Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H7K1_LEIDO

TriTrypDb:

LdBPK_282830.1 , LdCL_280033400 , LDHU3_28.3810

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7K1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7K1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.569
CLV_C14_Caspase3-7	92	96	PF00656	0.581
CLV_NRD_NRD_1	139	141	PF00675	0.804
CLV_NRD_NRD_1	348	350	PF00675	0.644
CLV_NRD_NRD_1	357	359	PF00675	0.594
CLV_NRD_NRD_1	47	49	PF00675	0.646
CLV_PCSK_KEX2_1	138	140	PF00082	0.806
CLV_PCSK_KEX2_1	348	350	PF00082	0.644
CLV_PCSK_KEX2_1	357	359	PF00082	0.594
CLV_PCSK_KEX2_1	47	49	PF00082	0.646
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.854
CLV_PCSK_PC7_1	344	350	PF00082	0.632
CLV_PCSK_SKI1_1	387	391	PF00082	0.714
CLV_PCSK_SKI1_1	426	430	PF00082	0.704
DEG_APCC_DBOX_1	206	214	PF00400	0.644
DEG_SCF_FBW7_1	232	237	PF00400	0.713
DEG_SCF_FBW7_1	389	394	PF00400	0.707
DEG_SPOP_SBC_1	297	301	PF00917	0.690
DEG_SPOP_SBC_1	33	37	PF00917	0.719
DOC_CKS1_1	231	236	PF01111	0.716
DOC_CKS1_1	306	311	PF01111	0.685
DOC_CKS1_1	379	384	PF01111	0.585
DOC_CYCLIN_RxL_1	421	434	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	101	107	PF00134	0.554
DOC_MAPK_DCC_7	238	247	PF00069	0.733
DOC_MAPK_HePTP_8	235	247	PF00069	0.728
DOC_MAPK_MEF2A_6	238	247	PF00069	0.733
DOC_MAPK_RevD_3	336	349	PF00069	0.639
DOC_PP1_RVXF_1	424	431	PF00149	0.492
DOC_PP2B_LxvP_1	101	104	PF13499	0.665
DOC_PP2B_LxvP_1	240	243	PF13499	0.730
DOC_PP4_FxxP_1	231	234	PF00568	0.717
DOC_USP7_MATH_1	155	159	PF00917	0.760
DOC_USP7_MATH_1	171	175	PF00917	0.545
DOC_USP7_MATH_1	280	284	PF00917	0.568
DOC_USP7_MATH_1	298	302	PF00917	0.636
DOC_USP7_MATH_1	34	38	PF00917	0.760
DOC_USP7_MATH_1	391	395	PF00917	0.665
DOC_USP7_MATH_1	413	417	PF00917	0.609
DOC_WW_Pin1_4	128	133	PF00397	0.758
DOC_WW_Pin1_4	230	235	PF00397	0.721
DOC_WW_Pin1_4	305	310	PF00397	0.756
DOC_WW_Pin1_4	324	329	PF00397	0.437
DOC_WW_Pin1_4	332	337	PF00397	0.601
DOC_WW_Pin1_4	375	380	PF00397	0.711
DOC_WW_Pin1_4	387	392	PF00397	0.621
DOC_WW_Pin1_4	459	464	PF00397	0.516
LIG_14-3-3_CanoR_1	112	118	PF00244	0.699
LIG_14-3-3_CanoR_1	262	267	PF00244	0.747
LIG_14-3-3_CanoR_1	296	306	PF00244	0.741
LIG_14-3-3_CanoR_1	32	41	PF00244	0.570
LIG_14-3-3_CanoR_1	426	431	PF00244	0.632
LIG_14-3-3_CanoR_1	47	56	PF00244	0.568
LIG_14-3-3_CanoR_1	89	98	PF00244	0.580
LIG_AP2alpha_2	220	222	PF02296	0.737
LIG_BIR_III_2	24	28	PF00653	0.671
LIG_BRCT_BRCA1_1	415	419	PF00533	0.674
LIG_BRCT_BRCA1_1	98	102	PF00533	0.653
LIG_deltaCOP1_diTrp_1	364	374	PF00928	0.645
LIG_EVH1_2	382	386	PF00568	0.594
LIG_FHA_1	13	19	PF00498	0.811
LIG_FHA_1	235	241	PF00498	0.720
LIG_FHA_2	282	288	PF00498	0.749
LIG_FHA_2	328	334	PF00498	0.682
LIG_FHA_2	388	394	PF00498	0.707
LIG_FHA_2	429	435	PF00498	0.719
LIG_Integrin_RGD_1	395	397	PF01839	0.699
LIG_LIR_Gen_1	61	69	PF02991	0.707
LIG_LIR_Nem_3	61	65	PF02991	0.702
LIG_MAD2	351	359	PF02301	0.574
LIG_SH2_CRK	326	330	PF00017	0.676
LIG_SH2_STAP1	62	66	PF00017	0.711
LIG_SH2_STAT5	307	310	PF00017	0.682
LIG_SH3_2	379	384	PF14604	0.579
LIG_SH3_3	177	183	PF00018	0.671
LIG_SH3_3	20	26	PF00018	0.700
LIG_SH3_3	246	252	PF00018	0.735
LIG_SH3_3	322	328	PF00018	0.615
LIG_SH3_3	376	382	PF00018	0.622
LIG_SH3_3	403	409	PF00018	0.611
LIG_SH3_3	72	78	PF00018	0.695
LIG_SUMO_SIM_par_1	327	333	PF11976	0.680
LIG_TRAF2_1	183	186	PF00917	0.713
LIG_TRAF2_1	285	288	PF00917	0.753
LIG_TYR_ITIM	324	329	PF00017	0.682
LIG_WRC_WIRS_1	427	432	PF05994	0.506
LIG_WW_3	381	385	PF00397	0.550
MOD_CDK_SPxK_1	305	311	PF00069	0.757
MOD_CDK_SPxK_1	378	384	PF00069	0.549
MOD_CDK_SPxxK_3	459	466	PF00069	0.524
MOD_CK1_1	28	34	PF00069	0.738
MOD_CK1_1	281	287	PF00069	0.684
MOD_CK1_1	299	305	PF00069	0.586
MOD_CK1_1	3	9	PF00069	0.601
MOD_CK1_1	327	333	PF00069	0.680
MOD_CK1_1	36	42	PF00069	0.685
MOD_CK1_1	378	384	PF00069	0.586
MOD_CK1_1	61	67	PF00069	0.581
MOD_CK1_1	88	94	PF00069	0.756
MOD_CK2_1	111	117	PF00069	0.741
MOD_CK2_1	281	287	PF00069	0.750
MOD_CK2_1	387	393	PF00069	0.713
MOD_DYRK1A_RPxSP_1	387	391	PF00069	0.714
MOD_GlcNHglycan	191	195	PF01048	0.564
MOD_GlcNHglycan	222	225	PF01048	0.674
MOD_GlcNHglycan	280	283	PF01048	0.755
MOD_GlcNHglycan	317	320	PF01048	0.632
MOD_GlcNHglycan	359	362	PF01048	0.739
MOD_GlcNHglycan	398	404	PF01048	0.703
MOD_GlcNHglycan	445	449	PF01048	0.547
MOD_GlcNHglycan	51	54	PF01048	0.657
MOD_GSK3_1	124	131	PF00069	0.762
MOD_GSK3_1	190	197	PF00069	0.582
MOD_GSK3_1	230	237	PF00069	0.717
MOD_GSK3_1	28	35	PF00069	0.742
MOD_GSK3_1	297	304	PF00069	0.636
MOD_GSK3_1	374	381	PF00069	0.689
MOD_GSK3_1	387	394	PF00069	0.590
MOD_GSK3_1	85	92	PF00069	0.759
MOD_N-GLC_1	302	307	PF02516	0.687
MOD_NEK2_1	374	379	PF00069	0.691
MOD_OFUCOSY	115	120	PF10250	0.549
MOD_PIKK_1	250	256	PF00454	0.709
MOD_PIKK_1	407	413	PF00454	0.739
MOD_PKA_1	357	363	PF00069	0.672
MOD_PKA_2	111	117	PF00069	0.682
MOD_PKA_2	206	212	PF00069	0.771
MOD_PKA_2	357	363	PF00069	0.713
MOD_PKA_2	49	55	PF00069	0.585
MOD_PKA_2	88	94	PF00069	0.756
MOD_Plk_1	155	161	PF00069	0.605
MOD_Plk_1	302	308	PF00069	0.686
MOD_Plk_1	94	100	PF00069	0.559
MOD_Plk_2-3	143	149	PF00069	0.666
MOD_Plk_4	262	268	PF00069	0.742
MOD_Plk_4	302	308	PF00069	0.760
MOD_Plk_4	36	42	PF00069	0.762
MOD_Plk_4	61	67	PF00069	0.684
MOD_ProDKin_1	128	134	PF00069	0.757
MOD_ProDKin_1	230	236	PF00069	0.719
MOD_ProDKin_1	305	311	PF00069	0.757
MOD_ProDKin_1	324	330	PF00069	0.436
MOD_ProDKin_1	332	338	PF00069	0.604
MOD_ProDKin_1	375	381	PF00069	0.711
MOD_ProDKin_1	387	393	PF00069	0.621
MOD_ProDKin_1	459	465	PF00069	0.517
TRG_DiLeu_BaEn_1	423	428	PF01217	0.681
TRG_DiLeu_BaEn_1	435	440	PF01217	0.584
TRG_DiLeu_LyEn_5	423	428	PF01217	0.681
TRG_ENDOCYTIC_2	326	329	PF00928	0.677
TRG_ENDOCYTIC_2	62	65	PF00928	0.713
TRG_ER_diArg_1	139	141	PF00400	0.800
TRG_ER_diArg_1	348	351	PF00400	0.648
TRG_ER_diArg_1	357	359	PF00400	0.594
TRG_ER_diArg_1	47	50	PF00400	0.646
TRG_NLS_MonoExtC_3	137	142	PF00514	0.856

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HGW6	Leishmania braziliensis	56%	100%
E9B086	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q7Z9	Leishmania major	88%	100%