N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7N5_LEIDO

TriTrypDb:

LdBPK_302580.1 , LdCL_300031400 , LDHU3_30.3480

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S5H7N5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7N5

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0019538	protein metabolic process	3	12
GO:0030163	protein catabolic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008914	leucyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016755	aminoacyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.720
CLV_C14_Caspase3-7	270	274	PF00656	0.650
CLV_C14_Caspase3-7	65	69	PF00656	0.704
CLV_NRD_NRD_1	105	107	PF00675	0.675
CLV_NRD_NRD_1	271	273	PF00675	0.626
CLV_NRD_NRD_1	282	284	PF00675	0.437
CLV_NRD_NRD_1	288	290	PF00675	0.395
CLV_NRD_NRD_1	340	342	PF00675	0.526
CLV_NRD_NRD_1	454	456	PF00675	0.468
CLV_PCSK_KEX2_1	271	273	PF00082	0.644
CLV_PCSK_KEX2_1	282	284	PF00082	0.432
CLV_PCSK_KEX2_1	288	290	PF00082	0.365
CLV_PCSK_KEX2_1	322	324	PF00082	0.622
CLV_PCSK_KEX2_1	340	342	PF00082	0.345
CLV_PCSK_KEX2_1	454	456	PF00082	0.468
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.622
CLV_PCSK_SKI1_1	178	182	PF00082	0.547
CLV_PCSK_SKI1_1	187	191	PF00082	0.548
CLV_PCSK_SKI1_1	272	276	PF00082	0.687
CLV_PCSK_SKI1_1	449	453	PF00082	0.468
CLV_PCSK_SKI1_1	47	51	PF00082	0.699
CLV_PCSK_SKI1_1	67	71	PF00082	0.787
CLV_PCSK_SKI1_1	89	93	PF00082	0.668
DEG_SCF_TRCP1_1	262	268	PF00400	0.553
DEG_SPOP_SBC_1	137	141	PF00917	0.614
DEG_SPOP_SBC_1	254	258	PF00917	0.775
DOC_CYCLIN_yCln2_LP_2	127	133	PF00134	0.319
DOC_MAPK_gen_1	288	299	PF00069	0.493
DOC_MAPK_gen_1	359	368	PF00069	0.413
DOC_MAPK_MEF2A_6	361	370	PF00069	0.304
DOC_PP4_FxxP_1	190	193	PF00568	0.516
DOC_PP4_FxxP_1	215	218	PF00568	0.343
DOC_PP4_FxxP_1	232	235	PF00568	0.451
DOC_USP7_MATH_1	253	257	PF00917	0.794
DOC_USP7_MATH_1	265	269	PF00917	0.727
DOC_USP7_MATH_1	274	278	PF00917	0.592
DOC_USP7_MATH_1	76	80	PF00917	0.609
DOC_WW_Pin1_4	246	251	PF00397	0.694
LIG_14-3-3_CanoR_1	158	163	PF00244	0.646
LIG_14-3-3_CanoR_1	240	244	PF00244	0.537
LIG_14-3-3_CanoR_1	313	318	PF00244	0.538
LIG_14-3-3_CanoR_1	323	327	PF00244	0.519
LIG_14-3-3_CanoR_1	420	426	PF00244	0.521
LIG_14-3-3_CanoR_1	454	463	PF00244	0.424
LIG_14-3-3_CanoR_1	89	96	PF00244	0.692
LIG_APCC_ABBA_1	478	483	PF00400	0.538
LIG_BIR_III_2	461	465	PF00653	0.557
LIG_BRCT_BRCA1_1	168	172	PF00533	0.504
LIG_BRCT_BRCA1_1	40	44	PF00533	0.606
LIG_Clathr_ClatBox_1	365	369	PF01394	0.465
LIG_CtBP_PxDLS_1	154	158	PF00389	0.620
LIG_CtBP_PxDLS_1	218	222	PF00389	0.477
LIG_FHA_1	138	144	PF00498	0.583
LIG_FHA_1	175	181	PF00498	0.556
LIG_FHA_1	198	204	PF00498	0.486
LIG_FHA_1	240	246	PF00498	0.551
LIG_FHA_1	273	279	PF00498	0.662
LIG_FHA_1	302	308	PF00498	0.509
LIG_FHA_1	373	379	PF00498	0.482
LIG_FHA_1	409	415	PF00498	0.356
LIG_FHA_1	48	54	PF00498	0.711
LIG_FHA_1	483	489	PF00498	0.615
LIG_FHA_2	10	16	PF00498	0.719
LIG_FHA_2	268	274	PF00498	0.588
LIG_LIR_Apic_2	148	154	PF02991	0.565
LIG_LIR_Gen_1	293	300	PF02991	0.426
LIG_LIR_Gen_1	329	335	PF02991	0.424
LIG_LIR_Nem_3	186	191	PF02991	0.436
LIG_LIR_Nem_3	293	299	PF02991	0.430
LIG_LIR_Nem_3	329	334	PF02991	0.433
LIG_LIR_Nem_3	393	397	PF02991	0.367
LIG_LIR_Nem_3	424	430	PF02991	0.449
LIG_LIR_Nem_3	439	445	PF02991	0.437
LIG_PCNA_TLS_4	403	412	PF02747	0.504
LIG_PCNA_yPIPBox_3	282	291	PF02747	0.475
LIG_PCNA_yPIPBox_3	67	81	PF02747	0.704
LIG_Pex14_1	426	430	PF04695	0.395
LIG_Pex14_2	172	176	PF04695	0.504
LIG_Pex14_2	438	442	PF04695	0.523
LIG_Pex14_2	452	456	PF04695	0.305
LIG_SH2_CRK	211	215	PF00017	0.368
LIG_SH2_PTP2	191	194	PF00017	0.498
LIG_SH2_PTP2	296	299	PF00017	0.388
LIG_SH2_PTP2	362	365	PF00017	0.319
LIG_SH2_SRC	191	194	PF00017	0.576
LIG_SH2_STAP1	241	245	PF00017	0.548
LIG_SH2_STAP1	423	427	PF00017	0.405
LIG_SH2_STAT3	317	320	PF00017	0.529
LIG_SH2_STAT5	123	126	PF00017	0.512
LIG_SH2_STAT5	191	194	PF00017	0.507
LIG_SH2_STAT5	241	244	PF00017	0.452
LIG_SH2_STAT5	296	299	PF00017	0.466
LIG_SH2_STAT5	362	365	PF00017	0.319
LIG_SH2_STAT5	394	397	PF00017	0.483
LIG_SH2_STAT5	423	426	PF00017	0.498
LIG_SH2_STAT5	471	474	PF00017	0.382
LIG_SH3_3	168	174	PF00018	0.536
LIG_SH3_3	190	196	PF00018	0.578
LIG_SH3_3	244	250	PF00018	0.652
LIG_SH3_3	442	448	PF00018	0.523
LIG_SUMO_SIM_par_1	296	304	PF11976	0.441
LIG_TRAF2_1	63	66	PF00917	0.560
LIG_TYR_ITIM	209	214	PF00017	0.356
LIG_UBA3_1	365	373	PF00899	0.472
LIG_WRC_WIRS_1	406	411	PF05994	0.455
MOD_CK1_1	136	142	PF00069	0.586
MOD_CK1_1	346	352	PF00069	0.663
MOD_CK1_1	79	85	PF00069	0.622
MOD_CK2_1	213	219	PF00069	0.495
MOD_CK2_1	97	103	PF00069	0.641
MOD_GlcNHglycan	135	138	PF01048	0.590
MOD_GlcNHglycan	262	265	PF01048	0.679
MOD_GlcNHglycan	267	270	PF01048	0.742
MOD_GlcNHglycan	292	295	PF01048	0.490
MOD_GlcNHglycan	345	348	PF01048	0.609
MOD_GlcNHglycan	456	459	PF01048	0.505
MOD_GlcNHglycan	485	488	PF01048	0.564
MOD_GlcNHglycan	82	85	PF01048	0.650
MOD_GSK3_1	11	18	PF00069	0.766
MOD_GSK3_1	131	138	PF00069	0.592
MOD_GSK3_1	213	220	PF00069	0.486
MOD_GSK3_1	34	41	PF00069	0.567
MOD_GSK3_1	342	349	PF00069	0.666
MOD_GSK3_1	395	402	PF00069	0.424
MOD_GSK3_1	76	83	PF00069	0.675
MOD_NEK2_1	19	24	PF00069	0.716
MOD_NEK2_1	38	43	PF00069	0.553
MOD_NEK2_1	488	493	PF00069	0.712
MOD_NEK2_1	91	96	PF00069	0.588
MOD_NEK2_2	274	279	PF00069	0.578
MOD_PIKK_1	17	23	PF00454	0.559
MOD_PIKK_1	349	355	PF00454	0.655
MOD_PKA_1	282	288	PF00069	0.458
MOD_PKA_1	322	328	PF00069	0.577
MOD_PKA_1	454	460	PF00069	0.450
MOD_PKA_2	131	137	PF00069	0.569
MOD_PKA_2	166	172	PF00069	0.606
MOD_PKA_2	239	245	PF00069	0.546
MOD_PKA_2	282	288	PF00069	0.486
MOD_PKA_2	322	328	PF00069	0.586
MOD_PKA_2	399	405	PF00069	0.546
MOD_PKA_2	454	460	PF00069	0.446
MOD_Plk_1	392	398	PF00069	0.362
MOD_Plk_1	47	53	PF00069	0.590
MOD_Plk_4	110	116	PF00069	0.395
MOD_Plk_4	166	172	PF00069	0.531
MOD_Plk_4	274	280	PF00069	0.575
MOD_Plk_4	322	328	PF00069	0.419
MOD_Plk_4	34	40	PF00069	0.602
MOD_Plk_4	392	398	PF00069	0.407
MOD_Plk_4	405	411	PF00069	0.494
MOD_Plk_4	421	427	PF00069	0.320
MOD_Plk_4	48	54	PF00069	0.575
MOD_Plk_4	76	82	PF00069	0.681
MOD_Plk_4	91	97	PF00069	0.456
MOD_ProDKin_1	246	252	PF00069	0.705
MOD_SUMO_for_1	7	10	PF00179	0.621
MOD_SUMO_rev_2	41	49	PF00179	0.682
TRG_DiLeu_BaEn_1	66	71	PF01217	0.776
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.539
TRG_ENDOCYTIC_2	211	214	PF00928	0.368
TRG_ENDOCYTIC_2	296	299	PF00928	0.467
TRG_ENDOCYTIC_2	362	365	PF00928	0.319
TRG_ENDOCYTIC_2	427	430	PF00928	0.381
TRG_ER_diArg_1	281	283	PF00400	0.462
TRG_ER_diArg_1	287	289	PF00400	0.409
TRG_ER_diArg_1	453	455	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	364	369	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI6	Leptomonas seymouri	47%	99%
A0A1X0P1I4	Trypanosomatidae	31%	100%
A0A1X0P1L0	Trypanosomatidae	31%	100%
A0A3R7NR23	Trypanosoma rangeli	31%	100%
A4HIJ0	Leishmania braziliensis	73%	100%
A4I5T4	Leishmania infantum	99%	100%
C9ZR56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B129	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q736	Leishmania major	91%	100%
V5DNZ0	Trypanosoma cruzi	31%	100%