Acyltransferase, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7L8_LEIDO

TriTrypDb:

LdBPK_292390.1 , LdCL_290029900 , LDHU3_29.3540

Length:

324

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	24
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

A0A3S5H7L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7L8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006650	glycerophospholipid metabolic process	5	4
GO:0006654	phosphatidic acid biosynthetic process	6	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0008654	phospholipid biosynthetic process	5	4
GO:0009058	biosynthetic process	2	4
GO:0009987	cellular process	1	4
GO:0019637	organophosphate metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0045017	glycerolipid biosynthetic process	4	4
GO:0046473	phosphatidic acid metabolic process	6	4
GO:0046474	glycerophospholipid biosynthetic process	5	4
GO:0046486	glycerolipid metabolic process	4	4
GO:0071704	organic substance metabolic process	2	4
GO:0090407	organophosphate biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	30
GO:0016740	transferase activity	2	30
GO:0016746	acyltransferase activity	3	30
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7	5
GO:0008374	O-acyltransferase activity	5	5
GO:0016411	acylglycerol O-acyltransferase activity	6	5
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	5
GO:0042171	lysophosphatidic acid acyltransferase activity	6	5
GO:0071617	lysophospholipid acyltransferase activity	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.316
CLV_NRD_NRD_1	142	144	PF00675	0.531
CLV_NRD_NRD_1	22	24	PF00675	0.315
CLV_NRD_NRD_1	313	315	PF00675	0.614
CLV_PCSK_FUR_1	311	315	PF00082	0.634
CLV_PCSK_KEX2_1	292	294	PF00082	0.624
CLV_PCSK_KEX2_1	313	315	PF00082	0.614
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.631
CLV_PCSK_SKI1_1	135	139	PF00082	0.501
CLV_PCSK_SKI1_1	218	222	PF00082	0.496
CLV_PCSK_SKI1_1	292	296	PF00082	0.603
DOC_ANK_TNKS_1	313	320	PF00023	0.389
DOC_CYCLIN_RxL_1	189	199	PF00134	0.229
DOC_MAPK_DCC_7	21	30	PF00069	0.552
DOC_MAPK_gen_1	189	196	PF00069	0.350
DOC_MAPK_gen_1	21	29	PF00069	0.518
DOC_MAPK_MEF2A_6	21	30	PF00069	0.516
DOC_MAPK_MEF2A_6	83	91	PF00069	0.312
DOC_PP1_RVXF_1	190	197	PF00149	0.334
DOC_PP2B_PxIxI_1	86	92	PF00149	0.266
DOC_PP4_FxxP_1	84	87	PF00568	0.255
DOC_USP7_UBL2_3	135	139	PF12436	0.229
DOC_WW_Pin1_4	202	207	PF00397	0.270
DOC_WW_Pin1_4	83	88	PF00397	0.244
LIG_14-3-3_CanoR_1	31	37	PF00244	0.493
LIG_Actin_WH2_2	40	58	PF00022	0.334
LIG_APCC_ABBA_1	170	175	PF00400	0.187
LIG_BIR_II_1	1	5	PF00653	0.280
LIG_BRCT_BRCA1_1	113	117	PF00533	0.203
LIG_BRCT_BRCA1_1	192	196	PF00533	0.338
LIG_BRCT_BRCA1_1	96	100	PF00533	0.247
LIG_CORNRBOX	4	12	PF00104	0.211
LIG_CSL_BTD_1	238	241	PF09270	0.371
LIG_FHA_1	148	154	PF00498	0.269
LIG_FHA_1	203	209	PF00498	0.320
LIG_FHA_1	33	39	PF00498	0.337
LIG_FHA_2	163	169	PF00498	0.218
LIG_GBD_Chelix_1	272	280	PF00786	0.568
LIG_LIR_Gen_1	114	125	PF02991	0.246
LIG_LIR_Gen_1	252	262	PF02991	0.363
LIG_LIR_Gen_1	35	44	PF02991	0.445
LIG_LIR_Gen_1	5	13	PF02991	0.439
LIG_LIR_Gen_1	97	105	PF02991	0.328
LIG_LIR_Nem_3	114	120	PF02991	0.295
LIG_LIR_Nem_3	216	220	PF02991	0.275
LIG_LIR_Nem_3	252	257	PF02991	0.360
LIG_LIR_Nem_3	35	39	PF02991	0.414
LIG_LIR_Nem_3	5	9	PF02991	0.458
LIG_LIR_Nem_3	97	103	PF02991	0.332
LIG_MLH1_MIPbox_1	113	117	PF16413	0.187
LIG_Pex14_1	124	128	PF04695	0.336
LIG_Pex14_2	158	162	PF04695	0.298
LIG_REV1ctd_RIR_1	135	143	PF16727	0.319
LIG_SH2_CRK	128	132	PF00017	0.243
LIG_SH2_PTP2	254	257	PF00017	0.390
LIG_SH2_SRC	254	257	PF00017	0.338
LIG_SH2_STAP1	34	38	PF00017	0.395
LIG_SH2_STAT5	125	128	PF00017	0.271
LIG_SH2_STAT5	130	133	PF00017	0.266
LIG_SH2_STAT5	161	164	PF00017	0.259
LIG_SH2_STAT5	229	232	PF00017	0.290
LIG_SH2_STAT5	254	257	PF00017	0.321
LIG_SH2_STAT5	34	37	PF00017	0.402
LIG_SH3_1	244	250	PF00018	0.344
LIG_SH3_3	235	241	PF00018	0.302
LIG_SH3_3	244	250	PF00018	0.319
LIG_SUMO_SIM_anti_2	150	155	PF11976	0.197
LIG_TRAF2_1	264	267	PF00917	0.290
LIG_TYR_ITIM	126	131	PF00017	0.319
LIG_WRC_WIRS_1	134	139	PF05994	0.287
LIG_WRC_WIRS_1	214	219	PF05994	0.288
MOD_CDK_SPxxK_3	83	90	PF00069	0.295
MOD_CK1_1	2	8	PF00069	0.497
MOD_CK1_1	216	222	PF00069	0.292
MOD_CK1_1	271	277	PF00069	0.417
MOD_CK1_1	99	105	PF00069	0.326
MOD_CK2_1	99	105	PF00069	0.373
MOD_Cter_Amidation	290	293	PF01082	0.619
MOD_Cter_Amidation	311	314	PF01082	0.789
MOD_GSK3_1	112	119	PF00069	0.271
MOD_GSK3_1	162	169	PF00069	0.275
MOD_GSK3_1	94	101	PF00069	0.339
MOD_N-GLC_1	202	207	PF02516	0.466
MOD_N-GLC_2	108	110	PF02516	0.408
MOD_NEK2_1	111	116	PF00069	0.281
MOD_NEK2_1	138	143	PF00069	0.298
MOD_NEK2_1	147	152	PF00069	0.276
MOD_NEK2_1	98	103	PF00069	0.414
MOD_NEK2_2	112	117	PF00069	0.270
MOD_NEK2_2	32	37	PF00069	0.188
MOD_PIKK_1	63	69	PF00454	0.359
MOD_Plk_4	112	118	PF00069	0.277
MOD_Plk_4	133	139	PF00069	0.286
MOD_Plk_4	147	153	PF00069	0.256
MOD_Plk_4	2	8	PF00069	0.477
MOD_Plk_4	216	222	PF00069	0.332
MOD_Plk_4	50	56	PF00069	0.343
MOD_ProDKin_1	202	208	PF00069	0.270
MOD_ProDKin_1	83	89	PF00069	0.242
MOD_SUMO_for_1	294	297	PF00179	0.395
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.485
TRG_ENDOCYTIC_2	128	131	PF00928	0.319
TRG_ENDOCYTIC_2	13	16	PF00928	0.374
TRG_ENDOCYTIC_2	228	231	PF00928	0.278
TRG_ENDOCYTIC_2	254	257	PF00928	0.343
TRG_ER_diArg_1	311	314	PF00400	0.586
TRG_NLS_MonoExtC_3	291	297	PF00514	0.294
TRG_NLS_MonoExtN_4	290	296	PF00514	0.279
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P455	Leptomonas seymouri	37%	95%
A0A0N1HTP4	Leptomonas seymouri	34%	100%
A0A0N1I6V1	Leptomonas seymouri	49%	100%
A0A0N1IKX5	Leptomonas seymouri	69%	100%
A0A0S4IQ05	Bodo saltans	39%	96%
A0A0S4IR22	Bodo saltans	40%	100%
A0A0S4JRB2	Bodo saltans	39%	100%
A0A1X0P9F0	Trypanosomatidae	47%	100%
A0A3R7NKA0	Trypanosoma rangeli	46%	100%
A0A3S5H5E4	Leishmania donovani	34%	75%
A0A3S7WNW6	Leishmania donovani	33%	91%
A4H418	Leishmania braziliensis	38%	100%
A4H419	Leishmania braziliensis	34%	100%
A4H420	Leishmania braziliensis	33%	100%
A4HHM7	Leishmania braziliensis	71%	100%
A4HKI5	Leishmania braziliensis	22%	99%
A4HSA1	Leishmania infantum	34%	100%
A4HSA2	Leishmania infantum	33%	100%
A4I4U1	Leishmania infantum	65%	100%
A4I4U2	Leishmania infantum	95%	100%
C9ZLI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AE89	Leishmania major	60%	100%
E9AE90	Leishmania major	90%	100%
E9AK86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ALJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q9NF90	Leishmania major	34%	100%
Q9NF91	Leishmania major	35%	100%
V5C201	Trypanosoma cruzi	43%	100%