Peroxisomal biogenesis factor 11 (PEX11) family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosomal membrane protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H7J8_LEIDO

TriTrypDb:

LdBPK_282420.1 , LdCL_280029200 , LDHU3_28.3270

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0005778	peroxisomal membrane	6	1
GO:0016020	membrane	2	1
GO:0020015	glycosome	7	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H7J8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7J8

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016559	peroxisome fission	6	12
GO:0032535	regulation of cellular component size	4	1
GO:0044375	regulation of peroxisome size	5	1
GO:0048285	organelle fission	5	12
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090066	regulation of anatomical structure size	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.629
CLV_C14_Caspase3-7	147	151	PF00656	0.411
CLV_MEL_PAP_1	196	202	PF00089	0.388
CLV_NRD_NRD_1	125	127	PF00675	0.329
CLV_NRD_NRD_1	152	154	PF00675	0.547
CLV_NRD_NRD_1	85	87	PF00675	0.389
CLV_PCSK_SKI1_1	167	171	PF00082	0.505
CLV_PCSK_SKI1_1	20	24	PF00082	0.305
CLV_PCSK_SKI1_1	3	7	PF00082	0.393
CLV_PCSK_SKI1_1	48	52	PF00082	0.315
CLV_PCSK_SKI1_1	54	58	PF00082	0.270
CLV_PCSK_SKI1_1	87	91	PF00082	0.307
DOC_MAPK_gen_1	126	134	PF00069	0.462
DOC_MAPK_gen_1	58	67	PF00069	0.621
DOC_MAPK_gen_1	86	92	PF00069	0.556
DOC_PP1_RVXF_1	86	93	PF00149	0.531
DOC_USP7_MATH_1	198	202	PF00917	0.323
DOC_USP7_UBL2_3	163	167	PF12436	0.369
DOC_WW_Pin1_4	194	199	PF00397	0.442
LIG_14-3-3_CanoR_1	126	131	PF00244	0.585
LIG_14-3-3_CanoR_1	48	57	PF00244	0.471
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BRCT_BRCA1_1	59	63	PF00533	0.493
LIG_FHA_1	120	126	PF00498	0.574
LIG_FHA_1	13	19	PF00498	0.684
LIG_FHA_1	181	187	PF00498	0.378
LIG_FHA_1	33	39	PF00498	0.479
LIG_LIR_Gen_1	141	151	PF02991	0.213
LIG_LIR_Nem_3	141	146	PF02991	0.213
LIG_LIR_Nem_3	91	96	PF02991	0.517
LIG_NRBOX	144	150	PF00104	0.247
LIG_Pex14_2	63	67	PF04695	0.490
LIG_Pex14_2	89	93	PF04695	0.571
LIG_REV1ctd_RIR_1	90	98	PF16727	0.547
LIG_SH2_CRK	157	161	PF00017	0.383
LIG_SH2_GRB2like	43	46	PF00017	0.479
LIG_SH2_NCK_1	157	161	PF00017	0.393
LIG_SH2_SRC	157	160	PF00017	0.410
LIG_SH2_SRC	43	46	PF00017	0.489
LIG_SH2_STAP1	43	47	PF00017	0.503
LIG_SH2_STAT5	214	217	PF00017	0.529
LIG_SUMO_SIM_par_1	179	185	PF11976	0.321
LIG_UBA3_1	145	154	PF00899	0.247
LIG_UBA3_1	62	68	PF00899	0.422
MOD_CDK_SPK_2	194	199	PF00069	0.379
MOD_CK2_1	68	74	PF00069	0.511
MOD_GlcNHglycan	171	174	PF01048	0.340
MOD_GlcNHglycan	191	194	PF01048	0.653
MOD_GlcNHglycan	200	203	PF01048	0.402
MOD_GlcNHglycan	207	210	PF01048	0.341
MOD_GlcNHglycan	45	48	PF01048	0.508
MOD_GSK3_1	167	174	PF00069	0.444
MOD_GSK3_1	194	201	PF00069	0.390
MOD_GSK3_1	205	212	PF00069	0.428
MOD_GSK3_1	214	221	PF00069	0.560
MOD_GSK3_1	27	34	PF00069	0.436
MOD_GSK3_1	48	55	PF00069	0.411
MOD_LATS_1	124	130	PF00433	0.461
MOD_NEK2_1	138	143	PF00069	0.380
MOD_NEK2_1	149	154	PF00069	0.258
MOD_NEK2_1	31	36	PF00069	0.544
MOD_NEK2_1	57	62	PF00069	0.483
MOD_NEK2_1	6	11	PF00069	0.562
MOD_NEK2_1	63	68	PF00069	0.540
MOD_NEK2_2	209	214	PF00069	0.275
MOD_PIKK_1	214	220	PF00454	0.296
MOD_PK_1	14	20	PF00069	0.368
MOD_PK_1	68	74	PF00069	0.308
MOD_PKA_1	126	132	PF00069	0.310
MOD_PKA_2	198	204	PF00069	0.481
MOD_PKA_2	57	63	PF00069	0.341
MOD_Plk_4	138	144	PF00069	0.403
MOD_Plk_4	177	183	PF00069	0.355
MOD_Plk_4	209	215	PF00069	0.329
MOD_Plk_4	68	74	PF00069	0.424
MOD_ProDKin_1	194	200	PF00069	0.551
TRG_DiLeu_BaEn_2	84	90	PF01217	0.476
TRG_Pf-PMV_PEXEL_1	153	158	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG1	Leptomonas seymouri	47%	100%
A0A0N1PCA1	Leptomonas seymouri	31%	100%
A0A0S4IU25	Bodo saltans	28%	100%
A0A1X0NR15	Trypanosomatidae	26%	100%
A0A3S7X1W3	Leishmania donovani	33%	100%
A0A422N9F6	Trypanosoma rangeli	30%	100%
A4HGS9	Leishmania braziliensis	65%	100%
A4HGT0	Leishmania braziliensis	30%	100%
A4I3V6	Leishmania infantum	97%	100%
A4I3V7	Leishmania infantum	33%	100%
D0A924	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B046	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9B047	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q838	Leishmania major	33%	100%
Q4Q839	Leishmania major	91%	100%
V5BEE7	Trypanosoma cruzi	27%	100%