Spliceosome-associated_protein_putative/GeneDB:Lm jF.30.0570

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

spliceosome-associated protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7M4_LEIDO

TriTrypDb:

LdBPK_300590.1 , LdCL_300011000 , LDHU3_30.0770

Length:

474

Annotations

Annotations by Jardim et al.

RNA Processing, spliceosome-associated

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071011	precatalytic spliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S5H7M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7M4

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.459
CLV_NRD_NRD_1	127	129	PF00675	0.528
CLV_NRD_NRD_1	241	243	PF00675	0.447
CLV_NRD_NRD_1	298	300	PF00675	0.295
CLV_PCSK_KEX2_1	12	14	PF00082	0.459
CLV_PCSK_KEX2_1	274	276	PF00082	0.349
CLV_PCSK_KEX2_1	298	300	PF00082	0.295
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.349
CLV_PCSK_SKI1_1	102	106	PF00082	0.678
CLV_PCSK_SKI1_1	187	191	PF00082	0.295
CLV_PCSK_SKI1_1	221	225	PF00082	0.550
CLV_PCSK_SKI1_1	277	281	PF00082	0.337
CLV_PCSK_SKI1_1	29	33	PF00082	0.561
CLV_Separin_Metazoa	331	335	PF03568	0.551
DEG_APCC_DBOX_1	101	109	PF00400	0.566
DEG_COP1_1	369	377	PF00400	0.526
DEG_SIAH_1	425	433	PF03145	0.673
DOC_CKS1_1	222	227	PF01111	0.406
DOC_CKS1_1	408	413	PF01111	0.686
DOC_CKS1_1	50	55	PF01111	0.583
DOC_CYCLIN_RxL_1	25	34	PF00134	0.459
DOC_CYCLIN_yCln2_LP_2	312	318	PF00134	0.402
DOC_MAPK_DCC_7	406	414	PF00069	0.558
DOC_MAPK_FxFP_2	340	343	PF00069	0.437
DOC_MAPK_gen_1	242	249	PF00069	0.428
DOC_MAPK_gen_1	274	282	PF00069	0.419
DOC_PP2B_LxvP_1	307	310	PF13499	0.285
DOC_PP2B_LxvP_1	312	315	PF13499	0.267
DOC_PP4_FxxP_1	340	343	PF00568	0.437
DOC_USP7_MATH_1	351	355	PF00917	0.743
DOC_USP7_MATH_1	378	382	PF00917	0.795
DOC_USP7_MATH_1	91	95	PF00917	0.673
DOC_USP7_UBL2_3	260	264	PF12436	0.448
DOC_USP7_UBL2_3	5	9	PF12436	0.546
DOC_WW_Pin1_4	221	226	PF00397	0.414
DOC_WW_Pin1_4	235	240	PF00397	0.472
DOC_WW_Pin1_4	265	270	PF00397	0.526
DOC_WW_Pin1_4	384	389	PF00397	0.681
DOC_WW_Pin1_4	398	403	PF00397	0.687
DOC_WW_Pin1_4	407	412	PF00397	0.589
DOC_WW_Pin1_4	428	433	PF00397	0.632
DOC_WW_Pin1_4	49	54	PF00397	0.647
LIG_14-3-3_CanoR_1	119	125	PF00244	0.635
LIG_14-3-3_CanoR_1	132	136	PF00244	0.387
LIG_14-3-3_CanoR_1	242	246	PF00244	0.513
LIG_Actin_WH2_2	42	59	PF00022	0.558
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_BRCT_BRCA1_1	338	342	PF00533	0.577
LIG_EVH1_1	49	53	PF00568	0.586
LIG_FHA_1	149	155	PF00498	0.385
LIG_FHA_1	174	180	PF00498	0.316
LIG_FHA_1	242	248	PF00498	0.529
LIG_FHA_1	266	272	PF00498	0.355
LIG_FHA_1	444	450	PF00498	0.555
LIG_FHA_2	132	138	PF00498	0.558
LIG_FHA_2	353	359	PF00498	0.586
LIG_FHA_2	367	373	PF00498	0.457
LIG_FHA_2	429	435	PF00498	0.627
LIG_FHA_2	50	56	PF00498	0.650
LIG_LIR_Apic_2	327	332	PF02991	0.426
LIG_LIR_Apic_2	337	343	PF02991	0.456
LIG_LIR_Apic_2	44	50	PF02991	0.591
LIG_LIR_Gen_1	134	143	PF02991	0.456
LIG_LIR_Gen_1	434	440	PF02991	0.544
LIG_LIR_Nem_3	134	138	PF02991	0.467
LIG_LIR_Nem_3	339	345	PF02991	0.445
LIG_LIR_Nem_3	358	364	PF02991	0.378
LIG_LIR_Nem_3	434	438	PF02991	0.548
LIG_LYPXL_yS_3	304	307	PF13949	0.277
LIG_Pex14_2	230	234	PF04695	0.443
LIG_PTAP_UEV_1	283	288	PF05743	0.399
LIG_SH2_CRK	47	51	PF00017	0.609
LIG_SH2_NCK_1	47	51	PF00017	0.668
LIG_SH2_PTP2	435	438	PF00017	0.544
LIG_SH2_STAT3	292	295	PF00017	0.277
LIG_SH2_STAT3	419	422	PF00017	0.669
LIG_SH2_STAT5	419	422	PF00017	0.545
LIG_SH2_STAT5	435	438	PF00017	0.576
LIG_SH2_STAT5	47	50	PF00017	0.539
LIG_SH3_1	299	305	PF00018	0.295
LIG_SH3_1	47	53	PF00018	0.596
LIG_SH3_3	100	106	PF00018	0.572
LIG_SH3_3	174	180	PF00018	0.277
LIG_SH3_3	281	287	PF00018	0.283
LIG_SH3_3	299	305	PF00018	0.255
LIG_SH3_3	405	411	PF00018	0.634
LIG_SH3_3	47	53	PF00018	0.596
LIG_TRAF2_1	134	137	PF00917	0.482
LIG_TRAF2_1	370	373	PF00917	0.644
LIG_TRAF2_1	431	434	PF00917	0.563
LIG_TRAF2_1	58	61	PF00917	0.560
LIG_TRFH_1	47	51	PF08558	0.668
LIG_WW_1	301	304	PF00397	0.277
LIG_WW_3	331	335	PF00397	0.419
MOD_CDK_SPxxK_3	235	242	PF00069	0.428
MOD_CK1_1	123	129	PF00069	0.642
MOD_CK1_1	293	299	PF00069	0.349
MOD_CK2_1	1	7	PF00069	0.606
MOD_CK2_1	131	137	PF00069	0.577
MOD_CK2_1	352	358	PF00069	0.561
MOD_CK2_1	366	372	PF00069	0.475
MOD_CK2_1	428	434	PF00069	0.624
MOD_CK2_1	49	55	PF00069	0.602
MOD_Cter_Amidation	126	129	PF01082	0.638
MOD_GlcNHglycan	122	125	PF01048	0.685
MOD_GlcNHglycan	375	378	PF01048	0.727
MOD_GlcNHglycan	382	385	PF01048	0.727
MOD_GlcNHglycan	93	96	PF01048	0.586
MOD_GSK3_1	119	126	PF00069	0.714
MOD_GSK3_1	229	236	PF00069	0.442
MOD_GSK3_1	380	387	PF00069	0.680
MOD_GSK3_1	439	446	PF00069	0.525
MOD_GSK3_1	45	52	PF00069	0.655
MOD_LATS_1	18	24	PF00433	0.368
MOD_N-GLC_1	440	445	PF02516	0.692
MOD_NEK2_1	1	6	PF00069	0.651
MOD_NEK2_1	185	190	PF00069	0.364
MOD_NEK2_2	164	169	PF00069	0.320
MOD_NEK2_2	229	234	PF00069	0.454
MOD_PIKK_1	20	26	PF00454	0.548
MOD_PIKK_1	352	358	PF00454	0.595
MOD_PIKK_1	458	464	PF00454	0.732
MOD_PKA_1	20	26	PF00069	0.467
MOD_PKA_2	118	124	PF00069	0.590
MOD_PKA_2	131	137	PF00069	0.379
MOD_PKA_2	215	221	PF00069	0.325
MOD_PKA_2	241	247	PF00069	0.566
MOD_Plk_1	336	342	PF00069	0.530
MOD_Plk_1	443	449	PF00069	0.610
MOD_Plk_4	336	342	PF00069	0.469
MOD_ProDKin_1	221	227	PF00069	0.412
MOD_ProDKin_1	235	241	PF00069	0.477
MOD_ProDKin_1	265	271	PF00069	0.525
MOD_ProDKin_1	384	390	PF00069	0.678
MOD_ProDKin_1	398	404	PF00069	0.686
MOD_ProDKin_1	407	413	PF00069	0.577
MOD_ProDKin_1	428	434	PF00069	0.635
MOD_ProDKin_1	49	55	PF00069	0.650
MOD_SUMO_for_1	170	173	PF00179	0.409
MOD_SUMO_rev_2	136	140	PF00179	0.462
MOD_SUMO_rev_2	4	11	PF00179	0.594
TRG_DiLeu_BaEn_1	149	154	PF01217	0.393
TRG_DiLeu_BaEn_2	335	341	PF01217	0.452
TRG_DiLeu_BaEn_3	197	203	PF01217	0.409
TRG_ENDOCYTIC_2	304	307	PF00928	0.277
TRG_ENDOCYTIC_2	435	438	PF00928	0.544
TRG_ENDOCYTIC_2	451	454	PF00928	0.698
TRG_ER_diArg_1	297	299	PF00400	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T1	Leptomonas seymouri	71%	98%
A0A1X0P248	Trypanosomatidae	48%	100%
A0A3R7MML5	Trypanosoma rangeli	49%	100%
A4HI08	Leishmania braziliensis	86%	100%
A4I585	Leishmania infantum	100%	100%
C9ZQL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	99%
E9B0I2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q7P9	Leishmania major	95%	100%
V5B7R6	Trypanosoma cruzi	48%	100%