LeishMANIAdb
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ABC transporter-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ABC transporter-like protein
Gene product:
ABC transporter-like protein
Species:
Leishmania donovani
UniProt:
A0A3S5H7K9_LEIDO
TriTrypDb:
LdBPK_291010.1 * , LdCL_290014700 , LDHU3_29.1380
Length:
720

Annotations

LeishMANIAdb annotations

Related to other Eukaryotic ABC transporters.. Expanded on the Trypanosoma rangeli and theileri lineages

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A0A3S5H7K9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7K9

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0009987 cellular process 1 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0005215 transporter activity 1 4
GO:0015399 primary active transmembrane transporter activity 4 4
GO:0022804 active transmembrane transporter activity 3 4
GO:0022857 transmembrane transporter activity 2 4
GO:0042626 ATPase-coupled transmembrane transporter activity 2 4
GO:0140657 ATP-dependent activity 1 4
GO:0140359 ABC-type transporter activity 3 3
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 156 160 PF00656 0.556
CLV_NRD_NRD_1 543 545 PF00675 0.438
CLV_NRD_NRD_1 611 613 PF00675 0.456
CLV_NRD_NRD_1 79 81 PF00675 0.465
CLV_NRD_NRD_1 93 95 PF00675 0.421
CLV_PCSK_KEX2_1 545 547 PF00082 0.439
CLV_PCSK_KEX2_1 611 613 PF00082 0.456
CLV_PCSK_KEX2_1 79 81 PF00082 0.415
CLV_PCSK_KEX2_1 93 95 PF00082 0.327
CLV_PCSK_PC1ET2_1 545 547 PF00082 0.439
CLV_PCSK_SKI1_1 306 310 PF00082 0.550
CLV_PCSK_SKI1_1 341 345 PF00082 0.547
CLV_PCSK_SKI1_1 363 367 PF00082 0.588
CLV_PCSK_SKI1_1 538 542 PF00082 0.354
CLV_PCSK_SKI1_1 561 565 PF00082 0.316
CLV_PCSK_SKI1_1 612 616 PF00082 0.331
DEG_APCC_DBOX_1 362 370 PF00400 0.626
DEG_APCC_DBOX_1 467 475 PF00400 0.579
DEG_APCC_DBOX_1 93 101 PF00400 0.596
DEG_Nend_Nbox_1 1 3 PF02207 0.734
DOC_CDC14_PxL_1 635 643 PF14671 0.447
DOC_CKS1_1 354 359 PF01111 0.746
DOC_CYCLIN_yCln2_LP_2 214 220 PF00134 0.555
DOC_CYCLIN_yCln2_LP_2 572 578 PF00134 0.353
DOC_MAPK_DCC_7 636 644 PF00069 0.427
DOC_MAPK_FxFP_2 221 224 PF00069 0.607
DOC_MAPK_gen_1 203 212 PF00069 0.509
DOC_MAPK_gen_1 544 554 PF00069 0.637
DOC_MAPK_gen_1 93 99 PF00069 0.607
DOC_MAPK_MEF2A_6 203 212 PF00069 0.555
DOC_MAPK_MEF2A_6 512 519 PF00069 0.447
DOC_MAPK_MEF2A_6 52 60 PF00069 0.570
DOC_MAPK_MEF2A_6 534 541 PF00069 0.628
DOC_MAPK_MEF2A_6 566 574 PF00069 0.378
DOC_MAPK_MEF2A_6 582 591 PF00069 0.313
DOC_MAPK_MEF2A_6 636 644 PF00069 0.427
DOC_PP1_RVXF_1 510 517 PF00149 0.296
DOC_PP1_RVXF_1 610 617 PF00149 0.639
DOC_PP1_SILK_1 645 650 PF00149 0.346
DOC_PP2B_LxvP_1 150 153 PF13499 0.601
DOC_PP2B_LxvP_1 214 217 PF13499 0.546
DOC_PP2B_LxvP_1 294 297 PF13499 0.635
DOC_PP2B_LxvP_1 572 575 PF13499 0.383
DOC_PP4_FxxP_1 221 224 PF00568 0.607
DOC_PP4_FxxP_1 325 328 PF00568 0.750
DOC_SPAK_OSR1_1 462 466 PF12202 0.621
DOC_USP7_MATH_1 107 111 PF00917 0.569
DOC_USP7_MATH_1 120 124 PF00917 0.552
DOC_USP7_MATH_1 261 265 PF00917 0.584
DOC_USP7_MATH_1 332 336 PF00917 0.808
DOC_USP7_MATH_1 387 391 PF00917 0.726
DOC_USP7_MATH_1 497 501 PF00917 0.552
DOC_USP7_MATH_1 529 533 PF00917 0.496
DOC_WW_Pin1_4 3 8 PF00397 0.674
DOC_WW_Pin1_4 333 338 PF00397 0.778
DOC_WW_Pin1_4 353 358 PF00397 0.734
DOC_WW_Pin1_4 370 375 PF00397 0.734
DOC_WW_Pin1_4 446 451 PF00397 0.698
LIG_14-3-3_CanoR_1 349 354 PF00244 0.734
LIG_14-3-3_CanoR_1 359 367 PF00244 0.689
LIG_14-3-3_CanoR_1 441 451 PF00244 0.725
LIG_14-3-3_CanoR_1 468 472 PF00244 0.604
LIG_14-3-3_CanoR_1 582 588 PF00244 0.367
LIG_14-3-3_CanoR_1 611 617 PF00244 0.554
LIG_Actin_WH2_2 453 470 PF00022 0.623
LIG_Actin_WH2_2 523 540 PF00022 0.499
LIG_Actin_WH2_2 567 584 PF00022 0.471
LIG_Actin_WH2_2 703 720 PF00022 0.447
LIG_BIR_III_4 226 230 PF00653 0.565
LIG_BRCT_BRCA1_1 200 204 PF00533 0.547
LIG_BRCT_BRCA1_1 221 225 PF00533 0.583
LIG_BRCT_BRCA1_1 334 338 PF00533 0.814
LIG_BRCT_BRCA1_1 361 365 PF00533 0.740
LIG_BRCT_BRCA1_1 550 554 PF00533 0.558
LIG_BRCT_BRCA1_1 624 628 PF00533 0.496
LIG_BRCT_BRCA1_1 88 92 PF00533 0.576
LIG_EH1_1 508 516 PF00400 0.357
LIG_eIF4E_1 509 515 PF01652 0.362
LIG_eIF4E_1 585 591 PF01652 0.408
LIG_EVH1_2 216 220 PF00568 0.530
LIG_FHA_1 174 180 PF00498 0.629
LIG_FHA_1 235 241 PF00498 0.563
LIG_FHA_1 246 252 PF00498 0.479
LIG_FHA_1 266 272 PF00498 0.415
LIG_FHA_1 387 393 PF00498 0.729
LIG_FHA_1 4 10 PF00498 0.673
LIG_FHA_1 493 499 PF00498 0.398
LIG_FHA_2 395 401 PF00498 0.652
LIG_FHA_2 676 682 PF00498 0.391
LIG_Integrin_isoDGR_2 77 79 PF01839 0.437
LIG_LIR_Apic_2 324 328 PF02991 0.774
LIG_LIR_Gen_1 222 231 PF02991 0.611
LIG_LIR_Gen_1 289 297 PF02991 0.620
LIG_LIR_Gen_1 348 358 PF02991 0.752
LIG_LIR_Gen_1 567 577 PF02991 0.474
LIG_LIR_Gen_1 618 627 PF02991 0.422
LIG_LIR_Gen_1 680 688 PF02991 0.347
LIG_LIR_Nem_3 148 154 PF02991 0.601
LIG_LIR_Nem_3 159 165 PF02991 0.529
LIG_LIR_Nem_3 289 294 PF02991 0.583
LIG_LIR_Nem_3 348 354 PF02991 0.757
LIG_LIR_Nem_3 567 572 PF02991 0.388
LIG_LIR_Nem_3 615 619 PF02991 0.415
LIG_LIR_Nem_3 625 631 PF02991 0.375
LIG_LIR_Nem_3 680 685 PF02991 0.332
LIG_MYND_1 328 332 PF01753 0.741
LIG_Pex14_1 70 74 PF04695 0.651
LIG_Pex14_2 221 225 PF04695 0.583
LIG_SH2_CRK 351 355 PF00017 0.776
LIG_SH2_CRK 47 51 PF00017 0.614
LIG_SH2_CRK 549 553 PF00017 0.562
LIG_SH2_CRK 624 628 PF00017 0.355
LIG_SH2_CRK 652 656 PF00017 0.359
LIG_SH2_GRB2like 290 293 PF00017 0.589
LIG_SH2_NCK_1 624 628 PF00017 0.408
LIG_SH2_STAP1 418 422 PF00017 0.544
LIG_SH2_STAP1 423 427 PF00017 0.551
LIG_SH2_STAP1 585 589 PF00017 0.408
LIG_SH2_STAP1 624 628 PF00017 0.480
LIG_SH2_STAT5 144 147 PF00017 0.637
LIG_SH2_STAT5 290 293 PF00017 0.537
LIG_SH2_STAT5 378 381 PF00017 0.746
LIG_SH2_STAT5 469 472 PF00017 0.601
LIG_SH2_STAT5 569 572 PF00017 0.372
LIG_SH2_STAT5 603 606 PF00017 0.438
LIG_SH2_STAT5 621 624 PF00017 0.173
LIG_SH2_STAT5 657 660 PF00017 0.363
LIG_SH2_STAT5 675 678 PF00017 0.363
LIG_SH2_STAT5 682 685 PF00017 0.321
LIG_SH3_3 210 216 PF00018 0.515
LIG_SH3_3 325 331 PF00018 0.781
LIG_SH3_3 340 346 PF00018 0.668
LIG_SH3_3 447 453 PF00018 0.770
LIG_SH3_3 6 12 PF00018 0.778
LIG_SH3_3 63 69 PF00018 0.647
LIG_Sin3_3 478 485 PF02671 0.502
LIG_SUMO_SIM_anti_2 586 591 PF11976 0.381
LIG_SUMO_SIM_par_1 153 159 PF11976 0.566
LIG_SUMO_SIM_par_1 248 255 PF11976 0.520
LIG_SUMO_SIM_par_1 388 398 PF11976 0.681
LIG_SUMO_SIM_par_1 490 495 PF11976 0.443
LIG_SUMO_SIM_par_1 519 525 PF11976 0.447
LIG_SUMO_SIM_par_1 561 567 PF11976 0.480
LIG_SUMO_SIM_par_1 710 716 PF11976 0.384
LIG_TRAF2_1 317 320 PF00917 0.780
LIG_TYR_ITIM 655 660 PF00017 0.518
LIG_UBA3_1 150 158 PF00899 0.516
LIG_WRC_WIRS_1 322 327 PF05994 0.738
LIG_WW_1 375 378 PF00397 0.724
LIG_WW_3 356 360 PF00397 0.701
LIG_WW_3 451 455 PF00397 0.623
MOD_CDK_SPxK_1 353 359 PF00069 0.705
MOD_CK1_1 110 116 PF00069 0.510
MOD_CK1_1 254 260 PF00069 0.510
MOD_CK1_1 333 339 PF00069 0.720
MOD_CK1_1 386 392 PF00069 0.656
MOD_CK1_1 442 448 PF00069 0.715
MOD_CK1_1 583 589 PF00069 0.413
MOD_CK1_1 692 698 PF00069 0.456
MOD_CK2_1 196 202 PF00069 0.421
MOD_CK2_1 497 503 PF00069 0.565
MOD_CMANNOS 613 616 PF00535 0.480
MOD_Cter_Amidation 191 194 PF01082 0.443
MOD_Cter_Amidation 77 80 PF01082 0.554
MOD_GlcNHglycan 122 125 PF01048 0.479
MOD_GlcNHglycan 18 21 PF01048 0.720
MOD_GlcNHglycan 263 266 PF01048 0.539
MOD_GlcNHglycan 280 283 PF01048 0.223
MOD_GlcNHglycan 385 388 PF01048 0.674
MOD_GlcNHglycan 389 392 PF01048 0.686
MOD_GlcNHglycan 397 400 PF01048 0.616
MOD_GlcNHglycan 628 631 PF01048 0.378
MOD_GlcNHglycan 695 698 PF01048 0.482
MOD_GlcNHglycan 88 91 PF01048 0.482
MOD_GSK3_1 234 241 PF00069 0.465
MOD_GSK3_1 247 254 PF00069 0.285
MOD_GSK3_1 261 268 PF00069 0.379
MOD_GSK3_1 286 293 PF00069 0.448
MOD_GSK3_1 326 333 PF00069 0.684
MOD_GSK3_1 345 352 PF00069 0.704
MOD_GSK3_1 383 390 PF00069 0.698
MOD_GSK3_1 408 415 PF00069 0.492
MOD_GSK3_1 439 446 PF00069 0.644
MOD_GSK3_1 46 53 PF00069 0.491
MOD_GSK3_1 603 610 PF00069 0.494
MOD_GSK3_1 622 629 PF00069 0.337
MOD_GSK3_1 671 678 PF00069 0.489
MOD_GSK3_1 689 696 PF00069 0.453
MOD_N-GLC_1 370 375 PF02516 0.685
MOD_N-GLC_1 671 676 PF02516 0.502
MOD_N-GLC_1 689 694 PF02516 0.467
MOD_N-GLC_2 234 236 PF02516 0.539
MOD_NEK2_1 219 224 PF00069 0.460
MOD_NEK2_1 467 472 PF00069 0.509
MOD_NEK2_1 548 553 PF00069 0.423
MOD_NEK2_1 564 569 PF00069 0.331
MOD_NEK2_1 581 586 PF00069 0.364
MOD_NEK2_1 622 627 PF00069 0.468
MOD_NEK2_1 703 708 PF00069 0.481
MOD_NEK2_2 146 151 PF00069 0.566
MOD_NEK2_2 153 158 PF00069 0.383
MOD_NEK2_2 290 295 PF00069 0.531
MOD_NEK2_2 423 428 PF00069 0.488
MOD_NEK2_2 46 51 PF00069 0.485
MOD_NEK2_2 529 534 PF00069 0.530
MOD_PIKK_1 196 202 PF00454 0.546
MOD_PIKK_1 234 240 PF00454 0.513
MOD_PIKK_1 336 342 PF00454 0.752
MOD_PIKK_1 410 416 PF00454 0.557
MOD_PIKK_1 497 503 PF00454 0.565
MOD_PK_1 349 355 PF00069 0.674
MOD_PKA_2 358 364 PF00069 0.651
MOD_PKA_2 467 473 PF00069 0.459
MOD_PKA_2 581 587 PF00069 0.566
MOD_Plk_1 234 240 PF00069 0.439
MOD_Plk_1 423 429 PF00069 0.491
MOD_Plk_1 671 677 PF00069 0.491
MOD_Plk_1 689 695 PF00069 0.493
MOD_Plk_4 107 113 PF00069 0.464
MOD_Plk_4 146 152 PF00069 0.531
MOD_Plk_4 247 253 PF00069 0.388
MOD_Plk_4 265 271 PF00069 0.268
MOD_Plk_4 349 355 PF00069 0.736
MOD_Plk_4 412 418 PF00069 0.477
MOD_Plk_4 46 52 PF00069 0.493
MOD_Plk_4 550 556 PF00069 0.442
MOD_Plk_4 603 609 PF00069 0.477
MOD_Plk_4 612 618 PF00069 0.482
MOD_Plk_4 622 628 PF00069 0.402
MOD_Plk_4 643 649 PF00069 0.420
MOD_Plk_4 655 661 PF00069 0.462
MOD_Plk_4 703 709 PF00069 0.397
MOD_ProDKin_1 3 9 PF00069 0.604
MOD_ProDKin_1 333 339 PF00069 0.749
MOD_ProDKin_1 353 359 PF00069 0.687
MOD_ProDKin_1 370 376 PF00069 0.690
MOD_ProDKin_1 446 452 PF00069 0.637
TRG_DiLeu_BaEn_1 235 240 PF01217 0.490
TRG_DiLeu_BaLyEn_6 137 142 PF01217 0.547
TRG_DiLeu_BaLyEn_6 150 155 PF01217 0.285
TRG_DiLeu_BaLyEn_6 637 642 PF01217 0.548
TRG_ENDOCYTIC_2 351 354 PF00928 0.716
TRG_ENDOCYTIC_2 47 50 PF00928 0.528
TRG_ENDOCYTIC_2 549 552 PF00928 0.487
TRG_ENDOCYTIC_2 569 572 PF00928 0.150
TRG_ENDOCYTIC_2 619 622 PF00928 0.355
TRG_ENDOCYTIC_2 624 627 PF00928 0.315
TRG_ENDOCYTIC_2 652 655 PF00928 0.442
TRG_ENDOCYTIC_2 657 660 PF00928 0.474
TRG_ENDOCYTIC_2 682 685 PF00928 0.417
TRG_ER_diArg_1 138 141 PF00400 0.554
TRG_ER_diArg_1 611 613 PF00400 0.550
TRG_ER_diArg_1 79 82 PF00400 0.621
TRG_ER_diArg_1 92 94 PF00400 0.554
TRG_NES_CRM1_1 54 67 PF08389 0.463
TRG_NLS_MonoCore_2 543 548 PF00514 0.558
TRG_NLS_MonoExtN_4 544 549 PF00514 0.558
TRG_Pf-PMV_PEXEL_1 298 302 PF00026 0.621

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I174 Leptomonas seymouri 53% 100%
A0A0S4JPC7 Bodo saltans 30% 85%
A0A1X0NZQ7 Trypanosomatidae 33% 100%
A0A3R7KD05 Trypanosoma rangeli 34% 100%
A4HHA4 Leishmania braziliensis 83% 100%
A4I4F0 Leishmania infantum 100% 100%
E9ADV0 Leishmania major 94% 100%
E9ALY0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
V5BLN9 Trypanosoma cruzi 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS