RNA recognition motif family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7Q7_LEIDO

TriTrypDb:

LdBPK_312860.1 , LdCL_310036900 , LDHU3_31.4990

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S5H7Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Q7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.485
CLV_NRD_NRD_1	128	130	PF00675	0.542
CLV_NRD_NRD_1	61	63	PF00675	0.285
CLV_PCSK_KEX2_1	128	130	PF00082	0.542
CLV_PCSK_KEX2_1	61	63	PF00082	0.292
CLV_Separin_Metazoa	125	129	PF03568	0.515
DEG_APCC_DBOX_1	225	233	PF00400	0.598
DEG_SCF_FBW7_2	55	60	PF00400	0.485
DOC_PP4_FxxP_1	89	92	PF00568	0.468
DOC_USP7_MATH_1	176	180	PF00917	0.671
DOC_USP7_MATH_1	235	239	PF00917	0.556
DOC_USP7_MATH_1	250	254	PF00917	0.631
DOC_USP7_MATH_1	280	284	PF00917	0.516
DOC_USP7_MATH_1	5	9	PF00917	0.417
DOC_USP7_MATH_2	250	256	PF00917	0.591
DOC_WW_Pin1_4	107	112	PF00397	0.313
DOC_WW_Pin1_4	156	161	PF00397	0.572
DOC_WW_Pin1_4	53	58	PF00397	0.494
DOC_WW_Pin1_4	88	93	PF00397	0.470
LIG_14-3-3_CanoR_1	118	127	PF00244	0.544
LIG_14-3-3_CanoR_1	178	186	PF00244	0.598
LIG_14-3-3_CanoR_1	261	270	PF00244	0.588
LIG_14-3-3_CanoR_1	284	294	PF00244	0.630
LIG_14-3-3_CanoR_1	50	56	PF00244	0.485
LIG_14-3-3_CanoR_1	9	19	PF00244	0.452
LIG_APCC_ABBA_1	202	207	PF00400	0.568
LIG_BIR_II_1	1	5	PF00653	0.570
LIG_FHA_1	304	310	PF00498	0.557
LIG_FHA_1	63	69	PF00498	0.485
LIG_FHA_2	120	126	PF00498	0.506
LIG_FHA_2	27	33	PF00498	0.492
LIG_FHA_2	276	282	PF00498	0.729
LIG_FHA_2	290	296	PF00498	0.557
LIG_FHA_2	54	60	PF00498	0.485
LIG_FHA_2	70	76	PF00498	0.520
LIG_LIR_Apic_2	155	160	PF02991	0.581
LIG_LIR_Apic_2	288	294	PF02991	0.613
LIG_LIR_Apic_2	88	92	PF02991	0.471
LIG_LIR_Gen_1	216	223	PF02991	0.555
LIG_LIR_Nem_3	216	220	PF02991	0.655
LIG_LIR_Nem_3	32	37	PF02991	0.484
LIG_LIR_Nem_3	38	43	PF02991	0.470
LIG_LIR_Nem_3	65	70	PF02991	0.476
LIG_LYPXL_S_1	33	37	PF13949	0.285
LIG_SH2_CRK	157	161	PF00017	0.583
LIG_SH2_CRK	217	221	PF00017	0.556
LIG_SH2_CRK	40	44	PF00017	0.498
LIG_SH2_GRB2like	217	220	PF00017	0.562
LIG_SH2_NCK_1	146	150	PF00017	0.724
LIG_SH2_NCK_1	157	161	PF00017	0.525
LIG_SH2_NCK_1	291	295	PF00017	0.600
LIG_SH2_PTP2	101	104	PF00017	0.427
LIG_SH2_STAP1	217	221	PF00017	0.556
LIG_SH2_STAT5	101	104	PF00017	0.445
LIG_SH2_STAT5	191	194	PF00017	0.547
LIG_SH2_STAT5	242	245	PF00017	0.595
LIG_SH2_STAT5	27	30	PF00017	0.485
LIG_SH2_STAT5	291	294	PF00017	0.605
LIG_TRAF2_1	57	60	PF00917	0.485
LIG_TRAF2_1	92	95	PF00917	0.533
LIG_TYR_ITIM	99	104	PF00017	0.443
LIG_WRC_WIRS_1	86	91	PF05994	0.454
MOD_CDK_SPxxK_3	111	118	PF00069	0.422
MOD_CK1_1	147	153	PF00069	0.687
MOD_CK1_1	155	161	PF00069	0.561
MOD_CK1_1	179	185	PF00069	0.576
MOD_CK1_1	253	259	PF00069	0.673
MOD_CK1_1	263	269	PF00069	0.581
MOD_CK1_1	305	311	PF00069	0.435
MOD_CK2_1	119	125	PF00069	0.469
MOD_CK2_1	289	295	PF00069	0.592
MOD_CK2_1	53	59	PF00069	0.485
MOD_CK2_1	69	75	PF00069	0.520
MOD_CK2_1	88	94	PF00069	0.542
MOD_CMANNOS	116	119	PF00535	0.456
MOD_GlcNHglycan	132	135	PF01048	0.612
MOD_GlcNHglycan	170	173	PF01048	0.612
MOD_GlcNHglycan	182	185	PF01048	0.577
MOD_GlcNHglycan	252	255	PF01048	0.611
MOD_GlcNHglycan	310	313	PF01048	0.567
MOD_GSK3_1	107	114	PF00069	0.509
MOD_GSK3_1	130	137	PF00069	0.600
MOD_GSK3_1	152	159	PF00069	0.607
MOD_GSK3_1	166	173	PF00069	0.539
MOD_GSK3_1	176	183	PF00069	0.559
MOD_GSK3_1	185	192	PF00069	0.476
MOD_GSK3_1	285	292	PF00069	0.625
MOD_GSK3_1	303	310	PF00069	0.583
MOD_GSK3_1	49	56	PF00069	0.502
MOD_N-GLC_1	268	273	PF02516	0.750
MOD_NEK2_1	127	132	PF00069	0.516
MOD_NEK2_1	168	173	PF00069	0.560
MOD_NEK2_1	189	194	PF00069	0.590
MOD_NEK2_1	285	290	PF00069	0.613
MOD_NEK2_1	302	307	PF00069	0.491
MOD_NEK2_1	87	92	PF00069	0.466
MOD_NEK2_2	35	40	PF00069	0.485
MOD_PIKK_1	10	16	PF00454	0.452
MOD_PIKK_1	119	125	PF00454	0.469
MOD_PIKK_1	177	183	PF00454	0.590
MOD_PKA_1	275	281	PF00069	0.577
MOD_PKA_2	127	133	PF00069	0.584
MOD_PKA_2	177	183	PF00069	0.623
MOD_PKA_2	189	195	PF00069	0.618
MOD_PKA_2	260	266	PF00069	0.597
MOD_PKA_2	285	291	PF00069	0.630
MOD_PKA_2	49	55	PF00069	0.496
MOD_PKA_2	5	11	PF00069	0.517
MOD_Plk_1	184	190	PF00069	0.581
MOD_Plk_2-3	71	77	PF00069	0.485
MOD_Plk_4	263	269	PF00069	0.599
MOD_ProDKin_1	107	113	PF00069	0.310
MOD_ProDKin_1	156	162	PF00069	0.574
MOD_ProDKin_1	53	59	PF00069	0.494
MOD_ProDKin_1	88	94	PF00069	0.481
MOD_SUMO_rev_2	271	277	PF00179	0.511
MOD_SUMO_rev_2	90	99	PF00179	0.521
TRG_ENDOCYTIC_2	101	104	PF00928	0.427
TRG_ENDOCYTIC_2	146	149	PF00928	0.610
TRG_ENDOCYTIC_2	217	220	PF00928	0.609
TRG_ENDOCYTIC_2	34	37	PF00928	0.481
TRG_ENDOCYTIC_2	40	43	PF00928	0.474
TRG_ER_diArg_1	127	129	PF00400	0.532
TRG_ER_diArg_1	61	63	PF00400	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M2	Leptomonas seymouri	67%	100%
A0A422NJ32	Trypanosoma rangeli	28%	78%
A4HJR5	Leishmania braziliensis	85%	100%
A4HLK6	Leishmania braziliensis	30%	100%
A4I782	Leishmania infantum	99%	100%
E9B276	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q5Y3	Leishmania major	96%	100%