Tob55_putative/GeneDB:LmjF.29.1820

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7L5_LEIDO

TriTrypDb:

LdBPK_291940.1 , LdCL_290025100 , LDHU3_29.2780

Length:

473

Annotations

Annotations by Jardim et al.

Mitochondrial protein, Tob55

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0019867	outer membrane	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0001401	SAM complex	5	1
GO:0005742	mitochondrial outer membrane translocase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098799	outer mitochondrial membrane protein complex	3	1

Expansion

Sequence features

A0A3S5H7L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7L5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0007006	mitochondrial membrane organization	5	1
GO:0007008	outer mitochondrial membrane organization	6	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045040	protein insertion into mitochondrial outer membrane	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051204	protein insertion into mitochondrial membrane	5	1
GO:0051205	protein insertion into membrane	5	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0061024	membrane organization	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:0090151	establishment of protein localization to mitochondrial membrane	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	393	397	PF00656	0.415
CLV_NRD_NRD_1	167	169	PF00675	0.451
CLV_NRD_NRD_1	192	194	PF00675	0.537
CLV_NRD_NRD_1	207	209	PF00675	0.356
CLV_PCSK_KEX2_1	207	209	PF00082	0.434
CLV_PCSK_KEX2_1	49	51	PF00082	0.388
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.388
CLV_PCSK_SKI1_1	208	212	PF00082	0.379
CLV_PCSK_SKI1_1	213	217	PF00082	0.433
CLV_PCSK_SKI1_1	322	326	PF00082	0.276
CLV_PCSK_SKI1_1	331	335	PF00082	0.276
CLV_PCSK_SKI1_1	455	459	PF00082	0.474
CLV_PCSK_SKI1_1	75	79	PF00082	0.425
DOC_CYCLIN_RxL_1	205	212	PF00134	0.380
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.488
DOC_CYCLIN_yCln2_LP_2	365	371	PF00134	0.403
DOC_MAPK_gen_1	102	109	PF00069	0.548
DOC_MAPK_MEF2A_6	431	440	PF00069	0.403
DOC_MAPK_MEF2A_6	89	98	PF00069	0.487
DOC_PP2B_LxvP_1	20	23	PF13499	0.416
DOC_PP2B_PxIxI_1	116	122	PF00149	0.507
DOC_USP7_MATH_1	103	107	PF00917	0.442
DOC_USP7_UBL2_3	169	173	PF12436	0.492
LIG_14-3-3_CanoR_1	130	134	PF00244	0.384
LIG_14-3-3_CanoR_1	168	175	PF00244	0.472
LIG_14-3-3_CanoR_1	207	211	PF00244	0.475
LIG_14-3-3_CanoR_1	235	241	PF00244	0.405
LIG_14-3-3_CanoR_1	331	337	PF00244	0.302
LIG_14-3-3_CanoR_1	50	55	PF00244	0.482
LIG_14-3-3_CanoR_1	67	74	PF00244	0.310
LIG_Actin_WH2_2	385	401	PF00022	0.348
LIG_BRCT_BRCA1_1	145	149	PF00533	0.447
LIG_BRCT_BRCA1_1	363	367	PF00533	0.276
LIG_BRCT_BRCA1_1	428	432	PF00533	0.386
LIG_BRCT_BRCA1_1	469	473	PF00533	0.517
LIG_Clathr_ClatBox_1	30	34	PF01394	0.499
LIG_deltaCOP1_diTrp_1	342	350	PF00928	0.386
LIG_EH_1	247	251	PF12763	0.523
LIG_FHA_1	118	124	PF00498	0.422
LIG_FHA_1	172	178	PF00498	0.512
LIG_FHA_1	6	12	PF00498	0.609
LIG_FHA_2	237	243	PF00498	0.499
LIG_FHA_2	34	40	PF00498	0.544
LIG_FHA_2	51	57	PF00498	0.268
LIG_LIR_Gen_1	146	157	PF02991	0.440
LIG_LIR_Gen_1	278	286	PF02991	0.403
LIG_LIR_Gen_1	456	466	PF02991	0.554
LIG_LIR_Nem_3	146	152	PF02991	0.429
LIG_LIR_Nem_3	278	282	PF02991	0.356
LIG_LIR_Nem_3	289	294	PF02991	0.272
LIG_LIR_Nem_3	364	370	PF02991	0.276
LIG_LIR_Nem_3	400	405	PF02991	0.319
LIG_LIR_Nem_3	456	461	PF02991	0.561
LIG_LYPXL_S_1	309	313	PF13949	0.403
LIG_PDZ_Class_1	468	473	PF00595	0.427
LIG_Pex14_2	367	371	PF04695	0.295
LIG_Pex14_2	463	467	PF04695	0.422
LIG_Pex14_2	469	473	PF04695	0.494
LIG_PTB_Apo_2	73	80	PF02174	0.362
LIG_PTB_Phospho_1	73	79	PF10480	0.358
LIG_REV1ctd_RIR_1	310	317	PF16727	0.403
LIG_SH2_PTP2	137	140	PF00017	0.380
LIG_SH2_PTP2	291	294	PF00017	0.403
LIG_SH2_SRC	137	140	PF00017	0.380
LIG_SH2_STAT3	260	263	PF00017	0.403
LIG_SH2_STAT5	137	140	PF00017	0.395
LIG_SH2_STAT5	165	168	PF00017	0.373
LIG_SH2_STAT5	291	294	PF00017	0.417
LIG_SH3_1	290	296	PF00018	0.276
LIG_SH3_3	290	296	PF00018	0.276
LIG_SUMO_SIM_par_1	118	124	PF11976	0.388
LIG_TRAF2_1	53	56	PF00917	0.490
LIG_UBA3_1	391	399	PF00899	0.343
LIG_WRC_WIRS_1	466	471	PF05994	0.391
MOD_CK1_1	150	156	PF00069	0.346
MOD_CK1_1	199	205	PF00069	0.343
MOD_CK1_1	262	268	PF00069	0.386
MOD_CK2_1	112	118	PF00069	0.548
MOD_CK2_1	50	56	PF00069	0.394
MOD_Cter_Amidation	166	169	PF01082	0.394
MOD_GlcNHglycan	13	19	PF01048	0.600
MOD_GlcNHglycan	160	163	PF01048	0.514
MOD_GlcNHglycan	225	229	PF01048	0.441
MOD_GlcNHglycan	302	305	PF01048	0.403
MOD_GlcNHglycan	428	431	PF01048	0.320
MOD_GlcNHglycan	69	72	PF01048	0.472
MOD_GSK3_1	1	8	PF00069	0.619
MOD_GSK3_1	108	115	PF00069	0.581
MOD_GSK3_1	139	146	PF00069	0.413
MOD_GSK3_1	167	174	PF00069	0.462
MOD_GSK3_1	277	284	PF00069	0.280
MOD_GSK3_1	296	303	PF00069	0.229
MOD_GSK3_1	332	339	PF00069	0.287
MOD_GSK3_1	465	472	PF00069	0.457
MOD_GSK3_1	59	66	PF00069	0.461
MOD_N-GLC_1	171	176	PF02516	0.477
MOD_N-GLC_1	345	350	PF02516	0.356
MOD_N-GLC_1	434	439	PF02516	0.287
MOD_N-GLC_2	10	12	PF02516	0.524
MOD_NEK2_1	1	6	PF00069	0.589
MOD_NEK2_1	286	291	PF00069	0.403
MOD_NEK2_1	300	305	PF00069	0.403
MOD_NEK2_1	312	317	PF00069	0.285
MOD_NEK2_1	323	328	PF00069	0.246
MOD_NEK2_1	350	355	PF00069	0.276
MOD_NEK2_1	358	363	PF00069	0.276
MOD_NEK2_1	434	439	PF00069	0.320
MOD_NEK2_1	465	470	PF00069	0.448
MOD_NEK2_2	129	134	PF00069	0.482
MOD_NEK2_2	376	381	PF00069	0.403
MOD_PIKK_1	2	8	PF00454	0.485
MOD_PIKK_1	259	265	PF00454	0.403
MOD_PK_1	143	149	PF00069	0.485
MOD_PKA_2	129	135	PF00069	0.361
MOD_PKA_2	167	173	PF00069	0.449
MOD_PKA_2	206	212	PF00069	0.472
MOD_PKB_1	65	73	PF00069	0.454
MOD_Plk_1	112	118	PF00069	0.440
MOD_Plk_1	171	177	PF00069	0.474
MOD_Plk_1	199	205	PF00069	0.365
MOD_Plk_1	277	283	PF00069	0.403
MOD_Plk_1	345	351	PF00069	0.386
MOD_Plk_1	434	440	PF00069	0.287
MOD_Plk_4	453	459	PF00069	0.570
MOD_SUMO_for_1	282	285	PF00179	0.363
MOD_SUMO_rev_2	180	189	PF00179	0.462
MOD_SUMO_rev_2	97	103	PF00179	0.390
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.494
TRG_ENDOCYTIC_2	291	294	PF00928	0.276
TRG_ENDOCYTIC_2	310	313	PF00928	0.276
TRG_ENDOCYTIC_2	402	405	PF00928	0.320
TRG_ER_diArg_1	64	67	PF00400	0.409
TRG_Pf-PMV_PEXEL_1	403	407	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1R7	Leptomonas seymouri	79%	100%
A0A1X0NZZ7	Trypanosomatidae	60%	99%
A0A3R7L3S8	Trypanosoma rangeli	59%	99%
A4HIY6	Leishmania braziliensis	91%	100%
A4I4P0	Leishmania infantum	100%	100%
C9ZLC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	99%
E9AE43	Leishmania major	95%	100%
E9ALP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q10478	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
Q5U3I0	Danio rerio	26%	100%
Q6AXV4	Rattus norvegicus	26%	100%
Q7ZWS5	Xenopus laevis	24%	100%
Q803G5	Danio rerio	24%	100%
Q8BGH2	Mus musculus	25%	100%
Q9Y512	Homo sapiens	23%	100%
V5D9V3	Trypanosoma cruzi	61%	92%