WD domain, G-beta repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7H4_LEIDO

TriTrypDb:

LdCL_270010700 , LDHU3_27.0750

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071011	precatalytic spliceosome	4	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S5H7H4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7H4

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	471	475	PF00656	0.467
CLV_C14_Caspase3-7	513	517	PF00656	0.552
CLV_C14_Caspase3-7	548	552	PF00656	0.413
CLV_NRD_NRD_1	189	191	PF00675	0.546
CLV_NRD_NRD_1	231	233	PF00675	0.713
CLV_NRD_NRD_1	260	262	PF00675	0.741
CLV_NRD_NRD_1	292	294	PF00675	0.491
CLV_NRD_NRD_1	380	382	PF00675	0.406
CLV_NRD_NRD_1	385	387	PF00675	0.396
CLV_NRD_NRD_1	485	487	PF00675	0.521
CLV_PCSK_KEX2_1	189	191	PF00082	0.421
CLV_PCSK_KEX2_1	262	264	PF00082	0.735
CLV_PCSK_KEX2_1	291	293	PF00082	0.511
CLV_PCSK_KEX2_1	385	387	PF00082	0.388
CLV_PCSK_KEX2_1	485	487	PF00082	0.608
CLV_PCSK_KEX2_1	71	73	PF00082	0.740
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.735
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.740
CLV_PCSK_PC7_1	381	387	PF00082	0.370
CLV_PCSK_PC7_1	481	487	PF00082	0.568
CLV_PCSK_SKI1_1	135	139	PF00082	0.397
CLV_PCSK_SKI1_1	180	184	PF00082	0.524
CLV_PCSK_SKI1_1	190	194	PF00082	0.351
CLV_PCSK_SKI1_1	593	597	PF00082	0.421
CLV_PCSK_SKI1_1	661	665	PF00082	0.516
CLV_Separin_Metazoa	497	501	PF03568	0.544
DEG_SPOP_SBC_1	234	238	PF00917	0.686
DEG_SPOP_SBC_1	545	549	PF00917	0.434
DEG_SPOP_SBC_1	7	11	PF00917	0.619
DOC_CYCLIN_yCln2_LP_2	280	286	PF00134	0.603
DOC_MAPK_gen_1	385	395	PF00069	0.481
DOC_MAPK_gen_1	557	566	PF00069	0.455
DOC_MAPK_MEF2A_6	560	568	PF00069	0.446
DOC_PP2B_LxvP_1	106	109	PF13499	0.389
DOC_PP2B_LxvP_1	139	142	PF13499	0.526
DOC_PP2B_LxvP_1	284	287	PF13499	0.547
DOC_PP4_FxxP_1	400	403	PF00568	0.507
DOC_USP7_MATH_1	133	137	PF00917	0.501
DOC_USP7_MATH_1	2	6	PF00917	0.616
DOC_USP7_MATH_1	234	238	PF00917	0.782
DOC_USP7_MATH_1	257	261	PF00917	0.725
DOC_USP7_MATH_1	332	336	PF00917	0.476
DOC_USP7_MATH_1	517	521	PF00917	0.513
DOC_USP7_MATH_1	57	61	PF00917	0.724
DOC_USP7_MATH_1	591	595	PF00917	0.480
DOC_USP7_MATH_1	64	68	PF00917	0.716
DOC_USP7_MATH_1	649	653	PF00917	0.451
DOC_USP7_MATH_1	659	663	PF00917	0.459
DOC_USP7_MATH_1	79	83	PF00917	0.393
DOC_USP7_MATH_1	8	12	PF00917	0.578
DOC_WW_Pin1_4	148	153	PF00397	0.441
DOC_WW_Pin1_4	180	185	PF00397	0.576
DOC_WW_Pin1_4	357	362	PF00397	0.393
LIG_14-3-3_CanoR_1	167	174	PF00244	0.641
LIG_14-3-3_CanoR_1	189	197	PF00244	0.550
LIG_14-3-3_CanoR_1	202	209	PF00244	0.402
LIG_14-3-3_CanoR_1	248	256	PF00244	0.677
LIG_14-3-3_CanoR_1	341	349	PF00244	0.505
LIG_14-3-3_CanoR_1	404	410	PF00244	0.576
LIG_14-3-3_CanoR_1	565	575	PF00244	0.478
LIG_14-3-3_CanoR_1	72	78	PF00244	0.688
LIG_Actin_WH2_2	579	595	PF00022	0.480
LIG_APCC_ABBA_1	99	104	PF00400	0.509
LIG_BIR_II_1	1	5	PF00653	0.675
LIG_BIR_III_1	1	5	PF00653	0.561
LIG_BIR_III_2	516	520	PF00653	0.536
LIG_BIR_III_3	1	5	PF00653	0.561
LIG_Clathr_ClatBox_1	451	455	PF01394	0.521
LIG_deltaCOP1_diTrp_1	272	279	PF00928	0.682
LIG_deltaCOP1_diTrp_1	627	636	PF00928	0.507
LIG_eIF4E_1	102	108	PF01652	0.388
LIG_FHA_1	177	183	PF00498	0.630
LIG_FHA_1	189	195	PF00498	0.528
LIG_FHA_1	390	396	PF00498	0.386
LIG_FHA_1	430	436	PF00498	0.389
LIG_FHA_1	474	480	PF00498	0.481
LIG_FHA_1	618	624	PF00498	0.355
LIG_FHA_2	113	119	PF00498	0.434
LIG_FHA_2	166	172	PF00498	0.580
LIG_FHA_2	457	463	PF00498	0.560
LIG_FHA_2	546	552	PF00498	0.587
LIG_FHA_2	565	571	PF00498	0.345
LIG_LIR_Apic_2	520	526	PF02991	0.505
LIG_LIR_Gen_1	115	125	PF02991	0.350
LIG_LIR_Gen_1	326	332	PF02991	0.505
LIG_LIR_Gen_1	360	368	PF02991	0.385
LIG_LIR_Gen_1	370	378	PF02991	0.338
LIG_LIR_Gen_1	633	643	PF02991	0.534
LIG_LIR_Gen_1	92	103	PF02991	0.394
LIG_LIR_Nem_3	115	120	PF02991	0.359
LIG_LIR_Nem_3	326	330	PF02991	0.481
LIG_LIR_Nem_3	360	366	PF02991	0.398
LIG_LIR_Nem_3	370	375	PF02991	0.334
LIG_LIR_Nem_3	463	469	PF02991	0.408
LIG_LIR_Nem_3	594	599	PF02991	0.462
LIG_LIR_Nem_3	633	639	PF02991	0.472
LIG_LIR_Nem_3	92	98	PF02991	0.396
LIG_LRP6_Inhibitor_1	45	51	PF00058	0.427
LIG_PCNA_yPIPBox_3	135	147	PF02747	0.509
LIG_Pex14_1	275	279	PF04695	0.680
LIG_Pex14_1	372	376	PF04695	0.380
LIG_SH2_CRK	466	470	PF00017	0.450
LIG_SH2_CRK	47	51	PF00017	0.523
LIG_SH2_CRK	523	527	PF00017	0.523
LIG_SH2_NCK_1	523	527	PF00017	0.422
LIG_SH2_PTP2	155	158	PF00017	0.518
LIG_SH2_SRC	102	105	PF00017	0.420
LIG_SH2_STAP1	117	121	PF00017	0.356
LIG_SH2_STAP1	685	689	PF00017	0.548
LIG_SH2_STAT5	102	105	PF00017	0.401
LIG_SH2_STAT5	155	158	PF00017	0.518
LIG_SH2_STAT5	466	469	PF00017	0.475
LIG_SH2_STAT5	523	526	PF00017	0.528
LIG_SH2_STAT5	527	530	PF00017	0.620
LIG_SH2_STAT5	575	578	PF00017	0.474
LIG_SH3_3	237	243	PF00018	0.671
LIG_SH3_3	264	270	PF00018	0.664
LIG_SUMO_SIM_anti_2	312	319	PF11976	0.494
LIG_SUMO_SIM_anti_2	494	500	PF11976	0.536
LIG_SUMO_SIM_anti_2	652	658	PF11976	0.448
LIG_SUMO_SIM_par_1	426	432	PF11976	0.357
LIG_SUMO_SIM_par_1	652	658	PF11976	0.422
LIG_TRAF2_1	311	314	PF00917	0.593
LIG_TYR_ITIM	45	50	PF00017	0.452
LIG_TYR_ITIM	464	469	PF00017	0.435
LIG_TYR_ITSM	113	120	PF00017	0.471
LIG_UBA3_1	193	198	PF00899	0.544
MOD_CDK_SPxK_1	148	154	PF00069	0.512
MOD_CK1_1	170	176	PF00069	0.580
MOD_CK1_1	3	9	PF00069	0.714
MOD_CK1_1	539	545	PF00069	0.686
MOD_CK2_1	112	118	PF00069	0.473
MOD_CK2_1	165	171	PF00069	0.598
MOD_CK2_1	307	313	PF00069	0.548
MOD_CK2_1	491	497	PF00069	0.567
MOD_CK2_1	91	97	PF00069	0.474
MOD_Cter_Amidation	69	72	PF01082	0.733
MOD_GlcNHglycan	237	240	PF01048	0.751
MOD_GlcNHglycan	309	312	PF01048	0.565
MOD_GlcNHglycan	400	403	PF01048	0.422
MOD_GlcNHglycan	444	447	PF01048	0.529
MOD_GlcNHglycan	470	473	PF01048	0.382
MOD_GlcNHglycan	59	62	PF01048	0.704
MOD_GlcNHglycan	593	596	PF01048	0.482
MOD_GlcNHglycan	646	649	PF01048	0.581
MOD_GlcNHglycan	650	654	PF01048	0.499
MOD_GlcNHglycan	673	676	PF01048	0.298
MOD_GlcNHglycan	68	71	PF01048	0.699
MOD_GlcNHglycan	685	688	PF01048	0.483
MOD_GlcNHglycan	73	76	PF01048	0.706
MOD_GSK3_1	172	179	PF00069	0.681
MOD_GSK3_1	2	9	PF00069	0.718
MOD_GSK3_1	247	254	PF00069	0.694
MOD_GSK3_1	347	354	PF00069	0.565
MOD_GSK3_1	389	396	PF00069	0.345
MOD_GSK3_1	411	418	PF00069	0.424
MOD_GSK3_1	456	463	PF00069	0.630
MOD_GSK3_1	517	524	PF00069	0.391
MOD_GSK3_1	535	542	PF00069	0.720
MOD_GSK3_1	666	673	PF00069	0.497
MOD_NEK2_1	393	398	PF00069	0.428
MOD_NEK2_1	415	420	PF00069	0.425
MOD_NEK2_1	468	473	PF00069	0.417
MOD_NEK2_1	553	558	PF00069	0.415
MOD_NEK2_1	576	581	PF00069	0.430
MOD_NEK2_1	643	648	PF00069	0.547
MOD_NEK2_1	666	671	PF00069	0.431
MOD_NEK2_1	91	96	PF00069	0.492
MOD_NEK2_2	608	613	PF00069	0.347
MOD_NEK2_2	619	624	PF00069	0.471
MOD_NEK2_2	659	664	PF00069	0.342
MOD_PIKK_1	517	523	PF00454	0.521
MOD_PIKK_1	546	552	PF00454	0.570
MOD_PKA_1	71	77	PF00069	0.728
MOD_PKA_2	188	194	PF00069	0.558
MOD_PKA_2	201	207	PF00069	0.384
MOD_PKA_2	247	253	PF00069	0.669
MOD_PKA_2	340	346	PF00069	0.521
MOD_PKA_2	350	356	PF00069	0.581
MOD_PKA_2	456	462	PF00069	0.443
MOD_PKA_2	564	570	PF00069	0.450
MOD_PKA_2	643	649	PF00069	0.505
MOD_PKA_2	71	77	PF00069	0.698
MOD_PKB_1	263	271	PF00069	0.510
MOD_Plk_1	170	176	PF00069	0.614
MOD_Plk_1	251	257	PF00069	0.637
MOD_Plk_1	539	545	PF00069	0.637
MOD_Plk_1	649	655	PF00069	0.430
MOD_Plk_4	112	118	PF00069	0.444
MOD_Plk_4	275	281	PF00069	0.614
MOD_Plk_4	405	411	PF00069	0.493
MOD_Plk_4	456	462	PF00069	0.607
MOD_Plk_4	475	481	PF00069	0.485
MOD_Plk_4	598	604	PF00069	0.471
MOD_Plk_4	608	614	PF00069	0.273
MOD_Plk_4	678	684	PF00069	0.437
MOD_ProDKin_1	148	154	PF00069	0.436
MOD_ProDKin_1	180	186	PF00069	0.564
MOD_ProDKin_1	357	363	PF00069	0.376
MOD_SUMO_rev_2	110	115	PF00179	0.495
MOD_SUMO_rev_2	228	234	PF00179	0.721
TRG_DiLeu_BaEn_4	122	128	PF01217	0.403
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.463
TRG_DiLeu_BaLyEn_6	605	610	PF01217	0.401
TRG_ENDOCYTIC_2	117	120	PF00928	0.358
TRG_ENDOCYTIC_2	155	158	PF00928	0.406
TRG_ENDOCYTIC_2	24	27	PF00928	0.398
TRG_ENDOCYTIC_2	466	469	PF00928	0.454
TRG_ENDOCYTIC_2	47	50	PF00928	0.444
TRG_ER_diArg_1	290	293	PF00400	0.511
TRG_ER_diArg_1	384	386	PF00400	0.401
TRG_NES_CRM1_1	97	111	PF08389	0.481
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYM3	Leptomonas seymouri	63%	100%
A0A1X0P521	Trypanosomatidae	31%	100%
A0A3R7KHV4	Trypanosoma rangeli	33%	100%
A4HFI4	Leishmania braziliensis	78%	100%
D0A5R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AD35	Leishmania major	93%	100%
E9AHC8	Leishmania infantum	99%	100%
E9AYV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q2TAY7	Homo sapiens	24%	100%
Q2TBS9	Bos taurus	24%	100%
Q3UKJ7	Mus musculus	24%	100%
Q5ZME8	Gallus gallus	25%	100%
Q6NRT3	Xenopus laevis	24%	100%
Q6P4J8	Xenopus tropicalis	24%	100%
Q76B40	Cricetulus griseus	24%	100%
Q7ZVA0	Danio rerio	23%	100%
Q99M63	Rattus norvegicus	24%	100%
V5B9I2	Trypanosoma cruzi	33%	100%