Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7N6_LEIDO

TriTrypDb:

LdBPK_302710.1 , LdCL_300032700 , LDHU3_30.3630

Length:

932

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7N6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	691	695	PF00656	0.564
CLV_C14_Caspase3-7	738	742	PF00656	0.587
CLV_NRD_NRD_1	118	120	PF00675	0.641
CLV_NRD_NRD_1	133	135	PF00675	0.576
CLV_NRD_NRD_1	170	172	PF00675	0.698
CLV_NRD_NRD_1	226	228	PF00675	0.640
CLV_NRD_NRD_1	288	290	PF00675	0.691
CLV_NRD_NRD_1	461	463	PF00675	0.541
CLV_NRD_NRD_1	477	479	PF00675	0.531
CLV_NRD_NRD_1	499	501	PF00675	0.546
CLV_NRD_NRD_1	524	526	PF00675	0.622
CLV_NRD_NRD_1	642	644	PF00675	0.634
CLV_NRD_NRD_1	829	831	PF00675	0.585
CLV_PCSK_FUR_1	168	172	PF00082	0.709
CLV_PCSK_KEX2_1	133	135	PF00082	0.672
CLV_PCSK_KEX2_1	170	172	PF00082	0.741
CLV_PCSK_KEX2_1	226	228	PF00082	0.640
CLV_PCSK_KEX2_1	288	290	PF00082	0.708
CLV_PCSK_KEX2_1	449	451	PF00082	0.766
CLV_PCSK_KEX2_1	461	463	PF00082	0.482
CLV_PCSK_KEX2_1	499	501	PF00082	0.384
CLV_PCSK_KEX2_1	524	526	PF00082	0.622
CLV_PCSK_KEX2_1	59	61	PF00082	0.574
CLV_PCSK_KEX2_1	829	831	PF00082	0.585
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.651
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.668
CLV_PCSK_SKI1_1	20	24	PF00082	0.468
CLV_PCSK_SKI1_1	25	29	PF00082	0.475
CLV_PCSK_SKI1_1	288	292	PF00082	0.678
CLV_PCSK_SKI1_1	30	34	PF00082	0.508
CLV_PCSK_SKI1_1	492	496	PF00082	0.462
CLV_PCSK_SKI1_1	539	543	PF00082	0.576
CLV_PCSK_SKI1_1	595	599	PF00082	0.562
CLV_PCSK_SKI1_1	683	687	PF00082	0.524
DEG_Nend_UBRbox_2	1	3	PF02207	0.607
DEG_SCF_FBW7_2	417	423	PF00400	0.604
DEG_SCF_TRCP1_1	876	881	PF00400	0.666
DEG_SPOP_SBC_1	631	635	PF00917	0.605
DEG_SPOP_SBC_1	69	73	PF00917	0.641
DOC_ANK_TNKS_1	501	508	PF00023	0.607
DOC_CKS1_1	290	295	PF01111	0.692
DOC_CKS1_1	417	422	PF01111	0.580
DOC_MAPK_JIP1_4	774	780	PF00069	0.612
DOC_MAPK_MEF2A_6	59	68	PF00069	0.625
DOC_PP2B_LxvP_1	294	297	PF13499	0.748
DOC_PP2B_LxvP_1	610	613	PF13499	0.618
DOC_PP2B_LxvP_1	687	690	PF13499	0.575
DOC_PP2B_LxvP_1	920	923	PF13499	0.636
DOC_PP4_FxxP_1	331	334	PF00568	0.657
DOC_PP4_FxxP_1	809	812	PF00568	0.649
DOC_USP7_MATH_1	108	112	PF00917	0.723
DOC_USP7_MATH_1	283	287	PF00917	0.629
DOC_USP7_MATH_1	631	635	PF00917	0.656
DOC_USP7_MATH_1	70	74	PF00917	0.685
DOC_USP7_MATH_1	745	749	PF00917	0.562
DOC_USP7_MATH_1	856	860	PF00917	0.695
DOC_USP7_UBL2_3	50	54	PF12436	0.523
DOC_USP7_UBL2_3	504	508	PF12436	0.650
DOC_WW_Pin1_4	127	132	PF00397	0.643
DOC_WW_Pin1_4	289	294	PF00397	0.657
DOC_WW_Pin1_4	307	312	PF00397	0.612
DOC_WW_Pin1_4	319	324	PF00397	0.643
DOC_WW_Pin1_4	330	335	PF00397	0.711
DOC_WW_Pin1_4	338	343	PF00397	0.756
DOC_WW_Pin1_4	352	357	PF00397	0.517
DOC_WW_Pin1_4	370	375	PF00397	0.609
DOC_WW_Pin1_4	382	387	PF00397	0.572
DOC_WW_Pin1_4	416	421	PF00397	0.603
DOC_WW_Pin1_4	435	440	PF00397	0.602
DOC_WW_Pin1_4	451	456	PF00397	0.605
DOC_WW_Pin1_4	460	465	PF00397	0.498
DOC_WW_Pin1_4	608	613	PF00397	0.660
DOC_WW_Pin1_4	652	657	PF00397	0.662
DOC_WW_Pin1_4	811	816	PF00397	0.636
DOC_WW_Pin1_4	93	98	PF00397	0.691
LIG_14-3-3_CanoR_1	113	119	PF00244	0.599
LIG_14-3-3_CanoR_1	134	140	PF00244	0.635
LIG_14-3-3_CanoR_1	288	293	PF00244	0.749
LIG_14-3-3_CanoR_1	301	305	PF00244	0.615
LIG_14-3-3_CanoR_1	450	455	PF00244	0.684
LIG_14-3-3_CanoR_1	595	600	PF00244	0.564
LIG_14-3-3_CanoR_1	632	638	PF00244	0.605
LIG_14-3-3_CanoR_1	683	688	PF00244	0.497
LIG_14-3-3_CanoR_1	744	750	PF00244	0.633
LIG_14-3-3_CanoR_1	843	849	PF00244	0.510
LIG_APCC_ABBA_1	400	405	PF00400	0.605
LIG_BIR_III_4	247	251	PF00653	0.649
LIG_deltaCOP1_diTrp_1	720	726	PF00928	0.404
LIG_FHA_1	122	128	PF00498	0.735
LIG_FHA_1	201	207	PF00498	0.651
LIG_FHA_1	260	266	PF00498	0.588
LIG_FHA_1	289	295	PF00498	0.826
LIG_FHA_1	314	320	PF00498	0.695
LIG_FHA_1	387	393	PF00498	0.633
LIG_FHA_1	429	435	PF00498	0.606
LIG_FHA_1	680	686	PF00498	0.661
LIG_FHA_1	775	781	PF00498	0.691
LIG_FHA_1	818	824	PF00498	0.661
LIG_FHA_1	87	93	PF00498	0.823
LIG_FHA_2	139	145	PF00498	0.665
LIG_FHA_2	155	161	PF00498	0.699
LIG_FHA_2	236	242	PF00498	0.601
LIG_FHA_2	452	458	PF00498	0.824
LIG_FHA_2	526	532	PF00498	0.609
LIG_FHA_2	596	602	PF00498	0.612
LIG_FHA_2	667	673	PF00498	0.602
LIG_FHA_2	793	799	PF00498	0.579
LIG_FHA_2	893	899	PF00498	0.699
LIG_FHA_2	914	920	PF00498	0.637
LIG_Integrin_isoDGR_2	805	807	PF01839	0.586
LIG_Integrin_isoDGR_2	853	855	PF01839	0.641
LIG_Integrin_RGD_1	763	765	PF01839	0.637
LIG_LIR_Apic_2	329	334	PF02991	0.660
LIG_LIR_Apic_2	58	64	PF02991	0.599
LIG_LIR_Gen_1	421	430	PF02991	0.654
LIG_LIR_Gen_1	720	730	PF02991	0.474
LIG_LIR_Gen_1	915	923	PF02991	0.649
LIG_LIR_Nem_3	341	347	PF02991	0.646
LIG_LIR_Nem_3	421	427	PF02991	0.615
LIG_LIR_Nem_3	592	597	PF02991	0.587
LIG_LIR_Nem_3	604	610	PF02991	0.643
LIG_LIR_Nem_3	720	726	PF02991	0.404
LIG_LIR_Nem_3	847	851	PF02991	0.487
LIG_LIR_Nem_3	915	920	PF02991	0.660
LIG_MYND_1	352	356	PF01753	0.619
LIG_MYND_1	398	402	PF01753	0.599
LIG_MYND_1	614	618	PF01753	0.599
LIG_SH2_CRK	344	348	PF00017	0.626
LIG_SH2_CRK	424	428	PF00017	0.619
LIG_SH2_CRK	8	12	PF00017	0.499
LIG_SH2_CRK	848	852	PF00017	0.640
LIG_SH2_NCK_1	424	428	PF00017	0.619
LIG_SH2_PTP2	383	386	PF00017	0.668
LIG_SH2_SRC	6	9	PF00017	0.542
LIG_SH2_STAT3	260	263	PF00017	0.657
LIG_SH2_STAT5	383	386	PF00017	0.668
LIG_SH2_STAT5	6	9	PF00017	0.557
LIG_SH2_STAT5	606	609	PF00017	0.652
LIG_SH2_STAT5	810	813	PF00017	0.651
LIG_SH3_1	462	468	PF00018	0.492
LIG_SH3_2	444	449	PF14604	0.549
LIG_SH3_2	534	539	PF14604	0.681
LIG_SH3_3	279	285	PF00018	0.669
LIG_SH3_3	287	293	PF00018	0.693
LIG_SH3_3	396	402	PF00018	0.702
LIG_SH3_3	414	420	PF00018	0.607
LIG_SH3_3	441	447	PF00018	0.653
LIG_SH3_3	462	468	PF00018	0.636
LIG_SH3_3	531	537	PF00018	0.614
LIG_SH3_3	611	617	PF00018	0.587
LIG_SH3_3	63	69	PF00018	0.659
LIG_SH3_3	809	815	PF00018	0.667
LIG_SH3_3	820	826	PF00018	0.682
LIG_SH3_3	89	95	PF00018	0.675
LIG_SUMO_SIM_par_1	412	419	PF11976	0.780
LIG_SUMO_SIM_par_1	776	781	PF11976	0.664
LIG_SUMO_SIM_par_1	9	17	PF11976	0.472
LIG_TRAF2_1	474	477	PF00917	0.600
LIG_TRAF2_1	670	673	PF00917	0.599
LIG_TRAF2_1	837	840	PF00917	0.565
LIG_WRC_WIRS_1	661	666	PF05994	0.629
LIG_WRC_WIRS_1	914	919	PF05994	0.668
LIG_WW_2	444	447	PF00397	0.538
MOD_CDC14_SPxK_1	130	133	PF00782	0.623
MOD_CDK_SPK_2	382	387	PF00069	0.661
MOD_CDK_SPxK_1	127	133	PF00069	0.621
MOD_CDK_SPxK_1	289	295	PF00069	0.680
MOD_CDK_SPxK_1	416	422	PF00069	0.605
MOD_CDK_SPxxK_3	127	134	PF00069	0.648
MOD_CDK_SPxxK_3	370	377	PF00069	0.660
MOD_CDK_SPxxK_3	451	458	PF00069	0.687
MOD_CK1_1	190	196	PF00069	0.656
MOD_CK1_1	246	252	PF00069	0.784
MOD_CK1_1	264	270	PF00069	0.513
MOD_CK1_1	299	305	PF00069	0.628
MOD_CK1_1	322	328	PF00069	0.663
MOD_CK1_1	435	441	PF00069	0.665
MOD_CK1_1	634	640	PF00069	0.612
MOD_CK1_1	654	660	PF00069	0.623
MOD_CK1_1	666	672	PF00069	0.516
MOD_CK1_1	679	685	PF00069	0.437
MOD_CK1_1	747	753	PF00069	0.783
MOD_CK1_1	96	102	PF00069	0.666
MOD_CK2_1	138	144	PF00069	0.677
MOD_CK2_1	154	160	PF00069	0.696
MOD_CK2_1	235	241	PF00069	0.596
MOD_CK2_1	451	457	PF00069	0.686
MOD_CK2_1	460	466	PF00069	0.745
MOD_CK2_1	595	601	PF00069	0.582
MOD_CK2_1	630	636	PF00069	0.675
MOD_CK2_1	666	672	PF00069	0.624
MOD_CK2_1	714	720	PF00069	0.444
MOD_CK2_1	773	779	PF00069	0.622
MOD_CK2_1	834	840	PF00069	0.593
MOD_CK2_1	892	898	PF00069	0.705
MOD_CK2_1	913	919	PF00069	0.641
MOD_Cter_Amidation	168	171	PF01082	0.647
MOD_Cter_Amidation	217	220	PF01082	0.654
MOD_DYRK1A_RPxSP_1	289	293	PF00069	0.648
MOD_GlcNHglycan	141	144	PF01048	0.659
MOD_GlcNHglycan	179	182	PF01048	0.691
MOD_GlcNHglycan	238	241	PF01048	0.695
MOD_GlcNHglycan	247	251	PF01048	0.805
MOD_GlcNHglycan	298	301	PF01048	0.685
MOD_GlcNHglycan	319	322	PF01048	0.657
MOD_GlcNHglycan	368	371	PF01048	0.625
MOD_GlcNHglycan	410	414	PF01048	0.752
MOD_GlcNHglycan	434	437	PF01048	0.727
MOD_GlcNHglycan	440	443	PF01048	0.779
MOD_GlcNHglycan	550	553	PF01048	0.688
MOD_GlcNHglycan	669	672	PF01048	0.626
MOD_GlcNHglycan	726	729	PF01048	0.478
MOD_GlcNHglycan	73	76	PF01048	0.745
MOD_GlcNHglycan	737	740	PF01048	0.569
MOD_GlcNHglycan	752	755	PF01048	0.651
MOD_GlcNHglycan	820	823	PF01048	0.624
MOD_GlcNHglycan	860	863	PF01048	0.719
MOD_GlcNHglycan	868	871	PF01048	0.601
MOD_GlcNHglycan	876	879	PF01048	0.657
MOD_GSK3_1	134	141	PF00069	0.768
MOD_GSK3_1	172	179	PF00069	0.687
MOD_GSK3_1	232	239	PF00069	0.660
MOD_GSK3_1	295	302	PF00069	0.658
MOD_GSK3_1	313	320	PF00069	0.523
MOD_GSK3_1	366	373	PF00069	0.676
MOD_GSK3_1	382	389	PF00069	0.507
MOD_GSK3_1	418	425	PF00069	0.644
MOD_GSK3_1	428	435	PF00069	0.664
MOD_GSK3_1	460	467	PF00069	0.636
MOD_GSK3_1	608	615	PF00069	0.667
MOD_GSK3_1	630	637	PF00069	0.796
MOD_GSK3_1	647	654	PF00069	0.583
MOD_GSK3_1	660	667	PF00069	0.699
MOD_GSK3_1	679	686	PF00069	0.625
MOD_GSK3_1	745	752	PF00069	0.711
MOD_GSK3_1	78	85	PF00069	0.649
MOD_GSK3_1	813	820	PF00069	0.590
MOD_GSK3_1	830	837	PF00069	0.573
MOD_GSK3_1	874	881	PF00069	0.677
MOD_GSK3_1	96	103	PF00069	0.650
MOD_N-GLC_1	114	119	PF02516	0.633
MOD_N-GLC_1	208	213	PF02516	0.659
MOD_N-GLC_1	403	408	PF02516	0.641
MOD_N-GLC_1	451	456	PF02516	0.646
MOD_N-GLC_1	78	83	PF02516	0.653
MOD_NEK2_1	100	105	PF00069	0.657
MOD_NEK2_1	135	140	PF00069	0.654
MOD_NEK2_1	498	503	PF00069	0.564
MOD_NEK2_1	664	669	PF00069	0.678
MOD_NEK2_1	749	754	PF00069	0.654
MOD_NEK2_1	844	849	PF00069	0.501
MOD_NEK2_1	913	918	PF00069	0.676
MOD_NEK2_2	114	119	PF00069	0.671
MOD_NEK2_2	671	676	PF00069	0.584
MOD_OFUCOSY	231	236	PF10250	0.645
MOD_PIKK_1	259	265	PF00454	0.654
MOD_PIKK_1	714	720	PF00454	0.397
MOD_PIKK_1	78	84	PF00454	0.651
MOD_PIKK_1	813	819	PF00454	0.642
MOD_PIKK_1	830	836	PF00454	0.514
MOD_PK_1	422	428	PF00069	0.654
MOD_PKA_1	226	232	PF00069	0.635
MOD_PKA_1	288	294	PF00069	0.665
MOD_PKA_1	830	836	PF00069	0.573
MOD_PKA_2	135	141	PF00069	0.576
MOD_PKA_2	187	193	PF00069	0.691
MOD_PKA_2	226	232	PF00069	0.672
MOD_PKA_2	288	294	PF00069	0.744
MOD_PKA_2	300	306	PF00069	0.624
MOD_PKA_2	386	392	PF00069	0.633
MOD_PKA_2	498	504	PF00069	0.569
MOD_PKA_2	631	637	PF00069	0.686
MOD_PKA_2	857	863	PF00069	0.781
MOD_Plk_1	109	115	PF00069	0.802
MOD_Plk_1	208	214	PF00069	0.642
MOD_Plk_1	409	415	PF00069	0.650
MOD_Plk_1	422	428	PF00069	0.641
MOD_Plk_1	601	607	PF00069	0.576
MOD_Plk_1	671	677	PF00069	0.609
MOD_Plk_4	422	428	PF00069	0.654
MOD_Plk_4	602	608	PF00069	0.581
MOD_ProDKin_1	127	133	PF00069	0.646
MOD_ProDKin_1	289	295	PF00069	0.660
MOD_ProDKin_1	307	313	PF00069	0.612
MOD_ProDKin_1	319	325	PF00069	0.644
MOD_ProDKin_1	330	336	PF00069	0.710
MOD_ProDKin_1	338	344	PF00069	0.758
MOD_ProDKin_1	352	358	PF00069	0.521
MOD_ProDKin_1	370	376	PF00069	0.608
MOD_ProDKin_1	382	388	PF00069	0.572
MOD_ProDKin_1	416	422	PF00069	0.605
MOD_ProDKin_1	435	441	PF00069	0.604
MOD_ProDKin_1	451	457	PF00069	0.607
MOD_ProDKin_1	460	466	PF00069	0.497
MOD_ProDKin_1	608	614	PF00069	0.658
MOD_ProDKin_1	652	658	PF00069	0.662
MOD_ProDKin_1	811	817	PF00069	0.638
MOD_ProDKin_1	93	99	PF00069	0.692
MOD_SUMO_for_1	46	49	PF00179	0.508
MOD_SUMO_for_1	494	497	PF00179	0.461
MOD_SUMO_for_1	511	514	PF00179	0.592
MOD_SUMO_for_1	926	929	PF00179	0.529
MOD_SUMO_rev_2	475	481	PF00179	0.493
MOD_SUMO_rev_2	58	66	PF00179	0.548
MOD_SUMO_rev_2	72	81	PF00179	0.568
TRG_DiLeu_BaEn_4	672	678	PF01217	0.593
TRG_ENDOCYTIC_2	344	347	PF00928	0.627
TRG_ENDOCYTIC_2	424	427	PF00928	0.655
TRG_ENDOCYTIC_2	606	609	PF00928	0.661
TRG_ENDOCYTIC_2	848	851	PF00928	0.638
TRG_ER_diArg_1	133	136	PF00400	0.675
TRG_ER_diArg_1	167	170	PF00400	0.696
TRG_ER_diArg_1	226	228	PF00400	0.640
TRG_ER_diArg_1	287	289	PF00400	0.690
TRG_ER_diArg_1	498	500	PF00400	0.382
TRG_ER_diArg_1	523	525	PF00400	0.622
TRG_ER_diArg_1	828	830	PF00400	0.587
TRG_ER_FFAT_2	720	731	PF00635	0.394
TRG_Pf-PMV_PEXEL_1	830	834	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXH7	Leptomonas seymouri	40%	100%
A0A1X0P323	Trypanosomatidae	26%	100%
A4HIK3	Leishmania braziliensis	68%	98%
A4I5U8	Leishmania infantum	100%	100%
E9B143	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q723	Leishmania major	92%	100%