Hypothetical_protein_conserved

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flabarin

Species:

Leishmania donovani

UniProt:

A0A3S5H7I1_LEIDO

TriTrypDb:

LdBPK_271630.1 , LdCL_270023300 , LDHU3_27.2500

Length:

339

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 6
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote: 260, 265
Promastigote/Amastigote: 266, 269, 275

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S5H7I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7I1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.500
CLV_NRD_NRD_1	246	248	PF00675	0.584
CLV_NRD_NRD_1	249	251	PF00675	0.600
CLV_NRD_NRD_1	68	70	PF00675	0.427
CLV_PCSK_KEX2_1	160	162	PF00082	0.545
CLV_PCSK_KEX2_1	246	248	PF00082	0.584
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.481
CLV_PCSK_SKI1_1	111	115	PF00082	0.424
CLV_PCSK_SKI1_1	172	176	PF00082	0.470
CLV_PCSK_SKI1_1	187	191	PF00082	0.486
CLV_PCSK_SKI1_1	27	31	PF00082	0.459
CLV_PCSK_SKI1_1	80	84	PF00082	0.460
DEG_ODPH_VHL_1	301	314	PF01847	0.537
DOC_MAPK_gen_1	111	122	PF00069	0.517
DOC_PP1_RVXF_1	113	120	PF00149	0.277
DOC_PP2B_LxvP_1	301	304	PF13499	0.609
DOC_USP7_MATH_1	113	117	PF00917	0.433
DOC_USP7_MATH_1	150	154	PF00917	0.576
DOC_USP7_MATH_1	35	39	PF00917	0.368
DOC_USP7_UBL2_3	107	111	PF12436	0.430
DOC_USP7_UBL2_3	139	143	PF12436	0.485
DOC_USP7_UBL2_3	156	160	PF12436	0.419
DOC_USP7_UBL2_3	234	238	PF12436	0.479
LIG_Actin_WH2_2	96	113	PF00022	0.361
LIG_BRCT_BRCA1_1	115	119	PF00533	0.295
LIG_BRCT_BRCA1_1	223	227	PF00533	0.514
LIG_BRCT_BRCA1_1	254	258	PF00533	0.556
LIG_CaM_IQ_9	179	194	PF13499	0.364
LIG_EH_1	255	259	PF12763	0.550
LIG_FHA_1	15	21	PF00498	0.378
LIG_FHA_1	184	190	PF00498	0.511
LIG_FHA_1	97	103	PF00498	0.433
LIG_FHA_2	215	221	PF00498	0.630
LIG_FHA_2	258	264	PF00498	0.821
LIG_FHA_2	311	317	PF00498	0.592
LIG_FHA_2	46	52	PF00498	0.464
LIG_LIR_Gen_1	116	127	PF02991	0.449
LIG_LIR_Gen_1	48	57	PF02991	0.403
LIG_LIR_Nem_3	116	122	PF02991	0.455
LIG_LIR_Nem_3	126	130	PF02991	0.533
LIG_LIR_Nem_3	48	53	PF02991	0.397
LIG_SH2_CRK	127	131	PF00017	0.420
LIG_SH2_CRK	43	47	PF00017	0.426
LIG_SH2_CRK	57	61	PF00017	0.445
LIG_SH2_GRB2like	318	321	PF00017	0.592
LIG_SH2_GRB2like	43	46	PF00017	0.352
LIG_SH2_STAP1	318	322	PF00017	0.561
LIG_SH2_STAT5	197	200	PF00017	0.468
LIG_SH2_STAT5	21	24	PF00017	0.424
LIG_SH3_3	65	71	PF00018	0.465
LIG_SH3_3	99	105	PF00018	0.419
LIG_SUMO_SIM_anti_2	99	104	PF11976	0.358
LIG_SUMO_SIM_par_1	98	104	PF11976	0.355
LIG_WRC_WIRS_1	88	93	PF05994	0.453
MOD_CK1_1	266	272	PF00069	0.627
MOD_CK2_1	310	316	PF00069	0.671
MOD_GlcNHglycan	291	294	PF01048	0.736
MOD_GlcNHglycan	33	36	PF01048	0.462
MOD_GSK3_1	150	157	PF00069	0.489
MOD_GSK3_1	164	171	PF00069	0.423
MOD_GSK3_1	262	269	PF00069	0.594
MOD_GSK3_1	283	290	PF00069	0.600
MOD_GSK3_1	3	10	PF00069	0.490
MOD_GSK3_1	31	38	PF00069	0.514
MOD_N-GLC_1	266	271	PF02516	0.690
MOD_NEK2_1	148	153	PF00069	0.514
MOD_NEK2_1	182	187	PF00069	0.521
MOD_NEK2_1	190	195	PF00069	0.471
MOD_NEK2_1	198	203	PF00069	0.448
MOD_NEK2_1	3	8	PF00069	0.524
MOD_NEK2_1	36	41	PF00069	0.378
MOD_NEK2_2	113	118	PF00069	0.355
MOD_PKA_1	283	289	PF00069	0.594
MOD_Plk_1	137	143	PF00069	0.482
MOD_Plk_1	208	214	PF00069	0.400
MOD_Plk_1	310	316	PF00069	0.618
MOD_Plk_2-3	310	316	PF00069	0.592
MOD_Plk_4	185	191	PF00069	0.463
MOD_Plk_4	283	289	PF00069	0.566
MOD_SUMO_rev_2	104	113	PF00179	0.493
TRG_ENDOCYTIC_2	127	130	PF00928	0.472
TRG_ENDOCYTIC_2	43	46	PF00928	0.415
TRG_ENDOCYTIC_2	57	60	PF00928	0.416
TRG_NLS_MonoExtC_3	142	147	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	18	23	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG41	Leptomonas seymouri	57%	100%
A0A1X0NY72	Trypanosomatidae	25%	92%
A0A3Q8IKU7	Leishmania donovani	26%	100%
A0A3S5H792	Leishmania donovani	24%	100%
A4HBK0	Leishmania braziliensis	21%	100%
A4HFU7	Leishmania braziliensis	74%	100%
A4HZL5	Leishmania infantum	24%	100%
A4HZL6	Leishmania infantum	27%	100%
A4I2W4	Leishmania infantum	100%	100%
E9ADF0	Leishmania major	93%	100%
E9AUW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AUW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AZ74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCL3	Leishmania major	22%	100%
Q4QCL4	Leishmania major	27%	100%