LeishMANIAdb
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JAB1/Mov34/MPN/PAD-1 ubiquitin protease family protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
JAB1/Mov34/MPN/PAD-1 ubiquitin protease family protein
Gene product:
19S proteasome non-atpase subunit 8
Species:
Leishmania donovani
UniProt:
A0A3S5H7R2_LEIDO
TriTrypDb:
LdBPK_320400.1 , LdCL_320008900 , LDHU3_32.0490
Length:
359

Annotations

Annotations by Jardim et al.

Proteasome, proteasome regulatory non-ATP-ase subunit 8

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000502 proteasome complex 3 12
GO:0032991 protein-containing complex 1 12
GO:0140535 intracellular protein-containing complex 2 12
GO:1902494 catalytic complex 2 12
GO:1905368 peptidase complex 3 12
GO:1905369 endopeptidase complex 4 12
GO:0005838 proteasome regulatory particle 2 1

Phosphorylation

Promastigote: 16, 21, 25

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S5H7R2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7R2

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 3
GO:0006807 nitrogen compound metabolic process 2 3
GO:0008152 metabolic process 1 3
GO:0019538 protein metabolic process 3 3
GO:0043170 macromolecule metabolic process 3 3
GO:0044238 primary metabolic process 2 3
GO:0071704 organic substance metabolic process 2 3
GO:1901564 organonitrogen compound metabolic process 3 3
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030163 protein catabolic process 4 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0008233 peptidase activity 3 12
GO:0008237 metallopeptidase activity 4 12
GO:0016787 hydrolase activity 2 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 217 221 PF00656 0.433
CLV_C14_Caspase3-7 23 27 PF00656 0.476
CLV_NRD_NRD_1 282 284 PF00675 0.335
CLV_NRD_NRD_1 318 320 PF00675 0.321
CLV_NRD_NRD_1 331 333 PF00675 0.342
CLV_PCSK_KEX2_1 124 126 PF00082 0.471
CLV_PCSK_KEX2_1 282 284 PF00082 0.301
CLV_PCSK_KEX2_1 318 320 PF00082 0.319
CLV_PCSK_KEX2_1 331 333 PF00082 0.350
CLV_PCSK_KEX2_1 69 71 PF00082 0.439
CLV_PCSK_PC1ET2_1 124 126 PF00082 0.552
CLV_PCSK_PC1ET2_1 69 71 PF00082 0.439
CLV_PCSK_SKI1_1 124 128 PF00082 0.444
CLV_PCSK_SKI1_1 216 220 PF00082 0.233
CLV_PCSK_SKI1_1 6 10 PF00082 0.791
DEG_APCC_DBOX_1 155 163 PF00400 0.388
DOC_MAPK_DCC_7 124 132 PF00069 0.257
DOC_MAPK_DCC_7 43 51 PF00069 0.233
DOC_MAPK_gen_1 124 132 PF00069 0.245
DOC_MAPK_gen_1 68 76 PF00069 0.233
DOC_MAPK_MEF2A_6 124 132 PF00069 0.233
DOC_MAPK_MEF2A_6 43 52 PF00069 0.233
DOC_PP1_RVXF_1 129 136 PF00149 0.300
DOC_PP1_RVXF_1 188 195 PF00149 0.285
DOC_PP4_FxxP_1 95 98 PF00568 0.233
DOC_USP7_MATH_1 281 285 PF00917 0.453
LIG_14-3-3_CanoR_1 178 184 PF00244 0.374
LIG_14-3-3_CanoR_1 282 289 PF00244 0.539
LIG_Actin_WH2_2 236 254 PF00022 0.487
LIG_BIR_II_1 1 5 PF00653 0.485
LIG_BRCT_BRCA1_1 190 194 PF00533 0.285
LIG_deltaCOP1_diTrp_1 107 111 PF00928 0.279
LIG_DLG_GKlike_1 233 240 PF00625 0.433
LIG_FHA_1 187 193 PF00498 0.327
LIG_FHA_1 61 67 PF00498 0.335
LIG_FHA_1 86 92 PF00498 0.278
LIG_FHA_2 290 296 PF00498 0.480
LIG_FHA_2 336 342 PF00498 0.648
LIG_HP1_1 48 52 PF01393 0.233
LIG_LIR_Apic_2 94 98 PF02991 0.244
LIG_LIR_Gen_1 56 66 PF02991 0.244
LIG_LIR_Nem_3 191 197 PF02991 0.271
LIG_NRBOX 147 153 PF00104 0.244
LIG_PCNA_yPIPBox_3 145 156 PF02747 0.293
LIG_Pex14_2 95 99 PF04695 0.233
LIG_PTB_Apo_2 157 164 PF02174 0.295
LIG_PTB_Phospho_1 157 163 PF10480 0.279
LIG_RPA_C_Fungi 314 326 PF08784 0.480
LIG_SH2_CRK 163 167 PF00017 0.324
LIG_SH2_CRK 180 184 PF00017 0.392
LIG_SH2_NCK_1 180 184 PF00017 0.407
LIG_SH2_STAP1 115 119 PF00017 0.270
LIG_SH2_STAT5 163 166 PF00017 0.316
LIG_SH2_STAT5 180 183 PF00017 0.380
LIG_SH2_STAT5 250 253 PF00017 0.270
LIG_SH2_STAT5 79 82 PF00017 0.413
LIG_SH3_3 28 34 PF00018 0.617
LIG_SUMO_SIM_anti_2 234 239 PF11976 0.413
LIG_SUMO_SIM_anti_2 262 271 PF11976 0.250
LIG_SUMO_SIM_par_1 47 53 PF11976 0.270
LIG_TRFH_1 157 161 PF08558 0.488
LIG_UBA3_1 119 124 PF00899 0.363
LIG_UBA3_1 237 242 PF00899 0.390
LIG_WRC_WIRS_1 297 302 PF05994 0.363
MOD_CK1_1 138 144 PF00069 0.363
MOD_CK1_1 221 227 PF00069 0.270
MOD_CK2_1 281 287 PF00069 0.321
MOD_CK2_1 289 295 PF00069 0.342
MOD_CK2_1 335 341 PF00069 0.514
MOD_GlcNHglycan 137 140 PF01048 0.293
MOD_GlcNHglycan 63 66 PF01048 0.346
MOD_GSK3_1 134 141 PF00069 0.281
MOD_GSK3_1 18 25 PF00069 0.717
MOD_GSK3_1 218 225 PF00069 0.286
MOD_GSK3_1 81 88 PF00069 0.427
MOD_N-GLC_1 61 66 PF02516 0.413
MOD_N-GLC_1 91 96 PF02516 0.285
MOD_NEK2_1 110 115 PF00069 0.285
MOD_NEK2_1 218 223 PF00069 0.270
MOD_NEK2_1 61 66 PF00069 0.413
MOD_PIKK_1 225 231 PF00454 0.303
MOD_PK_1 282 288 PF00069 0.237
MOD_PKA_1 282 288 PF00069 0.366
MOD_PKA_2 281 287 PF00069 0.325
MOD_PKA_2 289 295 PF00069 0.278
MOD_PKA_2 80 86 PF00069 0.381
MOD_Plk_1 219 225 PF00069 0.270
MOD_Plk_1 233 239 PF00069 0.270
MOD_Plk_1 61 67 PF00069 0.413
MOD_Plk_1 91 97 PF00069 0.285
MOD_Plk_2-3 18 24 PF00069 0.688
MOD_Plk_4 233 239 PF00069 0.413
MOD_Plk_4 296 302 PF00069 0.332
MOD_Plk_4 50 56 PF00069 0.270
MOD_SUMO_for_1 345 348 PF00179 0.564
MOD_SUMO_rev_2 2 8 PF00179 0.714
TRG_ENDOCYTIC_2 163 166 PF00928 0.316
TRG_ENDOCYTIC_2 180 183 PF00928 0.380
TRG_ENDOCYTIC_2 58 61 PF00928 0.285
TRG_ER_diArg_1 331 334 PF00400 0.502
TRG_Pf-PMV_PEXEL_1 216 220 PF00026 0.270
TRG_Pf-PMV_PEXEL_1 319 324 PF00026 0.431

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0V5 Leptomonas seymouri 89% 100%
A0A0S4IMY0 Bodo saltans 60% 100%
A0A1X0P6H9 Trypanosomatidae 71% 93%
A0A3R7LWY5 Trypanosoma rangeli 70% 97%
A1CQH7 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 25% 100%
A1D3E1 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 25% 100%
A2QQ10 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 25% 96%
A4HK19 Leishmania braziliensis 94% 100%
A4I7K3 Leishmania infantum 100% 100%
A4R0E5 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 22% 97%
A5A6I3 Pan troglodytes 27% 99%
A6QQ21 Bos taurus 23% 100%
A7TX81 Sus scrofa 24% 100%
B0X2G0 Culex quinquefasciatus 29% 100%
B0XQ55 Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) 25% 100%
D0A0A6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 94%
E9B2G0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O00303 Homo sapiens 27% 100%
O04202 Arabidopsis thaliana 29% 100%
O24412 Arabidopsis thaliana 38% 100%
O43060 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
O74440 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 100%
O88545 Mus musculus 23% 100%
P26270 Drosophila melanogaster 40% 100%
P26516 Mus musculus 39% 100%
P51665 Homo sapiens 39% 100%
Q07G98 Xenopus tropicalis 24% 100%
Q08723 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 100%
Q0CCM5 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 24% 100%
Q0UTQ6 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) 25% 100%
Q18967 Caenorhabditis elegans 25% 100%
Q1DRC9 Coccidioides immitis (strain RS) 25% 100%
Q1HR47 Aedes aegypti 28% 100%
Q2HGJ2 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 22% 100%
Q2UPM0 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 25% 100%
Q3ZBD0 Bos taurus 39% 100%
Q4Q5P6 Leishmania major 98% 100%
Q4R5B8 Macaca fascicularis 27% 99%
Q4WTH0 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 25% 100%
Q54C92 Dictyostelium discoideum 25% 100%
Q54WI8 Dictyostelium discoideum 39% 100%
Q5REY0 Pongo abelii 24% 100%
Q6FMD8 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 34% 100%
Q6NUC2 Xenopus laevis 24% 100%
Q6ZKM2 Oryza sativa subsp. japonica 25% 100%
Q75F44 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 34% 100%
Q7L5N1 Homo sapiens 23% 100%
Q7QD36 Anopheles gambiae 26% 100%
Q8W1P0 Arabidopsis thaliana 25% 100%
Q8W206 Arabidopsis thaliana 26% 100%
Q8WZY4 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 36% 100%
Q9C774 Arabidopsis thaliana 38% 100%
Q9DCH4 Mus musculus 26% 99%
V5C1Q5 Trypanosoma cruzi 69% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS