Reductase_putative/GeneDB:LmjF.27.0730

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

reductase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7H5_LEIDO

TriTrypDb:

LdBPK_270580.1 , LdCL_270012300 , LDHU3_27.0950

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 17
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H7H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7H5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	22
GO:0016491	oxidoreductase activity	2	22
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	5	11
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	5	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	11
GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.469
CLV_NRD_NRD_1	123	125	PF00675	0.263
CLV_NRD_NRD_1	18	20	PF00675	0.651
CLV_NRD_NRD_1	219	221	PF00675	0.377
CLV_NRD_NRD_1	257	259	PF00675	0.256
CLV_NRD_NRD_1	41	43	PF00675	0.634
CLV_PCSK_KEX2_1	123	125	PF00082	0.286
CLV_PCSK_KEX2_1	18	20	PF00082	0.651
CLV_PCSK_KEX2_1	219	221	PF00082	0.384
CLV_PCSK_KEX2_1	257	259	PF00082	0.256
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.286
CLV_PCSK_SKI1_1	179	183	PF00082	0.355
CLV_PCSK_SKI1_1	206	210	PF00082	0.285
CLV_PCSK_SKI1_1	70	74	PF00082	0.303
DEG_APCC_DBOX_1	192	200	PF00400	0.370
DEG_Nend_UBRbox_1	1	4	PF02207	0.476
DEG_SCF_FBW7_1	282	289	PF00400	0.396
DOC_CKS1_1	105	110	PF01111	0.296
DOC_CYCLIN_RxL_1	67	77	PF00134	0.324
DOC_MAPK_gen_1	224	233	PF00069	0.382
DOC_MAPK_MEF2A_6	226	235	PF00069	0.379
DOC_PP1_RVXF_1	144	151	PF00149	0.302
DOC_PP1_RVXF_1	193	199	PF00149	0.286
DOC_PP4_FxxP_1	105	108	PF00568	0.303
DOC_PP4_FxxP_1	37	40	PF00568	0.500
DOC_SPAK_OSR1_1	2	6	PF12202	0.635
DOC_USP7_MATH_1	185	189	PF00917	0.416
DOC_WW_Pin1_4	104	109	PF00397	0.295
DOC_WW_Pin1_4	169	174	PF00397	0.270
DOC_WW_Pin1_4	282	287	PF00397	0.358
LIG_14-3-3_CanoR_1	179	185	PF00244	0.296
LIG_14-3-3_CanoR_1	193	199	PF00244	0.296
LIG_14-3-3_CanoR_1	2	12	PF00244	0.605
LIG_14-3-3_CanoR_1	257	261	PF00244	0.354
LIG_14-3-3_CanoR_1	45	54	PF00244	0.353
LIG_14-3-3_CanoR_1	83	89	PF00244	0.426
LIG_BRCT_BRCA1_1	146	150	PF00533	0.356
LIG_BRCT_BRCA1_1	196	200	PF00533	0.273
LIG_FHA_1	129	135	PF00498	0.296
LIG_FHA_1	170	176	PF00498	0.265
LIG_FHA_1	181	187	PF00498	0.222
LIG_FHA_1	228	234	PF00498	0.360
LIG_FHA_1	251	257	PF00498	0.417
LIG_FHA_1	61	67	PF00498	0.348
LIG_LIR_Apic_2	36	40	PF02991	0.501
LIG_LIR_Gen_1	172	182	PF02991	0.408
LIG_LIR_Nem_3	114	120	PF02991	0.304
LIG_LIR_Nem_3	142	148	PF02991	0.362
LIG_LIR_Nem_3	169	174	PF02991	0.402
LIG_LIR_Nem_3	244	250	PF02991	0.277
LIG_LIR_Nem_3	26	31	PF02991	0.520
LIG_LIR_Nem_3	48	54	PF02991	0.383
LIG_NRBOX	311	317	PF00104	0.337
LIG_PDZ_Class_2	324	329	PF00595	0.364
LIG_PTB_Apo_2	129	136	PF02174	0.345
LIG_SH2_CRK	106	110	PF00017	0.288
LIG_SH2_CRK	28	32	PF00017	0.638
LIG_SH2_GRB2like	321	324	PF00017	0.423
LIG_SH2_NCK_1	106	110	PF00017	0.295
LIG_SH2_STAP1	229	233	PF00017	0.299
LIG_SH2_STAT3	94	97	PF00017	0.302
LIG_SH2_STAT5	106	109	PF00017	0.288
LIG_SH2_STAT5	117	120	PF00017	0.288
LIG_SH2_STAT5	229	232	PF00017	0.295
LIG_SH2_STAT5	250	253	PF00017	0.382
LIG_TRAF2_1	262	265	PF00917	0.291
LIG_TRFH_1	80	84	PF08558	0.303
MOD_CK1_1	288	294	PF00069	0.477
MOD_CK2_1	73	79	PF00069	0.410
MOD_GlcNHglycan	20	23	PF01048	0.579
MOD_GlcNHglycan	293	296	PF01048	0.450
MOD_GSK3_1	107	114	PF00069	0.296
MOD_GSK3_1	282	289	PF00069	0.385
MOD_N-GLC_1	111	116	PF02516	0.295
MOD_N-GLC_1	201	206	PF02516	0.303
MOD_NEK2_1	144	149	PF00069	0.283
MOD_NEK2_1	293	298	PF00069	0.549
MOD_NEK2_1	3	8	PF00069	0.552
MOD_PIKK_1	45	51	PF00454	0.414
MOD_PKA_1	18	24	PF00069	0.482
MOD_PKA_2	17	23	PF00069	0.537
MOD_PKA_2	256	262	PF00069	0.411
MOD_Plk_4	139	145	PF00069	0.367
MOD_Plk_4	194	200	PF00069	0.270
MOD_ProDKin_1	104	110	PF00069	0.295
MOD_ProDKin_1	169	175	PF00069	0.270
MOD_ProDKin_1	282	288	PF00069	0.370
MOD_SUMO_rev_2	184	191	PF00179	0.461
TRG_DiLeu_BaEn_1	205	210	PF01217	0.295
TRG_DiLeu_BaEn_3	264	270	PF01217	0.323
TRG_DiLeu_BaLyEn_6	274	279	PF01217	0.415
TRG_ENDOCYTIC_2	106	109	PF00928	0.288
TRG_ENDOCYTIC_2	117	120	PF00928	0.288
TRG_ENDOCYTIC_2	28	31	PF00928	0.520
TRG_ER_diArg_1	17	19	PF00400	0.650
TRG_ER_diArg_1	219	221	PF00400	0.417
TRG_ER_diArg_1	256	258	PF00400	0.256

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L4	Leptomonas seymouri	28%	100%
A0A0N0P705	Leptomonas seymouri	29%	100%
A0A0N1I0P2	Leptomonas seymouri	24%	77%
A0A0N1I279	Leptomonas seymouri	41%	97%
A0A0N1IAZ4	Leptomonas seymouri	28%	100%
A0A0N1ILC4	Leptomonas seymouri	84%	100%
A0A0N1PBS9	Leptomonas seymouri	34%	100%
A0A0S4IMP5	Bodo saltans	42%	90%
A0A0S4ITW4	Bodo saltans	23%	80%
A0A0S4JV75	Bodo saltans	67%	93%
A0A0S4KHI4	Bodo saltans	31%	100%
A0A1X0NN09	Trypanosomatidae	25%	99%
A0A1X0NRH2	Trypanosomatidae	42%	100%
A0A1X0NT99	Trypanosomatidae	30%	100%
A0A1X0NTX4	Trypanosomatidae	28%	100%
A0A1X0NV22	Trypanosomatidae	30%	100%
A0A1X0NWV9	Trypanosomatidae	27%	83%
A0A1X0P541	Trypanosomatidae	69%	100%
A0A3Q8I8J2	Leishmania donovani	26%	100%
A0A3Q8I905	Leishmania donovani	22%	100%
A0A3Q8IBE7	Leishmania donovani	27%	88%
A0A3Q8ILI9	Leishmania donovani	30%	100%
A0A3R7JSY9	Trypanosoma rangeli	30%	100%
A0A3R7JUA9	Trypanosoma rangeli	26%	100%
A0A3R7JZZ7	Trypanosoma rangeli	46%	100%
A0A3R7MD20	Trypanosoma rangeli	31%	100%
A0A3S5H6T5	Leishmania donovani	32%	88%
A0A3S7X5Q8	Leishmania donovani	42%	97%
A0A422NMZ5	Trypanosoma rangeli	70%	100%
A1C7E9	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	30%	100%
A1CRK9	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	31%	100%
A1D4H0	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	30%	100%
A1DHW1	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	34%	100%
A2Q898	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	31%	100%
A2QCV4	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	31%	100%
A3GF86	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	31%	100%
A3LT66	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	30%	100%
A4H794	Leishmania braziliensis	28%	100%
A4H7X5	Leishmania braziliensis	35%	98%
A4HCD2	Leishmania braziliensis	28%	87%
A4HCD3	Leishmania braziliensis	30%	92%
A4HKM5	Leishmania braziliensis	40%	95%
A4HUT9	Leishmania infantum	22%	100%
A4HVN4	Leishmania infantum	26%	100%
A4HWA2	Leishmania infantum	32%	88%
A4HZV4	Leishmania infantum	30%	100%
A4HZV5	Leishmania infantum	27%	88%
A4I862	Leishmania infantum	39%	97%
A4QR21	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	31%	99%
A4R935	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	31%	100%
A5DQ25	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	30%	100%
A5DQE4	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	26%	100%
A5E5C5	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	28%	100%
A5E7U2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	29%	100%
A6R1T7	Ajellomyces capsulatus (strain NAm1 / WU24)	30%	100%
A6R2K7	Ajellomyces capsulatus (strain NAm1 / WU24)	33%	100%
A6SI59	Botryotinia fuckeliana (strain B05.10)	31%	95%
A6ZVM6	Saccharomyces cerevisiae (strain YJM789)	29%	100%
A6ZZH2	Saccharomyces cerevisiae (strain YJM789)	29%	100%
A7EKT5	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	31%	95%
A7THS1	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	32%	100%
A7TM72	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	28%	100%
B1AS42	Mus musculus	24%	100%
C9ZNT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZSH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZSH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A5S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
D0A6L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A7L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	85%
D0AAC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AD50	Leishmania major	96%	100%
E9AHE4	Leishmania infantum	100%	100%
E9ANH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9APD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AQ02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AVR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	88%
E9AVR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AYX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B313	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	95%
O74557	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P00387	Homo sapiens	31%	100%
P07514	Bos taurus	31%	100%
P0CP14	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	30%	100%
P0CP15	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	30%	100%
P20070	Rattus norvegicus	31%	100%
P36060	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P38626	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P83291	Arabidopsis thaliana	29%	100%
P83686	Sus scrofa	32%	100%
Q0CRD8	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	30%	100%
Q0CY37	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	35%	100%
Q0P487	Danio rerio	31%	100%
Q0U9W5	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	32%	98%
Q0UEY4	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	29%	100%
Q0X0E5	Canis lupus familiaris	32%	100%
Q12746	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
Q1DWN4	Coccidioides immitis (strain RS)	32%	100%
Q1DXN1	Coccidioides immitis (strain RS)	36%	100%
Q2HG02	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	27%	95%
Q2UFN3	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	33%	100%
Q2UKB8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	30%	100%
Q4P7Y8	Ustilago maydis (strain 521 / FGSC 9021)	30%	94%
Q4PGW7	Ustilago maydis (strain 521 / FGSC 9021)	31%	100%
Q4Q541	Leishmania major	41%	100%
Q4QBR9	Leishmania major	30%	100%
Q4QBS0	Leishmania major	26%	88%
Q4QFH9	Leishmania major	35%	100%
Q4QG48	Leishmania major	27%	100%
Q4QH53	Leishmania major	23%	100%
Q4WJW8	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	100%
Q4X0B5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	34%	100%
Q54NC1	Dictyostelium discoideum	30%	100%
Q59M70	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	100%
Q59P03	Candida albicans (strain SC5314 / ATCC MYA-2876)	32%	100%
Q5AZB4	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	33%	100%
Q5BG98	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	30%	100%
Q5BJ68	Xenopus tropicalis	33%	100%
Q5PQA4	Xenopus laevis	32%	100%
Q5ZHX7	Gallus gallus	33%	100%
Q60HG4	Macaca fascicularis	31%	100%
Q6BCY4	Homo sapiens	31%	100%
Q6BQ54	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	100%
Q6BUX2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	30%	100%
Q6C9G8	Yarrowia lipolytica (strain CLIB 122 / E 150)	30%	100%
Q6CID0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	100%
Q6CS27	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	30%	100%
Q6FLT3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	100%
Q6FUX5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	100%
Q6IPT4	Homo sapiens	25%	100%
Q75AL4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	100%
Q75C62	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q7RXL1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	100%
Q7SFY2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	96%
Q9DCN2	Mus musculus	31%	100%
Q9UR35	Mortierella alpina	31%	100%
Q9ZNT1	Arabidopsis thaliana	29%	100%
V5AQN7	Trypanosoma cruzi	24%	100%
V5AU35	Trypanosoma cruzi	68%	100%
V5B8B1	Trypanosoma cruzi	43%	100%
V5BVT5	Trypanosoma cruzi	31%	100%
V5DSW9	Trypanosoma cruzi	24%	88%