DNA replication licensing factor MCM6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication licensing factor, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7J9_LEIDO

TriTrypDb:

LdBPK_282550.1 , LdCL_280030600 , LDHU3_28.3460

Length:

880

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0032991	protein-containing complex	1	12
GO:0042555	MCM complex	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S5H7J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7J9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006270	DNA replication initiation	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0007049	cell cycle	2	11
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006260	DNA replication	5	1
GO:0006261	DNA-templated DNA replication	6	1
GO:0006268	DNA unwinding involved in DNA replication	9	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0032392	DNA geometric change	7	1
GO:0032508	DNA duplex unwinding	8	1
GO:0033260	nuclear DNA replication	4	1
GO:0033554	cellular response to stress	3	1
GO:0044786	cell cycle DNA replication	3	1
GO:0050896	response to stimulus	1	1
GO:0051276	chromosome organization	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071103	DNA conformation change	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902969	mitotic DNA replication	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003678	DNA helicase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003697	single-stranded DNA binding	5	1
GO:0016462	pyrophosphatase activity	5	3
GO:0016817	hydrolase activity, acting on acid anhydrides	3	3
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	3
GO:0016887	ATP hydrolysis activity	7	3
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.446
CLV_C14_Caspase3-7	361	365	PF00656	0.487
CLV_C14_Caspase3-7	722	726	PF00656	0.602
CLV_NRD_NRD_1	299	301	PF00675	0.527
CLV_NRD_NRD_1	352	354	PF00675	0.497
CLV_NRD_NRD_1	386	388	PF00675	0.309
CLV_NRD_NRD_1	558	560	PF00675	0.250
CLV_NRD_NRD_1	784	786	PF00675	0.385
CLV_PCSK_KEX2_1	299	301	PF00082	0.527
CLV_PCSK_KEX2_1	386	388	PF00082	0.308
CLV_PCSK_KEX2_1	557	559	PF00082	0.238
CLV_PCSK_KEX2_1	784	786	PF00082	0.385
CLV_PCSK_SKI1_1	153	157	PF00082	0.464
CLV_PCSK_SKI1_1	304	308	PF00082	0.676
CLV_PCSK_SKI1_1	353	357	PF00082	0.517
CLV_PCSK_SKI1_1	360	364	PF00082	0.584
CLV_PCSK_SKI1_1	393	397	PF00082	0.259
CLV_PCSK_SKI1_1	428	432	PF00082	0.269
CLV_PCSK_SKI1_1	625	629	PF00082	0.271
CLV_PCSK_SKI1_1	832	836	PF00082	0.324
CLV_Separin_Metazoa	695	699	PF03568	0.447
DEG_APCC_DBOX_1	573	581	PF00400	0.459
DEG_APCC_DBOX_1	697	705	PF00400	0.465
DEG_Kelch_Keap1_1	481	486	PF01344	0.508
DEG_Nend_UBRbox_3	1	3	PF02207	0.664
DEG_SCF_FBW7_1	627	632	PF00400	0.533
DEG_SIAH_1	14	22	PF03145	0.685
DOC_ANK_TNKS_1	276	283	PF00023	0.552
DOC_CKS1_1	373	378	PF01111	0.589
DOC_CYCLIN_RxL_1	828	838	PF00134	0.533
DOC_MAPK_DCC_7	861	870	PF00069	0.585
DOC_MAPK_gen_1	139	148	PF00069	0.432
DOC_MAPK_gen_1	31	40	PF00069	0.387
DOC_MAPK_gen_1	630	640	PF00069	0.458
DOC_MAPK_gen_1	848	858	PF00069	0.447
DOC_MAPK_HePTP_8	858	870	PF00069	0.651
DOC_MAPK_MEF2A_6	139	148	PF00069	0.432
DOC_MAPK_MEF2A_6	182	189	PF00069	0.447
DOC_MAPK_MEF2A_6	31	40	PF00069	0.442
DOC_MAPK_MEF2A_6	405	413	PF00069	0.458
DOC_MAPK_MEF2A_6	432	439	PF00069	0.459
DOC_MAPK_MEF2A_6	49	56	PF00069	0.561
DOC_MAPK_MEF2A_6	574	582	PF00069	0.459
DOC_MAPK_MEF2A_6	686	694	PF00069	0.488
DOC_MAPK_MEF2A_6	851	860	PF00069	0.447
DOC_MAPK_MEF2A_6	861	870	PF00069	0.585
DOC_MAPK_NFAT4_5	410	418	PF00069	0.447
DOC_MAPK_RevD_3	285	300	PF00069	0.643
DOC_PP4_MxPP_1	1	4	PF00568	0.709
DOC_USP7_MATH_1	394	398	PF00917	0.533
DOC_USP7_MATH_1	540	544	PF00917	0.438
DOC_USP7_MATH_1	57	61	PF00917	0.653
DOC_USP7_MATH_1	570	574	PF00917	0.447
DOC_USP7_MATH_1	68	72	PF00917	0.582
DOC_USP7_MATH_1	735	739	PF00917	0.740
DOC_USP7_MATH_1	756	760	PF00917	0.694
DOC_USP7_MATH_1	773	777	PF00917	0.714
DOC_USP7_UBL2_3	509	513	PF12436	0.447
DOC_USP7_UBL2_3	531	535	PF12436	0.447
DOC_USP7_UBL2_3	786	790	PF12436	0.533
DOC_WW_Pin1_4	114	119	PF00397	0.415
DOC_WW_Pin1_4	372	377	PF00397	0.490
DOC_WW_Pin1_4	625	630	PF00397	0.480
LIG_14-3-3_CanoR_1	161	165	PF00244	0.466
LIG_14-3-3_CanoR_1	177	185	PF00244	0.416
LIG_14-3-3_CanoR_1	609	619	PF00244	0.414
LIG_14-3-3_CanoR_1	622	628	PF00244	0.434
LIG_14-3-3_CanoR_1	660	666	PF00244	0.447
LIG_14-3-3_CanoR_1	671	679	PF00244	0.447
LIG_14-3-3_CanoR_1	698	706	PF00244	0.539
LIG_14-3-3_CanoR_1	736	745	PF00244	0.768
LIG_14-3-3_CanoR_1	81	88	PF00244	0.439
LIG_Actin_WH2_2	148	163	PF00022	0.441
LIG_BIR_III_2	811	815	PF00653	0.552
LIG_BIR_III_4	26	30	PF00653	0.493
LIG_BIR_III_4	347	351	PF00653	0.553
LIG_BRCT_BRCA1_1	144	148	PF00533	0.423
LIG_Clathr_ClatBox_1	855	859	PF01394	0.426
LIG_DLG_GKlike_1	387	395	PF00625	0.522
LIG_FHA_1	176	182	PF00498	0.447
LIG_FHA_1	195	201	PF00498	0.447
LIG_FHA_1	257	263	PF00498	0.467
LIG_FHA_1	321	327	PF00498	0.613
LIG_FHA_1	354	360	PF00498	0.541
LIG_FHA_1	394	400	PF00498	0.456
LIG_FHA_1	473	479	PF00498	0.456
LIG_FHA_1	524	530	PF00498	0.447
LIG_FHA_1	540	546	PF00498	0.447
LIG_FHA_1	566	572	PF00498	0.447
LIG_FHA_1	626	632	PF00498	0.464
LIG_FHA_1	660	666	PF00498	0.447
LIG_FHA_1	674	680	PF00498	0.488
LIG_FHA_1	819	825	PF00498	0.512
LIG_FHA_1	88	94	PF00498	0.382
LIG_FHA_2	342	348	PF00498	0.421
LIG_FHA_2	373	379	PF00498	0.481
LIG_FHA_2	422	428	PF00498	0.533
LIG_FHA_2	611	617	PF00498	0.515
LIG_FHA_2	686	692	PF00498	0.513
LIG_FHA_2	705	711	PF00498	0.486
LIG_FHA_2	717	723	PF00498	0.608
LIG_FHA_2	813	819	PF00498	0.508
LIG_GBD_Chelix_1	797	805	PF00786	0.288
LIG_Integrin_RGD_1	432	434	PF01839	0.247
LIG_LIR_Gen_1	110	120	PF02991	0.368
LIG_LIR_Gen_1	145	155	PF02991	0.465
LIG_LIR_Gen_1	238	244	PF02991	0.456
LIG_LIR_Gen_1	505	512	PF02991	0.447
LIG_LIR_Gen_1	573	582	PF02991	0.447
LIG_LIR_Gen_1	792	803	PF02991	0.488
LIG_LIR_Gen_1	838	849	PF02991	0.448
LIG_LIR_Gen_1	97	106	PF02991	0.420
LIG_LIR_Nem_3	110	116	PF02991	0.366
LIG_LIR_Nem_3	145	151	PF02991	0.424
LIG_LIR_Nem_3	238	242	PF02991	0.456
LIG_LIR_Nem_3	576	582	PF02991	0.447
LIG_LIR_Nem_3	614	620	PF02991	0.317
LIG_LIR_Nem_3	792	798	PF02991	0.447
LIG_LIR_Nem_3	838	844	PF02991	0.448
LIG_LIR_Nem_3	97	101	PF02991	0.396
LIG_NRBOX	410	416	PF00104	0.459
LIG_PCNA_yPIPBox_3	115	128	PF02747	0.485
LIG_PCNA_yPIPBox_3	840	850	PF02747	0.459
LIG_Pex14_2	575	579	PF04695	0.447
LIG_SH2_GRB2like	136	139	PF00017	0.488
LIG_SH2_GRB2like	841	844	PF00017	0.459
LIG_SH2_NCK_1	208	212	PF00017	0.459
LIG_SH2_PTP2	841	844	PF00017	0.459
LIG_SH2_SRC	869	872	PF00017	0.618
LIG_SH2_STAP1	623	627	PF00017	0.459
LIG_SH2_STAT3	823	826	PF00017	0.459
LIG_SH2_STAT5	208	211	PF00017	0.459
LIG_SH2_STAT5	463	466	PF00017	0.447
LIG_SH2_STAT5	620	623	PF00017	0.441
LIG_SH2_STAT5	74	77	PF00017	0.420
LIG_SH2_STAT5	794	797	PF00017	0.459
LIG_SH2_STAT5	823	826	PF00017	0.528
LIG_SH2_STAT5	841	844	PF00017	0.454
LIG_SH2_STAT5	869	872	PF00017	0.591
LIG_SH3_1	7	13	PF00018	0.725
LIG_SH3_3	226	232	PF00018	0.459
LIG_SH3_3	268	274	PF00018	0.445
LIG_SH3_3	370	376	PF00018	0.601
LIG_SH3_3	437	443	PF00018	0.459
LIG_SH3_3	605	611	PF00018	0.449
LIG_SH3_3	7	13	PF00018	0.725
LIG_SUMO_SIM_anti_2	707	713	PF11976	0.511
LIG_SUMO_SIM_par_1	21	26	PF11976	0.581
LIG_SUMO_SIM_par_1	854	859	PF11976	0.426
LIG_TRAF2_1	815	818	PF00917	0.533
LIG_TRFH_1	225	229	PF08558	0.438
LIG_TYR_ITIM	839	844	PF00017	0.459
LIG_WW_3	864	868	PF00397	0.469
MOD_CDK_SPK_2	625	630	PF00069	0.472
MOD_CDK_SPxxK_3	372	379	PF00069	0.585
MOD_CK1_1	422	428	PF00069	0.447
MOD_CK1_1	469	475	PF00069	0.471
MOD_CK1_1	653	659	PF00069	0.447
MOD_CK1_1	673	679	PF00069	0.479
MOD_CK1_1	700	706	PF00069	0.547
MOD_CK1_1	740	746	PF00069	0.759
MOD_CK1_1	774	780	PF00069	0.694
MOD_CK1_1	83	89	PF00069	0.459
MOD_CK2_1	372	378	PF00069	0.475
MOD_CK2_1	421	427	PF00069	0.488
MOD_CK2_1	685	691	PF00069	0.533
MOD_CK2_1	704	710	PF00069	0.482
MOD_CK2_1	716	722	PF00069	0.604
MOD_CK2_1	812	818	PF00069	0.466
MOD_DYRK1A_RPxSP_1	625	629	PF00069	0.472
MOD_GlcNHglycan	454	457	PF01048	0.280
MOD_GlcNHglycan	464	467	PF01048	0.210
MOD_GlcNHglycan	471	474	PF01048	0.173
MOD_GlcNHglycan	583	587	PF01048	0.333
MOD_GlcNHglycan	59	62	PF01048	0.661
MOD_GlcNHglycan	63	68	PF01048	0.645
MOD_GlcNHglycan	725	728	PF01048	0.740
MOD_GlcNHglycan	737	740	PF01048	0.785
MOD_GlcNHglycan	757	761	PF01048	0.433
MOD_GlcNHglycan	773	776	PF01048	0.659
MOD_GSK3_1	142	149	PF00069	0.432
MOD_GSK3_1	156	163	PF00069	0.295
MOD_GSK3_1	190	197	PF00069	0.528
MOD_GSK3_1	206	213	PF00069	0.447
MOD_GSK3_1	441	448	PF00069	0.447
MOD_GSK3_1	462	469	PF00069	0.447
MOD_GSK3_1	472	479	PF00069	0.447
MOD_GSK3_1	481	488	PF00069	0.447
MOD_GSK3_1	625	632	PF00069	0.512
MOD_GSK3_1	63	70	PF00069	0.682
MOD_GSK3_1	700	707	PF00069	0.554
MOD_GSK3_1	735	742	PF00069	0.728
MOD_GSK3_1	80	87	PF00069	0.462
MOD_N-GLC_1	653	658	PF02516	0.259
MOD_N-GLC_1	716	721	PF02516	0.532
MOD_N-GLC_2	436	438	PF02516	0.247
MOD_NEK2_1	146	151	PF00069	0.380
MOD_NEK2_1	160	165	PF00069	0.419
MOD_NEK2_1	320	325	PF00069	0.712
MOD_NEK2_1	340	345	PF00069	0.247
MOD_NEK2_1	38	43	PF00069	0.469
MOD_NEK2_1	474	479	PF00069	0.447
MOD_NEK2_1	648	653	PF00069	0.463
MOD_NEK2_1	665	670	PF00069	0.447
MOD_NEK2_1	697	702	PF00069	0.440
MOD_NEK2_1	844	849	PF00069	0.528
MOD_NEK2_2	716	721	PF00069	0.666
MOD_PIKK_1	176	182	PF00454	0.447
MOD_PIKK_1	353	359	PF00454	0.603
MOD_PIKK_1	445	451	PF00454	0.459
MOD_PIKK_1	633	639	PF00454	0.513
MOD_PK_1	785	791	PF00069	0.533
MOD_PKA_1	353	359	PF00069	0.533
MOD_PKA_1	785	791	PF00069	0.533
MOD_PKA_2	160	166	PF00069	0.456
MOD_PKA_2	176	182	PF00069	0.416
MOD_PKA_2	190	196	PF00069	0.447
MOD_PKA_2	629	635	PF00069	0.469
MOD_PKA_2	659	665	PF00069	0.447
MOD_PKA_2	670	676	PF00069	0.447
MOD_PKA_2	685	691	PF00069	0.508
MOD_PKA_2	697	703	PF00069	0.374
MOD_PKA_2	735	741	PF00069	0.781
MOD_PKA_2	80	86	PF00069	0.428
MOD_Plk_1	485	491	PF00069	0.447
MOD_Plk_1	633	639	PF00069	0.474
MOD_Plk_1	716	722	PF00069	0.707
MOD_Plk_4	142	148	PF00069	0.439
MOD_Plk_4	160	166	PF00069	0.372
MOD_Plk_4	387	393	PF00069	0.522
MOD_Plk_4	540	546	PF00069	0.447
MOD_Plk_4	665	671	PF00069	0.442
MOD_Plk_4	818	824	PF00069	0.488
MOD_ProDKin_1	114	120	PF00069	0.408
MOD_ProDKin_1	372	378	PF00069	0.483
MOD_ProDKin_1	625	631	PF00069	0.480
MOD_SUMO_for_1	728	731	PF00179	0.758
MOD_SUMO_rev_2	347	356	PF00179	0.501
MOD_SUMO_rev_2	847	856	PF00179	0.506
TRG_DiLeu_BaEn_1	490	495	PF01217	0.447
TRG_DiLeu_BaEn_1	634	639	PF01217	0.459
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.493
TRG_DiLeu_BaLyEn_6	661	666	PF01217	0.447
TRG_DiLeu_BaLyEn_6	830	835	PF01217	0.533
TRG_ENDOCYTIC_2	643	646	PF00928	0.447
TRG_ENDOCYTIC_2	794	797	PF00928	0.447
TRG_ENDOCYTIC_2	841	844	PF00928	0.454
TRG_ER_diArg_1	30	33	PF00400	0.475
TRG_ER_diArg_1	379	382	PF00400	0.526
TRG_ER_diArg_1	385	387	PF00400	0.499
TRG_ER_diArg_1	557	559	PF00400	0.528
TRG_ER_diArg_1	783	785	PF00400	0.664
TRG_NES_CRM1_1	695	710	PF08389	0.562
TRG_Pf-PMV_PEXEL_1	832	836	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2J6	Leptomonas seymouri	87%	99%
A0A0N1PC47	Leptomonas seymouri	28%	100%
A0A0S4IK09	Bodo saltans	31%	89%
A0A0S4IVB8	Bodo saltans	60%	100%
A0A0S4IYQ3	Bodo saltans	28%	100%
A0A1X0NQM5	Trypanosomatidae	70%	99%
A0A1X0NT66	Trypanosomatidae	32%	100%
A0A1X0NVE7	Trypanosomatidae	29%	100%
A0A3S5H7S8	Leishmania donovani	32%	100%
A0A3S7WY81	Leishmania donovani	28%	100%
A0A422N694	Trypanosoma rangeli	75%	100%
A0A422NHH5	Trypanosoma rangeli	29%	100%
A4FUD9	Bos taurus	31%	100%
A4HDE7	Leishmania braziliensis	29%	100%
A4HGU2	Leishmania braziliensis	94%	100%
A4HKT9	Leishmania braziliensis	33%	100%
A4I0T0	Leishmania infantum	30%	100%
A4I3W9	Leishmania infantum	100%	100%
A4I8B8	Leishmania infantum	32%	100%
B8AZ14	Oryza sativa subsp. indica	29%	100%
B8AZ99	Oryza sativa subsp. indica	33%	100%
B8AZX3	Oryza sativa subsp. indica	40%	100%
B9FKM7	Oryza sativa subsp. japonica	29%	100%
D0A759	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A936	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
D0A999	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0AAI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D3ZVK1	Rattus norvegicus	31%	100%
E1BPX4	Bos taurus	31%	100%
E9AWT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B059	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9B377	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
F4KAB8	Arabidopsis thaliana	38%	100%
F6RIX4	Xenopus tropicalis	31%	79%
I0IUP3	Gallus gallus	32%	100%
O80786	Arabidopsis thaliana	32%	100%
P25205	Homo sapiens	32%	100%
P25206	Mus musculus	31%	100%
P29469	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P30664	Xenopus laevis	33%	100%
P30666	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P33991	Homo sapiens	31%	100%
P33992	Homo sapiens	30%	100%
P34647	Caenorhabditis elegans	38%	100%
P40377	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
P41389	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P49718	Mus musculus	30%	100%
P49731	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	99%
P49736	Homo sapiens	32%	97%
P49739	Xenopus laevis	31%	100%
P53091	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	87%
P55861	Xenopus laevis	33%	99%
P55862	Xenopus laevis	29%	100%
P97310	Mus musculus	32%	97%
P97311	Mus musculus	42%	100%
Q0DHC4	Oryza sativa subsp. japonica	33%	100%
Q0V8B7	Bos taurus	31%	100%
Q0V9Q6	Xenopus tropicalis	31%	100%
Q14566	Homo sapiens	42%	100%
Q21902	Caenorhabditis elegans	30%	100%
Q26454	Drosophila melanogaster	32%	100%
Q28BS0	Xenopus tropicalis	32%	100%
Q28CM3	Xenopus tropicalis	40%	100%
Q29JI9	Drosophila pseudoobscura pseudoobscura	40%	100%
Q2KIZ8	Bos taurus	41%	100%
Q43704	Zea mays	31%	100%
Q498J7	Xenopus laevis	40%	100%
Q4Q826	Leishmania major	97%	100%
Q4QAP2	Leishmania major	30%	100%
Q54CP4	Dictyostelium discoideum	29%	100%
Q561P5	Xenopus tropicalis	29%	100%
Q5F310	Xenopus laevis	31%	100%
Q5FWY4	Xenopus laevis	44%	100%
Q5R8G6	Pongo abelii	32%	100%
Q5XK83	Xenopus laevis	31%	100%
Q5ZMN2	Gallus gallus	32%	100%
Q61J08	Caenorhabditis briggsae	36%	100%
Q6DIH3	Xenopus tropicalis	33%	100%
Q6F353	Oryza sativa subsp. japonica	40%	100%
Q6GL41	Xenopus tropicalis	31%	100%
Q6NRM6	Xenopus laevis	31%	77%
Q6P1V8	Xenopus tropicalis	40%	100%
Q6PCI7	Xenopus laevis	28%	100%
Q7Q0Q1	Anopheles gambiae	40%	100%
Q7ZXZ0	Xenopus laevis	32%	100%
Q7ZY18	Xenopus laevis	39%	100%
Q86B14	Dictyostelium discoideum	36%	100%
Q95XQ8	Caenorhabditis elegans	35%	100%
Q9CWV1	Mus musculus	31%	100%
Q9FL33	Arabidopsis thaliana	33%	100%
Q9SF37	Arabidopsis thaliana	29%	100%
Q9SX03	Zea mays	31%	100%
Q9SX04	Zea mays	31%	100%
Q9U1E0	Leishmania major	32%	100%
Q9UJA3	Homo sapiens	31%	100%
Q9UXG1	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	33%	100%
Q9V461	Drosophila melanogaster	39%	100%
Q9VGW6	Drosophila melanogaster	32%	100%
Q9XYU1	Drosophila melanogaster	30%	100%
V5BGQ5	Trypanosoma cruzi	71%	100%
V5BQA9	Trypanosoma cruzi	32%	100%
V5C0K6	Trypanosoma cruzi	29%	100%