Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7N2_LEIDO

TriTrypDb:

LdBPK_302110.1 , LdCL_300026600 , LDHU3_30.2870

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7N2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	172	178	PF00089	0.558
CLV_NRD_NRD_1	126	128	PF00675	0.610
CLV_NRD_NRD_1	208	210	PF00675	0.470
CLV_NRD_NRD_1	343	345	PF00675	0.640
CLV_NRD_NRD_1	382	384	PF00675	0.640
CLV_NRD_NRD_1	75	77	PF00675	0.757
CLV_PCSK_KEX2_1	126	128	PF00082	0.630
CLV_PCSK_KEX2_1	343	345	PF00082	0.640
CLV_PCSK_KEX2_1	382	384	PF00082	0.640
CLV_PCSK_KEX2_1	423	425	PF00082	0.404
CLV_PCSK_KEX2_1	75	77	PF00082	0.765
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.404
CLV_PCSK_SKI1_1	242	246	PF00082	0.639
CLV_PCSK_SKI1_1	275	279	PF00082	0.644
CLV_PCSK_SKI1_1	423	427	PF00082	0.389
CLV_PCSK_SKI1_1	470	474	PF00082	0.499
DEG_APCC_DBOX_1	501	509	PF00400	0.428
DEG_MDM2_SWIB_1	258	265	PF02201	0.528
DEG_SPOP_SBC_1	560	564	PF00917	0.368
DOC_CYCLIN_RxL_1	420	428	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	202	208	PF00134	0.520
DOC_MAPK_RevD_3	329	344	PF00069	0.572
DOC_MIT_MIM_1	498	508	PF04212	0.511
DOC_PP1_RVXF_1	326	333	PF00149	0.527
DOC_PP1_RVXF_1	411	418	PF00149	0.420
DOC_PP2B_LxvP_1	247	250	PF13499	0.542
DOC_PP4_FxxP_1	122	125	PF00568	0.678
DOC_PP4_FxxP_1	309	312	PF00568	0.633
DOC_PP4_FxxP_1	417	420	PF00568	0.380
DOC_SPAK_OSR1_1	328	332	PF12202	0.442
DOC_USP7_MATH_1	108	112	PF00917	0.677
DOC_USP7_MATH_1	214	218	PF00917	0.596
DOC_USP7_MATH_1	368	372	PF00917	0.704
DOC_USP7_MATH_1	395	399	PF00917	0.616
DOC_USP7_MATH_1	408	412	PF00917	0.348
DOC_USP7_MATH_1	560	564	PF00917	0.482
DOC_USP7_MATH_1	608	612	PF00917	0.535
DOC_USP7_MATH_1	87	91	PF00917	0.775
DOC_WW_Pin1_4	104	109	PF00397	0.680
DOC_WW_Pin1_4	125	130	PF00397	0.673
DOC_WW_Pin1_4	162	167	PF00397	0.533
DOC_WW_Pin1_4	201	206	PF00397	0.435
DOC_WW_Pin1_4	364	369	PF00397	0.792
DOC_WW_Pin1_4	38	43	PF00397	0.467
DOC_WW_Pin1_4	416	421	PF00397	0.432
DOC_WW_Pin1_4	58	63	PF00397	0.409
DOC_WW_Pin1_4	83	88	PF00397	0.765
LIG_14-3-3_CanoR_1	291	295	PF00244	0.622
LIG_14-3-3_CanoR_1	424	433	PF00244	0.396
LIG_14-3-3_CanoR_1	533	539	PF00244	0.500
LIG_14-3-3_CanoR_1	54	62	PF00244	0.593
LIG_14-3-3_CanoR_1	82	87	PF00244	0.769
LIG_14-3-3_CanoR_1	95	99	PF00244	0.593
LIG_BIR_II_1	1	5	PF00653	0.393
LIG_BIR_III_4	547	551	PF00653	0.402
LIG_CaM_NSCaTE_8	52	59	PF13499	0.484
LIG_Clathr_ClatBox_1	264	268	PF01394	0.430
LIG_CSL_BTD_1	417	420	PF09270	0.414
LIG_deltaCOP1_diTrp_1	260	267	PF00928	0.500
LIG_deltaCOP1_diTrp_1	456	465	PF00928	0.414
LIG_eIF4E_1	17	23	PF01652	0.443
LIG_FHA_1	154	160	PF00498	0.590
LIG_FHA_1	340	346	PF00498	0.607
LIG_FHA_1	533	539	PF00498	0.491
LIG_FHA_1	7	13	PF00498	0.413
LIG_FHA_2	16	22	PF00498	0.442
LIG_FHA_2	276	282	PF00498	0.650
LIG_FHA_2	446	452	PF00498	0.376
LIG_Integrin_isoDGR_2	354	356	PF01839	0.699
LIG_LIR_Apic_2	119	125	PF02991	0.680
LIG_LIR_Apic_2	307	312	PF02991	0.637
LIG_LIR_Apic_2	414	420	PF02991	0.390
LIG_LIR_Gen_1	2	12	PF02991	0.489
LIG_LIR_Gen_1	27	37	PF02991	0.440
LIG_LIR_Gen_1	303	312	PF02991	0.577
LIG_LIR_Gen_1	471	479	PF02991	0.452
LIG_LIR_Gen_1	497	505	PF02991	0.512
LIG_LIR_Gen_1	585	593	PF02991	0.518
LIG_LIR_Nem_3	167	172	PF02991	0.605
LIG_LIR_Nem_3	2	8	PF02991	0.393
LIG_LIR_Nem_3	260	265	PF02991	0.621
LIG_LIR_Nem_3	27	33	PF02991	0.409
LIG_LIR_Nem_3	303	309	PF02991	0.584
LIG_LIR_Nem_3	471	476	PF02991	0.519
LIG_LIR_Nem_3	497	501	PF02991	0.421
LIG_LIR_Nem_3	585	590	PF02991	0.466
LIG_NBox_RRM_1	267	277	PF00076	0.608
LIG_Pex14_2	258	262	PF04695	0.540
LIG_SH2_SRC	587	590	PF00017	0.531
LIG_SH2_STAP1	240	244	PF00017	0.565
LIG_SH2_STAT5	138	141	PF00017	0.595
LIG_SH2_STAT5	17	20	PF00017	0.471
LIG_SH2_STAT5	24	27	PF00017	0.464
LIG_SH2_STAT5	629	632	PF00017	0.432
LIG_SH3_3	358	364	PF00018	0.710
LIG_SH3_3	616	622	PF00018	0.468
LIG_SUMO_SIM_anti_2	26	35	PF11976	0.482
LIG_SUMO_SIM_anti_2	561	571	PF11976	0.429
LIG_SUMO_SIM_par_1	156	163	PF11976	0.527
LIG_SUMO_SIM_par_1	337	342	PF11976	0.607
LIG_SUMO_SIM_par_1	580	585	PF11976	0.525
LIG_TRAF2_1	250	253	PF00917	0.588
LIG_TRAF2_1	278	281	PF00917	0.673
LIG_TRAF2_1	448	451	PF00917	0.525
LIG_TRAF2_1	601	604	PF00917	0.529
LIG_WW_3	123	127	PF00397	0.657
MOD_CDC14_SPxK_1	128	131	PF00782	0.648
MOD_CDK_SPxK_1	125	131	PF00069	0.672
MOD_CDK_SPxxK_3	416	423	PF00069	0.435
MOD_CK1_1	111	117	PF00069	0.663
MOD_CK1_1	15	21	PF00069	0.579
MOD_CK1_1	204	210	PF00069	0.469
MOD_CK1_1	26	32	PF00069	0.375
MOD_CK1_1	396	402	PF00069	0.638
MOD_CK1_1	411	417	PF00069	0.626
MOD_CK1_1	532	538	PF00069	0.476
MOD_CK1_1	611	617	PF00069	0.530
MOD_CK2_1	144	150	PF00069	0.562
MOD_CK2_1	151	157	PF00069	0.513
MOD_CK2_1	275	281	PF00069	0.625
MOD_CK2_1	331	337	PF00069	0.607
MOD_CK2_1	416	422	PF00069	0.412
MOD_CK2_1	445	451	PF00069	0.383
MOD_CK2_1	582	588	PF00069	0.524
MOD_GlcNHglycan	1	4	PF01048	0.469
MOD_GlcNHglycan	14	17	PF01048	0.395
MOD_GlcNHglycan	146	149	PF01048	0.553
MOD_GlcNHglycan	186	189	PF01048	0.679
MOD_GlcNHglycan	216	219	PF01048	0.616
MOD_GlcNHglycan	234	237	PF01048	0.526
MOD_GlcNHglycan	370	373	PF01048	0.708
MOD_GlcNHglycan	56	59	PF01048	0.544
MOD_GlcNHglycan	570	573	PF01048	0.511
MOD_GlcNHglycan	584	587	PF01048	0.580
MOD_GlcNHglycan	594	598	PF01048	0.539
MOD_GlcNHglycan	66	69	PF01048	0.756
MOD_GlcNHglycan	90	93	PF01048	0.764
MOD_GSK3_1	104	111	PF00069	0.622
MOD_GSK3_1	180	187	PF00069	0.653
MOD_GSK3_1	364	371	PF00069	0.675
MOD_GSK3_1	395	402	PF00069	0.642
MOD_GSK3_1	54	61	PF00069	0.669
MOD_GSK3_1	62	69	PF00069	0.647
MOD_GSK3_1	77	84	PF00069	0.666
MOD_GSK3_1	94	101	PF00069	0.565
MOD_N-GLC_1	108	113	PF02516	0.649
MOD_NEK2_1	12	17	PF00069	0.466
MOD_NEK2_1	221	226	PF00069	0.574
MOD_NEK2_1	232	237	PF00069	0.570
MOD_NEK2_1	345	350	PF00069	0.714
MOD_NEK2_1	425	430	PF00069	0.402
MOD_NEK2_1	527	532	PF00069	0.441
MOD_NEK2_1	568	573	PF00069	0.410
MOD_PIKK_1	434	440	PF00454	0.541
MOD_PIKK_1	463	469	PF00454	0.474
MOD_PIKK_1	481	487	PF00454	0.514
MOD_PKA_2	174	180	PF00069	0.612
MOD_PKA_2	184	190	PF00069	0.559
MOD_PKA_2	290	296	PF00069	0.594
MOD_PKA_2	355	361	PF00069	0.746
MOD_PKA_2	381	387	PF00069	0.660
MOD_PKA_2	396	402	PF00069	0.440
MOD_PKA_2	532	538	PF00069	0.438
MOD_PKA_2	6	12	PF00069	0.419
MOD_PKA_2	81	87	PF00069	0.660
MOD_PKA_2	94	100	PF00069	0.543
MOD_Plk_1	108	114	PF00069	0.777
MOD_Plk_1	118	124	PF00069	0.684
MOD_Plk_1	242	248	PF00069	0.657
MOD_Plk_1	26	32	PF00069	0.515
MOD_Plk_1	78	84	PF00069	0.631
MOD_Plk_2-3	468	474	PF00069	0.482
MOD_Plk_4	118	124	PF00069	0.652
MOD_Plk_4	26	32	PF00069	0.515
MOD_Plk_4	468	474	PF00069	0.474
MOD_ProDKin_1	104	110	PF00069	0.679
MOD_ProDKin_1	125	131	PF00069	0.667
MOD_ProDKin_1	162	168	PF00069	0.530
MOD_ProDKin_1	201	207	PF00069	0.429
MOD_ProDKin_1	364	370	PF00069	0.786
MOD_ProDKin_1	38	44	PF00069	0.466
MOD_ProDKin_1	416	422	PF00069	0.435
MOD_ProDKin_1	58	64	PF00069	0.413
MOD_ProDKin_1	83	89	PF00069	0.761
MOD_SUMO_for_1	132	135	PF00179	0.601
MOD_SUMO_rev_2	466	472	PF00179	0.486
TRG_DiLeu_BaEn_1	135	140	PF01217	0.587
TRG_DiLeu_BaEn_1	260	265	PF01217	0.506
TRG_DiLeu_BaEn_4	280	286	PF01217	0.550
TRG_DiLeu_BaEn_4	450	456	PF01217	0.515
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.582
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.497
TRG_ENDOCYTIC_2	587	590	PF00928	0.437
TRG_ER_diArg_1	125	127	PF00400	0.644
TRG_ER_diArg_1	343	345	PF00400	0.640
TRG_ER_diArg_1	501	504	PF00400	0.492
TRG_NES_CRM1_1	283	295	PF08389	0.509
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBM3	Leptomonas seymouri	63%	96%
A0A1X0P209	Trypanosomatidae	33%	100%
A4HIE2	Leishmania braziliensis	85%	100%
A4I5N9	Leishmania infantum	100%	100%
E9B0Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q783	Leishmania major	95%	100%
V5BL95	Trypanosoma cruzi	35%	100%