Hypothetical_protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H7H6_LEIDO

TriTrypDb:

LdCL_270013900 , LDHU3_27.1140

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H7H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7H6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.469
CLV_NRD_NRD_1	160	162	PF00675	0.493
CLV_NRD_NRD_1	61	63	PF00675	0.289
CLV_PCSK_FUR_1	109	113	PF00082	0.283
CLV_PCSK_KEX2_1	108	110	PF00082	0.353
CLV_PCSK_KEX2_1	111	113	PF00082	0.283
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.415
CLV_PCSK_SKI1_1	5	9	PF00082	0.500
CLV_PCSK_SKI1_1	51	55	PF00082	0.363
DEG_APCC_DBOX_1	85	93	PF00400	0.334
DEG_Nend_UBRbox_1	1	4	PF02207	0.428
DOC_CYCLIN_RxL_1	47	56	PF00134	0.324
DOC_MAPK_gen_1	2	11	PF00069	0.400
DOC_MAPK_MEF2A_6	2	11	PF00069	0.445
DOC_PP1_RVXF_1	116	123	PF00149	0.324
DOC_USP7_MATH_1	21	25	PF00917	0.502
DOC_USP7_MATH_2	98	104	PF00917	0.295
LIG_14-3-3_CanoR_1	94	98	PF00244	0.296
LIG_Actin_WH2_2	76	92	PF00022	0.339
LIG_BRCT_BRCA1_1	126	130	PF00533	0.550
LIG_FHA_1	108	114	PF00498	0.412
LIG_FHA_1	143	149	PF00498	0.458
LIG_FHA_1	2	8	PF00498	0.506
LIG_FHA_2	28	34	PF00498	0.324
LIG_FHA_2	54	60	PF00498	0.465
LIG_LIR_Gen_1	4	14	PF02991	0.395
LIG_LIR_Nem_3	114	120	PF02991	0.361
LIG_LIR_Nem_3	127	133	PF02991	0.318
LIG_LIR_Nem_3	4	9	PF02991	0.395
LIG_SH2_STAT5	116	119	PF00017	0.457
LIG_SH2_STAT5	82	85	PF00017	0.459
LIG_SH3_3	20	26	PF00018	0.395
LIG_SUMO_SIM_par_1	132	139	PF11976	0.341
LIG_SUMO_SIM_par_1	17	24	PF11976	0.476
LIG_SUMO_SIM_par_1	51	56	PF11976	0.300
LIG_WRC_WIRS_1	119	124	PF05994	0.254
MOD_CK1_1	67	73	PF00069	0.375
MOD_CK2_1	118	124	PF00069	0.308
MOD_GlcNHglycan	151	154	PF01048	0.498
MOD_GlcNHglycan	83	86	PF01048	0.481
MOD_GSK3_1	142	149	PF00069	0.401
MOD_GSK3_1	96	103	PF00069	0.331
MOD_NEK2_1	1	6	PF00069	0.499
MOD_NEK2_1	107	112	PF00069	0.355
MOD_NEK2_1	146	151	PF00069	0.388
MOD_NEK2_1	53	58	PF00069	0.337
MOD_PIKK_1	53	59	PF00454	0.439
MOD_PKA_2	1	7	PF00069	0.401
MOD_PKA_2	93	99	PF00069	0.295
MOD_Plk_1	123	129	PF00069	0.357
MOD_Plk_1	142	148	PF00069	0.328
MOD_Plk_1	78	84	PF00069	0.359
MOD_Plk_4	124	130	PF00069	0.450
MOD_Plk_4	14	20	PF00069	0.585
MOD_Plk_4	78	84	PF00069	0.443
TRG_ENDOCYTIC_2	119	122	PF00928	0.482
TRG_ER_diArg_1	109	112	PF00400	0.369
TRG_NLS_MonoExtC_3	107	112	PF00514	0.315
TRG_NLS_MonoExtC_3	160	165	PF00514	0.265
TRG_NLS_MonoExtN_4	161	166	PF00514	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2C9	Leptomonas seymouri	42%	99%
A0A0S4JU13	Bodo saltans	28%	96%
A0A1X0P4U3	Trypanosomatidae	33%	98%
A0A3R7KEH5	Trypanosoma rangeli	32%	98%
A4HFL0	Leishmania braziliensis	66%	100%