_USP7_MATH_1	345	349	PF00917	0.535
DOC_USP7_MATH_1	403	407	PF00917	0.549
DOC_USP7_MATH_1	514	518	PF00917	0.725
DOC_USP7_MATH_1	630	634	PF00917	0.545
DOC_USP7_MATH_1	639	643	PF00917	0.634
DOC_USP7_MATH_1	644	648	PF00917	0.643
DOC_USP7_MATH_1	679	683	PF00917	0.604
DOC_USP7_MATH_1	83	87	PF00917	0.619
DOC_USP7_UBL2_3	596	600	PF12436	0.656
DOC_WW_Pin1_4	123	128	PF00397	0.731
DOC_WW_Pin1_4	361	366	PF00397	0.548
DOC_WW_Pin1_4	428	433	PF00397	0.594
DOC_WW_Pin1_4	474	479	PF00397	0.620
DOC_WW_Pin1_4	502	507	PF00397	0.704
DOC_WW_Pin1_4	546	551	PF00397	0.599
LIG_14-3-3_CanoR_1	167	171	PF00244	0.560
LIG_14-3-3_CanoR_1	21	30	PF00244	0.587
LIG_14-3-3_CanoR_1	214	224	PF00244	0.669
LIG_14-3-3_CanoR_1	237	243	PF00244	0.506
LIG_14-3-3_CanoR_1	301	306	PF00244	0.494
LIG_14-3-3_CanoR_1	416	423	PF00244	0.624
LIG_14-3-3_CanoR_1	513	523	PF00244	0.709
LIG_14-3-3_CanoR_1	544	552	PF00244	0.581
LIG_14-3-3_CanoR_1	608	616	PF00244	0.639
LIG_14-3-3_CanoR_1	683	688	PF00244	0.604
LIG_14-3-3_CanoR_1	98	103	PF00244	0.605
LIG_BRCT_BRCA1_1	240	244	PF00533	0.480
LIG_BRCT_BRCA1_1	562	566	PF00533	0.591
LIG_BRCT_BRCA1_1	633	637	PF00533	0.579
LIG_DLG_GKlike_1	683	691	PF00625	0.517
LIG_EH1_1	481	489	PF00400	0.544
LIG_FHA_1	183	189	PF00498	0.541
LIG_FHA_1	23	29	PF00498	0.648
LIG_FHA_1	248	254	PF00498	0.595
LIG_FHA_1	258	264	PF00498	0.626
LIG_FHA_1	36	42	PF00498	0.492
LIG_FHA_1	384	390	PF00498	0.619
LIG_FHA_1	481	487	PF00498	0.520
LIG_FHA_1	547	553	PF00498	0.654
LIG_FHA_1	565	571	PF00498	0.501
LIG_FHA_1	64	70	PF00498	0.478
LIG_FHA_1	693	699	PF00498	0.615
LIG_FHA_2	124	130	PF00498	0.724
LIG_FHA_2	150	156	PF00498	0.662
LIG_FHA_2	308	314	PF00498	0.587
LIG_FHA_2	608	614	PF00498	0.531
LIG_FHA_2	683	689	PF00498	0.556
LIG_Integrin_RGD_1	340	342	PF01839	0.347
LIG_LIR_Gen_1	307	317	PF02991	0.558
LIG_LIR_Gen_1	45	54	PF02991	0.494
LIG_LIR_Gen_1	563	571	PF02991	0.609
LIG_LIR_Gen_1	666	676	PF02991	0.628
LIG_LIR_Nem_3	307	312	PF02991	0.552
LIG_LIR_Nem_3	45	49	PF02991	0.495
LIG_LIR_Nem_3	563	569	PF02991	0.600
LIG_LIR_Nem_3	666	672	PF02991	0.640
LIG_MYND_1	428	432	PF01753	0.554
LIG_Pex14_1	16	20	PF04695	0.413
LIG_RPA_C_Fungi	678	690	PF08784	0.360
LIG_SH2_CRK	168	172	PF00017	0.520
LIG_SH2_GRB2like	17	20	PF00017	0.312
LIG_SH2_NCK_1	309	313	PF00017	0.372
LIG_SH2_PTP2	46	49	PF00017	0.390
LIG_SH2_SRC	619	622	PF00017	0.476
LIG_SH2_STAT3	131	134	PF00017	0.650
LIG_SH2_STAT5	131	134	PF00017	0.522
LIG_SH2_STAT5	17	20	PF00017	0.312
LIG_SH2_STAT5	257	260	PF00017	0.543
LIG_SH2_STAT5	274	277	PF00017	0.222
LIG_SH2_STAT5	309	312	PF00017	0.454
LIG_SH2_STAT5	429	432	PF00017	0.524
LIG_SH2_STAT5	46	49	PF00017	0.390
LIG_SH2_STAT5	619	622	PF00017	0.337
LIG_SH3_3	104	110	PF00018	0.573
LIG_SH3_3	144	150	PF00018	0.529
LIG_SH3_3	233	239	PF00018	0.529
LIG_SH3_3	253	259	PF00018	0.505
LIG_SH3_3	266	272	PF00018	0.521
LIG_SH3_3	344	350	PF00018	0.568
LIG_SH3_3	376	382	PF00018	0.543
LIG_SH3_3	451	457	PF00018	0.491
LIG_SH3_5	42	46	PF00018	0.476
LIG_SUMO_SIM_anti_2	4	10	PF11976	0.413
LIG_SUMO_SIM_anti_2	483	489	PF11976	0.419
LIG_SUMO_SIM_par_1	562	574	PF11976	0.520
LIG_SUMO_SIM_par_1	71	77	PF11976	0.376
LIG_TYR_ITSM	305	312	PF00017	0.357
LIG_WRC_WIRS_1	99	104	PF05994	0.510
MOD_CDK_SPK_2	361	366	PF00069	0.429
MOD_CK1_1	210	216	PF00069	0.503
MOD_CK1_1	219	225	PF00069	0.680
MOD_CK1_1	304	310	PF00069	0.413
MOD_CK1_1	31	37	PF00069	0.560
MOD_CK1_1	406	412	PF00069	0.620
MOD_CK1_1	553	559	PF00069	0.428
MOD_CK1_1	589	595	PF00069	0.525
MOD_CK1_1	631	637	PF00069	0.415
MOD_CK1_1	640	646	PF00069	0.550
MOD_CK1_1	648	654	PF00069	0.499
MOD_CK1_1	662	668	PF00069	0.401
MOD_CK1_1	682	688	PF00069	0.236
MOD_CK2_1	123	129	PF00069	0.681
MOD_CK2_1	149	155	PF00069	0.717
MOD_CK2_1	215	221	PF00069	0.620
MOD_CK2_1	607	613	PF00069	0.399
MOD_Cter_Amidation	280	283	PF01082	0.385
MOD_Cter_Amidation	672	675	PF01082	0.493
MOD_Cter_Amidation	93	96	PF01082	0.529
MOD_GlcNHglycan	209	212	PF01048	0.528
MOD_GlcNHglycan	287	290	PF01048	0.473
MOD_GlcNHglycan	405	408	PF01048	0.482
MOD_GlcNHglycan	591	594	PF01048	0.593
MOD_GlcNHglycan	630	633	PF01048	0.317
MOD_GlcNHglycan	642	645	PF01048	0.502
MOD_GlcNHglycan	660	664	PF01048	0.384
MOD_GlcNHglycan	76	79	PF01048	0.588
MOD_GlcNHglycan	86	89	PF01048	0.565
MOD_GSK3_1	215	222	PF00069	0.737
MOD_GSK3_1	31	38	PF00069	0.455
MOD_GSK3_1	470	477	PF00069	0.500
MOD_GSK3_1	546	553	PF00069	0.404
MOD_GSK3_1	560	567	PF00069	0.440
MOD_GSK3_1	603	610	PF00069	0.538
MOD_GSK3_1	638	645	PF00069	0.493
MOD_GSK3_1	658	665	PF00069	0.440
MOD_GSK3_1	679	686	PF00069	0.399
MOD_N-GLC_1	553	558	PF02516	0.432
MOD_NEK2_1	182	187	PF00069	0.501
MOD_NEK2_1	329	334	PF00069	0.574
MOD_NEK2_1	397	402	PF00069	0.534
MOD_NEK2_1	433	438	PF00069	0.407
MOD_NEK2_1	637	642	PF00069	0.619
MOD_NEK2_1	697	702	PF00069	0.412
MOD_NEK2_1	74	79	PF00069	0.553
MOD_NEK2_2	247	252	PF00069	0.345
MOD_NEK2_2	295	300	PF00069	0.413
MOD_PIKK_1	315	321	PF00454	0.490
MOD_PIKK_1	421	427	PF00454	0.521
MOD_PK_1	301	307	PF00069	0.450
MOD_PKA_1	301	307	PF00069	0.418
MOD_PKA_1	544	550	PF00069	0.441
MOD_PKA_1	674	680	PF00069	0.456
MOD_PKA_2	166	172	PF00069	0.559
MOD_PKA_2	22	28	PF00069	0.491
MOD_PKA_2	301	307	PF00069	0.363
MOD_PKA_2	329	335	PF00069	0.446
MOD_PKA_2	336	342	PF00069	0.447
MOD_PKA_2	415	421	PF00069	0.440
MOD_PKA_2	544	550	PF00069	0.525
MOD_PKA_2	607	613	PF00069	0.535
MOD_PKA_2	63	69	PF00069	0.440
MOD_PKA_2	648	654	PF00069	0.409
MOD_PKA_2	674	680	PF00069	0.516
MOD_PKA_2	682	688	PF00069	0.514
MOD_PKB_1	96	104	PF00069	0.514
MOD_Plk_1	154	160	PF00069	0.553
MOD_Plk_1	553	559	PF00069	0.476
MOD_Plk_1	564	570	PF00069	0.352
MOD_Plk_1	659	665	PF00069	0.350
MOD_Plk_4	118	124	PF00069	0.704
MOD_Plk_4	166	172	PF00069	0.610
MOD_Plk_4	193	199	PF00069	0.435
MOD_Plk_4	301	307	PF00069	0.363
MOD_Plk_4	433	439	PF00069	0.406
MOD_Plk_4	470	476	PF00069	0.504
MOD_Plk_4	611	617	PF00069	0.484
MOD_ProDKin_1	123	129	PF00069	0.681
MOD_ProDKin_1	361	367	PF00069	0.425
MOD_ProDKin_1	428	434	PF00069	0.488
MOD_ProDKin_1	474	480	PF00069	0.524
MOD_ProDKin_1	502	508	PF00069	0.646
MOD_ProDKin_1	546	552	PF00069	0.497
MOD_SUMO_rev_2	495	505	PF00179	0.481
MOD_SUMO_rev_2	572	578	PF00179	0.457
MOD_SUMO_rev_2	592	602	PF00179	0.494
TRG_DiLeu_BaEn_1	4	9	PF01217	0.287
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.474
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.323
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.510
TRG_ENDOCYTIC_2	168	171	PF00928	0.613
TRG_ENDOCYTIC_2	17	20	PF00928	0.413
TRG_ENDOCYTIC_2	274	277	PF00928	0.448
TRG_ENDOCYTIC_2	309	312	PF00928	0.454
TRG_ENDOCYTIC_2	46	49	PF00928	0.390
TRG_ER_diArg_1	20	23	PF00400	0.453
TRG_ER_diArg_1	282	284	PF00400	0.411
TRG_ER_diArg_1	301	303	PF00400	0.468
TRG_ER_diArg_1	544	546	PF00400	0.444
TRG_ER_diArg_1	616	618	PF00400	0.393
TRG_ER_diArg_1	63	65	PF00400	0.421
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	600	604	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAY3	Leptomonas seymouri	60%	99%
A0A1X0NUW5	Trypanosomatidae	31%	100%
A0A422N8N4	Trypanosoma rangeli	31%	100%
A4HK74	Leishmania braziliensis	78%	100%
A4I7Q9	Leishmania infantum	100%	100%
D0A9W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B2L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5I9	Leishmania major	92%	100%
V5BGK4	Trypanosoma cruzi	32%	100%