ATP_synthase_epsilon_chain_putative/GeneDB:LmjF.3 0.3600

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP synthase, epsilon chain, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7P0_LEIDO

TriTrypDb:

LdBPK_303660.1 , LdCL_300042000 , LDHU3_30.4860

Length:

181

Annotations

Annotations by Jardim et al.

ATP metabolism, ATP synthase, epsilon chain

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	11
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	4	11
GO:0098796	membrane protein complex	2	11
GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)	4	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H7P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7P0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006754	ATP biosynthetic process	8	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009141	nucleoside triphosphate metabolic process	5	1
GO:0009142	nucleoside triphosphate biosynthetic process	6	1
GO:0009144	purine nucleoside triphosphate metabolic process	6	1
GO:0009145	purine nucleoside triphosphate biosynthetic process	7	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009152	purine ribonucleotide biosynthetic process	7	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009199	ribonucleoside triphosphate metabolic process	6	1
GO:0009201	ribonucleoside triphosphate biosynthetic process	7	1
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	1
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	8	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009260	ribonucleotide biosynthetic process	6	1
GO:0009987	cellular process	1	1
GO:0015986	proton motive force-driven ATP synthesis	9	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046034	ATP metabolic process	7	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005215	transporter activity	1	11
GO:0005216	monoatomic ion channel activity	4	11
GO:0005261	monoatomic cation channel activity	5	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015078	proton transmembrane transporter activity	5	11
GO:0015252	proton channel activity	6	11
GO:0015267	channel activity	4	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11
GO:0016787	hydrolase activity	2	8
GO:0016874	ligase activity	2	11
GO:0022803	passive transmembrane transporter activity	3	11
GO:0022857	transmembrane transporter activity	2	11
GO:0022890	inorganic cation transmembrane transporter activity	4	11
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	99	103	PF00656	0.264
CLV_NRD_NRD_1	7	9	PF00675	0.492
CLV_PCSK_KEX2_1	7	9	PF00082	0.492
CLV_PCSK_PC7_1	3	9	PF00082	0.489
CLV_PCSK_SKI1_1	107	111	PF00082	0.396
CLV_PCSK_SKI1_1	67	71	PF00082	0.264
DEG_Nend_Nbox_1	1	3	PF02207	0.489
DOC_CKS1_1	90	95	PF01111	0.285
DOC_CYCLIN_RxL_1	7	19	PF00134	0.545
DOC_MAPK_gen_1	159	168	PF00069	0.366
DOC_MAPK_MEF2A_6	159	168	PF00069	0.357
DOC_USP7_MATH_1	151	155	PF00917	0.432
DOC_USP7_UBL2_3	33	37	PF12436	0.439
DOC_WW_Pin1_4	89	94	PF00397	0.428
LIG_14-3-3_CanoR_1	50	54	PF00244	0.244
LIG_Actin_WH2_2	163	181	PF00022	0.367
LIG_BRCT_BRCA1_1	110	114	PF00533	0.264
LIG_FHA_1	11	17	PF00498	0.468
LIG_FHA_1	46	52	PF00498	0.342
LIG_FHA_2	132	138	PF00498	0.475
LIG_FHA_2	52	58	PF00498	0.264
LIG_LIR_Gen_1	111	120	PF02991	0.264
LIG_LIR_Gen_1	19	27	PF02991	0.484
LIG_LIR_Gen_1	41	51	PF02991	0.528
LIG_LIR_Nem_3	111	117	PF02991	0.264
LIG_Rb_LxCxE_1	120	142	PF01857	0.471
LIG_SH2_GRB2like	43	46	PF00017	0.486
LIG_SH2_STAT5	108	111	PF00017	0.311
LIG_SH3_3	95	101	PF00018	0.285
LIG_SUMO_SIM_par_1	94	99	PF11976	0.264
MOD_CK2_1	38	44	PF00069	0.587
MOD_Cter_Amidation	5	8	PF01082	0.508
MOD_GlcNHglycan	110	113	PF01048	0.264
MOD_GlcNHglycan	149	152	PF01048	0.402
MOD_GlcNHglycan	153	156	PF01048	0.391
MOD_GlcNHglycan	40	43	PF01048	0.498
MOD_GSK3_1	147	154	PF00069	0.611
MOD_GSK3_1	170	177	PF00069	0.467
MOD_GSK3_1	45	52	PF00069	0.385
MOD_NEK2_1	49	54	PF00069	0.264
MOD_NEK2_2	101	106	PF00069	0.377
MOD_PIKK_1	86	92	PF00454	0.397
MOD_PKA_2	49	55	PF00069	0.264
MOD_Plk_1	86	92	PF00069	0.377
MOD_Plk_4	170	176	PF00069	0.386
MOD_Plk_4	67	73	PF00069	0.329
MOD_ProDKin_1	89	95	PF00069	0.428
MOD_SUMO_rev_2	154	160	PF00179	0.398
MOD_SUMO_rev_2	25	35	PF00179	0.412
TRG_DiLeu_BaEn_2	24	30	PF01217	0.474
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.495
TRG_ENDOCYTIC_2	20	23	PF00928	0.450
TRG_ENDOCYTIC_2	43	46	PF00928	0.535
TRG_ER_diArg_1	7	9	PF00400	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHI5	Leptomonas seymouri	82%	100%
A0A0S4JHX9	Bodo saltans	61%	100%
A0A1X0P1V7	Trypanosomatidae	69%	99%
A0A3R7L340	Trypanosoma rangeli	70%	99%
A1V8T0	Burkholderia mallei (strain SAVP1)	27%	100%
A1VIV3	Polaromonas naphthalenivorans (strain CJ2)	29%	100%
A2S6J7	Burkholderia mallei (strain NCTC 10229)	27%	100%
A3MQK0	Burkholderia mallei (strain NCTC 10247)	27%	100%
A3NF39	Burkholderia pseudomallei (strain 668)	27%	100%
A3P0Y9	Burkholderia pseudomallei (strain 1106a)	27%	100%
A4HIU6	Leishmania braziliensis	87%	100%
A4I651	Leishmania infantum	100%	100%
A6Q4B9	Nitratiruptor sp. (strain SB155-2)	32%	100%
A7HT53	Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)	30%	100%
A9AJG5	Burkholderia multivorans (strain ATCC 17616 / 249)	27%	100%
A9BPU8	Delftia acidovorans (strain DSM 14801 / SPH-1)	28%	100%
B1YQL5	Burkholderia ambifaria (strain MC40-6)	27%	100%
C0HK54	Pichia angusta	32%	100%
C9ZRH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
E9B1D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P05630	Bos taurus	31%	100%
P0DPG2	Trypanosoma brucei brucei	68%	99%
P30049	Homo sapiens	30%	100%
P35434	Rattus norvegicus	32%	100%
P56525	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	30%	100%
P78700	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	100%
Q09544	Caenorhabditis elegans	34%	100%
Q0BJL4	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	27%	100%
Q12165	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q1BRB1	Burkholderia cenocepacia (strain AU 1054)	27%	100%
Q39KX5	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	27%	100%
Q3JXW0	Burkholderia pseudomallei (strain 1710b)	27%	100%
Q40089	Ipomoea batatas	38%	90%
Q4Q6S8	Leishmania major	98%	100%
Q55F42	Dictyostelium discoideum	33%	100%
Q62FR4	Burkholderia mallei (strain ATCC 23344)	27%	100%
Q63PI1	Burkholderia pseudomallei (strain K96243)	27%	100%
Q757N0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	100%
Q92196	Agaricus bisporus	29%	100%
Q96252	Arabidopsis thaliana	39%	89%
Q9D3D9	Mus musculus	33%	100%
Q9P6R6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%