Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7N1_LEIDO

TriTrypDb:

LdBPK_301950.1 , LdCL_300024800 , LDHU3_30.2680

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7N1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7N1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.489
CLV_NRD_NRD_1	144	146	PF00675	0.650
CLV_NRD_NRD_1	241	243	PF00675	0.504
CLV_NRD_NRD_1	344	346	PF00675	0.574
CLV_NRD_NRD_1	395	397	PF00675	0.507
CLV_PCSK_KEX2_1	144	146	PF00082	0.742
CLV_PCSK_KEX2_1	241	243	PF00082	0.513
CLV_PCSK_KEX2_1	288	290	PF00082	0.546
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.546
CLV_PCSK_SKI1_1	201	205	PF00082	0.604
CLV_PCSK_SKI1_1	24	28	PF00082	0.519
CLV_PCSK_SKI1_1	365	369	PF00082	0.682
CLV_PCSK_SKI1_1	423	427	PF00082	0.572
CLV_PCSK_SKI1_1	47	51	PF00082	0.538
CLV_PCSK_SKI1_1	64	68	PF00082	0.500
CLV_PCSK_SKI1_1	73	77	PF00082	0.448
DEG_APCC_DBOX_1	340	348	PF00400	0.597
DOC_CDC14_PxL_1	33	41	PF14671	0.516
DOC_CYCLIN_RxL_1	420	429	PF00134	0.677
DOC_MAPK_gen_1	226	233	PF00069	0.477
DOC_MAPK_gen_1	288	296	PF00069	0.445
DOC_MAPK_MEF2A_6	376	384	PF00069	0.656
DOC_MAPK_MEF2A_6	423	432	PF00069	0.644
DOC_PP1_RVXF_1	22	28	PF00149	0.551
DOC_USP7_MATH_1	287	291	PF00917	0.470
DOC_USP7_MATH_1	88	92	PF00917	0.602
DOC_USP7_UBL2_3	184	188	PF12436	0.397
DOC_WW_Pin1_4	3	8	PF00397	0.688
DOC_WW_Pin1_4	352	357	PF00397	0.626
LIG_14-3-3_CanoR_1	144	151	PF00244	0.709
LIG_14-3-3_CanoR_1	201	210	PF00244	0.566
LIG_14-3-3_CanoR_1	242	252	PF00244	0.586
LIG_14-3-3_CanoR_1	365	375	PF00244	0.698
LIG_14-3-3_CanoR_1	396	400	PF00244	0.537
LIG_14-3-3_CanoR_1	73	79	PF00244	0.564
LIG_14-3-3_CanoR_1	89	93	PF00244	0.473
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_deltaCOP1_diTrp_1	209	214	PF00928	0.550
LIG_FHA_1	202	208	PF00498	0.460
LIG_FHA_1	244	250	PF00498	0.596
LIG_FHA_1	296	302	PF00498	0.512
LIG_FHA_1	349	355	PF00498	0.637
LIG_FHA_1	95	101	PF00498	0.531
LIG_FHA_2	107	113	PF00498	0.631
LIG_FHA_2	124	130	PF00498	0.599
LIG_FHA_2	137	143	PF00498	0.564
LIG_FHA_2	422	428	PF00498	0.635
LIG_FHA_2	55	61	PF00498	0.602
LIG_LIR_Gen_1	176	185	PF02991	0.435
LIG_LIR_Gen_1	45	53	PF02991	0.532
LIG_LIR_Nem_3	176	182	PF02991	0.602
LIG_LIR_Nem_3	263	267	PF02991	0.494
LIG_LIR_Nem_3	45	51	PF02991	0.531
LIG_LIR_Nem_3	74	78	PF02991	0.477
LIG_SH2_CRK	48	52	PF00017	0.564
LIG_SH2_NCK_1	179	183	PF00017	0.436
LIG_SH2_SRC	28	31	PF00017	0.644
LIG_SH2_SRC	299	302	PF00017	0.442
LIG_SH2_STAP1	179	183	PF00017	0.436
LIG_SH2_STAP1	28	32	PF00017	0.567
LIG_SH2_STAP1	292	296	PF00017	0.538
LIG_SH2_STAT3	303	306	PF00017	0.481
LIG_SH2_STAT5	179	182	PF00017	0.323
LIG_SUMO_SIM_anti_2	152	161	PF11976	0.575
LIG_SUMO_SIM_anti_2	326	331	PF11976	0.492
LIG_SUMO_SIM_par_1	152	161	PF11976	0.582
LIG_SUMO_SIM_par_1	350	355	PF11976	0.653
LIG_TRAF2_1	254	257	PF00917	0.488
LIG_TRAF2_1	91	94	PF00917	0.552
LIG_UBA3_1	249	253	PF00899	0.373
LIG_UBA3_1	39	47	PF00899	0.567
LIG_WRC_WIRS_1	50	55	PF05994	0.588
MOD_CDK_SPK_2	3	8	PF00069	0.688
MOD_CDK_SPxK_1	352	358	PF00069	0.679
MOD_CK1_1	2	8	PF00069	0.754
MOD_CK1_1	54	60	PF00069	0.550
MOD_CK1_1	81	87	PF00069	0.558
MOD_CK1_1	9	15	PF00069	0.726
MOD_CK2_1	106	112	PF00069	0.366
MOD_CK2_1	123	129	PF00069	0.643
MOD_CK2_1	136	142	PF00069	0.613
MOD_CK2_1	287	293	PF00069	0.517
MOD_CK2_1	309	315	PF00069	0.503
MOD_CK2_1	387	393	PF00069	0.595
MOD_CK2_1	421	427	PF00069	0.670
MOD_CK2_1	49	55	PF00069	0.602
MOD_CK2_1	88	94	PF00069	0.507
MOD_GlcNHglycan	109	112	PF01048	0.582
MOD_GlcNHglycan	117	120	PF01048	0.617
MOD_GlcNHglycan	134	137	PF01048	0.697
MOD_GlcNHglycan	146	149	PF01048	0.589
MOD_GlcNHglycan	175	178	PF01048	0.481
MOD_GlcNHglycan	222	225	PF01048	0.493
MOD_GlcNHglycan	404	407	PF01048	0.643
MOD_GlcNHglycan	414	418	PF01048	0.544
MOD_GlcNHglycan	44	47	PF01048	0.519
MOD_GlcNHglycan	64	67	PF01048	0.310
MOD_GSK3_1	103	110	PF00069	0.617
MOD_GSK3_1	132	139	PF00069	0.713
MOD_GSK3_1	173	180	PF00069	0.328
MOD_GSK3_1	2	9	PF00069	0.758
MOD_GSK3_1	348	355	PF00069	0.555
MOD_GSK3_1	409	416	PF00069	0.602
MOD_GSK3_1	67	74	PF00069	0.579
MOD_N-GLC_1	132	137	PF02516	0.795
MOD_N-GLC_1	79	84	PF02516	0.621
MOD_NEK2_1	11	16	PF00069	0.688
MOD_NEK2_1	114	119	PF00069	0.627
MOD_NEK2_1	319	324	PF00069	0.592
MOD_NEK2_1	348	353	PF00069	0.474
MOD_NEK2_1	380	385	PF00069	0.590
MOD_NEK2_1	402	407	PF00069	0.641
MOD_NEK2_1	67	72	PF00069	0.609
MOD_NEK2_1	78	83	PF00069	0.494
MOD_PKA_1	144	150	PF00069	0.640
MOD_PKA_2	144	150	PF00069	0.640
MOD_PKA_2	387	393	PF00069	0.564
MOD_PKA_2	395	401	PF00069	0.516
MOD_PKA_2	88	94	PF00069	0.569
MOD_Plk_1	20	26	PF00069	0.512
MOD_Plk_1	363	369	PF00069	0.651
MOD_Plk_1	54	60	PF00069	0.434
MOD_Plk_1	9	15	PF00069	0.648
MOD_Plk_2-3	309	315	PF00069	0.503
MOD_Plk_4	103	109	PF00069	0.643
MOD_Plk_4	35	41	PF00069	0.495
MOD_Plk_4	380	386	PF00069	0.516
MOD_Plk_4	81	87	PF00069	0.626
MOD_ProDKin_1	3	9	PF00069	0.690
MOD_ProDKin_1	352	358	PF00069	0.629
MOD_SUMO_for_1	281	284	PF00179	0.602
MOD_SUMO_rev_2	91	100	PF00179	0.553
TRG_DiLeu_BaEn_1	315	320	PF01217	0.607
TRG_ENDOCYTIC_2	179	182	PF00928	0.440
TRG_ENDOCYTIC_2	28	31	PF00928	0.603
TRG_ENDOCYTIC_2	48	51	PF00928	0.348
TRG_ER_diArg_1	143	145	PF00400	0.656
TRG_ER_diArg_1	289	292	PF00400	0.603
TRG_NLS_MonoExtC_3	287	293	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	144	149	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD9	Leptomonas seymouri	59%	100%
A0A1X0P1Q4	Trypanosomatidae	37%	95%
A0A3S5ISM8	Trypanosoma rangeli	34%	93%
A4HIC9	Leishmania braziliensis	76%	100%
A4I5M2	Leishmania infantum	99%	100%
E9B0W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q799	Leishmania major	91%	100%
V5B8X3	Trypanosoma cruzi	33%	93%