Autophagy protein 10 (ATG10)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagy protein 10

Species:

Leishmania donovani

UniProt:

A0A3S5H7Q9_LEIDO

TriTrypDb:

LdBPK_313230.1 , LdCL_310040600 , LDHU3_31.5490

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7Q9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Q9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	184	186	PF00675	0.389
CLV_NRD_NRD_1	215	217	PF00675	0.531
CLV_PCSK_FUR_1	98	102	PF00082	0.608
CLV_PCSK_KEX2_1	100	102	PF00082	0.532
CLV_PCSK_KEX2_1	184	186	PF00082	0.389
CLV_PCSK_KEX2_1	215	217	PF00082	0.531
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.586
DEG_APCC_DBOX_1	40	48	PF00400	0.549
DEG_Nend_UBRbox_2	1	3	PF02207	0.429
DOC_CDC14_PxL_1	236	244	PF14671	0.499
DOC_MAPK_DCC_7	159	167	PF00069	0.493
DOC_MAPK_gen_1	184	190	PF00069	0.362
DOC_MAPK_MEF2A_6	159	167	PF00069	0.493
DOC_MAPK_RevD_3	200	216	PF00069	0.552
DOC_PP2B_LxvP_1	104	107	PF13499	0.400
DOC_PP2B_LxvP_1	241	244	PF13499	0.555
DOC_PP4_FxxP_1	140	143	PF00568	0.427
DOC_PP4_FxxP_1	24	27	PF00568	0.427
DOC_USP7_MATH_1	186	190	PF00917	0.454
DOC_USP7_MATH_1	34	38	PF00917	0.591
DOC_USP7_MATH_2	94	100	PF00917	0.593
DOC_WW_Pin1_4	59	64	PF00397	0.549
DOC_WW_Pin1_4	90	95	PF00397	0.590
LIG_14-3-3_CanoR_1	185	191	PF00244	0.498
LIG_14-3-3_CanoR_1	230	238	PF00244	0.435
LIG_14-3-3_CanoR_1	41	49	PF00244	0.546
LIG_14-3-3_CanoR_1	79	83	PF00244	0.476
LIG_Actin_WH2_2	40	57	PF00022	0.528
LIG_BH_BH3_1	221	237	PF00452	0.530
LIG_BRCT_BRCA1_1	232	236	PF00533	0.439
LIG_FHA_1	112	118	PF00498	0.458
LIG_FHA_1	129	135	PF00498	0.367
LIG_FHA_1	206	212	PF00498	0.425
LIG_FHA_1	70	76	PF00498	0.599
LIG_FHA_2	151	157	PF00498	0.476
LIG_LIR_Apic_2	139	143	PF02991	0.416
LIG_LIR_Gen_1	81	86	PF02991	0.385
LIG_LIR_Nem_3	233	238	PF02991	0.539
LIG_LIR_Nem_3	81	85	PF02991	0.496
LIG_MLH1_MIPbox_1	232	236	PF16413	0.439
LIG_MYND_1	240	244	PF01753	0.513
LIG_PCNA_yPIPBox_3	215	228	PF02747	0.473
LIG_Pex14_2	136	140	PF04695	0.442
LIG_PTB_Apo_2	134	141	PF02174	0.513
LIG_PTB_Apo_2	161	168	PF02174	0.494
LIG_SH2_PTP2	20	23	PF00017	0.501
LIG_SH2_STAT5	17	20	PF00017	0.468
LIG_SH2_STAT5	235	238	PF00017	0.479
LIG_SH3_1	20	26	PF00018	0.430
LIG_SH3_3	165	171	PF00018	0.603
LIG_SH3_3	20	26	PF00018	0.499
LIG_SH3_3	234	240	PF00018	0.469
LIG_SH3_3	28	34	PF00018	0.458
LIG_SH3_3	57	63	PF00018	0.630
LIG_Sin3_3	239	246	PF02671	0.584
LIG_WRC_WIRS_1	187	192	PF05994	0.560
MOD_CK1_1	150	156	PF00069	0.550
MOD_CK1_1	37	43	PF00069	0.559
MOD_CK2_1	116	122	PF00069	0.532
MOD_CK2_1	150	156	PF00069	0.513
MOD_CK2_1	169	175	PF00069	0.494
MOD_CK2_1	90	96	PF00069	0.592
MOD_GlcNHglycan	122	126	PF01048	0.639
MOD_GSK3_1	117	124	PF00069	0.589
MOD_GSK3_1	147	154	PF00069	0.526
MOD_GSK3_1	33	40	PF00069	0.472
MOD_GSK3_1	67	74	PF00069	0.641
MOD_N-GLC_1	148	153	PF02516	0.588
MOD_N-GLC_1	163	168	PF02516	0.336
MOD_N-GLC_2	116	118	PF02516	0.506
MOD_NEK2_1	111	116	PF00069	0.449
MOD_NEK2_1	121	126	PF00069	0.479
MOD_NEK2_1	147	152	PF00069	0.521
MOD_NEK2_2	64	69	PF00069	0.558
MOD_PKA_2	37	43	PF00069	0.557
MOD_PKA_2	78	84	PF00069	0.564
MOD_Plk_1	111	117	PF00069	0.467
MOD_Plk_1	148	154	PF00069	0.590
MOD_Plk_1	163	169	PF00069	0.351
MOD_Plk_4	163	169	PF00069	0.505
MOD_Plk_4	223	229	PF00069	0.508
MOD_ProDKin_1	59	65	PF00069	0.550
MOD_ProDKin_1	90	96	PF00069	0.592
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.562
TRG_ENDOCYTIC_2	199	202	PF00928	0.483
TRG_ENDOCYTIC_2	235	238	PF00928	0.479
TRG_ER_diArg_1	183	185	PF00400	0.430
TRG_ER_diArg_1	215	217	PF00400	0.528
TRG_ER_diArg_1	41	44	PF00400	0.660
TRG_ER_diArg_1	51	54	PF00400	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N4	Leptomonas seymouri	50%	100%
A0A1X0NI81	Trypanosomatidae	28%	100%
A4HJV5	Leishmania braziliensis	77%	100%
A4I7B7	Leishmania infantum	100%	100%
C9ZWJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B2B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q5U6	Leishmania major	90%	100%