RNA-binding protein 42 (RNA-binding motif protein 42), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 42 (RNA-binding motif protein 42), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7N8_LEIDO

TriTrypDb:

LdBPK_303130.1 , LdCL_300036900 , LDHU3_30.4150

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S5H7N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7N8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	248	250	PF00675	0.741
CLV_PCSK_KEX2_1	242	244	PF00082	0.751
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.751
CLV_PCSK_SKI1_1	18	22	PF00082	0.460
CLV_PCSK_SKI1_1	258	262	PF00082	0.484
CLV_PCSK_SKI1_1	273	277	PF00082	0.496
CLV_PCSK_SKI1_1	32	36	PF00082	0.454
DEG_APCC_DBOX_1	272	280	PF00400	0.575
DEG_SCF_FBW7_2	150	155	PF00400	0.828
DOC_MAPK_MEF2A_6	311	318	PF00069	0.415
DOC_PP1_RVXF_1	256	262	PF00149	0.496
DOC_PP2B_PxIxI_1	313	319	PF00149	0.417
DOC_USP7_MATH_1	144	148	PF00917	0.751
DOC_USP7_MATH_1	191	195	PF00917	0.687
DOC_WW_Pin1_4	128	133	PF00397	0.618
DOC_WW_Pin1_4	137	142	PF00397	0.599
DOC_WW_Pin1_4	146	151	PF00397	0.736
LIG_14-3-3_CanoR_1	287	296	PF00244	0.480
LIG_14-3-3_CanoR_1	32	37	PF00244	0.519
LIG_APCC_ABBA_1	303	308	PF00400	0.618
LIG_APCC_ABBAyCdc20_2	292	298	PF00400	0.540
LIG_APCC_ABBAyCdc20_2	302	308	PF00400	0.576
LIG_BIR_II_1	1	5	PF00653	0.548
LIG_BIR_III_3	1	5	PF00653	0.548
LIG_FHA_1	262	268	PF00498	0.659
LIG_FHA_1	310	316	PF00498	0.321
LIG_FHA_1	33	39	PF00498	0.428
LIG_FHA_2	101	107	PF00498	0.458
LIG_FHA_2	266	272	PF00498	0.577
LIG_FHA_2	35	41	PF00498	0.423
LIG_IRF3_LxIS_1	41	46	PF10401	0.571
LIG_LIR_Gen_1	198	207	PF02991	0.610
LIG_LIR_Nem_3	198	202	PF02991	0.582
LIG_LIR_Nem_3	50	55	PF02991	0.537
LIG_Pex14_2	11	15	PF04695	0.397
LIG_SH2_CRK	80	84	PF00017	0.458
LIG_SH2_CRK	99	103	PF00017	0.224
LIG_SH2_PTP2	52	55	PF00017	0.568
LIG_SH2_SRC	52	55	PF00017	0.568
LIG_SH2_STAT5	118	121	PF00017	0.427
LIG_SH2_STAT5	52	55	PF00017	0.541
LIG_SH3_3	129	135	PF00018	0.655
LIG_SH3_3	155	161	PF00018	0.784
LIG_SUMO_SIM_par_1	34	40	PF11976	0.482
LIG_TRAF2_1	167	170	PF00917	0.810
LIG_WRC_WIRS_1	105	110	PF05994	0.586
LIG_WW_3	244	248	PF00397	0.750
MOD_CK1_1	198	204	PF00069	0.632
MOD_CK2_1	100	106	PF00069	0.460
MOD_CK2_1	265	271	PF00069	0.511
MOD_Cter_Amidation	223	226	PF01082	0.828
MOD_GlcNHglycan	172	175	PF01048	0.771
MOD_GlcNHglycan	279	282	PF01048	0.559
MOD_GlcNHglycan	289	292	PF01048	0.438
MOD_GSK3_1	100	107	PF00069	0.478
MOD_GSK3_1	144	151	PF00069	0.767
MOD_GSK3_1	191	198	PF00069	0.632
MOD_GSK3_1	261	268	PF00069	0.603
MOD_GSK3_1	60	67	PF00069	0.522
MOD_N-GLC_1	261	266	PF02516	0.604
MOD_N-GLC_1	287	292	PF02516	0.496
MOD_NEK2_1	108	113	PF00069	0.645
MOD_NEK2_1	260	265	PF00069	0.641
MOD_NEK2_1	309	314	PF00069	0.504
MOD_NEK2_1	64	69	PF00069	0.535
MOD_PIKK_1	309	315	PF00454	0.393
MOD_PK_1	70	76	PF00069	0.527
MOD_PKA_1	225	231	PF00069	0.750
MOD_PKA_1	249	255	PF00069	0.759
MOD_PKB_1	247	255	PF00069	0.767
MOD_PKB_1	68	76	PF00069	0.582
MOD_Plk_4	198	204	PF00069	0.674
MOD_Plk_4	321	327	PF00069	0.524
MOD_Plk_4	48	54	PF00069	0.527
MOD_ProDKin_1	128	134	PF00069	0.626
MOD_ProDKin_1	137	143	PF00069	0.602
MOD_ProDKin_1	146	152	PF00069	0.733
MOD_SUMO_for_1	163	166	PF00179	0.828
MOD_SUMO_rev_2	179	188	PF00179	0.772
TRG_ENDOCYTIC_2	52	55	PF00928	0.580
TRG_ENDOCYTIC_2	80	83	PF00928	0.462
TRG_ENDOCYTIC_2	98	101	PF00928	0.426
TRG_ER_diArg_1	326	329	PF00400	0.554
TRG_ER_diArg_1	68	71	PF00400	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL25	Leptomonas seymouri	65%	96%
A0A3R7N1J6	Trypanosoma rangeli	37%	86%
A4HIP3	Leishmania braziliensis	85%	100%
A4I5Z0	Leishmania infantum	100%	100%
E9B183	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q6Y1	Leishmania major	93%	100%
V5BX42	Trypanosoma cruzi	38%	80%