Alpha/beta hydrolase family/X-Pro dipeptidyl-peptidase (S15 family), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7M3_LEIDO

TriTrypDb:

LdBPK_300400.1 , LdCL_300009100 , LDHU3_30.0570

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7M3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.411
CLV_C14_Caspase3-7	16	20	PF00656	0.403
CLV_C14_Caspase3-7	231	235	PF00656	0.562
CLV_C14_Caspase3-7	3	7	PF00656	0.717
CLV_C14_Caspase3-7	484	488	PF00656	0.617
CLV_NRD_NRD_1	218	220	PF00675	0.474
CLV_NRD_NRD_1	79	81	PF00675	0.454
CLV_PCSK_KEX2_1	220	222	PF00082	0.477
CLV_PCSK_KEX2_1	224	226	PF00082	0.490
CLV_PCSK_KEX2_1	79	81	PF00082	0.454
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.477
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.490
CLV_PCSK_SKI1_1	221	225	PF00082	0.431
CLV_PCSK_SKI1_1	237	241	PF00082	0.392
CLV_PCSK_SKI1_1	266	270	PF00082	0.577
CLV_PCSK_SKI1_1	295	299	PF00082	0.437
DEG_APCC_DBOX_1	132	140	PF00400	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.633
DEG_SCF_FBW7_1	441	448	PF00400	0.607
DEG_SPOP_SBC_1	378	382	PF00917	0.765
DEG_SPOP_SBC_1	389	393	PF00917	0.761
DOC_CKS1_1	276	281	PF01111	0.532
DOC_CYCLIN_RxL_1	310	323	PF00134	0.649
DOC_CYCLIN_yCln2_LP_2	342	348	PF00134	0.600
DOC_CYCLIN_yCln2_LP_2	353	356	PF00134	0.663
DOC_CYCLIN_yCln2_LP_2	399	405	PF00134	0.692
DOC_MAPK_DCC_7	201	211	PF00069	0.436
DOC_MAPK_DCC_7	240	249	PF00069	0.449
DOC_MAPK_gen_1	201	211	PF00069	0.513
DOC_MAPK_MEF2A_6	204	211	PF00069	0.436
DOC_MAPK_MEF2A_6	240	249	PF00069	0.449
DOC_MAPK_MEF2A_6	286	294	PF00069	0.487
DOC_MAPK_MEF2A_6	295	302	PF00069	0.384
DOC_MAPK_NFAT4_5	295	303	PF00069	0.481
DOC_PP1_RVXF_1	62	69	PF00149	0.458
DOC_PP2B_LxvP_1	342	345	PF13499	0.593
DOC_PP2B_LxvP_1	353	356	PF13499	0.663
DOC_PP2B_LxvP_1	399	402	PF13499	0.658
DOC_PP2B_LxvP_1	405	408	PF13499	0.660
DOC_PP2B_PxIxI_1	206	212	PF00149	0.436
DOC_PP4_FxxP_1	256	259	PF00568	0.568
DOC_PP4_FxxP_1	269	272	PF00568	0.301
DOC_USP7_MATH_1	183	187	PF00917	0.513
DOC_USP7_MATH_1	376	380	PF00917	0.770
DOC_USP7_MATH_1	385	389	PF00917	0.555
DOC_USP7_MATH_1	445	449	PF00917	0.652
DOC_USP7_MATH_1	454	458	PF00917	0.671
DOC_USP7_MATH_1	482	486	PF00917	0.619
DOC_USP7_UBL2_3	220	224	PF12436	0.469
DOC_WW_Pin1_4	179	184	PF00397	0.411
DOC_WW_Pin1_4	255	260	PF00397	0.507
DOC_WW_Pin1_4	275	280	PF00397	0.482
DOC_WW_Pin1_4	322	327	PF00397	0.635
DOC_WW_Pin1_4	381	386	PF00397	0.687
DOC_WW_Pin1_4	407	412	PF00397	0.654
DOC_WW_Pin1_4	423	428	PF00397	0.760
DOC_WW_Pin1_4	441	446	PF00397	0.505
DOC_WW_Pin1_4	477	482	PF00397	0.601
LIG_14-3-3_CanoR_1	27	35	PF00244	0.595
LIG_14-3-3_CanoR_1	341	345	PF00244	0.564
LIG_14-3-3_CanoR_1	453	463	PF00244	0.655
LIG_14-3-3_CanoR_1	67	73	PF00244	0.432
LIG_AP2alpha_2	172	174	PF02296	0.389
LIG_BIR_III_2	267	271	PF00653	0.581
LIG_BRCT_BRCA1_1	126	130	PF00533	0.411
LIG_BRCT_BRCA1_1	391	395	PF00533	0.746
LIG_Clathr_ClatBox_1	110	114	PF01394	0.411
LIG_CtBP_PxDLS_1	440	444	PF00389	0.601
LIG_eIF4E_1	131	137	PF01652	0.513
LIG_FHA_1	200	206	PF00498	0.459
LIG_FHA_1	30	36	PF00498	0.525
LIG_FHA_1	364	370	PF00498	0.727
LIG_FHA_1	458	464	PF00498	0.744
LIG_FHA_1	484	490	PF00498	0.719
LIG_FHA_2	258	264	PF00498	0.474
LIG_FHA_2	391	397	PF00498	0.748
LIG_LIR_Apic_2	253	259	PF02991	0.580
LIG_LIR_Apic_2	267	272	PF02991	0.278
LIG_LIR_Gen_1	106	115	PF02991	0.492
LIG_LIR_Gen_1	122	131	PF02991	0.331
LIG_LIR_Gen_1	141	150	PF02991	0.411
LIG_LIR_Gen_1	181	191	PF02991	0.411
LIG_LIR_Nem_3	106	111	PF02991	0.492
LIG_LIR_Nem_3	122	128	PF02991	0.331
LIG_LIR_Nem_3	141	145	PF02991	0.411
LIG_LIR_Nem_3	181	187	PF02991	0.411
LIG_LIR_Nem_3	71	76	PF02991	0.542
LIG_MYND_1	441	445	PF01753	0.599
LIG_Pex14_1	72	76	PF04695	0.547
LIG_Pex14_2	111	115	PF04695	0.411
LIG_Pex14_2	68	72	PF04695	0.425
LIG_SH2_PTP2	125	128	PF00017	0.411
LIG_SH2_STAT3	131	134	PF00017	0.411
LIG_SH2_STAT5	125	128	PF00017	0.384
LIG_SH2_STAT5	301	304	PF00017	0.458
LIG_SH2_STAT5	86	89	PF00017	0.416
LIG_SH3_3	405	411	PF00018	0.682
LIG_SH3_3	472	478	PF00018	0.606
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.513
LIG_SUMO_SIM_par_1	135	141	PF11976	0.513
LIG_WW_3	27	31	PF00397	0.499
MOD_CDK_SPxK_1	441	447	PF00069	0.613
MOD_CDK_SPxxK_3	407	414	PF00069	0.703
MOD_CDK_SPxxK_3	423	430	PF00069	0.517
MOD_CK1_1	118	124	PF00069	0.411
MOD_CK1_1	13	19	PF00069	0.562
MOD_CK1_1	340	346	PF00069	0.701
MOD_CK1_1	370	376	PF00069	0.697
MOD_CK1_1	379	385	PF00069	0.619
MOD_CK1_1	388	394	PF00069	0.704
MOD_CK1_1	422	428	PF00069	0.807
MOD_CK1_1	449	455	PF00069	0.691
MOD_CK1_1	457	463	PF00069	0.620
MOD_CK1_1	471	477	PF00069	0.676
MOD_CK2_1	118	124	PF00069	0.411
MOD_CK2_1	257	263	PF00069	0.468
MOD_CK2_1	28	34	PF00069	0.526
MOD_GlcNHglycan	117	120	PF01048	0.411
MOD_GlcNHglycan	12	15	PF01048	0.563
MOD_GlcNHglycan	2	5	PF01048	0.625
MOD_GlcNHglycan	342	345	PF01048	0.694
MOD_GlcNHglycan	374	377	PF01048	0.780
MOD_GlcNHglycan	387	390	PF01048	0.753
MOD_GlcNHglycan	449	452	PF01048	0.763
MOD_GlcNHglycan	456	459	PF01048	0.629
MOD_GlcNHglycan	470	473	PF01048	0.677
MOD_GSK3_1	179	186	PF00069	0.375
MOD_GSK3_1	363	370	PF00069	0.737
MOD_GSK3_1	372	379	PF00069	0.636
MOD_GSK3_1	380	387	PF00069	0.764
MOD_GSK3_1	390	397	PF00069	0.757
MOD_GSK3_1	403	410	PF00069	0.551
MOD_GSK3_1	419	426	PF00069	0.768
MOD_GSK3_1	431	438	PF00069	0.728
MOD_GSK3_1	441	448	PF00069	0.627
MOD_GSK3_1	467	474	PF00069	0.656
MOD_GSK3_1	68	75	PF00069	0.454
MOD_GSK3_1	9	16	PF00069	0.603
MOD_N-GLC_1	490	495	PF02516	0.607
MOD_NEK2_1	115	120	PF00069	0.411
MOD_NEK2_1	17	22	PF00069	0.471
MOD_NEK2_1	320	325	PF00069	0.541
MOD_NEK2_1	368	373	PF00069	0.665
MOD_NEK2_1	395	400	PF00069	0.682
MOD_NEK2_1	435	440	PF00069	0.664
MOD_NEK2_1	446	451	PF00069	0.712
MOD_NEK2_1	68	73	PF00069	0.405
MOD_NEK2_1	9	14	PF00069	0.685
MOD_NEK2_2	183	188	PF00069	0.411
MOD_PKA_2	29	35	PF00069	0.574
MOD_PKA_2	340	346	PF00069	0.646
MOD_PKA_2	422	428	PF00069	0.648
MOD_PKA_2	446	452	PF00069	0.651
MOD_Plk_1	395	401	PF00069	0.707
MOD_Plk_4	13	19	PF00069	0.562
MOD_Plk_4	68	74	PF00069	0.381
MOD_ProDKin_1	179	185	PF00069	0.411
MOD_ProDKin_1	255	261	PF00069	0.502
MOD_ProDKin_1	275	281	PF00069	0.481
MOD_ProDKin_1	322	328	PF00069	0.636
MOD_ProDKin_1	381	387	PF00069	0.688
MOD_ProDKin_1	407	413	PF00069	0.651
MOD_ProDKin_1	423	429	PF00069	0.762
MOD_ProDKin_1	441	447	PF00069	0.507
MOD_ProDKin_1	477	483	PF00069	0.604
TRG_DiLeu_BaEn_1	132	137	PF01217	0.513
TRG_DiLeu_BaEn_1	99	104	PF01217	0.436
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.411
TRG_ENDOCYTIC_2	125	128	PF00928	0.411
TRG_ENDOCYTIC_2	95	98	PF00928	0.411
TRG_ER_diArg_1	218	221	PF00400	0.476
TRG_ER_diArg_1	79	81	PF00400	0.458
TRG_NES_CRM1_1	134	149	PF08389	0.411
TRG_NES_CRM1_1	288	304	PF08389	0.465
TRG_NES_CRM1_1	99	114	PF08389	0.411
TRG_NLS_MonoExtN_4	217	223	PF00514	0.474
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRJ3	Leptomonas seymouri	68%	100%
A4HHZ0	Leishmania braziliensis	80%	100%
A4I567	Leishmania infantum	99%	100%
E9B0G4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q7R9	Leishmania major	92%	100%