G2 M phase-specific E3 ubiquitin- ligase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7K0_LEIDO

TriTrypDb:

LdBPK_282680.1 , LdCL_280031900 , LDHU3_28.3620

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7K0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.655
CLV_C14_Caspase3-7	280	284	PF00656	0.646
CLV_C14_Caspase3-7	397	401	PF00656	0.598
CLV_C14_Caspase3-7	64	68	PF00656	0.689
CLV_NRD_NRD_1	200	202	PF00675	0.531
CLV_NRD_NRD_1	213	215	PF00675	0.571
CLV_NRD_NRD_1	491	493	PF00675	0.429
CLV_NRD_NRD_1	52	54	PF00675	0.599
CLV_NRD_NRD_1	75	77	PF00675	0.709
CLV_PCSK_FUR_1	213	217	PF00082	0.580
CLV_PCSK_KEX2_1	200	202	PF00082	0.531
CLV_PCSK_KEX2_1	213	215	PF00082	0.571
CLV_PCSK_KEX2_1	277	279	PF00082	0.596
CLV_PCSK_KEX2_1	491	493	PF00082	0.415
CLV_PCSK_KEX2_1	52	54	PF00082	0.599
CLV_PCSK_KEX2_1	75	77	PF00082	0.709
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.586
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.596
CLV_PCSK_SKI1_1	160	164	PF00082	0.653
CLV_PCSK_SKI1_1	466	470	PF00082	0.438
CLV_PCSK_SKI1_1	55	59	PF00082	0.592
CLV_PCSK_SKI1_1	75	79	PF00082	0.500
DEG_Nend_UBRbox_2	1	3	PF02207	0.600
DEG_SPOP_SBC_1	175	179	PF00917	0.602
DEG_SPOP_SBC_1	262	266	PF00917	0.684
DEG_SPOP_SBC_1	374	378	PF00917	0.690
DOC_CYCLIN_RxL_1	460	473	PF00134	0.418
DOC_MAPK_gen_1	310	319	PF00069	0.660
DOC_MAPK_gen_1	502	510	PF00069	0.506
DOC_MAPK_gen_1	52	59	PF00069	0.594
DOC_PP2B_PxIxI_1	451	457	PF00149	0.499
DOC_USP7_MATH_1	119	123	PF00917	0.728
DOC_USP7_MATH_1	147	151	PF00917	0.576
DOC_USP7_MATH_1	174	178	PF00917	0.632
DOC_USP7_MATH_1	187	191	PF00917	0.619
DOC_USP7_MATH_1	23	27	PF00917	0.628
DOC_USP7_MATH_1	243	247	PF00917	0.722
DOC_USP7_MATH_1	248	252	PF00917	0.799
DOC_USP7_MATH_1	254	258	PF00917	0.672
DOC_USP7_MATH_1	262	266	PF00917	0.532
DOC_WW_Pin1_4	228	233	PF00397	0.637
DOC_WW_Pin1_4	255	260	PF00397	0.717
DOC_WW_Pin1_4	41	46	PF00397	0.648
DOC_WW_Pin1_4	475	480	PF00397	0.569
DOC_WW_Pin1_4	503	508	PF00397	0.510
LIG_14-3-3_CanoR_1	75	80	PF00244	0.704
LIG_APCC_ABBA_1	57	62	PF00400	0.596
LIG_BIR_III_2	346	350	PF00653	0.707
LIG_BIR_III_4	125	129	PF00653	0.592
LIG_BRCT_BRCA1_1	147	151	PF00533	0.628
LIG_deltaCOP1_diTrp_1	411	418	PF00928	0.606
LIG_FHA_1	119	125	PF00498	0.655
LIG_FHA_1	376	382	PF00498	0.586
LIG_FHA_1	471	477	PF00498	0.543
LIG_FHA_1	52	58	PF00498	0.593
LIG_FHA_2	240	246	PF00498	0.613
LIG_FHA_2	30	36	PF00498	0.706
LIG_FHA_2	316	322	PF00498	0.557
LIG_FXI_DFP_1	415	419	PF00024	0.702
LIG_Integrin_isoDGR_2	302	304	PF01839	0.597
LIG_LIR_Gen_1	414	422	PF02991	0.613
LIG_LIR_Nem_3	294	299	PF02991	0.628
LIG_LIR_Nem_3	411	415	PF02991	0.612
LIG_PDZ_Class_1	512	517	PF00595	0.625
LIG_SH2_CRK	497	501	PF00017	0.441
LIG_SH2_STAP1	315	319	PF00017	0.665
LIG_SH3_3	159	165	PF00018	0.598
LIG_SH3_3	256	262	PF00018	0.707
LIG_SH3_3	267	273	PF00018	0.632
LIG_SH3_3	39	45	PF00018	0.740
LIG_SH3_3	473	479	PF00018	0.572
LIG_SUMO_SIM_par_1	433	439	PF11976	0.420
LIG_SUMO_SIM_par_1	505	511	PF11976	0.625
LIG_TRAF2_1	134	137	PF00917	0.608
LIG_TRAF2_1	3	6	PF00917	0.561
LIG_WW_3	49	53	PF00397	0.720
MOD_CDK_SPK_2	228	233	PF00069	0.690
MOD_CK1_1	150	156	PF00069	0.645
MOD_CK1_1	263	269	PF00069	0.790
MOD_CK1_1	27	33	PF00069	0.767
MOD_CK2_1	11	17	PF00069	0.681
MOD_CK2_1	131	137	PF00069	0.607
MOD_CK2_1	239	245	PF00069	0.654
MOD_CK2_1	261	267	PF00069	0.718
MOD_CK2_1	315	321	PF00069	0.553
MOD_CK2_1	475	481	PF00069	0.612
MOD_Cter_Amidation	73	76	PF01082	0.717
MOD_GlcNHglycan	140	143	PF01048	0.585
MOD_GlcNHglycan	189	192	PF01048	0.629
MOD_GlcNHglycan	222	225	PF01048	0.661
MOD_GlcNHglycan	245	248	PF01048	0.700
MOD_GlcNHglycan	250	253	PF01048	0.652
MOD_GlcNHglycan	27	30	PF01048	0.711
MOD_GlcNHglycan	37	40	PF01048	0.682
MOD_GlcNHglycan	385	388	PF01048	0.763
MOD_GlcNHglycan	96	99	PF01048	0.511
MOD_GSK3_1	114	121	PF00069	0.679
MOD_GSK3_1	220	227	PF00069	0.691
MOD_GSK3_1	23	30	PF00069	0.699
MOD_GSK3_1	239	246	PF00069	0.551
MOD_NEK2_2	176	181	PF00069	0.642
MOD_PIKK_1	75	81	PF00454	0.702
MOD_PKA_1	75	81	PF00069	0.702
MOD_PKA_2	51	57	PF00069	0.597
MOD_PKA_2	75	81	PF00069	0.702
MOD_PKB_1	158	166	PF00069	0.652
MOD_Plk_1	109	115	PF00069	0.590
MOD_Plk_1	315	321	PF00069	0.671
MOD_Plk_2-3	333	339	PF00069	0.604
MOD_Plk_4	119	125	PF00069	0.730
MOD_Plk_4	147	153	PF00069	0.534
MOD_Plk_4	496	502	PF00069	0.611
MOD_ProDKin_1	228	234	PF00069	0.639
MOD_ProDKin_1	255	261	PF00069	0.718
MOD_ProDKin_1	41	47	PF00069	0.646
MOD_ProDKin_1	475	481	PF00069	0.567
MOD_ProDKin_1	503	509	PF00069	0.507
TRG_DiLeu_BaEn_1	194	199	PF01217	0.516
TRG_DiLeu_BaEn_2	456	462	PF01217	0.422
TRG_DiLeu_BaEn_4	424	430	PF01217	0.647
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.600
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.404
TRG_ENDOCYTIC_2	497	500	PF00928	0.442
TRG_ER_diArg_1	157	160	PF00400	0.721
TRG_ER_diArg_1	199	201	PF00400	0.523
TRG_ER_diArg_1	213	216	PF00400	0.570
TRG_ER_diArg_1	309	312	PF00400	0.627
TRG_ER_diArg_1	490	492	PF00400	0.418
TRG_ER_diArg_1	501	504	PF00400	0.482
TRG_ER_diArg_1	51	53	PF00400	0.721
TRG_NLS_Bipartite_1	200	218	PF00514	0.537
TRG_NLS_MonoExtC_3	213	218	PF00514	0.587
TRG_NLS_MonoExtN_4	213	218	PF00514	0.587
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA28	Leptomonas seymouri	43%	100%
A4HGV1	Leishmania braziliensis	64%	98%
A4I3Y1	Leishmania infantum	99%	100%
E9B071	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4Q814	Leishmania major	85%	99%