Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7L9_LEIDO

TriTrypDb:

LdBPK_292590.1 , LdCL_290032000 , LDHU3_29.3840

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7L9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.684
CLV_C14_Caspase3-7	224	228	PF00656	0.641
CLV_C14_Caspase3-7	292	296	PF00656	0.621
CLV_C14_Caspase3-7	301	305	PF00656	0.575
CLV_C14_Caspase3-7	561	565	PF00656	0.548
CLV_NRD_NRD_1	196	198	PF00675	0.580
CLV_NRD_NRD_1	366	368	PF00675	0.682
CLV_NRD_NRD_1	504	506	PF00675	0.790
CLV_NRD_NRD_1	551	553	PF00675	0.546
CLV_NRD_NRD_1	562	564	PF00675	0.422
CLV_NRD_NRD_1	630	632	PF00675	0.621
CLV_NRD_NRD_1	640	642	PF00675	0.553
CLV_NRD_NRD_1	705	707	PF00675	0.644
CLV_NRD_NRD_1	716	718	PF00675	0.523
CLV_NRD_NRD_1	727	729	PF00675	0.576
CLV_NRD_NRD_1	744	746	PF00675	0.539
CLV_NRD_NRD_1	757	759	PF00675	0.543
CLV_NRD_NRD_1	780	782	PF00675	0.646
CLV_NRD_NRD_1	834	836	PF00675	0.830
CLV_PCSK_FUR_1	364	368	PF00082	0.678
CLV_PCSK_FUR_1	560	564	PF00082	0.549
CLV_PCSK_FUR_1	628	632	PF00082	0.595
CLV_PCSK_FUR_1	755	759	PF00082	0.593
CLV_PCSK_KEX2_1	181	183	PF00082	0.577
CLV_PCSK_KEX2_1	196	198	PF00082	0.502
CLV_PCSK_KEX2_1	357	359	PF00082	0.666
CLV_PCSK_KEX2_1	364	366	PF00082	0.621
CLV_PCSK_KEX2_1	503	505	PF00082	0.797
CLV_PCSK_KEX2_1	527	529	PF00082	0.654
CLV_PCSK_KEX2_1	550	552	PF00082	0.547
CLV_PCSK_KEX2_1	562	564	PF00082	0.539
CLV_PCSK_KEX2_1	630	632	PF00082	0.621
CLV_PCSK_KEX2_1	640	642	PF00082	0.553
CLV_PCSK_KEX2_1	704	706	PF00082	0.650
CLV_PCSK_KEX2_1	716	718	PF00082	0.512
CLV_PCSK_KEX2_1	727	729	PF00082	0.573
CLV_PCSK_KEX2_1	744	746	PF00082	0.539
CLV_PCSK_KEX2_1	757	759	PF00082	0.543
CLV_PCSK_KEX2_1	780	782	PF00082	0.646
CLV_PCSK_KEX2_1	834	836	PF00082	0.830
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.577
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.502
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.666
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.654
CLV_PCSK_PC7_1	558	564	PF00082	0.546
CLV_PCSK_PC7_1	626	632	PF00082	0.562
CLV_PCSK_PC7_1	740	746	PF00082	0.585
CLV_PCSK_SKI1_1	348	352	PF00082	0.700
CLV_PCSK_SKI1_1	354	358	PF00082	0.666
CLV_PCSK_SKI1_1	403	407	PF00082	0.664
CLV_PCSK_SKI1_1	551	555	PF00082	0.546
CLV_PCSK_SKI1_1	573	577	PF00082	0.611
CLV_PCSK_SKI1_1	717	721	PF00082	0.665
DEG_APCC_DBOX_1	550	558	PF00400	0.546
DEG_Nend_UBRbox_3	1	3	PF02207	0.654
DEG_SPOP_SBC_1	676	680	PF00917	0.668
DEG_SPOP_SBC_1	84	88	PF00917	0.596
DOC_CYCLIN_RxL_1	549	556	PF00134	0.548
DOC_MAPK_DCC_7	758	768	PF00069	0.494
DOC_MAPK_gen_1	550	557	PF00069	0.548
DOC_MAPK_MEF2A_6	406	415	PF00069	0.589
DOC_MAPK_MEF2A_6	550	557	PF00069	0.644
DOC_MAPK_MEF2A_6	660	669	PF00069	0.570
DOC_PP1_RVXF_1	571	578	PF00149	0.699
DOC_PP2B_LxvP_1	246	249	PF13499	0.716
DOC_PP2B_LxvP_1	317	320	PF13499	0.664
DOC_PP2B_LxvP_1	544	547	PF13499	0.621
DOC_PP4_FxxP_1	619	622	PF00568	0.630
DOC_USP7_MATH_1	120	124	PF00917	0.681
DOC_USP7_MATH_1	142	146	PF00917	0.694
DOC_USP7_MATH_1	213	217	PF00917	0.654
DOC_USP7_MATH_1	257	261	PF00917	0.665
DOC_USP7_MATH_1	262	266	PF00917	0.674
DOC_USP7_MATH_1	298	302	PF00917	0.740
DOC_USP7_MATH_1	31	35	PF00917	0.694
DOC_USP7_MATH_1	320	324	PF00917	0.667
DOC_USP7_MATH_1	340	344	PF00917	0.669
DOC_USP7_MATH_1	405	409	PF00917	0.685
DOC_USP7_MATH_1	424	428	PF00917	0.510
DOC_USP7_MATH_1	476	480	PF00917	0.682
DOC_USP7_MATH_1	486	490	PF00917	0.569
DOC_USP7_MATH_1	496	500	PF00917	0.741
DOC_USP7_MATH_1	507	511	PF00917	0.647
DOC_USP7_MATH_1	659	663	PF00917	0.576
DOC_USP7_MATH_1	676	680	PF00917	0.555
DOC_USP7_MATH_1	715	719	PF00917	0.627
DOC_USP7_MATH_1	738	742	PF00917	0.675
DOC_USP7_MATH_1	826	830	PF00917	0.695
DOC_USP7_UBL2_3	348	352	PF12436	0.706
DOC_WW_Pin1_4	225	230	PF00397	0.709
DOC_WW_Pin1_4	253	258	PF00397	0.680
DOC_WW_Pin1_4	407	412	PF00397	0.589
DOC_WW_Pin1_4	422	427	PF00397	0.555
DOC_WW_Pin1_4	434	439	PF00397	0.603
DOC_WW_Pin1_4	446	451	PF00397	0.613
DOC_WW_Pin1_4	526	531	PF00397	0.565
DOC_WW_Pin1_4	589	594	PF00397	0.760
DOC_WW_Pin1_4	599	604	PF00397	0.607
DOC_WW_Pin1_4	630	635	PF00397	0.525
DOC_WW_Pin1_4	677	682	PF00397	0.646
DOC_WW_Pin1_4	710	715	PF00397	0.656
DOC_WW_Pin1_4	726	731	PF00397	0.525
DOC_WW_Pin1_4	734	739	PF00397	0.654
DOC_WW_Pin1_4	775	780	PF00397	0.674
DOC_WW_Pin1_4	782	787	PF00397	0.658
DOC_WW_Pin1_4	85	90	PF00397	0.652
DOC_WW_Pin1_4	93	98	PF00397	0.676
LIG_14-3-3_CanoR_1	175	180	PF00244	0.570
LIG_14-3-3_CanoR_1	197	205	PF00244	0.637
LIG_14-3-3_CanoR_1	289	297	PF00244	0.645
LIG_14-3-3_CanoR_1	3	9	PF00244	0.663
LIG_14-3-3_CanoR_1	395	404	PF00244	0.734
LIG_14-3-3_CanoR_1	677	681	PF00244	0.670
LIG_14-3-3_CanoR_1	716	720	PF00244	0.716
LIG_14-3-3_CanoR_1	728	734	PF00244	0.585
LIG_14-3-3_CanoR_1	757	766	PF00244	0.602
LIG_14-3-3_CanoR_1	774	778	PF00244	0.498
LIG_14-3-3_CanoR_1	811	820	PF00244	0.651
LIG_14-3-3_CanoR_1	823	832	PF00244	0.566
LIG_14-3-3_CanoR_1	834	843	PF00244	0.620
LIG_APCC_ABBA_1	154	159	PF00400	0.666
LIG_BIR_III_2	590	594	PF00653	0.648
LIG_BIR_III_2	711	715	PF00653	0.623
LIG_BRCT_BRCA1_1	606	610	PF00533	0.658
LIG_BRCT_BRCA1_1	619	623	PF00533	0.525
LIG_deltaCOP1_diTrp_1	571	577	PF00928	0.604
LIG_eIF4E_1	549	555	PF01652	0.547
LIG_FHA_1	108	114	PF00498	0.627
LIG_FHA_1	200	206	PF00498	0.580
LIG_FHA_1	218	224	PF00498	0.585
LIG_FHA_1	314	320	PF00498	0.673
LIG_FHA_1	408	414	PF00498	0.587
LIG_FHA_1	531	537	PF00498	0.694
LIG_FHA_1	797	803	PF00498	0.667
LIG_FHA_2	219	225	PF00498	0.621
LIG_FHA_2	828	834	PF00498	0.664
LIG_FHA_2	840	846	PF00498	0.624
LIG_FHA_2	93	99	PF00498	0.668
LIG_GSK3_LRP6_1	93	98	PF00069	0.671
LIG_Integrin_RGD_1	794	796	PF01839	0.646
LIG_LIR_Apic_2	617	622	PF02991	0.632
LIG_LIR_Gen_1	718	726	PF02991	0.759
LIG_LIR_Nem_3	571	575	PF02991	0.709
LIG_LIR_Nem_3	607	613	PF02991	0.586
LIG_LIR_Nem_3	718	723	PF02991	0.754
LIG_Pex14_2	619	623	PF04695	0.533
LIG_SH2_NCK_1	613	617	PF00017	0.610
LIG_SH2_STAP1	464	468	PF00017	0.627
LIG_SH2_STAP1	470	474	PF00017	0.595
LIG_SH2_STAT3	321	324	PF00017	0.598
LIG_SH2_STAT5	321	324	PF00017	0.598
LIG_SH2_STAT5	702	705	PF00017	0.648
LIG_SH3_1	432	438	PF00018	0.585
LIG_SH3_1	640	646	PF00018	0.672
LIG_SH3_3	158	164	PF00018	0.682
LIG_SH3_3	21	27	PF00018	0.603
LIG_SH3_3	330	336	PF00018	0.684
LIG_SH3_3	408	414	PF00018	0.609
LIG_SH3_3	432	438	PF00018	0.647
LIG_SH3_3	441	447	PF00018	0.666
LIG_SH3_3	63	69	PF00018	0.672
LIG_SH3_3	640	646	PF00018	0.672
LIG_SH3_3	647	653	PF00018	0.569
LIG_SH3_3	678	684	PF00018	0.645
LIG_SH3_3	686	692	PF00018	0.578
LIG_SH3_3	761	767	PF00018	0.524
LIG_SH3_3	88	94	PF00018	0.658
LIG_SH3_4	348	355	PF00018	0.727
LIG_TRAF2_1	216	219	PF00917	0.684
LIG_TRAF2_1	272	275	PF00917	0.703
LIG_TRAF2_1	842	845	PF00917	0.637
LIG_UBA3_1	191	199	PF00899	0.586
LIG_WRC_WIRS_1	176	181	PF05994	0.547
LIG_WW_3	713	717	PF00397	0.644
MOD_CDC14_SPxK_1	228	231	PF00782	0.597
MOD_CDC14_SPxK_1	733	736	PF00782	0.713
MOD_CDC14_SPxK_1	737	740	PF00782	0.703
MOD_CDC14_SPxK_1	778	781	PF00782	0.645
MOD_CDC14_SPxK_1	785	788	PF00782	0.603
MOD_CDK_SPK_2	630	635	PF00069	0.667
MOD_CDK_SPK_2	775	780	PF00069	0.634
MOD_CDK_SPxK_1	225	231	PF00069	0.599
MOD_CDK_SPxK_1	710	716	PF00069	0.656
MOD_CDK_SPxK_1	730	736	PF00069	0.506
MOD_CDK_SPxK_1	775	781	PF00069	0.637
MOD_CDK_SPxK_1	782	788	PF00069	0.600
MOD_CDK_SPxxK_3	710	717	PF00069	0.698
MOD_CK1_1	145	151	PF00069	0.730
MOD_CK1_1	261	267	PF00069	0.706
MOD_CK1_1	312	318	PF00069	0.660
MOD_CK1_1	35	41	PF00069	0.661
MOD_CK1_1	377	383	PF00069	0.664
MOD_CK1_1	387	393	PF00069	0.607
MOD_CK1_1	396	402	PF00069	0.620
MOD_CK1_1	422	428	PF00069	0.695
MOD_CK1_1	437	443	PF00069	0.603
MOD_CK1_1	45	51	PF00069	0.619
MOD_CK1_1	472	478	PF00069	0.687
MOD_CK1_1	489	495	PF00069	0.670
MOD_CK1_1	511	517	PF00069	0.682
MOD_CK1_1	523	529	PF00069	0.608
MOD_CK1_1	602	608	PF00069	0.705
MOD_CK1_1	614	620	PF00069	0.563
MOD_CK1_1	729	735	PF00069	0.709
MOD_CK1_1	813	819	PF00069	0.685
MOD_CK2_1	213	219	PF00069	0.657
MOD_CK2_1	269	275	PF00069	0.649
MOD_CK2_1	387	393	PF00069	0.673
MOD_CK2_1	839	845	PF00069	0.635
MOD_DYRK1A_RPxSP_1	599	603	PF00069	0.705
MOD_DYRK1A_RPxSP_1	677	681	PF00069	0.645
MOD_GlcNHglycan	103	107	PF01048	0.681
MOD_GlcNHglycan	120	123	PF01048	0.717
MOD_GlcNHglycan	170	173	PF01048	0.651
MOD_GlcNHglycan	211	214	PF01048	0.690
MOD_GlcNHglycan	215	218	PF01048	0.666
MOD_GlcNHglycan	260	263	PF01048	0.656
MOD_GlcNHglycan	292	295	PF01048	0.707
MOD_GlcNHglycan	300	303	PF01048	0.665
MOD_GlcNHglycan	342	345	PF01048	0.721
MOD_GlcNHglycan	37	40	PF01048	0.709
MOD_GlcNHglycan	376	379	PF01048	0.709
MOD_GlcNHglycan	395	398	PF01048	0.595
MOD_GlcNHglycan	407	410	PF01048	0.598
MOD_GlcNHglycan	421	424	PF01048	0.566
MOD_GlcNHglycan	426	429	PF01048	0.524
MOD_GlcNHglycan	454	457	PF01048	0.691
MOD_GlcNHglycan	460	463	PF01048	0.556
MOD_GlcNHglycan	474	477	PF01048	0.531
MOD_GlcNHglycan	491	494	PF01048	0.678
MOD_GlcNHglycan	505	508	PF01048	0.620
MOD_GlcNHglycan	510	513	PF01048	0.555
MOD_GlcNHglycan	517	520	PF01048	0.574
MOD_GlcNHglycan	523	526	PF01048	0.521
MOD_GlcNHglycan	614	617	PF01048	0.711
MOD_GlcNHglycan	740	743	PF01048	0.696
MOD_GlcNHglycan	759	762	PF01048	0.435
MOD_GSK3_1	108	115	PF00069	0.693
MOD_GSK3_1	145	152	PF00069	0.664
MOD_GSK3_1	209	216	PF00069	0.671
MOD_GSK3_1	235	242	PF00069	0.672
MOD_GSK3_1	253	260	PF00069	0.562
MOD_GSK3_1	281	288	PF00069	0.690
MOD_GSK3_1	309	316	PF00069	0.688
MOD_GSK3_1	31	38	PF00069	0.742
MOD_GSK3_1	380	387	PF00069	0.709
MOD_GSK3_1	405	412	PF00069	0.682
MOD_GSK3_1	422	429	PF00069	0.539
MOD_GSK3_1	446	453	PF00069	0.692
MOD_GSK3_1	454	461	PF00069	0.554
MOD_GSK3_1	464	471	PF00069	0.515
MOD_GSK3_1	472	479	PF00069	0.609
MOD_GSK3_1	480	487	PF00069	0.537
MOD_GSK3_1	503	510	PF00069	0.713
MOD_GSK3_1	511	518	PF00069	0.617
MOD_GSK3_1	526	533	PF00069	0.563
MOD_GSK3_1	589	596	PF00069	0.757
MOD_GSK3_1	700	707	PF00069	0.568
MOD_GSK3_1	726	733	PF00069	0.700
MOD_GSK3_1	734	741	PF00069	0.645
MOD_GSK3_1	801	808	PF00069	0.737
MOD_GSK3_1	812	819	PF00069	0.607
MOD_GSK3_1	822	829	PF00069	0.548
MOD_N-GLC_1	313	318	PF02516	0.591
MOD_N-GLC_1	45	50	PF02516	0.677
MOD_N-GLC_1	782	787	PF02516	0.688
MOD_N-GLC_2	586	588	PF02516	0.633
MOD_NEK2_1	102	107	PF00069	0.681
MOD_NEK2_1	285	290	PF00069	0.654
MOD_NEK2_1	480	485	PF00069	0.677
MOD_NEK2_1	604	609	PF00069	0.688
MOD_NEK2_1	636	641	PF00069	0.635
MOD_NEK2_1	836	841	PF00069	0.656
MOD_NEK2_2	142	147	PF00069	0.665
MOD_NEK2_2	659	664	PF00069	0.546
MOD_NEK2_2	715	720	PF00069	0.628
MOD_PIKK_1	129	135	PF00454	0.691
MOD_PIKK_1	163	169	PF00454	0.653
MOD_PIKK_1	320	326	PF00454	0.662
MOD_PIKK_1	61	67	PF00454	0.684
MOD_PIKK_1	813	819	PF00454	0.612
MOD_PIKK_1	834	840	PF00454	0.706
MOD_PK_1	190	196	PF00069	0.592
MOD_PK_1	244	250	PF00069	0.605
MOD_PKA_1	168	174	PF00069	0.675
MOD_PKA_1	197	203	PF00069	0.615
MOD_PKA_1	365	371	PF00069	0.679
MOD_PKA_1	503	509	PF00069	0.675
MOD_PKA_1	704	710	PF00069	0.593
MOD_PKA_1	744	750	PF00069	0.603
MOD_PKA_1	757	763	PF00069	0.540
MOD_PKA_1	834	840	PF00069	0.711
MOD_PKA_2	2	8	PF00069	0.661
MOD_PKA_2	235	241	PF00069	0.659
MOD_PKA_2	365	371	PF00069	0.679
MOD_PKA_2	503	509	PF00069	0.726
MOD_PKA_2	676	682	PF00069	0.671
MOD_PKA_2	704	710	PF00069	0.596
MOD_PKA_2	715	721	PF00069	0.578
MOD_PKA_2	744	750	PF00069	0.600
MOD_PKA_2	757	763	PF00069	0.558
MOD_PKA_2	773	779	PF00069	0.505
MOD_PKA_2	810	816	PF00069	0.653
MOD_PKA_2	822	828	PF00069	0.565
MOD_PKA_2	834	840	PF00069	0.611
MOD_PKB_1	287	295	PF00069	0.679
MOD_PKB_1	755	763	PF00069	0.590
MOD_Plk_1	218	224	PF00069	0.649
MOD_Plk_1	281	287	PF00069	0.689
MOD_Plk_1	313	319	PF00069	0.651
MOD_Plk_1	45	51	PF00069	0.652
MOD_Plk_1	573	579	PF00069	0.619
MOD_Plk_1	75	81	PF00069	0.700
MOD_Plk_2-3	219	225	PF00069	0.647
MOD_Plk_4	108	114	PF00069	0.672
MOD_Plk_4	531	537	PF00069	0.745
MOD_ProDKin_1	225	231	PF00069	0.712
MOD_ProDKin_1	253	259	PF00069	0.679
MOD_ProDKin_1	407	413	PF00069	0.590
MOD_ProDKin_1	422	428	PF00069	0.556
MOD_ProDKin_1	434	440	PF00069	0.603
MOD_ProDKin_1	446	452	PF00069	0.613
MOD_ProDKin_1	526	532	PF00069	0.565
MOD_ProDKin_1	589	595	PF00069	0.760
MOD_ProDKin_1	599	605	PF00069	0.607
MOD_ProDKin_1	630	636	PF00069	0.526
MOD_ProDKin_1	677	683	PF00069	0.648
MOD_ProDKin_1	710	716	PF00069	0.656
MOD_ProDKin_1	726	732	PF00069	0.528
MOD_ProDKin_1	734	740	PF00069	0.656
MOD_ProDKin_1	775	781	PF00069	0.677
MOD_ProDKin_1	782	788	PF00069	0.662
MOD_ProDKin_1	85	91	PF00069	0.652
MOD_ProDKin_1	93	99	PF00069	0.673
TRG_DiLeu_BaEn_4	539	545	PF01217	0.487
TRG_DiLeu_BaLyEn_6	632	637	PF01217	0.666
TRG_ER_diArg_1	363	366	PF00400	0.677
TRG_ER_diArg_1	502	505	PF00400	0.782
TRG_ER_diArg_1	549	552	PF00400	0.548
TRG_ER_diArg_1	557	560	PF00400	0.549
TRG_ER_diArg_1	627	630	PF00400	0.624
TRG_ER_diArg_1	704	706	PF00400	0.653
TRG_ER_diArg_1	715	717	PF00400	0.532
TRG_ER_diArg_1	726	728	PF00400	0.565
TRG_ER_diArg_1	743	745	PF00400	0.534
TRG_ER_diArg_1	755	758	PF00400	0.549
TRG_ER_diArg_1	779	781	PF00400	0.648
TRG_ER_diArg_1	787	790	PF00400	0.605
TRG_ER_diArg_1	834	836	PF00400	0.777
TRG_NLS_Bipartite_1	168	185	PF00514	0.648
TRG_NLS_MonoCore_2	195	200	PF00514	0.574
TRG_NLS_MonoExtN_4	196	201	PF00514	0.630
TRG_NLS_MonoExtN_4	354	361	PF00514	0.667
TRG_Pf-PMV_PEXEL_1	552	556	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	834	838	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HHP7	Leishmania braziliensis	52%	100%
A4I4W2	Leishmania infantum	99%	100%
E9AEB0	Leishmania major	88%	100%
E9ALH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	97%