Leucine Rich Repeat/Leucine rich repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7L7_LEIDO

TriTrypDb:

LdBPK_292240.1 , LdCL_290028500 , LDHU3_29.3320

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 0
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

A0A3S5H7L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7L7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.571
CLV_PCSK_KEX2_1	136	138	PF00082	0.491
CLV_PCSK_KEX2_1	17	19	PF00082	0.571
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.491
CLV_PCSK_SKI1_1	100	104	PF00082	0.540
CLV_PCSK_SKI1_1	133	137	PF00082	0.494
CLV_PCSK_SKI1_1	255	259	PF00082	0.489
CLV_Separin_Metazoa	234	238	PF03568	0.470
CLV_Separin_Metazoa	368	372	PF03568	0.381
CLV_Separin_Metazoa	385	389	PF03568	0.329
DEG_APCC_DBOX_1	285	293	PF00400	0.469
DEG_Nend_UBRbox_3	1	3	PF02207	0.579
DEG_SPOP_SBC_1	207	211	PF00917	0.498
DOC_CKS1_1	12	17	PF01111	0.558
DOC_CYCLIN_RxL_1	388	397	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	145	151	PF00134	0.499
DOC_MAPK_gen_1	144	151	PF00069	0.456
DOC_MAPK_gen_1	60	69	PF00069	0.534
DOC_PP2B_LxvP_1	174	177	PF13499	0.555
DOC_USP7_MATH_1	68	72	PF00917	0.685
DOC_WW_Pin1_4	11	16	PF00397	0.648
DOC_WW_Pin1_4	208	213	PF00397	0.619
LIG_14-3-3_CanoR_1	137	145	PF00244	0.460
LIG_14-3-3_CanoR_1	21	30	PF00244	0.575
LIG_14-3-3_CanoR_1	237	243	PF00244	0.481
LIG_14-3-3_CanoR_1	329	333	PF00244	0.470
LIG_14-3-3_CanoR_1	382	390	PF00244	0.484
LIG_14-3-3_CanoR_1	56	63	PF00244	0.601
LIG_BRCT_BRCA1_1	434	438	PF00533	0.444
LIG_CtBP_PxDLS_1	305	309	PF00389	0.633
LIG_FHA_1	1	7	PF00498	0.533
LIG_FHA_1	108	114	PF00498	0.599
LIG_FHA_1	209	215	PF00498	0.517
LIG_FHA_1	21	27	PF00498	0.533
LIG_FHA_1	331	337	PF00498	0.474
LIG_FHA_1	381	387	PF00498	0.443
LIG_FHA_1	399	405	PF00498	0.463
LIG_FHA_2	162	168	PF00498	0.505
LIG_FHA_2	251	257	PF00498	0.477
LIG_FHA_2	333	339	PF00498	0.340
LIG_GBD_Chelix_1	30	38	PF00786	0.485
LIG_IRF3_LxIS_1	264	271	PF10401	0.441
LIG_LIR_Apic_2	470	474	PF02991	0.654
LIG_LIR_Gen_1	215	222	PF02991	0.394
LIG_LIR_Gen_1	227	236	PF02991	0.403
LIG_LIR_Gen_1	245	254	PF02991	0.317
LIG_LIR_Gen_1	435	446	PF02991	0.353
LIG_LIR_Gen_1	61	69	PF02991	0.532
LIG_LIR_Nem_3	125	131	PF02991	0.534
LIG_LIR_Nem_3	215	219	PF02991	0.422
LIG_LIR_Nem_3	227	232	PF02991	0.396
LIG_LIR_Nem_3	245	249	PF02991	0.314
LIG_LIR_Nem_3	271	275	PF02991	0.395
LIG_LIR_Nem_3	442	446	PF02991	0.416
LIG_LIR_Nem_3	61	66	PF02991	0.622
LIG_PTB_Apo_2	266	273	PF02174	0.407
LIG_SH2_CRK	246	250	PF00017	0.456
LIG_SH2_GRB2like	415	418	PF00017	0.363
LIG_SH2_SRC	415	418	PF00017	0.391
LIG_SH2_STAP1	246	250	PF00017	0.464
LIG_SH2_STAP1	63	67	PF00017	0.533
LIG_SH2_STAT5	246	249	PF00017	0.451
LIG_SH2_STAT5	326	329	PF00017	0.533
LIG_SH2_STAT5	415	418	PF00017	0.437
LIG_SH2_STAT5	471	474	PF00017	0.600
LIG_SH3_2	12	17	PF14604	0.558
LIG_SH3_3	182	188	PF00018	0.599
LIG_SH3_3	299	305	PF00018	0.603
LIG_SH3_3	450	456	PF00018	0.381
LIG_SH3_3	9	15	PF00018	0.571
LIG_SUMO_SIM_anti_2	365	371	PF11976	0.440
LIG_SUMO_SIM_par_1	147	153	PF11976	0.503
LIG_SUMO_SIM_par_1	218	223	PF11976	0.445
LIG_SUMO_SIM_par_1	304	309	PF11976	0.485
LIG_SUMO_SIM_par_1	64	71	PF11976	0.526
LIG_TRAF2_1	112	115	PF00917	0.543
LIG_TYR_ITIM	244	249	PF00017	0.441
LIG_TYR_ITIM	413	418	PF00017	0.544
MOD_CDK_SPxK_1	11	17	PF00069	0.561
MOD_CDK_SPxxK_3	11	18	PF00069	0.560
MOD_CK1_1	20	26	PF00069	0.558
MOD_CK1_1	318	324	PF00069	0.413
MOD_CK2_1	161	167	PF00069	0.469
MOD_CK2_1	250	256	PF00069	0.485
MOD_CK2_1	292	298	PF00069	0.463
MOD_CK2_1	318	324	PF00069	0.485
MOD_CK2_1	40	46	PF00069	0.565
MOD_GlcNHglycan	100	103	PF01048	0.358
MOD_GlcNHglycan	178	181	PF01048	0.713
MOD_GlcNHglycan	222	225	PF01048	0.505
MOD_GlcNHglycan	23	26	PF01048	0.570
MOD_GlcNHglycan	283	286	PF01048	0.502
MOD_GlcNHglycan	293	297	PF01048	0.374
MOD_GlcNHglycan	312	315	PF01048	0.326
MOD_GlcNHglycan	317	320	PF01048	0.388
MOD_GlcNHglycan	405	409	PF01048	0.430
MOD_GlcNHglycan	41	45	PF01048	0.568
MOD_GlcNHglycan	423	426	PF01048	0.264
MOD_GlcNHglycan	57	60	PF01048	0.603
MOD_GlcNHglycan	86	89	PF01048	0.682
MOD_GSK3_1	17	24	PF00069	0.601
MOD_GSK3_1	238	245	PF00069	0.491
MOD_GSK3_1	292	299	PF00069	0.473
MOD_GSK3_1	306	313	PF00069	0.438
MOD_GSK3_1	328	335	PF00069	0.530
MOD_GSK3_1	389	396	PF00069	0.389
MOD_N-GLC_1	268	273	PF02516	0.438
MOD_N-GLC_1	340	345	PF02516	0.483
MOD_N-GLC_1	427	432	PF02516	0.523
MOD_N-GLC_1	444	449	PF02516	0.251
MOD_NEK2_1	149	154	PF00069	0.448
MOD_NEK2_1	161	166	PF00069	0.462
MOD_NEK2_1	220	225	PF00069	0.388
MOD_NEK2_1	242	247	PF00069	0.543
MOD_NEK2_1	249	254	PF00069	0.548
MOD_NEK2_1	268	273	PF00069	0.236
MOD_NEK2_1	292	297	PF00069	0.458
MOD_NEK2_1	306	311	PF00069	0.513
MOD_NEK2_1	325	330	PF00069	0.230
MOD_NEK2_1	332	337	PF00069	0.402
MOD_NEK2_1	348	353	PF00069	0.341
MOD_NEK2_1	89	94	PF00069	0.619
MOD_NEK2_1	98	103	PF00069	0.668
MOD_NEK2_2	250	255	PF00069	0.457
MOD_PIKK_1	244	250	PF00454	0.454
MOD_PIKK_1	306	312	PF00454	0.531
MOD_PIKK_1	427	433	PF00454	0.462
MOD_PK_1	62	68	PF00069	0.624
MOD_PKA_1	17	23	PF00069	0.543
MOD_PKA_2	107	113	PF00069	0.560
MOD_PKA_2	138	144	PF00069	0.538
MOD_PKA_2	17	23	PF00069	0.667
MOD_PKA_2	328	334	PF00069	0.467
MOD_PKA_2	381	387	PF00069	0.539
MOD_PKA_2	55	61	PF00069	0.483
MOD_Plk_1	268	274	PF00069	0.431
MOD_Plk_1	40	46	PF00069	0.534
MOD_Plk_1	404	410	PF00069	0.461
MOD_Plk_1	427	433	PF00069	0.407
MOD_Plk_4	169	175	PF00069	0.598
MOD_Plk_4	2	8	PF00069	0.532
MOD_Plk_4	263	269	PF00069	0.433
MOD_Plk_4	62	68	PF00069	0.609
MOD_ProDKin_1	11	17	PF00069	0.648
MOD_ProDKin_1	208	214	PF00069	0.610
MOD_SUMO_for_1	203	206	PF00179	0.536
TRG_DiLeu_BaEn_1	365	370	PF01217	0.478
TRG_DiLeu_BaEn_2	433	439	PF01217	0.441
TRG_ENDOCYTIC_2	246	249	PF00928	0.451
TRG_ENDOCYTIC_2	415	418	PF00928	0.449
TRG_ENDOCYTIC_2	443	446	PF00928	0.407
TRG_ENDOCYTIC_2	63	66	PF00928	0.601
TRG_ER_diArg_1	137	140	PF00400	0.489
TRG_ER_diArg_1	17	19	PF00400	0.568
TRG_NES_CRM1_1	234	248	PF08389	0.458
TRG_NES_CRM1_1	385	397	PF08389	0.401
TRG_NES_CRM1_1	431	442	PF08389	0.441
TRG_NLS_MonoExtN_4	133	140	PF00514	0.485
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P012	Trypanosomatidae	30%	100%
A0A3R7KGL7	Trypanosoma rangeli	29%	100%
A4HHL3	Leishmania braziliensis	70%	100%
A4I4S2	Leishmania infantum	98%	100%
E9AE75	Leishmania major	92%	100%
E9ALL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BBX4	Trypanosoma cruzi	31%	100%