Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7M2_LEIDO

TriTrypDb:

LdBPK_300190.1 , LdCL_300006900 , LDHU3_30.0310

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H7M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7M2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.559
CLV_C14_Caspase3-7	401	405	PF00656	0.732
CLV_NRD_NRD_1	188	190	PF00675	0.633
CLV_NRD_NRD_1	276	278	PF00675	0.623
CLV_NRD_NRD_1	319	321	PF00675	0.521
CLV_NRD_NRD_1	438	440	PF00675	0.582
CLV_NRD_NRD_1	488	490	PF00675	0.533
CLV_PCSK_KEX2_1	187	189	PF00082	0.565
CLV_PCSK_KEX2_1	276	278	PF00082	0.599
CLV_PCSK_KEX2_1	319	321	PF00082	0.518
CLV_PCSK_KEX2_1	338	340	PF00082	0.499
CLV_PCSK_KEX2_1	479	481	PF00082	0.541
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.499
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.541
CLV_PCSK_SKI1_1	121	125	PF00082	0.543
CLV_PCSK_SKI1_1	236	240	PF00082	0.581
CLV_PCSK_SKI1_1	440	444	PF00082	0.483
CLV_PCSK_SKI1_1	468	472	PF00082	0.463
CLV_PCSK_SKI1_1	480	484	PF00082	0.431
CLV_PCSK_SKI1_1	89	93	PF00082	0.459
CLV_Separin_Metazoa	133	137	PF03568	0.559
DEG_APCC_DBOX_1	438	446	PF00400	0.588
DEG_Kelch_Keap1_1	389	394	PF01344	0.648
DEG_SCF_FBW7_2	275	282	PF00400	0.618
DOC_CDC14_PxL_1	221	229	PF14671	0.549
DOC_CYCLIN_RxL_1	476	487	PF00134	0.505
DOC_CYCLIN_RxL_1	86	93	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.553
DOC_MAPK_MEF2A_6	451	460	PF00069	0.423
DOC_PP2B_LxvP_1	238	241	PF13499	0.458
DOC_PP4_FxxP_1	35	38	PF00568	0.639
DOC_PP4_MxPP_1	242	245	PF00568	0.605
DOC_USP7_MATH_1	178	182	PF00917	0.539
DOC_USP7_MATH_1	353	357	PF00917	0.580
DOC_USP7_MATH_1	39	43	PF00917	0.577
DOC_USP7_MATH_1	398	402	PF00917	0.678
DOC_USP7_MATH_1	408	412	PF00917	0.678
DOC_USP7_MATH_1	415	419	PF00917	0.728
DOC_USP7_MATH_1	82	86	PF00917	0.571
DOC_USP7_UBL2_3	468	472	PF12436	0.507
DOC_WW_Pin1_4	253	258	PF00397	0.635
DOC_WW_Pin1_4	275	280	PF00397	0.624
DOC_WW_Pin1_4	78	83	PF00397	0.587
DOC_WW_Pin1_4	9	14	PF00397	0.733
LIG_14-3-3_CanoR_1	319	329	PF00244	0.532
LIG_14-3-3_CanoR_1	331	340	PF00244	0.479
LIG_Actin_WH2_2	453	470	PF00022	0.510
LIG_CSL_BTD_1	225	228	PF09270	0.531
LIG_EH1_1	427	435	PF00400	0.585
LIG_EVH1_1	240	244	PF00568	0.554
LIG_FHA_1	151	157	PF00498	0.636
LIG_FHA_1	17	23	PF00498	0.611
LIG_FHA_1	259	265	PF00498	0.555
LIG_FHA_1	276	282	PF00498	0.390
LIG_FHA_1	332	338	PF00498	0.468
LIG_FHA_1	425	431	PF00498	0.478
LIG_FHA_1	451	457	PF00498	0.498
LIG_FHA_1	472	478	PF00498	0.465
LIG_FHA_2	1	7	PF00498	0.588
LIG_FHA_2	112	118	PF00498	0.586
LIG_FHA_2	323	329	PF00498	0.511
LIG_FHA_2	352	358	PF00498	0.502
LIG_FHA_2	366	372	PF00498	0.542
LIG_LIR_Apic_2	32	38	PF02991	0.642
LIG_LIR_Gen_1	209	217	PF02991	0.482
LIG_LIR_Nem_3	209	215	PF02991	0.482
LIG_LIR_Nem_3	260	265	PF02991	0.547
LIG_LIR_Nem_3	288	292	PF02991	0.483
LIG_LIR_Nem_3	369	375	PF02991	0.512
LIG_Pex14_2	212	216	PF04695	0.561
LIG_Pex14_2	471	475	PF04695	0.465
LIG_PTB_Apo_2	109	116	PF02174	0.529
LIG_PTB_Apo_2	210	217	PF02174	0.523
LIG_SH2_NCK_1	208	212	PF00017	0.512
LIG_SH2_SRC	208	211	PF00017	0.504
LIG_SH2_STAP1	208	212	PF00017	0.528
LIG_SH2_STAP1	64	68	PF00017	0.577
LIG_SH2_STAT5	23	26	PF00017	0.456
LIG_SH3_3	10	16	PF00018	0.726
LIG_SH3_3	125	131	PF00018	0.595
LIG_SH3_3	222	228	PF00018	0.487
LIG_SH3_3	238	244	PF00018	0.414
LIG_SH3_3	382	388	PF00018	0.508
LIG_SH3_3	43	49	PF00018	0.463
LIG_SH3_3	71	77	PF00018	0.472
LIG_SUMO_SIM_par_1	152	157	PF11976	0.621
LIG_SUMO_SIM_par_1	175	181	PF11976	0.626
LIG_SUMO_SIM_par_1	2	8	PF11976	0.554
MOD_CK1_1	253	259	PF00069	0.573
MOD_CK1_1	322	328	PF00069	0.525
MOD_CK1_1	351	357	PF00069	0.589
MOD_CK1_1	389	395	PF00069	0.690
MOD_CK1_1	400	406	PF00069	0.615
MOD_CK2_1	158	164	PF00069	0.731
MOD_CK2_1	28	34	PF00069	0.606
MOD_CK2_1	285	291	PF00069	0.545
MOD_CK2_1	351	357	PF00069	0.504
MOD_CK2_1	365	371	PF00069	0.589
MOD_CK2_1	416	422	PF00069	0.631
MOD_GlcNHglycan	145	148	PF01048	0.491
MOD_GlcNHglycan	391	394	PF01048	0.688
MOD_GlcNHglycan	400	403	PF01048	0.731
MOD_GlcNHglycan	417	421	PF01048	0.714
MOD_GSK3_1	24	31	PF00069	0.553
MOD_GSK3_1	319	326	PF00069	0.592
MOD_GSK3_1	344	351	PF00069	0.475
MOD_GSK3_1	396	403	PF00069	0.666
MOD_GSK3_1	471	478	PF00069	0.538
MOD_GSK3_1	5	12	PF00069	0.659
MOD_GSK3_1	78	85	PF00069	0.532
MOD_N-GLC_1	111	116	PF02516	0.566
MOD_NEK2_1	24	29	PF00069	0.482
MOD_NEK2_1	258	263	PF00069	0.557
MOD_NEK2_1	285	290	PF00069	0.526
MOD_NEK2_1	424	429	PF00069	0.553
MOD_NEK2_1	445	450	PF00069	0.533
MOD_NEK2_1	471	476	PF00069	0.460
MOD_NEK2_1	83	88	PF00069	0.516
MOD_PIKK_1	16	22	PF00454	0.626
MOD_PIKK_1	189	195	PF00454	0.670
MOD_PIKK_1	344	350	PF00454	0.592
MOD_PIKK_1	39	45	PF00454	0.563
MOD_PKA_1	319	325	PF00069	0.589
MOD_PKA_2	143	149	PF00069	0.591
MOD_PKA_2	319	325	PF00069	0.544
MOD_PKA_2	330	336	PF00069	0.507
MOD_PKA_2	373	379	PF00069	0.473
MOD_PKA_2	450	456	PF00069	0.550
MOD_PKB_1	187	195	PF00069	0.637
MOD_Plk_1	111	117	PF00069	0.482
MOD_Plk_4	18	24	PF00069	0.567
MOD_Plk_4	226	232	PF00069	0.515
MOD_Plk_4	83	89	PF00069	0.465
MOD_ProDKin_1	253	259	PF00069	0.624
MOD_ProDKin_1	275	281	PF00069	0.620
MOD_ProDKin_1	78	84	PF00069	0.588
MOD_ProDKin_1	9	15	PF00069	0.728
MOD_SUMO_for_1	159	162	PF00179	0.617
MOD_SUMO_rev_2	29	38	PF00179	0.634
MOD_SUMO_rev_2	463	470	PF00179	0.453
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.654
TRG_ENDOCYTIC_2	208	211	PF00928	0.504
TRG_ENDOCYTIC_2	289	292	PF00928	0.465
TRG_ER_diArg_1	187	189	PF00400	0.602
TRG_ER_diArg_1	275	277	PF00400	0.601
TRG_ER_diArg_1	313	316	PF00400	0.406
TRG_ER_diArg_1	319	321	PF00400	0.455
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH5	Leptomonas seymouri	66%	83%
A0A0S4JF66	Bodo saltans	27%	97%
A0A1X0P302	Trypanosomatidae	35%	95%
A0A3R7LKS4	Trypanosoma rangeli	35%	96%
A4HHW3	Leishmania braziliensis	84%	100%
A4I513	Leishmania infantum	100%	100%
C9ZQG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
E9B0E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q7V1	Leishmania major	95%	100%
V5BLF7	Trypanosoma cruzi	35%	88%