Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H7I7_LEIDO

TriTrypDb:

LdBPK_280510.1 , LdCL_280008600 , LDHU3_28.0470

Length:

125

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7I7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	98	102	PF00656	0.642
CLV_PCSK_SKI1_1	115	119	PF00082	0.587
DEG_Nend_Nbox_1	1	3	PF02207	0.709
DOC_MAPK_MEF2A_6	7	15	PF00069	0.667
DOC_USP7_MATH_1	66	70	PF00917	0.614
DOC_WW_Pin1_4	51	56	PF00397	0.650
LIG_14-3-3_CanoR_1	109	114	PF00244	0.690
LIG_14-3-3_CanoR_1	7	11	PF00244	0.618
LIG_14-3-3_CanoR_1	81	85	PF00244	0.563
LIG_FHA_1	44	50	PF00498	0.625
LIG_FHA_2	42	48	PF00498	0.614
LIG_LIR_Gen_1	87	93	PF02991	0.665
LIG_LIR_Nem_3	51	56	PF02991	0.650
LIG_LIR_Nem_3	87	92	PF02991	0.666
LIG_PDZ_Class_2	120	125	PF00595	0.652
LIG_Pex14_2	33	37	PF04695	0.607
LIG_SH2_CRK	53	57	PF00017	0.647
LIG_SH2_STAT5	23	26	PF00017	0.505
LIG_TRFH_1	104	108	PF08558	0.552
MOD_CK1_1	51	57	PF00069	0.724
MOD_CK1_1	6	12	PF00069	0.644
MOD_GlcNHglycan	50	53	PF01048	0.725
MOD_GlcNHglycan	8	11	PF01048	0.619
MOD_NEK2_1	13	18	PF00069	0.593
MOD_NEK2_1	48	53	PF00069	0.603
MOD_PIKK_1	13	19	PF00454	0.609
MOD_PKA_2	6	12	PF00069	0.621
MOD_PKA_2	80	86	PF00069	0.494
MOD_Plk_4	109	115	PF00069	0.658
MOD_ProDKin_1	51	57	PF00069	0.642
TRG_ENDOCYTIC_2	53	56	PF00928	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HG78	Leishmania braziliensis	74%	100%
A4I3C2	Leishmania infantum	100%	100%
E9AZJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q8N3	Leishmania major	90%	100%