Autophagy-related protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

autophagy protein APG9, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H7H3_LEIDO

TriTrypDb:

LdBPK_270400.1 , LdCL_270008800 , LDHU3_27.0480

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0000407	phagophore assembly site	2	1
GO:0000502	proteasome complex	3	2
GO:0005737	cytoplasm	2	1
GO:0005773	vacuole	5	1
GO:0005776	autophagosome	6	1
GO:0016020	membrane	2	12
GO:0032991	protein-containing complex	1	2
GO:0034045	phagophore assembly site membrane	3	12
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1

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Expansion

Sequence features

A0A3S5H7H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H7H3

Function

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Biological processes
Term	Name	Level	Count
GO:0000422	autophagy of mitochondrion	4	1
GO:0006810	transport	3	12
GO:0006869	lipid transport	5	12
GO:0006914	autophagy	3	12
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009987	cellular process	1	12

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.500
CLV_C14_Caspase3-7	504	508	PF00656	0.516
CLV_C14_Caspase3-7	602	606	PF00656	0.659
CLV_C14_Caspase3-7	667	671	PF00656	0.706
CLV_NRD_NRD_1	371	373	PF00675	0.332
CLV_NRD_NRD_1	653	655	PF00675	0.595
CLV_NRD_NRD_1	716	718	PF00675	0.522
CLV_PCSK_KEX2_1	371	373	PF00082	0.318
CLV_PCSK_KEX2_1	567	569	PF00082	0.451
CLV_PCSK_KEX2_1	653	655	PF00082	0.595

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S4	Leptomonas seymouri	69%	100%
A0A0S4JRE4	Bodo saltans	29%	93%
A0A1X0P5B9	Trypanosomatidae	36%	100%
A0A422NTE4	Trypanosoma rangeli	36%	100%
D0A5N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AD16	Leishmania major	97%	100%
E9AHC0	Leishmania infantum	100%	100%
E9AIS5	Leishmania braziliensis	83%	100%
E9AYU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P0CM40	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	21%	83%

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