LeishMANIAdb
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KH_domain_containing_protein_putative/Pfam:PF0001 3

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
KH_domain_containing_protein_putative/Pfam:PF0001 3
Gene product:
KH domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H7H8_LEIDO
TriTrypDb:
LdBPK_271220.1 * , LdCL_270018700 , LDHU3_27.1890
Length:
529

Annotations

Annotations by Jardim et al.

RNA Processing, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 90

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S5H7H8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7H8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 8
GO:0003723 RNA binding 4 8
GO:0005488 binding 1 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0097159 organic cyclic compound binding 2 8
GO:1901363 heterocyclic compound binding 2 8
GO:0003724 RNA helicase activity 3 1
GO:0003824 catalytic activity 1 1
GO:0004386 helicase activity 2 1
GO:0008186 ATP-dependent activity, acting on RNA 2 1
GO:0140098 catalytic activity, acting on RNA 3 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1
GO:0140657 ATP-dependent activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 157 159 PF00675 0.688
CLV_NRD_NRD_1 34 36 PF00675 0.505
CLV_NRD_NRD_1 416 418 PF00675 0.419
CLV_NRD_NRD_1 68 70 PF00675 0.790
CLV_PCSK_KEX2_1 156 158 PF00082 0.648
CLV_PCSK_KEX2_1 254 256 PF00082 0.529
CLV_PCSK_KEX2_1 351 353 PF00082 0.425
CLV_PCSK_KEX2_1 527 529 PF00082 0.760
CLV_PCSK_KEX2_1 68 70 PF00082 0.707
CLV_PCSK_PC1ET2_1 254 256 PF00082 0.529
CLV_PCSK_PC1ET2_1 351 353 PF00082 0.425
CLV_PCSK_PC1ET2_1 527 529 PF00082 0.760
CLV_PCSK_SKI1_1 133 137 PF00082 0.365
CLV_PCSK_SKI1_1 194 198 PF00082 0.279
CLV_PCSK_SKI1_1 244 248 PF00082 0.307
CLV_PCSK_SKI1_1 52 56 PF00082 0.583
DOC_CKS1_1 135 140 PF01111 0.555
DOC_CKS1_1 500 505 PF01111 0.599
DOC_CYCLIN_RxL_1 191 199 PF00134 0.555
DOC_MAPK_DCC_7 417 426 PF00069 0.382
DOC_MAPK_gen_1 242 249 PF00069 0.565
DOC_MAPK_MEF2A_6 181 188 PF00069 0.452
DOC_MAPK_MEF2A_6 417 426 PF00069 0.382
DOC_PP1_RVXF_1 470 477 PF00149 0.513
DOC_PP4_FxxP_1 308 311 PF00568 0.558
DOC_PP4_FxxP_1 430 433 PF00568 0.419
DOC_USP7_MATH_1 163 167 PF00917 0.695
DOC_USP7_MATH_1 169 173 PF00917 0.672
DOC_USP7_MATH_1 22 26 PF00917 0.584
DOC_USP7_MATH_1 58 62 PF00917 0.678
DOC_USP7_UBL2_3 142 146 PF12436 0.571
DOC_USP7_UBL2_3 414 418 PF12436 0.419
DOC_WD40_RPTOR_TOS_1 182 187 PF00400 0.477
DOC_WW_Pin1_4 134 139 PF00397 0.555
DOC_WW_Pin1_4 499 504 PF00397 0.565
LIG_14-3-3_CanoR_1 292 299 PF00244 0.526
LIG_14-3-3_CanoR_1 30 35 PF00244 0.537
LIG_14-3-3_CanoR_1 300 309 PF00244 0.475
LIG_14-3-3_CanoR_1 486 494 PF00244 0.559
LIG_Actin_WH2_2 27 45 PF00022 0.463
LIG_Actin_WH2_2 325 342 PF00022 0.431
LIG_BIR_II_1 1 5 PF00653 0.625
LIG_BIR_III_2 505 509 PF00653 0.466
LIG_BRCT_BRCA1_1 304 308 PF00533 0.576
LIG_EVH1_2 176 180 PF00568 0.699
LIG_FAT_LD_1 7 15 PF03623 0.471
LIG_FHA_1 188 194 PF00498 0.482
LIG_FHA_1 225 231 PF00498 0.540
LIG_FHA_1 289 295 PF00498 0.624
LIG_FHA_1 485 491 PF00498 0.495
LIG_FHA_2 211 217 PF00498 0.529
LIG_FHA_2 406 412 PF00498 0.398
LIG_FHA_2 486 492 PF00498 0.528
LIG_FHA_2 500 506 PF00498 0.359
LIG_Integrin_RGD_1 102 104 PF01839 0.813
LIG_LIR_Apic_2 305 311 PF02991 0.548
LIG_LIR_Gen_1 216 225 PF02991 0.533
LIG_LIR_Gen_1 304 314 PF02991 0.527
LIG_LIR_Gen_1 410 420 PF02991 0.396
LIG_LIR_Gen_1 455 462 PF02991 0.448
LIG_LIR_Nem_3 216 221 PF02991 0.517
LIG_LIR_Nem_3 304 309 PF02991 0.470
LIG_LIR_Nem_3 410 415 PF02991 0.390
LIG_LIR_Nem_3 436 441 PF02991 0.399
LIG_LIR_Nem_3 455 459 PF02991 0.192
LIG_LIR_Nem_3 464 470 PF02991 0.380
LIG_NRP_CendR_1 527 529 PF00754 0.760
LIG_PCNA_yPIPBox_3 4 13 PF02747 0.533
LIG_PTB_Apo_2 406 413 PF02174 0.400
LIG_PTB_Phospho_1 406 412 PF10480 0.402
LIG_SH2_CRK 376 380 PF00017 0.553
LIG_SH2_CRK 412 416 PF00017 0.376
LIG_SH2_GRB2like 423 426 PF00017 0.352
LIG_SH2_NCK_1 494 498 PF00017 0.468
LIG_SH2_PTP2 423 426 PF00017 0.367
LIG_SH2_SRC 462 465 PF00017 0.542
LIG_SH2_STAP1 412 416 PF00017 0.390
LIG_SH2_STAP1 462 466 PF00017 0.541
LIG_SH2_STAP1 494 498 PF00017 0.487
LIG_SH2_STAT3 439 442 PF00017 0.399
LIG_SH2_STAT5 195 198 PF00017 0.533
LIG_SH2_STAT5 320 323 PF00017 0.498
LIG_SH2_STAT5 423 426 PF00017 0.349
LIG_SH2_STAT5 439 442 PF00017 0.331
LIG_SH3_3 132 138 PF00018 0.520
LIG_SH3_3 183 189 PF00018 0.435
LIG_SH3_3 43 49 PF00018 0.570
LIG_SH3_3 497 503 PF00018 0.542
LIG_SH3_3 74 80 PF00018 0.756
LIG_SUMO_SIM_par_1 245 250 PF11976 0.555
LIG_SxIP_EBH_1 414 427 PF03271 0.431
LIG_TYR_ITAM 409 426 PF00017 0.404
LIG_TYR_ITIM 421 426 PF00017 0.361
LIG_UBA3_1 246 254 PF00899 0.655
LIG_UBA3_1 385 393 PF00899 0.555
LIG_UBA3_1 466 472 PF00899 0.557
LIG_WRC_WIRS_1 303 308 PF05994 0.488
LIG_WW_3 78 82 PF00397 0.667
MOD_CK1_1 493 499 PF00069 0.552
MOD_CK2_1 147 153 PF00069 0.520
MOD_CK2_1 210 216 PF00069 0.507
MOD_CK2_1 457 463 PF00069 0.439
MOD_CK2_1 485 491 PF00069 0.534
MOD_Cter_Amidation 525 528 PF01082 0.739
MOD_GlcNHglycan 165 168 PF01048 0.768
MOD_GlcNHglycan 249 252 PF01048 0.503
MOD_GlcNHglycan 81 84 PF01048 0.774
MOD_GlcNHglycan 89 92 PF01048 0.785
MOD_GSK3_1 288 295 PF00069 0.591
MOD_GSK3_1 330 337 PF00069 0.489
MOD_GSK3_1 448 455 PF00069 0.487
MOD_N-GLC_1 207 212 PF02516 0.298
MOD_N-GLC_1 428 433 PF02516 0.392
MOD_NEK2_1 16 21 PF00069 0.526
MOD_NEK2_1 196 201 PF00069 0.545
MOD_NEK2_1 247 252 PF00069 0.639
MOD_NEK2_1 294 299 PF00069 0.530
MOD_NEK2_1 319 324 PF00069 0.546
MOD_NEK2_1 457 462 PF00069 0.478
MOD_NEK2_1 485 490 PF00069 0.443
MOD_NEK2_1 87 92 PF00069 0.768
MOD_PIKK_1 196 202 PF00454 0.538
MOD_PIKK_1 334 340 PF00454 0.503
MOD_PIKK_1 357 363 PF00454 0.524
MOD_PIKK_1 440 446 PF00454 0.484
MOD_PKA_1 35 41 PF00069 0.526
MOD_PKA_2 147 153 PF00069 0.485
MOD_PKA_2 416 422 PF00069 0.415
MOD_PKA_2 485 491 PF00069 0.558
MOD_Plk_1 224 230 PF00069 0.539
MOD_Plk_1 428 434 PF00069 0.388
MOD_Plk_1 490 496 PF00069 0.526
MOD_Plk_4 294 300 PF00069 0.514
MOD_Plk_4 416 422 PF00069 0.407
MOD_Plk_4 452 458 PF00069 0.433
MOD_ProDKin_1 134 140 PF00069 0.555
MOD_ProDKin_1 499 505 PF00069 0.568
MOD_SUMO_for_1 253 256 PF00179 0.533
MOD_SUMO_rev_2 514 521 PF00179 0.588
TRG_DiLeu_BaEn_4 436 442 PF01217 0.399
TRG_DiLeu_BaLyEn_6 401 406 PF01217 0.393
TRG_ENDOCYTIC_2 376 379 PF00928 0.556
TRG_ENDOCYTIC_2 412 415 PF00928 0.380
TRG_ENDOCYTIC_2 423 426 PF00928 0.338
TRG_ENDOCYTIC_2 438 441 PF00928 0.381
TRG_ER_diArg_1 156 158 PF00400 0.667
TRG_ER_diArg_1 401 404 PF00400 0.558
TRG_NES_CRM1_1 18 29 PF08389 0.492
TRG_Pf-PMV_PEXEL_1 292 296 PF00026 0.479
TRG_Pf-PMV_PEXEL_1 377 382 PF00026 0.506

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4C0 Leptomonas seymouri 79% 99%
A0A0S4JP69 Bodo saltans 46% 100%
A0A1X0P4C7 Trypanosomatidae 48% 100%
A0A422NFN8 Trypanosoma rangeli 49% 100%
A4HFQ7 Leishmania braziliensis 88% 100%
A4I2T3 Leishmania infantum 100% 100%
D0A5Z7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9ADB1 Leishmania major 99% 100%
E9AZ36 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
V5BGH6 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS