Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7L3_LEIDO

TriTrypDb:

LdBPK_291580.1 , LdCL_290021400 , LDHU3_29.2290

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

A0A3S5H7L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7L3

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	299	301	PF00675	0.721
CLV_NRD_NRD_1	88	90	PF00675	0.450
CLV_PCSK_KEX2_1	299	301	PF00082	0.694
CLV_PCSK_KEX2_1	90	92	PF00082	0.449
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.449
CLV_PCSK_SKI1_1	24	28	PF00082	0.447
DEG_Nend_Nbox_1	1	3	PF02207	0.627
DEG_SCF_FBW7_1	143	150	PF00400	0.634
DEG_SPOP_SBC_1	59	63	PF00917	0.615
DEG_SPOP_SBC_1	9	13	PF00917	0.624

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4HHG0	Leishmania braziliensis	61%	81%
A4I4L0	Leishmania infantum	95%	100%
E9AE07	Leishmania major	80%	100%
E9ALS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%

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