Tctex-1_family_putative/Pfam:PF03645

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tctex-1 family, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7J0_LEIDO

TriTrypDb:

LdBPK_281040.1 , LdCL_280015000 , LDHU3_28.1250

Length:

126

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3S5H7J0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7J0

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045505	dynein intermediate chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	74	78	PF00082	0.445
DOC_PP4_FxxP_1	13	16	PF00568	0.646
DOC_USP7_MATH_1	9	13	PF00917	0.695
LIG_APCC_ABBA_1	121	126	PF00400	0.541
LIG_APCC_ABBAyCdc20_2	43	49	PF00400	0.420
LIG_BIR_II_1	1	5	PF00653	0.758
LIG_eIF4E_1	70	76	PF01652	0.445
LIG_FHA_1	115	121	PF00498	0.517
LIG_FHA_1	63	69	PF00498	0.561
LIG_FHA_2	78	84	PF00498	0.420
LIG_LIR_Apic_2	11	16	PF02991	0.709
LIG_LIR_Gen_1	110	121	PF02991	0.505
LIG_LIR_Nem_3	101	107	PF02991	0.440
LIG_LIR_Nem_3	110	116	PF02991	0.370
LIG_LIR_Nem_3	71	76	PF02991	0.414
LIG_Pex14_2	121	125	PF04695	0.524
LIG_SH2_CRK	73	77	PF00017	0.420
LIG_SH2_GRB2like	109	112	PF00017	0.505
LIG_SH2_NCK_1	47	51	PF00017	0.445
LIG_SH2_NCK_1	5	9	PF00017	0.692
LIG_SH2_SRC	47	50	PF00017	0.445
LIG_SH2_STAP1	109	113	PF00017	0.501
LIG_SH2_STAT3	109	112	PF00017	0.561
LIG_SH2_STAT5	107	110	PF00017	0.460
LIG_SH2_STAT5	45	48	PF00017	0.420
LIG_SH2_STAT5	5	8	PF00017	0.690
LIG_SH3_3	38	44	PF00018	0.505
LIG_TRAF2_1	16	19	PF00917	0.597
MOD_CK1_1	20	26	PF00069	0.644
MOD_CK1_1	3	9	PF00069	0.588
MOD_CK2_1	22	28	PF00069	0.499
MOD_CK2_1	77	83	PF00069	0.420
MOD_GlcNHglycan	24	27	PF01048	0.622
MOD_GSK3_1	103	110	PF00069	0.448
MOD_GSK3_1	79	86	PF00069	0.525
MOD_NEK2_1	114	119	PF00069	0.447
MOD_NEK2_1	22	27	PF00069	0.516
MOD_PIKK_1	83	89	PF00454	0.544
MOD_PKA_2	9	15	PF00069	0.673
MOD_Plk_4	114	120	PF00069	0.484
TRG_DiLeu_BaEn_1	71	76	PF01217	0.456
TRG_DiLeu_LyEn_5	49	54	PF01217	0.422
TRG_ENDOCYTIC_2	113	116	PF00928	0.503
TRG_ENDOCYTIC_2	73	76	PF00928	0.420
TRG_NES_CRM1_1	112	126	PF08389	0.520
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3B2	Leptomonas seymouri	33%	100%
A0A0N1PFP4	Leptomonas seymouri	78%	100%
A0A0S4IQE7	Bodo saltans	62%	100%
A0A0S4JDH6	Bodo saltans	31%	91%
A0A1X0NYC6	Trypanosomatidae	67%	100%
A0A1X0P6I3	Trypanosomatidae	30%	100%
A0A3R7LJS7	Trypanosoma rangeli	63%	100%
A0A3S7X9I4	Leishmania donovani	32%	100%
A0A422P2R8	Trypanosoma rangeli	30%	100%
A2VDD2	Xenopus laevis	34%	72%
A4HGD9	Leishmania braziliensis	86%	100%
A4HMV8	Leishmania braziliensis	32%	100%
A4I3H2	Leishmania infantum	100%	100%
A4IBH9	Leishmania infantum	32%	100%
C9ZZ62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A4G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AFB5	Leishmania major	31%	100%
E9AZR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B6H0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
F1QMY1	Danio rerio	29%	84%
P63171	Bos taurus	25%	100%
P63172	Homo sapiens	25%	100%
Q32P71	Bos taurus	30%	83%
Q3B8D7	Xenopus laevis	33%	71%
Q4Q8H2	Leishmania major	97%	100%
Q54PG1	Dictyostelium discoideum	26%	100%
Q66IC8	Danio rerio	30%	73%
Q8N7M0	Homo sapiens	31%	70%
Q8WW35	Homo sapiens	31%	89%
Q9CQ66	Mus musculus	31%	88%
Q9D5I4	Mus musculus	30%	73%
Q9Z336	Rattus norvegicus	24%	100%
V5BTL3	Trypanosoma cruzi	32%	100%