CDC16_putative/GeneDB:LmjF.30.0710

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CDC16, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7M5_LEIDO

TriTrypDb:

LdBPK_300740.1 , LdCL_300012500 , LDHU3_30.0940

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000152	nuclear ubiquitin ligase complex	3	1
GO:0005680	anaphase-promoting complex	4	1
GO:0005737	cytoplasm	2	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S5H7M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7M5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007088	regulation of mitotic nuclear division	6	1
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	5	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	3
GO:0010498	proteasomal protein catabolic process	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010638	positive regulation of organelle organization	6	1
GO:0010965	regulation of mitotic sister chromatid separation	6	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0022402	cell cycle process	2	1
GO:0030071	regulation of mitotic metaphase/anaphase transition	7	1
GO:0030163	protein catabolic process	4	1
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0033043	regulation of organelle organization	5	1
GO:0033044	regulation of chromosome organization	6	1
GO:0033045	regulation of sister chromatid segregation	5	1
GO:0036211	protein modification process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0044784	metaphase/anaphase transition of cell cycle	4	1
GO:0045787	positive regulation of cell cycle	5	1
GO:0045840	positive regulation of mitotic nuclear division	7	1
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	8	1
GO:0045931	positive regulation of mitotic cell cycle	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051301	cell division	2	3
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051726	regulation of cell cycle	4	1
GO:0051783	regulation of nuclear division	6	1
GO:0051785	positive regulation of nuclear division	7	1
GO:0051983	regulation of chromosome segregation	4	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090068	positive regulation of cell cycle process	6	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901970	positive regulation of mitotic sister chromatid separation	7	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901989	positive regulation of cell cycle phase transition	7	1
GO:1901990	regulation of mitotic cell cycle phase transition	6	1
GO:1901992	positive regulation of mitotic cell cycle phase transition	7	1
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	6	1
GO:1902101	positive regulation of metaphase/anaphase transition of cell cycle	7	1
GO:1903047	mitotic cell cycle process	3	1
GO:1905818	regulation of chromosome separation	5	1
GO:1905820	positive regulation of chromosome separation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	524	528	PF00656	0.716
CLV_NRD_NRD_1	322	324	PF00675	0.368
CLV_NRD_NRD_1	359	361	PF00675	0.532
CLV_NRD_NRD_1	417	419	PF00675	0.287
CLV_NRD_NRD_1	421	423	PF00675	0.284
CLV_NRD_NRD_1	481	483	PF00675	0.485
CLV_NRD_NRD_1	517	519	PF00675	0.665
CLV_PCSK_KEX2_1	322	324	PF00082	0.368
CLV_PCSK_KEX2_1	421	423	PF00082	0.342
CLV_PCSK_KEX2_1	481	483	PF00082	0.478
CLV_PCSK_KEX2_1	517	519	PF00082	0.667
CLV_PCSK_PC7_1	477	483	PF00082	0.493
CLV_PCSK_SKI1_1	130	134	PF00082	0.431
CLV_PCSK_SKI1_1	149	153	PF00082	0.195
CLV_PCSK_SKI1_1	213	217	PF00082	0.496
CLV_PCSK_SKI1_1	352	356	PF00082	0.450
CLV_PCSK_SKI1_1	383	387	PF00082	0.426
CLV_PCSK_SKI1_1	41	45	PF00082	0.459
CLV_PCSK_SKI1_1	477	481	PF00082	0.376
CLV_PCSK_SKI1_1	59	63	PF00082	0.341
CLV_PCSK_SKI1_1	80	84	PF00082	0.431
DEG_APCC_KENBOX_2	7	11	PF00400	0.444
DEG_Nend_UBRbox_2	1	3	PF02207	0.600
DEG_SCF_FBW7_1	186	191	PF00400	0.510
DOC_CKS1_1	185	190	PF01111	0.553
DOC_CYCLIN_RxL_1	146	156	PF00134	0.381
DOC_CYCLIN_RxL_1	477	487	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	164	170	PF00134	0.467
DOC_MAPK_gen_1	124	133	PF00069	0.458
DOC_MAPK_gen_1	258	267	PF00069	0.464
DOC_MAPK_gen_1	481	488	PF00069	0.511
DOC_MAPK_MEF2A_6	230	239	PF00069	0.329
DOC_MAPK_MEF2A_6	481	488	PF00069	0.511
DOC_MAPK_NFAT4_5	230	238	PF00069	0.450
DOC_MAPK_NFAT4_5	481	489	PF00069	0.519
DOC_PP1_RVXF_1	122	129	PF00149	0.485
DOC_PP1_RVXF_1	491	497	PF00149	0.686
DOC_PP1_RVXF_1	537	544	PF00149	0.624
DOC_PP2B_LxvP_1	164	167	PF13499	0.390
DOC_USP7_MATH_1	101	105	PF00917	0.530
DOC_USP7_MATH_1	392	396	PF00917	0.334
DOC_USP7_MATH_1	438	442	PF00917	0.425
DOC_USP7_MATH_1	525	529	PF00917	0.577
DOC_WW_Pin1_4	184	189	PF00397	0.558
DOC_WW_Pin1_4	243	248	PF00397	0.499
DOC_WW_Pin1_4	503	508	PF00397	0.584
DOC_WW_Pin1_4	529	534	PF00397	0.596
LIG_14-3-3_CanoR_1	13	21	PF00244	0.523
LIG_14-3-3_CanoR_1	174	178	PF00244	0.370
LIG_14-3-3_CanoR_1	213	219	PF00244	0.468
LIG_14-3-3_CanoR_1	230	234	PF00244	0.385
LIG_14-3-3_CanoR_1	289	297	PF00244	0.368
LIG_14-3-3_CanoR_1	360	365	PF00244	0.468
LIG_14-3-3_CanoR_1	437	447	PF00244	0.403
LIG_14-3-3_CanoR_1	491	497	PF00244	0.658
LIG_14-3-3_CanoR_1	500	506	PF00244	0.689
LIG_14-3-3_CanoR_1	536	542	PF00244	0.572
LIG_Actin_WH2_2	44	61	PF00022	0.509
LIG_AP2alpha_2	136	138	PF02296	0.401
LIG_BRCT_BRCA1_1	515	519	PF00533	0.627
LIG_BRCT_BRCA1_1	539	543	PF00533	0.503
LIG_BRCT_BRCA1_1	71	75	PF00533	0.495
LIG_FHA_1	185	191	PF00498	0.630
LIG_FHA_1	194	200	PF00498	0.473
LIG_FHA_1	217	223	PF00498	0.391
LIG_FHA_1	230	236	PF00498	0.348
LIG_FHA_1	244	250	PF00498	0.297
LIG_FHA_1	448	454	PF00498	0.315
LIG_FHA_2	522	528	PF00498	0.721
LIG_LIR_Apic_2	183	188	PF02991	0.610
LIG_LIR_Gen_1	141	151	PF02991	0.501
LIG_LIR_Gen_1	153	161	PF02991	0.312
LIG_LIR_Gen_1	509	519	PF02991	0.562
LIG_LIR_Gen_1	53	61	PF02991	0.488
LIG_LIR_Nem_3	141	146	PF02991	0.491
LIG_LIR_Nem_3	153	158	PF02991	0.317
LIG_LIR_Nem_3	299	304	PF02991	0.325
LIG_LIR_Nem_3	415	420	PF02991	0.329
LIG_LIR_Nem_3	428	433	PF02991	0.217
LIG_LIR_Nem_3	509	515	PF02991	0.558
LIG_LIR_Nem_3	53	57	PF02991	0.486
LIG_NBox_RRM_1	75	85	PF00076	0.489
LIG_Pex14_2	297	301	PF04695	0.325
LIG_SH2_CRK	342	346	PF00017	0.388
LIG_SH2_CRK	393	397	PF00017	0.315
LIG_SH2_CRK	417	421	PF00017	0.384
LIG_SH2_GRB2like	429	432	PF00017	0.446
LIG_SH2_NCK_1	280	284	PF00017	0.354
LIG_SH2_NCK_1	342	346	PF00017	0.514
LIG_SH2_SRC	268	271	PF00017	0.376
LIG_SH2_STAP1	262	266	PF00017	0.477
LIG_SH2_STAP1	423	427	PF00017	0.322
LIG_SH2_STAP1	94	98	PF00017	0.422
LIG_SH2_STAT3	228	231	PF00017	0.511
LIG_SH2_STAT3	429	432	PF00017	0.420
LIG_SH2_STAT5	185	188	PF00017	0.634
LIG_SH2_STAT5	262	265	PF00017	0.448
LIG_SH2_STAT5	286	289	PF00017	0.478
LIG_SH2_STAT5	296	299	PF00017	0.419
LIG_SH2_STAT5	337	340	PF00017	0.377
LIG_SH2_STAT5	433	436	PF00017	0.306
LIG_SUMO_SIM_anti_2	196	201	PF11976	0.514
LIG_SUMO_SIM_par_1	219	226	PF11976	0.441
LIG_SUMO_SIM_par_1	365	371	PF11976	0.292
LIG_SUMO_SIM_par_1	373	380	PF11976	0.314
LIG_TYR_ITAM	259	277	PF00017	0.472
LIG_WW_3	533	537	PF00397	0.648
MOD_CDK_SPxxK_3	529	536	PF00069	0.676
MOD_CK1_1	144	150	PF00069	0.486
MOD_CK1_1	217	223	PF00069	0.417
MOD_CK1_1	243	249	PF00069	0.455
MOD_CK1_1	288	294	PF00069	0.410
MOD_CK1_1	403	409	PF00069	0.422
MOD_CK1_1	495	501	PF00069	0.695
MOD_CK1_1	511	517	PF00069	0.562
MOD_CK1_1	521	527	PF00069	0.658
MOD_CK2_1	275	281	PF00069	0.380
MOD_CK2_1	503	509	PF00069	0.707
MOD_GlcNHglycan	117	121	PF01048	0.402
MOD_GlcNHglycan	143	146	PF01048	0.400
MOD_GlcNHglycan	15	18	PF01048	0.477
MOD_GlcNHglycan	190	193	PF01048	0.573
MOD_GlcNHglycan	21	24	PF01048	0.414
MOD_GlcNHglycan	453	456	PF01048	0.401
MOD_GSK3_1	180	187	PF00069	0.504
MOD_GSK3_1	447	454	PF00069	0.361
MOD_GSK3_1	459	466	PF00069	0.370
MOD_GSK3_1	521	528	PF00069	0.650
MOD_N-GLC_1	39	44	PF02516	0.522
MOD_N-GLC_1	438	443	PF02516	0.464
MOD_N-GLC_2	259	261	PF02516	0.533
MOD_N-GLC_2	332	334	PF02516	0.403
MOD_NEK2_1	160	165	PF00069	0.392
MOD_NEK2_1	240	245	PF00069	0.382
MOD_NEK2_1	273	278	PF00069	0.390
MOD_NEK2_1	340	345	PF00069	0.380
MOD_NEK2_1	355	360	PF00069	0.405
MOD_NEK2_1	447	452	PF00069	0.299
MOD_NEK2_2	173	178	PF00069	0.480
MOD_NEK2_2	459	464	PF00069	0.427
MOD_PKA_1	360	366	PF00069	0.456
MOD_PKA_2	173	179	PF00069	0.391
MOD_PKA_2	229	235	PF00069	0.443
MOD_PKA_2	288	294	PF00069	0.369
MOD_PKA_2	492	498	PF00069	0.667
MOD_PKB_1	518	526	PF00069	0.696
MOD_Plk_1	355	361	PF00069	0.491
MOD_Plk_1	39	45	PF00069	0.517
MOD_Plk_1	508	514	PF00069	0.548
MOD_Plk_4	333	339	PF00069	0.353
MOD_Plk_4	412	418	PF00069	0.350
MOD_Plk_4	53	59	PF00069	0.452
MOD_Plk_4	94	100	PF00069	0.456
MOD_ProDKin_1	184	190	PF00069	0.553
MOD_ProDKin_1	243	249	PF00069	0.490
MOD_ProDKin_1	503	509	PF00069	0.585
MOD_ProDKin_1	529	535	PF00069	0.587
MOD_SUMO_for_1	203	206	PF00179	0.489
MOD_SUMO_for_1	309	312	PF00179	0.378
MOD_SUMO_rev_2	84	90	PF00179	0.466
TRG_DiLeu_BaEn_1	156	161	PF01217	0.476
TRG_DiLeu_BaEn_2	250	256	PF01217	0.481
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.515
TRG_ENDOCYTIC_2	262	265	PF00928	0.485
TRG_ENDOCYTIC_2	274	277	PF00928	0.472
TRG_ENDOCYTIC_2	308	311	PF00928	0.357
TRG_ENDOCYTIC_2	337	340	PF00928	0.350
TRG_ENDOCYTIC_2	342	345	PF00928	0.359
TRG_ENDOCYTIC_2	393	396	PF00928	0.315
TRG_ENDOCYTIC_2	417	420	PF00928	0.384
TRG_ER_diArg_1	321	323	PF00400	0.368
TRG_ER_diArg_1	420	422	PF00400	0.351
TRG_ER_diArg_1	434	437	PF00400	0.389
TRG_ER_diArg_1	480	482	PF00400	0.489
TRG_ER_diArg_1	491	494	PF00400	0.648
TRG_ER_diArg_1	517	519	PF00400	0.670
TRG_NES_CRM1_1	156	169	PF08389	0.395
TRG_NES_CRM1_1	19	32	PF08389	0.520
TRG_NES_CRM1_1	50	63	PF08389	0.483
TRG_NES_CRM1_1	87	102	PF08389	0.514
TRG_NLS_MonoExtC_3	417	422	PF00514	0.271
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	539	544	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM16	Leptomonas seymouri	79%	100%
A0A0S4J8L2	Bodo saltans	39%	76%
A0A1X0P255	Trypanosomatidae	53%	100%
A0A422NIF3	Trypanosoma rangeli	53%	100%
A4HI23	Leishmania braziliensis	93%	100%
A4I5A0	Leishmania infantum	100%	100%
B3DNN5	Arabidopsis thaliana	30%	100%
C9ZQN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	91%
E9B0J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
P41889	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	81%
Q13042	Homo sapiens	29%	88%
Q4Q7N6	Leishmania major	98%	100%
Q8R349	Mus musculus	29%	88%
V5AS70	Trypanosoma cruzi	53%	100%