Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H7J3_LEIDO

TriTrypDb:

LdBPK_281560.1 , LdCL_280020300 , LDHU3_28.2010

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7J3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7J3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.499
CLV_C14_Caspase3-7	209	213	PF00656	0.538
CLV_C14_Caspase3-7	640	644	PF00656	0.620
CLV_NRD_NRD_1	18	20	PF00675	0.641
CLV_NRD_NRD_1	244	246	PF00675	0.379
CLV_NRD_NRD_1	26	28	PF00675	0.578
CLV_NRD_NRD_1	276	278	PF00675	0.395
CLV_NRD_NRD_1	326	328	PF00675	0.495
CLV_NRD_NRD_1	37	39	PF00675	0.533
CLV_NRD_NRD_1	545	547	PF00675	0.559
CLV_NRD_NRD_1	695	697	PF00675	0.593
CLV_NRD_NRD_1	713	715	PF00675	0.620
CLV_NRD_NRD_1	95	97	PF00675	0.644
CLV_PCSK_KEX2_1	18	20	PF00082	0.641
CLV_PCSK_KEX2_1	181	183	PF00082	0.417
CLV_PCSK_KEX2_1	244	246	PF00082	0.447
CLV_PCSK_KEX2_1	26	28	PF00082	0.578
CLV_PCSK_KEX2_1	276	278	PF00082	0.395
CLV_PCSK_KEX2_1	292	294	PF00082	0.490
CLV_PCSK_KEX2_1	326	328	PF00082	0.495
CLV_PCSK_KEX2_1	42	44	PF00082	0.642
CLV_PCSK_KEX2_1	468	470	PF00082	0.380
CLV_PCSK_KEX2_1	683	685	PF00082	0.456
CLV_PCSK_KEX2_1	695	697	PF00082	0.570
CLV_PCSK_KEX2_1	713	715	PF00082	0.600
CLV_PCSK_KEX2_1	95	97	PF00082	0.644
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.479
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.511
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.642
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.380
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.408
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.644
CLV_PCSK_PC7_1	38	44	PF00082	0.624
CLV_PCSK_SKI1_1	19	23	PF00082	0.639
CLV_PCSK_SKI1_1	327	331	PF00082	0.487
CLV_PCSK_SKI1_1	39	43	PF00082	0.628
CLV_PCSK_SKI1_1	425	429	PF00082	0.458
CLV_PCSK_SKI1_1	469	473	PF00082	0.452
CLV_PCSK_SKI1_1	588	592	PF00082	0.500
CLV_PCSK_SKI1_1	649	653	PF00082	0.440
CLV_PCSK_SKI1_1	683	687	PF00082	0.487
CLV_PCSK_SKI1_1	697	701	PF00082	0.416
CLV_PCSK_SKI1_1	96	100	PF00082	0.625
DEG_APCC_DBOX_1	600	608	PF00400	0.475
DEG_COP1_1	135	143	PF00400	0.498
DEG_Nend_Nbox_1	1	3	PF02207	0.602
DEG_ODPH_VHL_1	512	525	PF01847	0.460
DEG_SPOP_SBC_1	216	220	PF00917	0.604
DEG_SPOP_SBC_1	353	357	PF00917	0.607
DOC_CKS1_1	311	316	PF01111	0.495
DOC_CKS1_1	444	449	PF01111	0.419
DOC_CYCLIN_RxL_1	160	173	PF00134	0.393
DOC_MAPK_DCC_7	409	417	PF00069	0.408
DOC_MAPK_DCC_7	509	517	PF00069	0.408
DOC_MAPK_gen_1	3	13	PF00069	0.606
DOC_MAPK_gen_1	646	655	PF00069	0.424
DOC_MAPK_MEF2A_6	409	417	PF00069	0.441
DOC_MAPK_MEF2A_6	6	15	PF00069	0.621
DOC_MAPK_MEF2A_6	646	655	PF00069	0.424
DOC_PP1_RVXF_1	163	170	PF00149	0.394
DOC_PP1_RVXF_1	675	681	PF00149	0.454
DOC_PP2B_LxvP_1	13	16	PF13499	0.622
DOC_PP2B_LxvP_1	138	141	PF13499	0.504
DOC_PP2B_LxvP_1	502	505	PF13499	0.441
DOC_PP4_MxPP_1	663	666	PF00568	0.364
DOC_USP7_MATH_1	132	136	PF00917	0.447
DOC_USP7_MATH_1	196	200	PF00917	0.430
DOC_USP7_MATH_1	216	220	PF00917	0.651
DOC_USP7_MATH_1	304	308	PF00917	0.507
DOC_USP7_MATH_1	335	339	PF00917	0.546
DOC_USP7_MATH_1	413	417	PF00917	0.450
DOC_USP7_MATH_1	536	540	PF00917	0.464
DOC_USP7_MATH_1	57	61	PF00917	0.552
DOC_USP7_MATH_1	577	581	PF00917	0.457
DOC_WW_Pin1_4	310	315	PF00397	0.438
DOC_WW_Pin1_4	371	376	PF00397	0.394
DOC_WW_Pin1_4	443	448	PF00397	0.363
DOC_WW_Pin1_4	707	712	PF00397	0.616
LIG_14-3-3_CanoR_1	192	196	PF00244	0.515
LIG_14-3-3_CanoR_1	276	286	PF00244	0.392
LIG_14-3-3_CanoR_1	422	428	PF00244	0.427
LIG_14-3-3_CanoR_1	563	570	PF00244	0.450
LIG_14-3-3_CanoR_1	596	600	PF00244	0.455
LIG_14-3-3_CanoR_1	6	12	PF00244	0.610
LIG_14-3-3_CanoR_1	649	654	PF00244	0.444
LIG_Actin_WH2_2	495	511	PF00022	0.389
LIG_BIR_III_4	212	216	PF00653	0.637
LIG_BRCT_BRCA1_1	105	109	PF00533	0.610
LIG_BRCT_BRCA1_1	198	202	PF00533	0.488
LIG_BRCT_BRCA1_1	429	433	PF00533	0.521
LIG_BRCT_BRCA1_1	79	83	PF00533	0.618
LIG_CtBP_PxDLS_1	505	509	PF00389	0.471
LIG_eIF4E_1	466	472	PF01652	0.372
LIG_FHA_1	143	149	PF00498	0.472
LIG_FHA_1	360	366	PF00498	0.462
LIG_FHA_1	371	377	PF00498	0.319
LIG_FHA_1	454	460	PF00498	0.517
LIG_FHA_1	585	591	PF00498	0.425
LIG_FHA_1	650	656	PF00498	0.363
LIG_FHA_1	72	78	PF00498	0.535
LIG_FHA_1	8	14	PF00498	0.616
LIG_FHA_2	151	157	PF00498	0.488
LIG_FHA_2	184	190	PF00498	0.476
LIG_FHA_2	311	317	PF00498	0.441
LIG_FHA_2	459	465	PF00498	0.365
LIG_FHA_2	613	619	PF00498	0.490
LIG_FHA_2	97	103	PF00498	0.613
LIG_LIR_Apic_2	142	147	PF02991	0.494
LIG_LIR_Gen_1	199	210	PF02991	0.392
LIG_LIR_Gen_1	446	457	PF02991	0.352
LIG_LIR_Gen_1	647	658	PF02991	0.395
LIG_LIR_Nem_3	106	112	PF02991	0.603
LIG_LIR_Nem_3	199	205	PF02991	0.350
LIG_LIR_Nem_3	263	268	PF02991	0.369
LIG_LIR_Nem_3	446	452	PF02991	0.352
LIG_LIR_Nem_3	456	460	PF02991	0.349
LIG_LIR_Nem_3	467	473	PF02991	0.339
LIG_LIR_Nem_3	591	595	PF02991	0.478
LIG_LIR_Nem_3	647	653	PF02991	0.525
LIG_MLH1_MIPbox_1	198	202	PF16413	0.405
LIG_PCNA_PIPBox_1	578	587	PF02747	0.363
LIG_PDZ_Class_2	720	725	PF00595	0.529
LIG_Pex14_2	433	437	PF04695	0.465
LIG_Pex14_2	445	449	PF04695	0.293
LIG_SH2_CRK	144	148	PF00017	0.483
LIG_SH2_CRK	592	596	PF00017	0.432
LIG_SH2_NCK_1	485	489	PF00017	0.397
LIG_SH2_PTP2	650	653	PF00017	0.404
LIG_SH2_STAP1	265	269	PF00017	0.506
LIG_SH2_STAP1	466	470	PF00017	0.432
LIG_SH2_STAP1	485	489	PF00017	0.362
LIG_SH2_STAP1	84	88	PF00017	0.611
LIG_SH2_STAT3	64	67	PF00017	0.649
LIG_SH2_STAT5	125	128	PF00017	0.508
LIG_SH2_STAT5	144	147	PF00017	0.321
LIG_SH2_STAT5	178	181	PF00017	0.465
LIG_SH2_STAT5	201	204	PF00017	0.350
LIG_SH2_STAT5	246	249	PF00017	0.526
LIG_SH2_STAT5	268	271	PF00017	0.423
LIG_SH2_STAT5	470	473	PF00017	0.350
LIG_SH2_STAT5	474	477	PF00017	0.382
LIG_SH2_STAT5	493	496	PF00017	0.393
LIG_SH2_STAT5	586	589	PF00017	0.403
LIG_SH2_STAT5	650	653	PF00017	0.569
LIG_SH2_STAT5	679	682	PF00017	0.452
LIG_SH3_3	308	314	PF00018	0.547
LIG_SH3_3	441	447	PF00018	0.379
LIG_SH3_3	594	600	PF00018	0.398
LIG_SH3_3	60	66	PF00018	0.656
LIG_SH3_3	659	665	PF00018	0.433
LIG_SUMO_SIM_anti_2	385	391	PF11976	0.446
LIG_SUMO_SIM_par_1	135	142	PF11976	0.504
LIG_SUMO_SIM_par_1	413	419	PF11976	0.384
LIG_SUMO_SIM_par_1	665	671	PF11976	0.539
LIG_SUMO_SIM_par_1	9	14	PF11976	0.616
LIG_TRAF2_1	615	618	PF00917	0.473
LIG_TYR_ITIM	590	595	PF00017	0.427
LIG_UBA3_1	541	548	PF00899	0.555
LIG_WRC_WIRS_1	417	422	PF05994	0.460
LIG_WW_3	333	337	PF00397	0.531
MOD_CDC14_SPxK_1	710	713	PF00782	0.613
MOD_CDK_SPxK_1	707	713	PF00069	0.617
MOD_CDK_SPxxK_3	707	714	PF00069	0.613
MOD_CK1_1	218	224	PF00069	0.587
MOD_CK1_1	361	367	PF00069	0.447
MOD_CK1_1	37	43	PF00069	0.593
MOD_CK1_1	416	422	PF00069	0.374
MOD_CK1_1	477	483	PF00069	0.358
MOD_CK2_1	150	156	PF00069	0.428
MOD_CK2_1	302	308	PF00069	0.540
MOD_CK2_1	310	316	PF00069	0.451
MOD_CK2_1	612	618	PF00069	0.536
MOD_Cter_Amidation	711	714	PF01082	0.657
MOD_GlcNHglycan	206	209	PF01048	0.506
MOD_GlcNHglycan	337	340	PF01048	0.671
MOD_GlcNHglycan	39	42	PF01048	0.730
MOD_GlcNHglycan	409	412	PF01048	0.517
MOD_GlcNHglycan	592	595	PF01048	0.370
MOD_GlcNHglycan	646	649	PF01048	0.443
MOD_GSK3_1	260	267	PF00069	0.374
MOD_GSK3_1	354	361	PF00069	0.591
MOD_GSK3_1	423	430	PF00069	0.471
MOD_GSK3_1	433	440	PF00069	0.334
MOD_GSK3_1	517	524	PF00069	0.395
MOD_GSK3_1	584	591	PF00069	0.420
MOD_GSK3_1	7	14	PF00069	0.706
MOD_N-GLC_1	272	277	PF02516	0.401
MOD_N-GLC_2	552	554	PF02516	0.487
MOD_NEK2_1	191	196	PF00069	0.497
MOD_NEK2_1	204	209	PF00069	0.448
MOD_NEK2_1	22	27	PF00069	0.633
MOD_NEK2_1	272	277	PF00069	0.379
MOD_NEK2_1	31	36	PF00069	0.583
MOD_NEK2_1	433	438	PF00069	0.464
MOD_NEK2_1	453	458	PF00069	0.235
MOD_NEK2_1	508	513	PF00069	0.386
MOD_NEK2_1	517	522	PF00069	0.416
MOD_NEK2_1	590	595	PF00069	0.385
MOD_NEK2_1	656	661	PF00069	0.428
MOD_NEK2_1	678	683	PF00069	0.453
MOD_NEK2_1	83	88	PF00069	0.608
MOD_NEK2_2	196	201	PF00069	0.448
MOD_NEK2_2	413	418	PF00069	0.387
MOD_NEK2_2	577	582	PF00069	0.453
MOD_PIKK_1	277	283	PF00454	0.408
MOD_PIKK_1	328	334	PF00454	0.398
MOD_PIKK_1	55	61	PF00454	0.741
MOD_PIKK_1	554	560	PF00454	0.489
MOD_PKA_1	96	102	PF00069	0.618
MOD_PKA_2	191	197	PF00069	0.548
MOD_PKA_2	335	341	PF00069	0.650
MOD_PKA_2	37	43	PF00069	0.650
MOD_PKA_2	477	483	PF00069	0.423
MOD_PKA_2	508	514	PF00069	0.429
MOD_PKA_2	521	527	PF00069	0.402
MOD_PKA_2	562	568	PF00069	0.469
MOD_PKA_2	595	601	PF00069	0.397
MOD_PKA_2	7	13	PF00069	0.536
MOD_Plk_1	260	266	PF00069	0.392
MOD_Plk_1	277	283	PF00069	0.447
MOD_Plk_1	77	83	PF00069	0.595
MOD_Plk_1	84	90	PF00069	0.550
MOD_Plk_4	103	109	PF00069	0.589
MOD_Plk_4	196	202	PF00069	0.356
MOD_Plk_4	264	270	PF00069	0.454
MOD_Plk_4	498	504	PF00069	0.441
MOD_Plk_4	718	724	PF00069	0.585
MOD_Plk_4	78	84	PF00069	0.620
MOD_ProDKin_1	310	316	PF00069	0.438
MOD_ProDKin_1	371	377	PF00069	0.394
MOD_ProDKin_1	443	449	PF00069	0.356
MOD_ProDKin_1	707	713	PF00069	0.617
MOD_SUMO_for_1	117	120	PF00179	0.507
MOD_SUMO_for_1	41	44	PF00179	0.670
MOD_SUMO_rev_2	225	235	PF00179	0.470
MOD_SUMO_rev_2	702	710	PF00179	0.543
TRG_DiLeu_BaEn_1	467	472	PF01217	0.370
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.422
TRG_ENDOCYTIC_2	125	128	PF00928	0.518
TRG_ENDOCYTIC_2	171	174	PF00928	0.404
TRG_ENDOCYTIC_2	201	204	PF00928	0.350
TRG_ENDOCYTIC_2	268	271	PF00928	0.371
TRG_ENDOCYTIC_2	473	476	PF00928	0.399
TRG_ENDOCYTIC_2	592	595	PF00928	0.419
TRG_ENDOCYTIC_2	650	653	PF00928	0.426
TRG_ER_diArg_1	243	245	PF00400	0.375
TRG_ER_diArg_1	325	327	PF00400	0.479
TRG_ER_diArg_1	635	638	PF00400	0.470
TRG_ER_diArg_1	694	696	PF00400	0.490
TRG_NLS_MonoExtC_3	545	550	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	96	101	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D3	Leptomonas seymouri	34%	86%
A4HGJ6	Leishmania braziliensis	79%	99%
A4I3M3	Leishmania infantum	100%	100%
E9AZW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8C2	Leishmania major	92%	100%