Lipase (Class 3), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7I3_LEIDO

TriTrypDb:

LdBPK_272030.1 , LdCL_270027600 , LDHU3_27.3110

Length:

791

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7I3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	6
GO:0008152	metabolic process	1	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:0009056	catabolic process	2	1
GO:0016042	lipid catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016298	lipase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	462	466	PF00656	0.405
CLV_C14_Caspase3-7	690	694	PF00656	0.805
CLV_NRD_NRD_1	200	202	PF00675	0.602
CLV_NRD_NRD_1	254	256	PF00675	0.492
CLV_NRD_NRD_1	377	379	PF00675	0.402
CLV_NRD_NRD_1	403	405	PF00675	0.344
CLV_NRD_NRD_1	549	551	PF00675	0.332
CLV_NRD_NRD_1	712	714	PF00675	0.770
CLV_PCSK_KEX2_1	109	111	PF00082	0.677
CLV_PCSK_KEX2_1	254	256	PF00082	0.492
CLV_PCSK_KEX2_1	271	273	PF00082	0.458
CLV_PCSK_KEX2_1	403	405	PF00082	0.359
CLV_PCSK_KEX2_1	418	420	PF00082	0.296
CLV_PCSK_KEX2_1	514	516	PF00082	0.441
CLV_PCSK_KEX2_1	549	551	PF00082	0.332
CLV_PCSK_KEX2_1	712	714	PF00082	0.747
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.556
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.585
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.356
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.380
CLV_PCSK_SKI1_1	176	180	PF00082	0.714
CLV_PCSK_SKI1_1	192	196	PF00082	0.548
CLV_PCSK_SKI1_1	243	247	PF00082	0.426
CLV_PCSK_SKI1_1	60	64	PF00082	0.663
CLV_PCSK_SKI1_1	728	732	PF00082	0.489
CLV_PCSK_SKI1_1	760	764	PF00082	0.525
CLV_PCSK_SKI1_1	82	86	PF00082	0.530
DEG_APCC_DBOX_1	739	747	PF00400	0.409
DEG_Nend_UBRbox_1	1	4	PF02207	0.546
DEG_SPOP_SBC_1	222	226	PF00917	0.609
DEG_SPOP_SBC_1	33	37	PF00917	0.626
DOC_CDC14_PxL_1	572	580	PF14671	0.405
DOC_CDC14_PxL_1	96	104	PF14671	0.468
DOC_CKS1_1	461	466	PF01111	0.405
DOC_CYCLIN_RxL_1	724	734	PF00134	0.494
DOC_MAPK_DCC_7	98	107	PF00069	0.476
DOC_MAPK_gen_1	514	521	PF00069	0.405
DOC_MAPK_MEF2A_6	446	453	PF00069	0.356
DOC_PP1_RVXF_1	145	151	PF00149	0.555
DOC_PP2B_LxvP_1	290	293	PF13499	0.489
DOC_PP2B_LxvP_1	527	530	PF13499	0.525
DOC_PP4_FxxP_1	195	198	PF00568	0.664
DOC_USP7_MATH_1	285	289	PF00917	0.393
DOC_USP7_MATH_1	29	33	PF00917	0.648
DOC_USP7_MATH_1	340	344	PF00917	0.356
DOC_USP7_MATH_1	411	415	PF00917	0.300
DOC_USP7_MATH_1	431	435	PF00917	0.284
DOC_USP7_MATH_1	530	534	PF00917	0.405
DOC_USP7_MATH_1	553	557	PF00917	0.356
DOC_USP7_MATH_1	599	603	PF00917	0.639
DOC_USP7_MATH_1	677	681	PF00917	0.750
DOC_USP7_MATH_1	69	73	PF00917	0.563
DOC_USP7_MATH_1	706	710	PF00917	0.729
DOC_USP7_UBL2_3	82	86	PF12436	0.349
DOC_WW_Pin1_4	100	105	PF00397	0.538
DOC_WW_Pin1_4	160	165	PF00397	0.644
DOC_WW_Pin1_4	194	199	PF00397	0.691
DOC_WW_Pin1_4	203	208	PF00397	0.646
DOC_WW_Pin1_4	25	30	PF00397	0.592
DOC_WW_Pin1_4	391	396	PF00397	0.356
DOC_WW_Pin1_4	409	414	PF00397	0.258
DOC_WW_Pin1_4	460	465	PF00397	0.405
DOC_WW_Pin1_4	731	736	PF00397	0.522
LIG_14-3-3_CanoR_1	110	115	PF00244	0.648
LIG_14-3-3_CanoR_1	243	252	PF00244	0.435
LIG_14-3-3_CanoR_1	255	264	PF00244	0.410
LIG_14-3-3_CanoR_1	301	309	PF00244	0.464
LIG_14-3-3_CanoR_1	321	327	PF00244	0.233
LIG_14-3-3_CanoR_1	408	416	PF00244	0.314
LIG_14-3-3_CanoR_1	51	57	PF00244	0.451
LIG_14-3-3_CanoR_1	687	693	PF00244	0.643
LIG_Actin_WH2_2	282	300	PF00022	0.439
LIG_BIR_III_2	392	396	PF00653	0.356
LIG_BRCT_BRCA1_1	195	199	PF00533	0.612
LIG_BRCT_BRCA1_1	258	262	PF00533	0.475
LIG_BRCT_BRCA1_1	342	346	PF00533	0.356
LIG_EH1_1	231	239	PF00400	0.452
LIG_EH1_1	756	764	PF00400	0.524
LIG_eIF4E_1	232	238	PF01652	0.487
LIG_FHA_1	133	139	PF00498	0.529
LIG_FHA_1	21	27	PF00498	0.652
LIG_FHA_1	224	230	PF00498	0.660
LIG_FHA_1	259	265	PF00498	0.511
LIG_FHA_1	285	291	PF00498	0.484
LIG_FHA_1	29	35	PF00498	0.579
LIG_FHA_1	330	336	PF00498	0.405
LIG_FHA_1	434	440	PF00498	0.405
LIG_FHA_1	524	530	PF00498	0.405
LIG_FHA_1	625	631	PF00498	0.617
LIG_FHA_1	636	642	PF00498	0.569
LIG_FHA_2	111	117	PF00498	0.577
LIG_FHA_2	359	365	PF00498	0.405
LIG_FHA_2	383	389	PF00498	0.376
LIG_FHA_2	394	400	PF00498	0.316
LIG_FHA_2	430	436	PF00498	0.359
LIG_FHA_2	649	655	PF00498	0.642
LIG_FHA_2	670	676	PF00498	0.682
LIG_FHA_2	688	694	PF00498	0.684
LIG_LIR_Apic_2	65	69	PF02991	0.524
LIG_LIR_Gen_1	140	151	PF02991	0.591
LIG_LIR_Gen_1	163	174	PF02991	0.721
LIG_LIR_Gen_1	308	319	PF02991	0.464
LIG_LIR_Gen_1	332	341	PF02991	0.402
LIG_LIR_Gen_1	480	485	PF02991	0.405
LIG_LIR_Gen_1	533	543	PF02991	0.356
LIG_LIR_Nem_3	140	146	PF02991	0.575
LIG_LIR_Nem_3	163	169	PF02991	0.681
LIG_LIR_Nem_3	246	252	PF02991	0.440
LIG_LIR_Nem_3	308	314	PF02991	0.456
LIG_LIR_Nem_3	480	484	PF02991	0.405
LIG_LIR_Nem_3	533	538	PF02991	0.519
LIG_LYPXL_yS_3	99	102	PF13949	0.508
LIG_MYND_1	100	104	PF01753	0.483
LIG_PCNA_yPIPBox_3	678	687	PF02747	0.565
LIG_Pex14_2	195	199	PF04695	0.666
LIG_PTAP_UEV_1	643	648	PF05743	0.652
LIG_PTB_Apo_2	357	364	PF02174	0.405
LIG_PTB_Apo_2	778	785	PF02174	0.491
LIG_PTB_Phospho_1	778	784	PF10480	0.483
LIG_Rb_pABgroove_1	357	365	PF01858	0.405
LIG_SH2_CRK	311	315	PF00017	0.390
LIG_SH2_CRK	481	485	PF00017	0.380
LIG_SH2_SRC	504	507	PF00017	0.332
LIG_SH2_SRC	66	69	PF00017	0.552
LIG_SH2_STAP1	125	129	PF00017	0.509
LIG_SH2_STAP1	244	248	PF00017	0.473
LIG_SH2_STAP1	311	315	PF00017	0.390
LIG_SH2_STAP1	481	485	PF00017	0.380
LIG_SH2_STAP1	504	508	PF00017	0.405
LIG_SH2_STAP1	771	775	PF00017	0.512
LIG_SH2_STAT3	232	235	PF00017	0.508
LIG_SH2_STAT3	350	353	PF00017	0.356
LIG_SH2_STAT3	456	459	PF00017	0.356
LIG_SH2_STAT5	66	69	PF00017	0.721
LIG_SH3_2	413	418	PF14604	0.380
LIG_SH3_2	644	649	PF14604	0.675
LIG_SH3_3	339	345	PF00018	0.356
LIG_SH3_3	410	416	PF00018	0.326
LIG_SH3_3	47	53	PF00018	0.601
LIG_SH3_3	504	510	PF00018	0.356
LIG_SH3_3	587	593	PF00018	0.503
LIG_SH3_3	6	12	PF00018	0.677
LIG_SH3_3	638	644	PF00018	0.670
LIG_SH3_3	652	658	PF00018	0.572
LIG_SH3_3	741	747	PF00018	0.522
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.522
LIG_SUMO_SIM_par_1	449	454	PF11976	0.296
LIG_SUMO_SIM_par_1	728	734	PF11976	0.494
LIG_TRAF2_1	278	281	PF00917	0.488
LIG_TRAF2_1	786	789	PF00917	0.689
LIG_TRFH_1	456	460	PF08558	0.356
LIG_TYR_ITIM	502	507	PF00017	0.356
LIG_UBA3_1	266	271	PF00899	0.547
LIG_UBA3_1	756	760	PF00899	0.515
LIG_WRC_WIRS_1	323	328	PF05994	0.405
LIG_WRC_WIRS_1	330	335	PF05994	0.333
MOD_CDC14_SPxK_1	415	418	PF00782	0.332
MOD_CDK_SPxK_1	412	418	PF00069	0.332
MOD_CDK_SPxxK_3	194	201	PF00069	0.644
MOD_CDK_SPxxK_3	412	419	PF00069	0.378
MOD_CK1_1	24	30	PF00069	0.677
MOD_CK1_1	257	263	PF00069	0.543
MOD_CK1_1	284	290	PF00069	0.440
MOD_CK1_1	304	310	PF00069	0.355
MOD_CK1_1	32	38	PF00069	0.598
MOD_CK1_1	691	697	PF00069	0.641
MOD_CK1_1	704	710	PF00069	0.573
MOD_CK2_1	139	145	PF00069	0.587
MOD_CK2_1	174	180	PF00069	0.496
MOD_CK2_1	270	276	PF00069	0.617
MOD_CK2_1	285	291	PF00069	0.336
MOD_CK2_1	382	388	PF00069	0.356
MOD_CK2_1	393	399	PF00069	0.270
MOD_CK2_1	429	435	PF00069	0.380
MOD_CK2_1	437	443	PF00069	0.298
MOD_CK2_1	648	654	PF00069	0.645
MOD_CK2_1	677	683	PF00069	0.667
MOD_CK2_1	704	710	PF00069	0.728
MOD_CK2_1	771	777	PF00069	0.526
MOD_CK2_1	783	789	PF00069	0.567
MOD_GlcNHglycan	23	26	PF01048	0.703
MOD_GlcNHglycan	272	275	PF01048	0.590
MOD_GlcNHglycan	283	286	PF01048	0.389
MOD_GlcNHglycan	294	297	PF01048	0.401
MOD_GlcNHglycan	31	34	PF01048	0.613
MOD_GlcNHglycan	36	39	PF01048	0.566
MOD_GlcNHglycan	429	432	PF01048	0.339
MOD_GlcNHglycan	437	442	PF01048	0.293
MOD_GlcNHglycan	555	558	PF01048	0.356
MOD_GlcNHglycan	597	600	PF01048	0.670
MOD_GlcNHglycan	602	605	PF01048	0.665
MOD_GlcNHglycan	631	634	PF01048	0.656
MOD_GlcNHglycan	693	696	PF01048	0.738
MOD_GlcNHglycan	70	74	PF01048	0.525
MOD_GlcNHglycan	771	774	PF01048	0.514
MOD_GSK3_1	128	135	PF00069	0.552
MOD_GSK3_1	156	163	PF00069	0.657
MOD_GSK3_1	16	23	PF00069	0.724
MOD_GSK3_1	24	31	PF00069	0.671
MOD_GSK3_1	254	261	PF00069	0.516
MOD_GSK3_1	266	273	PF00069	0.482
MOD_GSK3_1	281	288	PF00069	0.360
MOD_GSK3_1	297	304	PF00069	0.369
MOD_GSK3_1	322	329	PF00069	0.395
MOD_GSK3_1	407	414	PF00069	0.302
MOD_GSK3_1	41	48	PF00069	0.533
MOD_GSK3_1	425	432	PF00069	0.317
MOD_GSK3_1	433	440	PF00069	0.320
MOD_GSK3_1	479	486	PF00069	0.380
MOD_GSK3_1	595	602	PF00069	0.627
MOD_GSK3_1	687	694	PF00069	0.657
MOD_GSK3_1	697	704	PF00069	0.724
MOD_GSK3_1	767	774	PF00069	0.460
MOD_N-GLC_1	281	286	PF02516	0.467
MOD_N-GLC_1	677	682	PF02516	0.562
MOD_NEK2_1	132	137	PF00069	0.519
MOD_NEK2_1	182	187	PF00069	0.698
MOD_NEK2_1	258	263	PF00069	0.547
MOD_NEK2_1	266	271	PF00069	0.513
MOD_NEK2_1	297	302	PF00069	0.480
MOD_NEK2_1	326	331	PF00069	0.405
MOD_NEK2_1	34	39	PF00069	0.611
MOD_NEK2_1	407	412	PF00069	0.272
MOD_NEK2_1	429	434	PF00069	0.344
MOD_NEK2_1	497	502	PF00069	0.405
MOD_NEK2_1	62	67	PF00069	0.502
MOD_NEK2_1	730	735	PF00069	0.507
MOD_NEK2_1	758	763	PF00069	0.535
MOD_NEK2_1	767	772	PF00069	0.409
MOD_NEK2_1	91	96	PF00069	0.449
MOD_NEK2_2	530	535	PF00069	0.405
MOD_OFUCOSY	534	540	PF10250	0.356
MOD_PIKK_1	301	307	PF00454	0.520
MOD_PIKK_1	340	346	PF00454	0.405
MOD_PKA_1	109	115	PF00069	0.542
MOD_PKA_1	254	260	PF00069	0.512
MOD_PKA_2	109	115	PF00069	0.542
MOD_PKA_2	254	260	PF00069	0.512
MOD_PKA_2	297	303	PF00069	0.435
MOD_PKA_2	326	332	PF00069	0.405
MOD_PKA_2	365	371	PF00069	0.405
MOD_PKA_2	407	413	PF00069	0.291
MOD_PKA_2	622	628	PF00069	0.628
MOD_Plk_1	132	138	PF00069	0.528
MOD_Plk_1	174	180	PF00069	0.556
MOD_Plk_1	281	287	PF00069	0.464
MOD_Plk_1	424	430	PF00069	0.332
MOD_Plk_1	661	667	PF00069	0.730
MOD_Plk_1	669	675	PF00069	0.791
MOD_Plk_1	677	683	PF00069	0.658
MOD_Plk_4	103	109	PF00069	0.462
MOD_Plk_4	174	180	PF00069	0.584
MOD_Plk_4	285	291	PF00069	0.484
MOD_Plk_4	358	364	PF00069	0.405
MOD_Plk_4	45	51	PF00069	0.596
MOD_Plk_4	479	485	PF00069	0.402
MOD_Plk_4	62	68	PF00069	0.628
MOD_Plk_4	758	764	PF00069	0.535
MOD_Plk_4	91	97	PF00069	0.475
MOD_ProDKin_1	100	106	PF00069	0.533
MOD_ProDKin_1	160	166	PF00069	0.644
MOD_ProDKin_1	194	200	PF00069	0.691
MOD_ProDKin_1	203	209	PF00069	0.649
MOD_ProDKin_1	25	31	PF00069	0.592
MOD_ProDKin_1	391	397	PF00069	0.356
MOD_ProDKin_1	409	415	PF00069	0.258
MOD_ProDKin_1	460	466	PF00069	0.405
MOD_ProDKin_1	731	737	PF00069	0.533
TRG_DiLeu_BaEn_4	424	430	PF01217	0.332
TRG_DiLeu_BaLyEn_6	582	587	PF01217	0.486
TRG_ENDOCYTIC_2	111	114	PF00928	0.455
TRG_ENDOCYTIC_2	249	252	PF00928	0.450
TRG_ENDOCYTIC_2	311	314	PF00928	0.440
TRG_ENDOCYTIC_2	481	484	PF00928	0.405
TRG_ENDOCYTIC_2	504	507	PF00928	0.356
TRG_ENDOCYTIC_2	89	92	PF00928	0.473
TRG_ENDOCYTIC_2	99	102	PF00928	0.444
TRG_ER_diArg_1	253	255	PF00400	0.487
TRG_ER_diArg_1	403	405	PF00400	0.344
TRG_ER_diArg_1	739	742	PF00400	0.440
TRG_NES_CRM1_1	755	765	PF08389	0.518
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.672
TRG_Pf-PMV_PEXEL_1	585	589	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	717	722	PF00026	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HFY8	Leishmania braziliensis	67%	100%
A4I2Y1	Leishmania infantum	99%	100%
E9ADJ1	Leishmania major	91%	98%
E9AZB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%