Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H7Q1_LEIDO

TriTrypDb:

LdBPK_311900.1 , LdCL_310026400 , LDHU3_31.3300

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S5H7Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7Q1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.675
CLV_NRD_NRD_1	29	31	PF00675	0.447
CLV_NRD_NRD_1	60	62	PF00675	0.609
CLV_PCSK_KEX2_1	29	31	PF00082	0.447
CLV_PCSK_KEX2_1	59	61	PF00082	0.606
CLV_PCSK_PC7_1	56	62	PF00082	0.571
CLV_PCSK_SKI1_1	30	34	PF00082	0.492
DOC_USP7_MATH_1	2	6	PF00917	0.504
DOC_USP7_MATH_1	35	39	PF00917	0.620
DOC_USP7_MATH_1	48	52	PF00917	0.750
DOC_USP7_MATH_1	62	66	PF00917	0.629
DOC_WW_Pin1_4	134	139	PF00397	0.764
DOC_WW_Pin1_4	54	59	PF00397	0.667
LIG_14-3-3_CanoR_1	29	33	PF00244	0.732
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_FHA_1	5	11	PF00498	0.355
LIG_FHA_1	67	73	PF00498	0.750
LIG_FHA_2	1	7	PF00498	0.509
LIG_SH2_CRK	102	106	PF00017	0.677
LIG_SH2_GRB2like	117	120	PF00017	0.812
LIG_SH2_PTP2	17	20	PF00017	0.411
LIG_SH2_STAT5	17	20	PF00017	0.411
LIG_SH2_STAT5	26	29	PF00017	0.631
LIG_SH3_2	55	60	PF14604	0.672
LIG_SH3_3	101	107	PF00018	0.679
LIG_SH3_3	52	58	PF00018	0.662
LIG_SH3_3	65	71	PF00018	0.578
LIG_SUMO_SIM_anti_2	3	12	PF11976	0.419
LIG_TRAF2_1	132	135	PF00917	0.724
LIG_TYR_ITIM	15	20	PF00017	0.411
MOD_CDC14_SPxK_1	57	60	PF00782	0.674
MOD_CDK_SPK_2	54	59	PF00069	0.667
MOD_CDK_SPxK_1	54	60	PF00069	0.670
MOD_CDK_SPxxK_3	54	61	PF00069	0.671
MOD_CK1_1	137	143	PF00069	0.781
MOD_GlcNHglycan	122	127	PF01048	0.518
MOD_GlcNHglycan	50	53	PF01048	0.541
MOD_GlcNHglycan	64	67	PF01048	0.465
MOD_GSK3_1	50	57	PF00069	0.751
MOD_GSK3_1	62	69	PF00069	0.687
MOD_PIKK_1	50	56	PF00454	0.784
MOD_PKA_2	28	34	PF00069	0.732
MOD_Plk_1	113	119	PF00069	0.716
MOD_Plk_1	122	128	PF00069	0.712
MOD_Plk_4	113	119	PF00069	0.749
MOD_Plk_4	4	10	PF00069	0.372
MOD_ProDKin_1	134	140	PF00069	0.766
MOD_ProDKin_1	54	60	PF00069	0.670
TRG_DiLeu_BaEn_1	28	33	PF01217	0.699
TRG_ENDOCYTIC_2	102	105	PF00928	0.680
TRG_ENDOCYTIC_2	17	20	PF00928	0.411
TRG_ER_diArg_1	58	61	PF00400	0.802

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P382	Leptomonas seymouri	38%	100%
E9AEF5	Leishmania major	91%	100%
E9AHL4	Leishmania infantum	99%	100%
E9AIU5	Leishmania braziliensis	70%	100%
E9B1Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%