CRAL/TRIO domain family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7P3_LEIDO

TriTrypDb:

LdBPK_310380.1 , LdCL_310008900 , LDHU3_31.0460

Length:

992

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0012505	endomembrane system	2	1
GO:0044232	organelle membrane contact site	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0140284	endoplasmic reticulum-endosome membrane contact site	3	1

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Expansion

Sequence features

A0A3S5H7P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7P3

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.564
CLV_C14_Caspase3-7	408	412	PF00656	0.797
CLV_C14_Caspase3-7	453	457	PF00656	0.632
CLV_C14_Caspase3-7	573	577	PF00656	0.506
CLV_C14_Caspase3-7	63	67	PF00656	0.529
CLV_C14_Caspase3-7	94	98	PF00656	0.389
CLV_NRD_NRD_1	122	124	PF00675	0.513
CLV_NRD_NRD_1	204	206	PF00675	0.315
CLV_NRD_NRD_1	343	345	PF00675	0.717
CLV_NRD_NRD_1	436	438	PF00675	0.709

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P961	Leptomonas seymouri	61%	100%
A4HJ11	Leishmania braziliensis	74%	100%
A4I6K1	Leishmania infantum	100%	100%
E9B1I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q6M7	Leishmania major	92%	100%

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