Protein_kinase_putative/GeneDB:LmjF.30.1780

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7N0_LEIDO

TriTrypDb:

LdBPK_301780.1 , LdCL_300023100 , LDHU3_30.2480

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0016592	mediator complex	3	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S5H7N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7N0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.552
CLV_C14_Caspase3-7	298	302	PF00656	0.575
CLV_C14_Caspase3-7	596	600	PF00656	0.769
CLV_NRD_NRD_1	140	142	PF00675	0.513
CLV_NRD_NRD_1	143	145	PF00675	0.402
CLV_NRD_NRD_1	268	270	PF00675	0.632
CLV_NRD_NRD_1	329	331	PF00675	0.413
CLV_NRD_NRD_1	590	592	PF00675	0.588
CLV_NRD_NRD_1	89	91	PF00675	0.549
CLV_PCSK_FUR_1	141	145	PF00082	0.428
CLV_PCSK_KEX2_1	140	142	PF00082	0.520
CLV_PCSK_KEX2_1	143	145	PF00082	0.402
CLV_PCSK_KEX2_1	148	150	PF00082	0.345
CLV_PCSK_KEX2_1	329	331	PF00082	0.413
CLV_PCSK_KEX2_1	590	592	PF00082	0.588
CLV_PCSK_KEX2_1	89	91	PF00082	0.551
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.371
CLV_PCSK_PC7_1	144	150	PF00082	0.477
CLV_PCSK_PC7_1	325	331	PF00082	0.413
CLV_PCSK_SKI1_1	114	118	PF00082	0.653
CLV_PCSK_SKI1_1	148	152	PF00082	0.393
CLV_PCSK_SKI1_1	168	172	PF00082	0.242
CLV_PCSK_SKI1_1	329	333	PF00082	0.300
CLV_PCSK_SKI1_1	347	351	PF00082	0.247
CLV_PCSK_SKI1_1	377	381	PF00082	0.312
CLV_PCSK_SKI1_1	449	453	PF00082	0.362
CLV_PCSK_SKI1_1	537	541	PF00082	0.390
CLV_PCSK_SKI1_1	569	573	PF00082	0.542
CLV_PCSK_SKI1_1	591	595	PF00082	0.629
DEG_APCC_DBOX_1	328	336	PF00400	0.290
DEG_APCC_DBOX_1	590	598	PF00400	0.580
DOC_CKS1_1	405	410	PF01111	0.362
DOC_CYCLIN_RxL_1	446	456	PF00134	0.356
DOC_CYCLIN_yCln2_LP_2	391	397	PF00134	0.224
DOC_MAPK_gen_1	137	147	PF00069	0.539
DOC_MAPK_gen_1	269	276	PF00069	0.647
DOC_MAPK_gen_1	329	337	PF00069	0.398
DOC_MAPK_gen_1	347	356	PF00069	0.217
DOC_MAPK_gen_1	587	597	PF00069	0.546
DOC_MAPK_MEF2A_6	590	597	PF00069	0.550
DOC_PP1_RVXF_1	331	338	PF00149	0.350
DOC_PP1_RVXF_1	561	567	PF00149	0.503
DOC_PP2B_LxvP_1	391	394	PF13499	0.224
DOC_PP2B_LxvP_1	468	471	PF13499	0.408
DOC_PP2B_LxvP_1	480	483	PF13499	0.423
DOC_PP4_FxxP_1	372	375	PF00568	0.413
DOC_USP7_MATH_1	187	191	PF00917	0.612
DOC_USP7_MATH_1	194	198	PF00917	0.657
DOC_USP7_MATH_1	375	379	PF00917	0.481
DOC_USP7_MATH_1	501	505	PF00917	0.349
DOC_USP7_MATH_1	71	75	PF00917	0.747
DOC_WW_Pin1_4	22	27	PF00397	0.692
DOC_WW_Pin1_4	309	314	PF00397	0.715
DOC_WW_Pin1_4	384	389	PF00397	0.372
DOC_WW_Pin1_4	404	409	PF00397	0.281
LIG_14-3-3_CanoR_1	412	416	PF00244	0.295
LIG_14-3-3_CanoR_1	533	540	PF00244	0.281
LIG_14-3-3_CanoR_1	569	574	PF00244	0.472
LIG_Actin_WH2_1	320	335	PF00022	0.434
LIG_Actin_WH2_2	348	365	PF00022	0.362
LIG_BIR_II_1	1	5	PF00653	0.597
LIG_BIR_III_2	306	310	PF00653	0.551
LIG_BRCT_BRCA1_1	368	372	PF00533	0.360
LIG_deltaCOP1_diTrp_1	434	442	PF00928	0.281
LIG_EH1_1	325	333	PF00400	0.278
LIG_eIF4E_1	326	332	PF01652	0.413
LIG_FHA_1	339	345	PF00498	0.354
LIG_FHA_1	577	583	PF00498	0.542
LIG_FHA_2	242	248	PF00498	0.465
LIG_FHA_2	296	302	PF00498	0.721
LIG_FHA_2	380	386	PF00498	0.354
LIG_FHA_2	429	435	PF00498	0.413
LIG_FHA_2	533	539	PF00498	0.278
LIG_FHA_2	553	559	PF00498	0.405
LIG_Integrin_RGD_1	260	262	PF01839	0.584
LIG_LIR_Apic_2	369	375	PF02991	0.413
LIG_LIR_Apic_2	414	420	PF02991	0.281
LIG_LIR_Apic_2	472	476	PF02991	0.409
LIG_LIR_Nem_3	25	31	PF02991	0.563
LIG_SH2_CRK	473	477	PF00017	0.312
LIG_SH2_NCK_1	191	195	PF00017	0.474
LIG_SH2_NCK_1	473	477	PF00017	0.312
LIG_SH2_STAT5	326	329	PF00017	0.281
LIG_SH2_STAT5	34	37	PF00017	0.601
LIG_SH3_3	225	231	PF00018	0.388
LIG_SH3_3	246	252	PF00018	0.368
LIG_SH3_3	310	316	PF00018	0.652
LIG_SH3_3	387	393	PF00018	0.361
LIG_SH3_3	41	47	PF00018	0.684
LIG_SH3_3	480	486	PF00018	0.410
LIG_SH3_3	60	66	PF00018	0.679
LIG_SUMO_SIM_anti_2	454	462	PF11976	0.335
LIG_SUMO_SIM_anti_2	517	523	PF11976	0.302
LIG_SUMO_SIM_par_1	593	599	PF11976	0.558
LIG_UBA3_1	441	449	PF00899	0.413
LIG_UBA3_1	460	466	PF00899	0.325
LIG_WW_3	487	491	PF00397	0.312
MOD_CK1_1	190	196	PF00069	0.729
MOD_CK1_1	197	203	PF00069	0.640
MOD_CK1_1	279	285	PF00069	0.617
MOD_CK1_1	292	298	PF00069	0.581
MOD_CK1_1	312	318	PF00069	0.644
MOD_CK1_1	410	416	PF00069	0.325
MOD_CK2_1	16	22	PF00069	0.626
MOD_CK2_1	241	247	PF00069	0.464
MOD_CK2_1	379	385	PF00069	0.331
MOD_CK2_1	451	457	PF00069	0.302
MOD_CK2_1	532	538	PF00069	0.322
MOD_Cter_Amidation	141	144	PF01082	0.474
MOD_GlcNHglycan	104	107	PF01048	0.681
MOD_GlcNHglycan	161	165	PF01048	0.588
MOD_GlcNHglycan	194	197	PF01048	0.686
MOD_GlcNHglycan	216	220	PF01048	0.493
MOD_GlcNHglycan	279	282	PF01048	0.641
MOD_GlcNHglycan	292	295	PF01048	0.583
MOD_GlcNHglycan	36	39	PF01048	0.641
MOD_GlcNHglycan	368	371	PF01048	0.329
MOD_GlcNHglycan	377	380	PF01048	0.308
MOD_GlcNHglycan	473	476	PF01048	0.385
MOD_GlcNHglycan	493	496	PF01048	0.456
MOD_GlcNHglycan	550	553	PF01048	0.566
MOD_GlcNHglycan	68	71	PF01048	0.767
MOD_GlcNHglycan	97	100	PF01048	0.512
MOD_GSK3_1	186	193	PF00069	0.574
MOD_GSK3_1	22	29	PF00069	0.685
MOD_GSK3_1	272	279	PF00069	0.702
MOD_GSK3_1	290	297	PF00069	0.715
MOD_GSK3_1	312	319	PF00069	0.710
MOD_GSK3_1	375	382	PF00069	0.343
MOD_GSK3_1	407	414	PF00069	0.304
MOD_GSK3_1	471	478	PF00069	0.298
MOD_GSK3_1	548	555	PF00069	0.657
MOD_NEK2_1	241	246	PF00069	0.348
MOD_NEK2_1	276	281	PF00069	0.725
MOD_NEK2_1	289	294	PF00069	0.457
MOD_NEK2_1	338	343	PF00069	0.354
MOD_NEK2_1	349	354	PF00069	0.237
MOD_NEK2_1	4	9	PF00069	0.559
MOD_NEK2_1	593	598	PF00069	0.691
MOD_NEK2_2	26	31	PF00069	0.587
MOD_NEK2_2	272	277	PF00069	0.641
MOD_NEK2_2	73	78	PF00069	0.528
MOD_OFUCOSY	336	342	PF10250	0.362
MOD_PIKK_1	115	121	PF00454	0.782
MOD_PIKK_1	36	42	PF00454	0.708
MOD_PKA_2	411	417	PF00069	0.281
MOD_PKA_2	491	497	PF00069	0.287
MOD_PKA_2	532	538	PF00069	0.294
MOD_Plk_1	168	174	PF00069	0.372
MOD_Plk_4	162	168	PF00069	0.455
MOD_Plk_4	272	278	PF00069	0.642
MOD_Plk_4	386	392	PF00069	0.331
MOD_Plk_4	475	481	PF00069	0.416
MOD_Plk_4	569	575	PF00069	0.514
MOD_ProDKin_1	22	28	PF00069	0.693
MOD_ProDKin_1	309	315	PF00069	0.714
MOD_ProDKin_1	384	390	PF00069	0.372
MOD_ProDKin_1	404	410	PF00069	0.281
MOD_SUMO_for_1	82	85	PF00179	0.507
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.468
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.511
TRG_ENDOCYTIC_2	225	228	PF00928	0.470
TRG_ENDOCYTIC_2	97	100	PF00928	0.440
TRG_ER_diArg_1	140	143	PF00400	0.502
TRG_ER_diArg_1	328	330	PF00400	0.413
TRG_ER_diArg_1	561	564	PF00400	0.448
TRG_ER_diArg_1	590	592	PF00400	0.588
TRG_ER_diArg_1	88	90	PF00400	0.526
TRG_Pf-PMV_PEXEL_1	524	528	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJY2	Leptomonas seymouri	48%	96%
A0A1X0P246	Trypanosomatidae	31%	100%
A0A422P3I6	Trypanosoma rangeli	30%	100%
A4H934	Leishmania braziliensis	76%	100%
A4I5K5	Leishmania infantum	100%	100%
C9ZQY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B0V0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q7B6	Leishmania major	93%	100%
V5DQL7	Trypanosoma cruzi	32%	100%