Elongation factor G 2, mitochondrial, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Elongation factor G 2, mitochondrial, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7J6_LEIDO

TriTrypDb:

LdBPK_282090.1 , LdCL_280025900 , LDHU3_28.2780

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A0A3S5H7J6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7J6

Function

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Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0019538	protein metabolic process	3	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003746	translation elongation factor activity	4	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.452
CLV_C14_Caspase3-7	226	230	PF00656	0.437
CLV_C14_Caspase3-7	608	612	PF00656	0.524
CLV_MEL_PAP_1	7	13	PF00089	0.279
CLV_NRD_NRD_1	199	201	PF00675	0.313
CLV_NRD_NRD_1	203	205	PF00675	0.313
CLV_NRD_NRD_1	237	239	PF00675	0.255
CLV_NRD_NRD_1	249	251	PF00675	0.170
CLV_NRD_NRD_1	271	273	PF00675	0.212
CLV_NRD_NRD_1	418	420	PF00675	0.716

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q5	Leptomonas seymouri	77%	88%
A0A0N1I8V7	Leptomonas seymouri	28%	100%
A0A0N1I9M7	Leptomonas seymouri	22%	86%
A0A0S4JCB6	Bodo saltans	50%	89%
A0A0S4JLF0	Bodo saltans	28%	100%
A0A0S4JP20	Bodo saltans	22%	77%
A0A1X0NQW1	Trypanosomatidae	62%	92%
A0A1X0P8A5	Trypanosomatidae	27%	100%
A0A3R7MX75	Trypanosoma rangeli	23%	86%
A0A3S7XAE9	Leishmania donovani	27%	95%

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