Inositol_polyphosphate_1-phosphatase_putative/Gen eDB:LmjF.31.2920

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol polyphosphate 1-phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7Q8_LEIDO

TriTrypDb:

LdBPK_313030.1 , LdCL_310038600 , LDHU3_31.5210

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Q8

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0006066	alcohol metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009987	cellular process	1	11
GO:0016311	dephosphorylation	5	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019751	polyol metabolic process	4	11
GO:0043647	inositol phosphate metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044262	obsolete cellular carbohydrate metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044282	small molecule catabolic process	3	11
GO:0046164	alcohol catabolic process	4	11
GO:0046174	polyol catabolic process	5	11
GO:0046434	organophosphate catabolic process	4	11
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	11
GO:0046855	obsolete inositol phosphate dephosphorylation	5	11
GO:0071545	inositol phosphate catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901575	organic substance catabolic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901616	organic hydroxy compound catabolic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004441	inositol-1,4-bisphosphate 1-phosphatase activity	8	6
GO:0016312	inositol bisphosphate phosphatase activity	7	6
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6
GO:0052745	inositol phosphate phosphatase activity	6	6
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	96	100	PF00656	0.331
CLV_NRD_NRD_1	285	287	PF00675	0.301
CLV_NRD_NRD_1	47	49	PF00675	0.321
CLV_PCSK_KEX2_1	285	287	PF00082	0.301
CLV_PCSK_KEX2_1	46	48	PF00082	0.322
CLV_PCSK_SKI1_1	163	167	PF00082	0.460
CLV_PCSK_SKI1_1	169	173	PF00082	0.253
CLV_PCSK_SKI1_1	194	198	PF00082	0.314
DEG_SPOP_SBC_1	257	261	PF00917	0.468
DOC_CKS1_1	119	124	PF01111	0.466
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.333
DOC_MAPK_DCC_7	109	117	PF00069	0.287
DOC_MAPK_FxFP_2	91	94	PF00069	0.377
DOC_MAPK_gen_1	285	293	PF00069	0.492
DOC_MAPK_gen_1	46	53	PF00069	0.249
DOC_MAPK_MEF2A_6	109	117	PF00069	0.287
DOC_MAPK_MEF2A_6	46	53	PF00069	0.244
DOC_PP1_RVXF_1	283	290	PF00149	0.343
DOC_PP2B_PxIxI_1	262	268	PF00149	0.296
DOC_PP4_FxxP_1	213	216	PF00568	0.244
DOC_PP4_FxxP_1	52	55	PF00568	0.236
DOC_PP4_FxxP_1	91	94	PF00568	0.377
DOC_USP7_MATH_1	258	262	PF00917	0.576
DOC_WW_Pin1_4	118	123	PF00397	0.405
DOC_WW_Pin1_4	149	154	PF00397	0.353
DOC_WW_Pin1_4	205	210	PF00397	0.308
DOC_WW_Pin1_4	273	278	PF00397	0.393
LIG_14-3-3_CanoR_1	158	167	PF00244	0.332
LIG_14-3-3_CanoR_1	169	176	PF00244	0.344
LIG_14-3-3_CanoR_1	286	292	PF00244	0.403
LIG_APCC_ABBA_1	35	40	PF00400	0.498
LIG_APCC_ABBA_1	49	54	PF00400	0.182
LIG_APCC_ABBAyCdc20_2	48	54	PF00400	0.218
LIG_BIR_II_1	1	5	PF00653	0.492
LIG_eIF4E_1	187	193	PF01652	0.377
LIG_FHA_1	119	125	PF00498	0.254
LIG_FHA_1	160	166	PF00498	0.359
LIG_FHA_1	257	263	PF00498	0.586
LIG_FHA_1	267	273	PF00498	0.496
LIG_FHA_1	288	294	PF00498	0.443
LIG_FHA_2	159	165	PF00498	0.322
LIG_FHA_2	170	176	PF00498	0.322
LIG_FHA_2	206	212	PF00498	0.377
LIG_FHA_2	94	100	PF00498	0.347
LIG_GBD_Chelix_1	283	291	PF00786	0.326
LIG_LIR_Apic_2	211	216	PF02991	0.244
LIG_LIR_Apic_2	64	70	PF02991	0.234
LIG_LIR_Gen_1	126	136	PF02991	0.373
LIG_LIR_Gen_1	16	23	PF02991	0.526
LIG_LIR_Nem_3	126	131	PF02991	0.373
LIG_LIR_Nem_3	16	21	PF02991	0.465
LIG_LYPXL_yS_3	249	252	PF13949	0.309
LIG_NRBOX	166	172	PF00104	0.287
LIG_PTB_Apo_2	85	92	PF02174	0.244
LIG_SH2_CRK	190	194	PF00017	0.393
LIG_SH2_CRK	5	9	PF00017	0.569
LIG_SH2_NCK_1	255	259	PF00017	0.502
LIG_SH2_STAP1	13	17	PF00017	0.396
LIG_SH3_3	133	139	PF00018	0.314
LIG_SH3_3	211	217	PF00018	0.366
LIG_SUMO_SIM_anti_2	264	270	PF11976	0.275
LIG_SUMO_SIM_par_1	269	276	PF11976	0.418
LIG_TYR_ITIM	247	252	PF00017	0.322
LIG_TYR_ITIM	90	95	PF00017	0.317
MOD_CK1_1	159	165	PF00069	0.264
MOD_CK1_1	24	30	PF00069	0.439
MOD_CK1_1	256	262	PF00069	0.527
MOD_CK2_1	158	164	PF00069	0.377
MOD_CK2_1	169	175	PF00069	0.377
MOD_CK2_1	258	264	PF00069	0.544
MOD_GlcNHglycan	255	258	PF01048	0.638
MOD_GlcNHglycan	8	11	PF01048	0.485
MOD_GSK3_1	253	260	PF00069	0.590
MOD_LATS_1	4	10	PF00433	0.398
MOD_NEK2_1	287	292	PF00069	0.370
MOD_PIKK_1	169	175	PF00454	0.352
MOD_PKA_2	157	163	PF00069	0.314
MOD_Plk_1	107	113	PF00069	0.188
MOD_Plk_4	113	119	PF00069	0.218
MOD_Plk_4	69	75	PF00069	0.244
MOD_ProDKin_1	118	124	PF00069	0.405
MOD_ProDKin_1	149	155	PF00069	0.353
MOD_ProDKin_1	205	211	PF00069	0.308
MOD_ProDKin_1	273	279	PF00069	0.392
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.309
TRG_ENDOCYTIC_2	18	21	PF00928	0.365
TRG_ENDOCYTIC_2	190	193	PF00928	0.393
TRG_ENDOCYTIC_2	249	252	PF00928	0.322
TRG_ENDOCYTIC_2	5	8	PF00928	0.515
TRG_ENDOCYTIC_2	92	95	PF00928	0.257
TRG_ER_diArg_1	285	287	PF00400	0.316
TRG_ER_diArg_1	45	48	PF00400	0.287
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.287

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U3	Leptomonas seymouri	58%	68%
A0A1X0NIY3	Trypanosomatidae	40%	75%
A0A3R7KA15	Trypanosoma rangeli	37%	69%
A4HJT1	Leishmania braziliensis	76%	100%
A4I797	Leishmania infantum	99%	100%
C9ZWL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	76%
E9B292	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P21327	Bos taurus	28%	74%
P49442	Mus musculus	27%	74%
Q4Q5W6	Leishmania major	90%	100%
V5AS37	Trypanosoma cruzi	37%	76%