SAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7K5_LEIDO

TriTrypDb:

LdBPK_290280.1 , LdCL_290007600 , LDHU3_29.0370

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005643	nuclear pore	3	1
GO:0020023	kinetoplast	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S5H7K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7K5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	89	93	PF00656	0.528
CLV_NRD_NRD_1	137	139	PF00675	0.657
CLV_NRD_NRD_1	192	194	PF00675	0.624
CLV_NRD_NRD_1	201	203	PF00675	0.593
CLV_NRD_NRD_1	47	49	PF00675	0.658
CLV_PCSK_FUR_1	190	194	PF00082	0.608
CLV_PCSK_KEX2_1	190	192	PF00082	0.588
CLV_PCSK_KEX2_1	201	203	PF00082	0.558
CLV_PCSK_KEX2_1	47	49	PF00082	0.625
CLV_PCSK_PC7_1	197	203	PF00082	0.575
CLV_PCSK_SKI1_1	203	207	PF00082	0.771
CLV_PCSK_SKI1_1	233	237	PF00082	0.447
DEG_SCF_FBW7_2	81	87	PF00400	0.686
DOC_CKS1_1	81	86	PF01111	0.619
DOC_USP7_MATH_1	105	109	PF00917	0.595
DOC_USP7_MATH_1	129	133	PF00917	0.589
DOC_USP7_MATH_1	152	156	PF00917	0.652
DOC_USP7_MATH_1	185	189	PF00917	0.607
DOC_USP7_UBL2_3	139	143	PF12436	0.620
DOC_USP7_UBL2_3	144	148	PF12436	0.572
DOC_USP7_UBL2_3	149	153	PF12436	0.559
DOC_USP7_UBL2_3	154	158	PF12436	0.541
DOC_USP7_UBL2_3	182	186	PF12436	0.619
DOC_USP7_UBL2_3	222	226	PF12436	0.462
DOC_WW_Pin1_4	101	106	PF00397	0.598
DOC_WW_Pin1_4	111	116	PF00397	0.587
DOC_WW_Pin1_4	121	126	PF00397	0.623
DOC_WW_Pin1_4	133	138	PF00397	0.541
DOC_WW_Pin1_4	148	153	PF00397	0.550
DOC_WW_Pin1_4	158	163	PF00397	0.641
DOC_WW_Pin1_4	166	171	PF00397	0.575
DOC_WW_Pin1_4	172	177	PF00397	0.561
DOC_WW_Pin1_4	208	213	PF00397	0.476
DOC_WW_Pin1_4	59	64	PF00397	0.560
DOC_WW_Pin1_4	80	85	PF00397	0.728
DOC_WW_Pin1_4	93	98	PF00397	0.614
LIG_14-3-3_CanoR_1	138	142	PF00244	0.526
LIG_14-3-3_CanoR_1	202	208	PF00244	0.595
LIG_Actin_WH2_2	70	88	PF00022	0.468
LIG_FHA_1	80	86	PF00498	0.608
LIG_FHA_2	235	241	PF00498	0.442
LIG_FHA_2	8	14	PF00498	0.483
LIG_LIR_Nem_3	23	27	PF02991	0.452
LIG_SH2_NCK_1	9	13	PF00017	0.518
LIG_SH2_STAT5	7	10	PF00017	0.481
LIG_SH3_3	175	181	PF00018	0.617
LIG_SH3_4	182	189	PF00018	0.577
MOD_CDC14_SPxK_1	114	117	PF00782	0.656
MOD_CDC14_SPxK_1	118	121	PF00782	0.651
MOD_CDC14_SPxK_1	141	144	PF00782	0.636
MOD_CDC14_SPxK_1	151	154	PF00782	0.574
MOD_CDC14_SPxK_1	161	164	PF00782	0.629
MOD_CDC14_SPxK_1	169	172	PF00782	0.589
MOD_CDC14_SPxK_1	177	180	PF00782	0.512
MOD_CDC14_SPxK_1	96	99	PF00782	0.641
MOD_CDK_SPK_2	133	138	PF00069	0.601
MOD_CDK_SPK_2	148	153	PF00069	0.550
MOD_CDK_SPK_2	158	163	PF00069	0.719
MOD_CDK_SPK_2	210	215	PF00069	0.480
MOD_CDK_SPxK_1	111	117	PF00069	0.649
MOD_CDK_SPxK_1	133	139	PF00069	0.574
MOD_CDK_SPxK_1	148	154	PF00069	0.513
MOD_CDK_SPxK_1	158	164	PF00069	0.642
MOD_CDK_SPxK_1	166	172	PF00069	0.577
MOD_CDK_SPxK_1	174	180	PF00069	0.530
MOD_CDK_SPxK_1	80	86	PF00069	0.755
MOD_CDK_SPxK_1	93	99	PF00069	0.664
MOD_CDK_SPxxK_3	208	215	PF00069	0.561
MOD_CK1_1	132	138	PF00069	0.640
MOD_CK1_1	157	163	PF00069	0.671
MOD_CK1_1	49	55	PF00069	0.671
MOD_CK1_1	93	99	PF00069	0.628
MOD_CK2_1	7	13	PF00069	0.486
MOD_DYRK1A_RPxSP_1	121	125	PF00069	0.732
MOD_DYRK1A_RPxSP_1	172	176	PF00069	0.691
MOD_GlcNHglycan	131	134	PF01048	0.624
MOD_GlcNHglycan	187	190	PF01048	0.625
MOD_GlcNHglycan	242	245	PF01048	0.370
MOD_GlcNHglycan	55	58	PF01048	0.617
MOD_GSK3_1	101	108	PF00069	0.620
MOD_GSK3_1	111	118	PF00069	0.652
MOD_GSK3_1	128	135	PF00069	0.632
MOD_GSK3_1	148	155	PF00069	0.650
MOD_GSK3_1	172	179	PF00069	0.668
MOD_GSK3_1	191	198	PF00069	0.586
MOD_GSK3_1	206	213	PF00069	0.459
MOD_GSK3_1	46	53	PF00069	0.569
MOD_GSK3_1	59	66	PF00069	0.593
MOD_GSK3_1	69	76	PF00069	0.529
MOD_GSK3_1	91	98	PF00069	0.678
MOD_NEK2_1	41	46	PF00069	0.493
MOD_NEK2_1	73	78	PF00069	0.560
MOD_NEK2_1	90	95	PF00069	0.640
MOD_PIKK_1	63	69	PF00454	0.713
MOD_PK_1	226	232	PF00069	0.517
MOD_PKA_1	153	159	PF00069	0.733
MOD_PKA_1	191	197	PF00069	0.692
MOD_PKA_1	47	53	PF00069	0.589
MOD_PKA_2	137	143	PF00069	0.533
MOD_PKA_2	191	197	PF00069	0.643
MOD_PKA_2	46	52	PF00069	0.606
MOD_PKB_1	191	199	PF00069	0.586
MOD_Plk_1	226	232	PF00069	0.544
MOD_Plk_4	69	75	PF00069	0.545
MOD_ProDKin_1	101	107	PF00069	0.597
MOD_ProDKin_1	111	117	PF00069	0.591
MOD_ProDKin_1	121	127	PF00069	0.620
MOD_ProDKin_1	133	139	PF00069	0.543
MOD_ProDKin_1	148	154	PF00069	0.536
MOD_ProDKin_1	158	164	PF00069	0.642
MOD_ProDKin_1	166	172	PF00069	0.577
MOD_ProDKin_1	174	180	PF00069	0.530
MOD_ProDKin_1	208	214	PF00069	0.474
MOD_ProDKin_1	59	65	PF00069	0.555
MOD_ProDKin_1	80	86	PF00069	0.734
MOD_ProDKin_1	93	99	PF00069	0.616
MOD_SUMO_rev_2	87	93	PF00179	0.584
TRG_ENDOCYTIC_2	24	27	PF00928	0.493
TRG_ER_diArg_1	190	193	PF00400	0.703
TRG_ER_diArg_1	46	48	PF00400	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS3	Leptomonas seymouri	53%	97%
A0A1X0NZQ5	Trypanosomatidae	33%	77%
A4HH60	Leishmania braziliensis	74%	100%
C9ZKP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	80%
E9ADM9	Leishmania major	93%	100%
E9AM51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	97%
V5DLD7	Trypanosoma cruzi	35%	94%