Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7M1_LEIDO

TriTrypDb:

LdBPK_292980.1 , LdCL_290035900 , LDHU3_29.4340

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7M1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7M1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.616
CLV_C14_Caspase3-7	380	384	PF00656	0.379
CLV_MEL_PAP_1	193	199	PF00089	0.552
CLV_NRD_NRD_1	122	124	PF00675	0.385
CLV_NRD_NRD_1	195	197	PF00675	0.506
CLV_PCSK_KEX2_1	122	124	PF00082	0.366
CLV_PCSK_KEX2_1	195	197	PF00082	0.506
CLV_PCSK_KEX2_1	241	243	PF00082	0.500
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.396
CLV_PCSK_SKI1_1	357	361	PF00082	0.406
DEG_SPOP_SBC_1	220	224	PF00917	0.462
DEG_SPOP_SBC_1	31	35	PF00917	0.754
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.457
DOC_PP1_RVXF_1	97	104	PF00149	0.350
DOC_PP2B_LxvP_1	278	281	PF13499	0.284
DOC_PP2B_PxIxI_1	95	101	PF00149	0.309
DOC_USP7_MATH_1	161	165	PF00917	0.503
DOC_USP7_MATH_1	19	23	PF00917	0.632
DOC_USP7_MATH_1	220	224	PF00917	0.586
DOC_USP7_MATH_1	227	231	PF00917	0.495
DOC_USP7_MATH_1	31	35	PF00917	0.583
DOC_USP7_MATH_1	47	51	PF00917	0.524
DOC_USP7_MATH_1	88	92	PF00917	0.491
DOC_WW_Pin1_4	329	334	PF00397	0.594
DOC_WW_Pin1_4	92	97	PF00397	0.493
LIG_14-3-3_CanoR_1	208	212	PF00244	0.372
LIG_14-3-3_CanoR_1	28	36	PF00244	0.628
LIG_14-3-3_CanoR_1	291	299	PF00244	0.462
LIG_Actin_WH2_2	109	124	PF00022	0.372
LIG_FHA_1	184	190	PF00498	0.509
LIG_FHA_1	309	315	PF00498	0.341
LIG_FHA_1	31	37	PF00498	0.545
LIG_FHA_1	333	339	PF00498	0.377
LIG_FHA_1	73	79	PF00498	0.445
LIG_FHA_2	109	115	PF00498	0.353
LIG_FHA_2	128	134	PF00498	0.312
LIG_FHA_2	140	146	PF00498	0.453
LIG_LIR_Gen_1	111	121	PF02991	0.385
LIG_LIR_Gen_1	126	135	PF02991	0.267
LIG_LIR_Gen_1	230	237	PF02991	0.460
LIG_LIR_Gen_1	271	282	PF02991	0.329
LIG_LIR_Nem_3	111	116	PF02991	0.385
LIG_LIR_Nem_3	126	132	PF02991	0.343
LIG_LIR_Nem_3	210	214	PF02991	0.304
LIG_LIR_Nem_3	230	236	PF02991	0.477
LIG_LIR_Nem_3	271	277	PF02991	0.331
LIG_MYND_1	348	352	PF01753	0.459
LIG_PCNA_PIPBox_1	1	10	PF02747	0.441
LIG_PDZ_Class_3	380	385	PF00595	0.443
LIG_Pex14_1	125	129	PF04695	0.335
LIG_SH2_CRK	233	237	PF00017	0.344
LIG_SH2_CRK	368	372	PF00017	0.397
LIG_SH2_GRB2like	129	132	PF00017	0.333
LIG_SH2_STAP1	211	215	PF00017	0.360
LIG_SH2_STAP1	233	237	PF00017	0.371
LIG_SH2_STAP1	25	29	PF00017	0.529
LIG_SH2_STAT5	129	132	PF00017	0.455
LIG_SH2_STAT5	214	217	PF00017	0.362
LIG_SH2_STAT5	370	373	PF00017	0.402
LIG_SH3_3	186	192	PF00018	0.448
LIG_SH3_3	34	40	PF00018	0.627
LIG_SH3_3	342	348	PF00018	0.361
LIG_Sin3_3	12	19	PF02671	0.473
LIG_SUMO_SIM_anti_2	335	341	PF11976	0.304
LIG_SUMO_SIM_par_1	304	311	PF11976	0.312
LIG_SUMO_SIM_par_1	334	341	PF11976	0.323
LIG_TRAF2_1	266	269	PF00917	0.501
LIG_TRAF2_1	374	377	PF00917	0.267
LIG_UBA3_1	359	366	PF00899	0.469
LIG_WW_1	2	5	PF00397	0.440
MOD_CDK_SPxxK_3	92	99	PF00069	0.378
MOD_CK1_1	240	246	PF00069	0.412
MOD_CK1_1	298	304	PF00069	0.402
MOD_CK1_1	30	36	PF00069	0.567
MOD_CK1_1	332	338	PF00069	0.523
MOD_CK1_1	361	367	PF00069	0.439
MOD_CK2_1	108	114	PF00069	0.538
MOD_CK2_1	127	133	PF00069	0.252
MOD_CK2_1	139	145	PF00069	0.371
MOD_CK2_1	32	38	PF00069	0.666
MOD_CK2_1	87	93	PF00069	0.494
MOD_GlcNHglycan	12	15	PF01048	0.543
MOD_GlcNHglycan	135	138	PF01048	0.516
MOD_GlcNHglycan	163	166	PF01048	0.529
MOD_GlcNHglycan	17	20	PF01048	0.582
MOD_GlcNHglycan	21	24	PF01048	0.600
MOD_GlcNHglycan	237	240	PF01048	0.285
MOD_GlcNHglycan	29	32	PF01048	0.571
MOD_GlcNHglycan	340	343	PF01048	0.378
MOD_GlcNHglycan	90	93	PF01048	0.404
MOD_GSK3_1	15	22	PF00069	0.589
MOD_GSK3_1	221	228	PF00069	0.549
MOD_GSK3_1	27	34	PF00069	0.518
MOD_GSK3_1	328	335	PF00069	0.558
MOD_GSK3_1	355	362	PF00069	0.436
MOD_GSK3_1	377	384	PF00069	0.452
MOD_GSK3_1	88	95	PF00069	0.553
MOD_N-GLC_1	117	122	PF02516	0.470
MOD_N-GLC_1	127	132	PF02516	0.381
MOD_NEK2_1	237	242	PF00069	0.455
MOD_NEK2_1	32	37	PF00069	0.679
MOD_NEK2_1	337	342	PF00069	0.393
MOD_NEK2_1	8	13	PF00069	0.609
MOD_NEK2_2	108	113	PF00069	0.338
MOD_NEK2_2	47	52	PF00069	0.402
MOD_PIKK_1	318	324	PF00454	0.438
MOD_PKA_2	207	213	PF00069	0.293
MOD_PKA_2	27	33	PF00069	0.650
MOD_PKA_2	290	296	PF00069	0.526
MOD_PKA_2	8	14	PF00069	0.646
MOD_Plk_1	117	123	PF00069	0.416
MOD_Plk_1	54	60	PF00069	0.482
MOD_Plk_2-3	207	213	PF00069	0.224
MOD_Plk_4	108	114	PF00069	0.532
MOD_Plk_4	166	172	PF00069	0.508
MOD_Plk_4	301	307	PF00069	0.311
MOD_Plk_4	32	38	PF00069	0.671
MOD_Plk_4	332	338	PF00069	0.322
MOD_Plk_4	355	361	PF00069	0.385
MOD_ProDKin_1	329	335	PF00069	0.581
MOD_ProDKin_1	92	98	PF00069	0.489
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.375
TRG_ENDOCYTIC_2	113	116	PF00928	0.393
TRG_ENDOCYTIC_2	129	132	PF00928	0.326
TRG_ENDOCYTIC_2	206	209	PF00928	0.356
TRG_ENDOCYTIC_2	233	236	PF00928	0.363
TRG_ENDOCYTIC_2	368	371	PF00928	0.338
TRG_ENDOCYTIC_2	5	8	PF00928	0.431
TRG_ER_diArg_1	121	123	PF00400	0.388
TRG_ER_diArg_1	194	196	PF00400	0.546
TRG_ER_diArg_1	81	84	PF00400	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG75	Leptomonas seymouri	52%	100%
A0A0S4J6P5	Bodo saltans	26%	90%
A0A1X0PAK7	Trypanosomatidae	36%	100%
A0A422NJ09	Trypanosoma rangeli	38%	100%
A4H3R2	Leishmania braziliensis	69%	100%
A4I4Y1	Leishmania infantum	99%	100%
C9ZLM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AEE9	Leishmania major	88%	100%
E9ALD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5B889	Trypanosoma cruzi	38%	93%