Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H7Q5_LEIDO

TriTrypDb:

LdBPK_312510.1 , LdCL_310033100 , LDHU3_31.4520

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Q5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	201	203	PF00675	0.407
CLV_NRD_NRD_1	27	29	PF00675	0.391
CLV_NRD_NRD_1	55	57	PF00675	0.483
CLV_PCSK_KEX2_1	142	144	PF00082	0.708
CLV_PCSK_KEX2_1	152	154	PF00082	0.582
CLV_PCSK_KEX2_1	201	203	PF00082	0.403
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.708
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.582
CLV_PCSK_SKI1_1	147	151	PF00082	0.582
CLV_PCSK_SKI1_1	202	206	PF00082	0.502
CLV_PCSK_SKI1_1	228	232	PF00082	0.526
CLV_PCSK_SKI1_1	41	45	PF00082	0.422
CLV_PCSK_SKI1_1	94	98	PF00082	0.480
DEG_APCC_DBOX_1	142	150	PF00400	0.494
DOC_MAPK_gen_1	92	99	PF00069	0.434
DOC_MAPK_MEF2A_6	92	99	PF00069	0.434
DOC_MAPK_NFAT4_5	92	100	PF00069	0.435
DOC_PP2B_PxIxI_1	22	28	PF00149	0.409
DOC_USP7_MATH_1	131	135	PF00917	0.662
DOC_USP7_MATH_1	138	142	PF00917	0.508
DOC_USP7_MATH_1	161	165	PF00917	0.760
DOC_USP7_MATH_1	166	170	PF00917	0.605
DOC_WW_Pin1_4	77	82	PF00397	0.392
LIG_14-3-3_CanoR_1	35	45	PF00244	0.376
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_deltaCOP1_diTrp_1	218	227	PF00928	0.334
LIG_FHA_1	171	177	PF00498	0.424
LIG_FHA_1	38	44	PF00498	0.415
LIG_FHA_2	177	183	PF00498	0.438
LIG_FHA_2	227	233	PF00498	0.492
LIG_FHA_2	98	104	PF00498	0.376
LIG_LIR_Gen_1	85	96	PF02991	0.484
LIG_LIR_Nem_3	62	68	PF02991	0.406
LIG_LIR_Nem_3	74	79	PF02991	0.472
LIG_LIR_Nem_3	85	91	PF02991	0.467
LIG_Pex14_1	174	178	PF04695	0.346
LIG_PTB_Apo_2	151	158	PF02174	0.504
LIG_SH2_CRK	65	69	PF00017	0.443
LIG_SH2_CRK	88	92	PF00017	0.337
LIG_SH2_STAP1	184	188	PF00017	0.415
LIG_SH3_4	6	13	PF00018	0.566
LIG_SUMO_SIM_anti_2	185	190	PF11976	0.437
LIG_SUMO_SIM_par_1	39	46	PF11976	0.421
LIG_SUMO_SIM_par_1	50	55	PF11976	0.479
LIG_TYR_ITIM	63	68	PF00017	0.534
LIG_UBA3_1	189	195	PF00899	0.458
MOD_CK1_1	123	129	PF00069	0.520
MOD_CK1_1	134	140	PF00069	0.692
MOD_CK1_1	164	170	PF00069	0.679
MOD_CK1_1	180	186	PF00069	0.433
MOD_CK1_1	55	61	PF00069	0.432
MOD_CK1_1	87	93	PF00069	0.433
MOD_CK2_1	176	182	PF00069	0.394
MOD_CK2_1	97	103	PF00069	0.364
MOD_GlcNHglycan	125	128	PF01048	0.615
MOD_GlcNHglycan	132	136	PF01048	0.737
MOD_GlcNHglycan	163	166	PF01048	0.619
MOD_GSK3_1	104	111	PF00069	0.605
MOD_GSK3_1	116	123	PF00069	0.473
MOD_GSK3_1	134	141	PF00069	0.585
MOD_GSK3_1	164	171	PF00069	0.543
MOD_GSK3_1	176	183	PF00069	0.388
MOD_GSK3_1	226	233	PF00069	0.514
MOD_GSK3_1	37	44	PF00069	0.391
MOD_N-GLC_1	17	22	PF02516	0.753
MOD_NEK2_1	116	121	PF00069	0.377
MOD_NEK2_1	156	161	PF00069	0.646
MOD_NEK2_1	64	69	PF00069	0.461
MOD_NEK2_1	97	102	PF00069	0.546
MOD_PKA_2	36	42	PF00069	0.491
MOD_PKA_2	55	61	PF00069	0.435
MOD_PKB_1	35	43	PF00069	0.392
MOD_Plk_1	102	108	PF00069	0.438
MOD_Plk_1	131	137	PF00069	0.639
MOD_Plk_1	167	173	PF00069	0.408
MOD_Plk_4	120	126	PF00069	0.486
MOD_ProDKin_1	77	83	PF00069	0.391
MOD_SUMO_for_1	194	197	PF00179	0.366
TRG_ENDOCYTIC_2	65	68	PF00928	0.462
TRG_ENDOCYTIC_2	88	91	PF00928	0.391
TRG_ER_diArg_1	35	38	PF00400	0.533
TRG_NLS_MonoExtC_3	55	60	PF00514	0.425
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I730	Leptomonas seymouri	25%	100%
A0A0N1I8Q6	Leptomonas seymouri	40%	100%
A0A0N1PCW5	Leptomonas seymouri	31%	100%
A0A3Q8IF19	Leishmania donovani	41%	100%
A4HJM7	Leishmania braziliensis	55%	100%
A4HJM8	Leishmania braziliensis	36%	100%
A4I749	Leishmania infantum	99%	99%
A4I750	Leishmania infantum	41%	100%
E9B243	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
E9B244	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4Q616	Leishmania major	23%	100%
Q4Q617	Leishmania major	40%	100%
Q4Q618	Leishmania major	84%	100%