Protein kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cdc2-related kinase 9

Species:

Leishmania donovani

UniProt:

A0A3S5H7I2_LEIDO

TriTrypDb:

LdBPK_271860.1 , LdCL_270025800 , LDHU3_27.2840

Length:

958

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S5H7I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7I2

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0000086	G2/M transition of mitotic cell cycle	5	1
GO:0000365	mRNA trans splicing, via spliceosome	9	1
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0008380	RNA splicing	7	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0022402	cell cycle process	2	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0044839	cell cycle G2/M phase transition	4	1
GO:0045291	mRNA trans splicing, SL addition	10	1
GO:0046483	heterocycle metabolic process	3	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.748
CLV_C14_Caspase3-7	903	907	PF00656	0.778
CLV_C14_Caspase3-7	91	95	PF00656	0.760
CLV_C14_Caspase3-7	935	939	PF00656	0.788
CLV_NRD_NRD_1	10	12	PF00675	0.564
CLV_NRD_NRD_1	380	382	PF00675	0.810
CLV_NRD_NRD_1	427	429	PF00675	0.768
CLV_NRD_NRD_1	512	514	PF00675	0.533
CLV_NRD_NRD_1	652	654	PF00675	0.438
CLV_NRD_NRD_1	750	752	PF00675	0.438
CLV_NRD_NRD_1	802	804	PF00675	0.745
CLV_NRD_NRD_1	924	926	PF00675	0.776
CLV_PCSK_KEX2_1	380	382	PF00082	0.772
CLV_PCSK_KEX2_1	427	429	PF00082	0.768
CLV_PCSK_KEX2_1	512	514	PF00082	0.579
CLV_PCSK_KEX2_1	652	654	PF00082	0.438
CLV_PCSK_KEX2_1	749	751	PF00082	0.415
CLV_PCSK_KEX2_1	802	804	PF00082	0.745
CLV_PCSK_KEX2_1	924	926	PF00082	0.776
CLV_PCSK_SKI1_1	196	200	PF00082	0.652
CLV_PCSK_SKI1_1	289	293	PF00082	0.562
CLV_PCSK_SKI1_1	331	335	PF00082	0.477
CLV_PCSK_SKI1_1	443	447	PF00082	0.765
CLV_PCSK_SKI1_1	461	465	PF00082	0.561
CLV_PCSK_SKI1_1	494	498	PF00082	0.502
CLV_PCSK_SKI1_1	513	517	PF00082	0.375
CLV_PCSK_SKI1_1	580	584	PF00082	0.332
CLV_PCSK_SKI1_1	653	657	PF00082	0.438
CLV_PCSK_SKI1_1	881	885	PF00082	0.580
CLV_Separin_Metazoa	774	778	PF03568	0.500
DEG_Nend_UBRbox_3	1	3	PF02207	0.753
DEG_SPOP_SBC_1	391	395	PF00917	0.777
DEG_SPOP_SBC_1	399	403	PF00917	0.733
DEG_SPOP_SBC_1	64	68	PF00917	0.742
DEG_SPOP_SBC_1	822	826	PF00917	0.702
DOC_CDC14_PxL_1	620	628	PF14671	0.357
DOC_CYCLIN_RxL_1	650	660	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	651	657	PF00134	0.438
DOC_MAPK_gen_1	580	589	PF00069	0.357
DOC_MAPK_MEF2A_6	351	359	PF00069	0.460
DOC_MAPK_MEF2A_6	492	500	PF00069	0.531
DOC_MAPK_MEF2A_6	97	104	PF00069	0.633
DOC_MAPK_RevD_3	637	653	PF00069	0.438
DOC_PP1_RVXF_1	565	572	PF00149	0.438
DOC_PP2B_LxvP_1	100	103	PF13499	0.648
DOC_PP2B_LxvP_1	672	675	PF13499	0.492
DOC_PP4_FxxP_1	82	85	PF00568	0.652
DOC_USP7_MATH_1	130	134	PF00917	0.784
DOC_USP7_MATH_1	147	151	PF00917	0.779
DOC_USP7_MATH_1	163	167	PF00917	0.518
DOC_USP7_MATH_1	212	216	PF00917	0.645
DOC_USP7_MATH_1	231	235	PF00917	0.643
DOC_USP7_MATH_1	314	318	PF00917	0.778
DOC_USP7_MATH_1	391	395	PF00917	0.739
DOC_USP7_MATH_1	399	403	PF00917	0.780
DOC_USP7_MATH_1	49	53	PF00917	0.731
DOC_USP7_MATH_1	550	554	PF00917	0.503
DOC_USP7_MATH_1	791	795	PF00917	0.660
DOC_USP7_MATH_1	83	87	PF00917	0.736
DOC_USP7_MATH_1	853	857	PF00917	0.797
DOC_USP7_MATH_1	867	871	PF00917	0.646
DOC_USP7_UBL2_3	331	335	PF12436	0.479
DOC_WW_Pin1_4	373	378	PF00397	0.674
DOC_WW_Pin1_4	381	386	PF00397	0.758
DOC_WW_Pin1_4	387	392	PF00397	0.775
DOC_WW_Pin1_4	395	400	PF00397	0.593
DOC_WW_Pin1_4	406	411	PF00397	0.564
DOC_WW_Pin1_4	539	544	PF00397	0.624
DOC_WW_Pin1_4	610	615	PF00397	0.438
DOC_WW_Pin1_4	81	86	PF00397	0.647
DOC_WW_Pin1_4	863	868	PF00397	0.771
DOC_WW_Pin1_4	869	874	PF00397	0.729
LIG_14-3-3_CanoR_1	236	243	PF00244	0.678
LIG_14-3-3_CanoR_1	278	286	PF00244	0.597
LIG_14-3-3_CanoR_1	289	296	PF00244	0.401
LIG_14-3-3_CanoR_1	512	521	PF00244	0.608
LIG_14-3-3_CanoR_1	698	708	PF00244	0.461
LIG_14-3-3_CanoR_1	828	836	PF00244	0.794
LIG_14-3-3_CanoR_1	924	931	PF00244	0.687
LIG_BIR_III_4	152	156	PF00653	0.659
LIG_Clathr_ClatBox_1	370	374	PF01394	0.576
LIG_deltaCOP1_diTrp_1	638	646	PF00928	0.492
LIG_EVH1_2	78	82	PF00568	0.720
LIG_FHA_1	123	129	PF00498	0.790
LIG_FHA_1	143	149	PF00498	0.766
LIG_FHA_1	156	162	PF00498	0.595
LIG_FHA_1	325	331	PF00498	0.500
LIG_FHA_1	33	39	PF00498	0.735
LIG_FHA_1	479	485	PF00498	0.745
LIG_FHA_1	582	588	PF00498	0.369
LIG_FHA_1	611	617	PF00498	0.357
LIG_FHA_1	700	706	PF00498	0.492
LIG_FHA_1	939	945	PF00498	0.731
LIG_FHA_2	152	158	PF00498	0.713
LIG_FHA_2	290	296	PF00498	0.582
LIG_FHA_2	430	436	PF00498	0.716
LIG_FHA_2	466	472	PF00498	0.753
LIG_FHA_2	514	520	PF00498	0.663
LIG_LIR_Apic_2	618	624	PF02991	0.357
LIG_LIR_Gen_1	495	505	PF02991	0.389
LIG_LIR_Gen_1	560	571	PF02991	0.438
LIG_LIR_Gen_1	591	602	PF02991	0.438
LIG_LIR_Nem_3	501	505	PF02991	0.373
LIG_LIR_Nem_3	560	566	PF02991	0.438
LIG_LIR_Nem_3	591	597	PF02991	0.438
LIG_LIR_Nem_3	625	631	PF02991	0.492
LIG_LIR_Nem_3	677	683	PF02991	0.369
LIG_NRBOX	112	118	PF00104	0.701
LIG_Pex14_2	646	650	PF04695	0.492
LIG_REV1ctd_RIR_1	760	766	PF16727	0.415
LIG_SH2_CRK	273	277	PF00017	0.478
LIG_SH2_CRK	284	288	PF00017	0.378
LIG_SH2_CRK	563	567	PF00017	0.492
LIG_SH2_CRK	684	688	PF00017	0.438
LIG_SH2_NCK_1	273	277	PF00017	0.522
LIG_SH2_NCK_1	514	518	PF00017	0.580
LIG_SH2_PTP2	594	597	PF00017	0.438
LIG_SH2_STAP1	514	518	PF00017	0.633
LIG_SH2_STAP1	633	637	PF00017	0.357
LIG_SH2_STAT3	296	299	PF00017	0.653
LIG_SH2_STAT5	273	276	PF00017	0.440
LIG_SH2_STAT5	348	351	PF00017	0.468
LIG_SH2_STAT5	502	505	PF00017	0.430
LIG_SH2_STAT5	538	541	PF00017	0.482
LIG_SH2_STAT5	554	557	PF00017	0.471
LIG_SH2_STAT5	594	597	PF00017	0.417
LIG_SH3_2	205	210	PF14604	0.720
LIG_SH3_3	202	208	PF00018	0.708
LIG_SH3_3	305	311	PF00018	0.763
LIG_SH3_3	340	346	PF00018	0.523
LIG_SH3_3	70	76	PF00018	0.732
LIG_SH3_3	766	772	PF00018	0.474
LIG_SH3_CIN85_PxpxPR_1	375	380	PF14604	0.717
LIG_SUMO_SIM_anti_2	352	357	PF11976	0.517
LIG_SUMO_SIM_anti_2	369	374	PF11976	0.371
LIG_SUMO_SIM_anti_2	615	621	PF11976	0.438
LIG_SUMO_SIM_anti_2	734	742	PF11976	0.441
LIG_SUMO_SIM_par_1	369	374	PF11976	0.493
LIG_SUMO_SIM_par_1	664	670	PF11976	0.438
LIG_TRAF2_1	675	678	PF00917	0.422
LIG_TYR_ITIM	536	541	PF00017	0.534
LIG_TYR_ITIM	561	566	PF00017	0.492
LIG_UBA3_1	6	12	PF00899	0.646
MOD_CDC14_SPxK_1	384	387	PF00782	0.724
MOD_CDK_SPK_2	539	544	PF00069	0.624
MOD_CDK_SPxK_1	381	387	PF00069	0.718
MOD_CDK_SPxxK_3	373	380	PF00069	0.692
MOD_CK1_1	124	130	PF00069	0.735
MOD_CK1_1	162	168	PF00069	0.807
MOD_CK1_1	215	221	PF00069	0.793
MOD_CK1_1	238	244	PF00069	0.629
MOD_CK1_1	313	319	PF00069	0.739
MOD_CK1_1	390	396	PF00069	0.813
MOD_CK1_1	398	404	PF00069	0.677
MOD_CK1_1	406	412	PF00069	0.552
MOD_CK1_1	659	665	PF00069	0.438
MOD_CK1_1	68	74	PF00069	0.682
MOD_CK1_1	808	814	PF00069	0.717
MOD_CK1_1	816	822	PF00069	0.715
MOD_CK1_1	830	836	PF00069	0.666
MOD_CK1_1	84	90	PF00069	0.595
MOD_CK1_1	856	862	PF00069	0.757
MOD_CK1_1	872	878	PF00069	0.564
MOD_CK2_1	176	182	PF00069	0.753
MOD_CK2_1	2	8	PF00069	0.666
MOD_CK2_1	391	397	PF00069	0.758
MOD_CK2_1	428	434	PF00069	0.736
MOD_CK2_1	465	471	PF00069	0.657
MOD_CK2_1	513	519	PF00069	0.657
MOD_CK2_1	750	756	PF00069	0.391
MOD_CK2_1	843	849	PF00069	0.725
MOD_CK2_1	854	860	PF00069	0.736
MOD_CK2_1	934	940	PF00069	0.726
MOD_GlcNHglycan	132	135	PF01048	0.771
MOD_GlcNHglycan	160	164	PF01048	0.811
MOD_GlcNHglycan	165	168	PF01048	0.736
MOD_GlcNHglycan	177	181	PF01048	0.686
MOD_GlcNHglycan	238	241	PF01048	0.705
MOD_GlcNHglycan	258	262	PF01048	0.416
MOD_GlcNHglycan	312	315	PF01048	0.711
MOD_GlcNHglycan	316	319	PF01048	0.710
MOD_GlcNHglycan	51	54	PF01048	0.750
MOD_GlcNHglycan	532	535	PF01048	0.640
MOD_GlcNHglycan	734	737	PF01048	0.403
MOD_GlcNHglycan	752	755	PF01048	0.246
MOD_GlcNHglycan	793	796	PF01048	0.771
MOD_GlcNHglycan	830	833	PF01048	0.727
MOD_GlcNHglycan	845	848	PF01048	0.774
MOD_GlcNHglycan	856	859	PF01048	0.792
MOD_GlcNHglycan	86	89	PF01048	0.741
MOD_GlcNHglycan	869	872	PF01048	0.642
MOD_GlcNHglycan	901	905	PF01048	0.781
MOD_GSK3_1	147	154	PF00069	0.715
MOD_GSK3_1	155	162	PF00069	0.705
MOD_GSK3_1	176	183	PF00069	0.614
MOD_GSK3_1	215	222	PF00069	0.742
MOD_GSK3_1	231	238	PF00069	0.701
MOD_GSK3_1	306	313	PF00069	0.731
MOD_GSK3_1	381	388	PF00069	0.726
MOD_GSK3_1	389	396	PF00069	0.741
MOD_GSK3_1	397	404	PF00069	0.769
MOD_GSK3_1	429	436	PF00069	0.716
MOD_GSK3_1	461	468	PF00069	0.718
MOD_GSK3_1	526	533	PF00069	0.723
MOD_GSK3_1	64	71	PF00069	0.741
MOD_GSK3_1	688	695	PF00069	0.446
MOD_GSK3_1	700	707	PF00069	0.455
MOD_GSK3_1	823	830	PF00069	0.813
MOD_GSK3_1	856	863	PF00069	0.695
MOD_GSK3_1	879	886	PF00069	0.753
MOD_GSK3_1	896	903	PF00069	0.565
MOD_GSK3_1	920	927	PF00069	0.817
MOD_GSK3_1	934	941	PF00069	0.569
MOD_LATS_1	922	928	PF00433	0.822
MOD_N-GLC_1	32	37	PF02516	0.723
MOD_N-GLC_1	699	704	PF02516	0.482
MOD_NEK2_1	338	343	PF00069	0.579
MOD_NEK2_1	572	577	PF00069	0.427
MOD_NEK2_1	582	587	PF00069	0.346
MOD_NEK2_1	692	697	PF00069	0.385
MOD_NEK2_1	739	744	PF00069	0.464
MOD_NEK2_1	877	882	PF00069	0.584
MOD_NEK2_2	231	236	PF00069	0.719
MOD_NEK2_2	879	884	PF00069	0.580
MOD_OFUCOSY	101	106	PF10250	0.704
MOD_PIKK_1	180	186	PF00454	0.723
MOD_PIKK_1	277	283	PF00454	0.551
MOD_PIKK_1	338	344	PF00454	0.569
MOD_PIKK_1	461	467	PF00454	0.817
MOD_PIKK_1	808	814	PF00454	0.845
MOD_PK_1	557	563	PF00069	0.438
MOD_PKA_1	750	756	PF00069	0.438
MOD_PKA_1	924	930	PF00069	0.825
MOD_PKA_2	175	181	PF00069	0.716
MOD_PKA_2	235	241	PF00069	0.687
MOD_PKA_2	277	283	PF00069	0.605
MOD_PKA_2	306	312	PF00069	0.782
MOD_PKA_2	429	435	PF00069	0.753
MOD_PKA_2	700	706	PF00069	0.438
MOD_PKA_2	750	756	PF00069	0.357
MOD_PKA_2	808	814	PF00069	0.752
MOD_PKA_2	827	833	PF00069	0.507
MOD_PKA_2	923	929	PF00069	0.771
MOD_Plk_1	159	165	PF00069	0.679
MOD_Plk_1	338	344	PF00069	0.617
MOD_Plk_1	676	682	PF00069	0.357
MOD_Plk_1	848	854	PF00069	0.723
MOD_Plk_2-3	934	940	PF00069	0.772
MOD_Plk_4	182	188	PF00069	0.609
MOD_Plk_4	2	8	PF00069	0.666
MOD_Plk_4	238	244	PF00069	0.616
MOD_Plk_4	506	512	PF00069	0.453
MOD_Plk_4	550	556	PF00069	0.561
MOD_Plk_4	557	563	PF00069	0.452
MOD_Plk_4	612	618	PF00069	0.366
MOD_Plk_4	65	71	PF00069	0.705
MOD_Plk_4	688	694	PF00069	0.458
MOD_Plk_4	704	710	PF00069	0.404
MOD_Plk_4	739	745	PF00069	0.436
MOD_Plk_4	872	878	PF00069	0.580
MOD_ProDKin_1	373	379	PF00069	0.683
MOD_ProDKin_1	381	387	PF00069	0.761
MOD_ProDKin_1	395	401	PF00069	0.592
MOD_ProDKin_1	406	412	PF00069	0.700
MOD_ProDKin_1	539	545	PF00069	0.617
MOD_ProDKin_1	610	616	PF00069	0.438
MOD_ProDKin_1	81	87	PF00069	0.649
MOD_ProDKin_1	863	869	PF00069	0.770
MOD_SUMO_for_1	763	766	PF00179	0.534
MOD_SUMO_rev_2	523	530	PF00179	0.733
MOD_SUMO_rev_2	575	585	PF00179	0.490
TRG_DiLeu_BaEn_1	352	357	PF01217	0.452
TRG_DiLeu_BaEn_4	914	920	PF01217	0.765
TRG_ENDOCYTIC_2	273	276	PF00928	0.457
TRG_ENDOCYTIC_2	284	287	PF00928	0.402
TRG_ENDOCYTIC_2	538	541	PF00928	0.477
TRG_ENDOCYTIC_2	563	566	PF00928	0.438
TRG_ENDOCYTIC_2	594	597	PF00928	0.438
TRG_ER_diArg_1	193	196	PF00400	0.736
TRG_ER_diArg_1	305	308	PF00400	0.762
TRG_ER_diArg_1	379	381	PF00400	0.794
TRG_ER_diArg_1	426	428	PF00400	0.766
TRG_ER_diArg_1	511	513	PF00400	0.545
TRG_ER_diArg_1	651	653	PF00400	0.438
TRG_ER_diArg_1	748	751	PF00400	0.438
TRG_NLS_Bipartite_1	427	447	PF00514	0.751
TRG_NLS_MonoExtC_3	10	16	PF00514	0.626
TRG_NLS_MonoExtC_3	442	448	PF00514	0.770
TRG_NLS_MonoExtN_4	9	15	PF00514	0.633
TRG_Pf-PMV_PEXEL_1	576	581	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	949	954	PF00026	0.766

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6G8	Leptomonas seymouri	49%	100%
A0A3R7KFZ3	Trypanosoma rangeli	38%	100%
A4HFW9	Leishmania braziliensis	77%	100%
A4I302	Leishmania infantum	99%	100%
C9ZJF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ADH4	Leishmania major	92%	100%
E9AZ98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%