LeishMANIAdb
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Ribosomal_protein_L1a_putative/GeneDB:LmjF.29.107 0/GeneDB:LmjF.29.1090

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ribosomal_protein_L1a_putative/GeneDB:LmjF.29.107 0/GeneDB:LmjF.29.1090
Gene product:
ribosomal protein L1a, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H7L0_LEIDO
TriTrypDb:
LdBPK_291160.1 , LdCL_290016700 , LdCL_290016800 , LdCL_290016900 , LDHU3_29.1610 , LDHU3_29.1620 , LDHU3_29.1630
Length:
373

Annotations

Annotations by Jardim et al.

Ribosomal Protein, ribosomal L1a

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 21
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 14
GO:0032991 protein-containing complex 1 15
GO:0043226 organelle 2 15
GO:0043228 non-membrane-bounded organelle 3 15
GO:0043229 intracellular organelle 3 15
GO:0043232 intracellular non-membrane-bounded organelle 4 15
GO:0110165 cellular anatomical entity 1 15
GO:1990904 ribonucleoprotein complex 2 15
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0015934 large ribosomal subunit 4 1
GO:0022625 cytosolic large ribosomal subunit 5 1
GO:0044391 ribosomal subunit 3 1

Expansion

Sequence features

A0A3S5H7L0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7L0

PDB structure(s): 6az3_C

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 15
GO:0006518 peptide metabolic process 4 15
GO:0006807 nitrogen compound metabolic process 2 15
GO:0008152 metabolic process 1 15
GO:0009058 biosynthetic process 2 15
GO:0009059 macromolecule biosynthetic process 4 15
GO:0009987 cellular process 1 15
GO:0019538 protein metabolic process 3 15
GO:0034641 cellular nitrogen compound metabolic process 3 15
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 15
GO:0043043 peptide biosynthetic process 5 15
GO:0043170 macromolecule metabolic process 3 15
GO:0043603 amide metabolic process 3 15
GO:0043604 amide biosynthetic process 4 15
GO:0044237 cellular metabolic process 2 15
GO:0044238 primary metabolic process 2 15
GO:0044249 cellular biosynthetic process 3 15
GO:0044260 obsolete cellular macromolecule metabolic process 3 15
GO:0044271 cellular nitrogen compound biosynthetic process 4 15
GO:0071704 organic substance metabolic process 2 15
GO:1901564 organonitrogen compound metabolic process 3 15
GO:1901566 organonitrogen compound biosynthetic process 4 15
GO:1901576 organic substance biosynthetic process 3 15
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 15
GO:0005198 structural molecule activity 1 15
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 108 110 PF00675 0.361
CLV_NRD_NRD_1 111 113 PF00675 0.361
CLV_NRD_NRD_1 198 200 PF00675 0.379
CLV_NRD_NRD_1 203 205 PF00675 0.356
CLV_NRD_NRD_1 297 299 PF00675 0.356
CLV_NRD_NRD_1 323 325 PF00675 0.369
CLV_NRD_NRD_1 352 354 PF00675 0.591
CLV_PCSK_FUR_1 196 200 PF00082 0.356
CLV_PCSK_KEX2_1 108 110 PF00082 0.356
CLV_PCSK_KEX2_1 119 121 PF00082 0.356
CLV_PCSK_KEX2_1 198 200 PF00082 0.382
CLV_PCSK_KEX2_1 203 205 PF00082 0.356
CLV_PCSK_KEX2_1 297 299 PF00082 0.356
CLV_PCSK_KEX2_1 323 325 PF00082 0.380
CLV_PCSK_KEX2_1 334 336 PF00082 0.369
CLV_PCSK_KEX2_1 352 354 PF00082 0.470
CLV_PCSK_PC1ET2_1 119 121 PF00082 0.356
CLV_PCSK_PC1ET2_1 334 336 PF00082 0.504
CLV_PCSK_PC7_1 199 205 PF00082 0.356
CLV_PCSK_SKI1_1 220 224 PF00082 0.356
CLV_PCSK_SKI1_1 252 256 PF00082 0.340
CLV_PCSK_SKI1_1 273 277 PF00082 0.461
CLV_PCSK_SKI1_1 297 301 PF00082 0.356
CLV_PCSK_SKI1_1 353 357 PF00082 0.594
CLV_PCSK_SKI1_1 365 369 PF00082 0.572
DEG_ODPH_VHL_1 238 249 PF01847 0.356
DOC_CKS1_1 313 318 PF01111 0.420
DOC_MAPK_DCC_7 142 151 PF00069 0.486
DOC_MAPK_gen_1 108 116 PF00069 0.356
DOC_MAPK_gen_1 162 169 PF00069 0.356
DOC_MAPK_gen_1 203 209 PF00069 0.356
DOC_MAPK_gen_1 217 227 PF00069 0.356
DOC_MAPK_gen_1 321 329 PF00069 0.369
DOC_MAPK_MEF2A_6 142 151 PF00069 0.510
DOC_MAPK_MEF2A_6 203 210 PF00069 0.377
DOC_MAPK_MEF2A_6 321 329 PF00069 0.369
DOC_PP1_RVXF_1 244 251 PF00149 0.384
DOC_PP2B_LxvP_1 208 211 PF13499 0.391
DOC_PP2B_LxvP_1 277 280 PF13499 0.356
DOC_PP4_FxxP_1 27 30 PF00568 0.369
DOC_PP4_FxxP_1 275 278 PF00568 0.369
DOC_SPAK_OSR1_1 120 124 PF12202 0.356
DOC_SPAK_OSR1_1 246 250 PF12202 0.356
DOC_USP7_MATH_1 122 126 PF00917 0.374
DOC_USP7_MATH_1 128 132 PF00917 0.360
DOC_USP7_MATH_1 228 232 PF00917 0.504
DOC_USP7_MATH_1 3 7 PF00917 0.515
DOC_USP7_MATH_1 367 371 PF00917 0.701
DOC_USP7_MATH_1 44 48 PF00917 0.331
DOC_USP7_UBL2_3 304 308 PF12436 0.369
DOC_USP7_UBL2_3 365 369 PF12436 0.626
DOC_WW_Pin1_4 312 317 PF00397 0.497
LIG_14-3-3_CanoR_1 289 299 PF00244 0.356
LIG_14-3-3_CanoR_1 4 10 PF00244 0.482
LIG_BIR_II_1 1 5 PF00653 0.691
LIG_FHA_1 18 24 PF00498 0.455
LIG_FHA_1 26 32 PF00498 0.360
LIG_FHA_1 315 321 PF00498 0.436
LIG_FHA_2 262 268 PF00498 0.461
LIG_FHA_2 281 287 PF00498 0.249
LIG_IBAR_NPY_1 330 332 PF08397 0.448
LIG_LIR_Apic_2 311 316 PF02991 0.385
LIG_LIR_Gen_1 253 262 PF02991 0.454
LIG_LIR_LC3C_4 148 153 PF02991 0.356
LIG_LIR_Nem_3 216 222 PF02991 0.359
LIG_LIR_Nem_3 253 258 PF02991 0.398
LIG_LIR_Nem_3 259 265 PF02991 0.430
LIG_Pex14_2 219 223 PF04695 0.356
LIG_PTB_Apo_2 194 201 PF02174 0.369
LIG_PTB_Phospho_1 194 200 PF10480 0.369
LIG_SH2_CRK 313 317 PF00017 0.376
LIG_SH2_STAT5 200 203 PF00017 0.384
LIG_SH2_STAT5 332 335 PF00017 0.561
LIG_SH3_3 144 150 PF00018 0.512
LIG_SH3_3 296 302 PF00018 0.369
LIG_SUMO_SIM_par_1 148 156 PF11976 0.356
LIG_UBA3_1 207 214 PF00899 0.349
LIG_WRC_WIRS_1 262 267 PF05994 0.441
MOD_CK1_1 131 137 PF00069 0.432
MOD_CK1_1 62 68 PF00069 0.357
MOD_CK1_1 8 14 PF00069 0.488
MOD_CK2_1 250 256 PF00069 0.406
MOD_CK2_1 261 267 PF00069 0.429
MOD_GlcNHglycan 1 4 PF01048 0.632
MOD_GlcNHglycan 10 13 PF01048 0.469
MOD_GlcNHglycan 124 127 PF01048 0.356
MOD_GlcNHglycan 230 233 PF01048 0.504
MOD_GlcNHglycan 252 255 PF01048 0.419
MOD_GlcNHglycan 267 271 PF01048 0.512
MOD_GlcNHglycan 369 372 PF01048 0.727
MOD_GlcNHglycan 56 59 PF01048 0.360
MOD_GlcNHglycan 61 64 PF01048 0.362
MOD_GlcNHglycan 78 81 PF01048 0.419
MOD_GlcNHglycan 85 88 PF01048 0.378
MOD_GSK3_1 127 134 PF00069 0.429
MOD_GSK3_1 13 20 PF00069 0.625
MOD_GSK3_1 308 315 PF00069 0.523
MOD_GSK3_1 76 83 PF00069 0.507
MOD_N-GLC_1 182 187 PF02516 0.356
MOD_N-GLC_1 228 233 PF02516 0.504
MOD_N-GLC_1 59 64 PF02516 0.429
MOD_N-GLC_2 93 95 PF02516 0.369
MOD_NEK2_1 127 132 PF00069 0.356
MOD_NEK2_1 135 140 PF00069 0.356
MOD_NEK2_1 38 43 PF00069 0.369
MOD_NEK2_1 59 64 PF00069 0.504
MOD_NEK2_2 5 10 PF00069 0.473
MOD_PKA_1 308 314 PF00069 0.369
MOD_PKA_1 334 340 PF00069 0.385
MOD_PKA_2 3 9 PF00069 0.484
MOD_PKA_2 334 340 PF00069 0.466
MOD_PKA_2 358 364 PF00069 0.688
MOD_PKA_2 54 60 PF00069 0.369
MOD_PKA_2 76 82 PF00069 0.514
MOD_Plk_1 153 159 PF00069 0.404
MOD_Plk_1 228 234 PF00069 0.504
MOD_Plk_1 266 272 PF00069 0.529
MOD_Plk_1 285 291 PF00069 0.235
MOD_Plk_4 13 19 PF00069 0.502
MOD_Plk_4 131 137 PF00069 0.431
MOD_Plk_4 5 11 PF00069 0.469
MOD_ProDKin_1 312 318 PF00069 0.497
MOD_SUMO_for_1 333 336 PF00179 0.448
TRG_DiLeu_BaEn_2 164 170 PF01217 0.366
TRG_ER_diArg_1 107 109 PF00400 0.356
TRG_ER_diArg_1 195 198 PF00400 0.356
TRG_ER_diArg_1 296 298 PF00400 0.356
TRG_ER_diArg_1 323 326 PF00400 0.378
TRG_NLS_MonoExtN_4 352 357 PF00514 0.630

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBP3 Leptomonas seymouri 96% 100%
A0A0S4JFT4 Bodo saltans 84% 100%
A0A1D8PFV1 Candida albicans (strain SC5314 / ATCC MYA-2876) 50% 100%
A0A1X0NDR6 Trypanosomatidae 89% 100%
A0A422MZW3 Trypanosoma rangeli 87% 100%
A4FVY1 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 35% 100%
A4HHB9 Leishmania braziliensis 98% 100%
A4I4G7 Leishmania infantum 100% 100%
A5UL88 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 38% 100%
A6UQJ1 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 34% 100%
A6UV67 Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) 34% 100%
A6VHD3 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 34% 100%
A9A9B7 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 34% 100%
B0R657 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) 34% 100%
B6YSL4 Thermococcus onnurineus (strain NA1) 36% 100%
C5A285 Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) 37% 100%
C6A160 Thermococcus sibiricus (strain DSM 12597 / MM 739) 37% 100%
C9ZLL4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 76% 100%
C9ZLL5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 87% 100%
E9ADW5 Leishmania major 98% 100%
E9AHI5 Leishmania infantum 100% 100%
E9ALW4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9ALW5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O02056 Caenorhabditis elegans 51% 100%
O26111 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 37% 100%
P02385 Xenopus laevis 53% 93%
P08429 Xenopus laevis 53% 94%
P09180 Drosophila melanogaster 53% 93%
P0DJ55 Tetrahymena thermophila (strain SB210) 52% 91%
P10664 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 53% 100%
P35679 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 55% 100%
P36578 Homo sapiens 58% 87%
P49165 Urechis caupo 55% 97%
P49626 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 53% 100%
P49669 Trypanosoma brucei brucei 83% 100%
P49691 Arabidopsis thaliana 54% 92%
P50878 Rattus norvegicus 57% 89%
P54015 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 33% 100%
P60846 Methanococcus maripaludis (strain S2 / LL) 35% 100%
P60847 Nanoarchaeum equitans (strain Kin4-M) 35% 100%
Q28346 Canis lupus familiaris 56% 89%
Q2NFV7 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 34% 100%
Q4R5P9 Macaca fascicularis 57% 87%
Q54Z69 Dictyostelium discoideum 56% 100%
Q58DW0 Bos taurus 58% 88%
Q5JDI0 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 35% 100%
Q5RCR3 Pongo abelii 58% 87%
Q97BX6 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 33% 100%
Q9D8E6 Mus musculus 58% 89%
Q9HIR0 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 35% 100%
Q9HPD3 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 34% 100%
Q9P784 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 55% 100%
Q9SF40 Arabidopsis thaliana 54% 92%
Q9XF97 Prunus armeniaca 56% 91%
Q9YFM1 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 35% 100%
V5BH60 Trypanosoma cruzi 86% 86%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS